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 Education

School — Major — Degree Duration

高雄醫學大學 — 天然藥物研究所(畢) — 博士

Doctorate, Graduate Institute of Natural Products, Kaohsiung Medical University

2012/09 — 2019/06

高雄醫學大學 — 天然藥物研究所(畢) — 碩士

Master, Graduate Institute of Natural Products, Kaohsiung Medical University

2010/09 — 2012/06

高雄醫學大學 — 藥學系(畢) — 學士

Bachelor, School of Pharmacy, Kaohsiung Medical University

2006/09 — 2010/06

 Intramural Experience

Office/Department/Institute Position Duration
藥學系 School of Pharmacy   Assistant Professor 2024/08/01 —  

 Extramural Experience

 

 Discipline

NO Discipline Expertise
1 生物醫農類 Biology, Medicine and Agriculture 生物學之生化及分子生物 Biochemistry and Molecular Biology
2 生物醫農類 Biology, Medicine and Agriculture 藥理及毒理 Pharmacology and Toxicology
3 生物醫農類 Biology, Medicine and Agriculture 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology

 Research & Technology Platform Open to the Outside

Protein drug production, cryo-EM (single particle analysis), and protein crystallography

 Interested Area(s)for Interdisciplinary Research

天然產物化學、藥物化學、和 藥物劑型和遞送系統的設計

Natural product chemistry, Medicinal chemistry, and Design of drug dosage form and delivery system

 Area(s) of Expertise & Research

抗凝血劑和抗癌藥物開發、蛋白質藥物開發、結構生物學、冷凍電顯(單粒子分析)和 X 射線蛋白質晶體學

Discovery of anticoagulants and anti-cancer drugs, protein drug development, structural biology, cryo-electron microscopy (single particle analysis), and protein crystallography.

 Publication

NO Publication
1

Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun's lipoprotein from peptidoglycan.
Hsiu-Jung Wang, Víctor M. Hernández-Rocamora, Chiao-I Kuo, 謝侃言, Szu-Hui Lee, Meng-Ru Ho, Zhijay Tu, Waldemar Vollmer, Chung-I Chang - - 1 - MBIO - MBIO 2023 14卷(5期):e0137923頁
(IF: 5.1, 領域排名: 27, 領域期刊數: 161, 領域排名: 16.77%)

Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun's lipoprotein from peptidoglycan.
Hsiu-Jung Wang, Víctor M. Hernández-Rocamora, Chiao-I Kuo, Kan-Yen Hsieh, Szu-Hui Lee, Meng-Ru Ho, Zhijay Tu, Waldemar Vollmer, Chung-I Chang - - 1 - MBIO - MBIO 2023;14(5):e0137923
(IF: 5.1, Journal Ranking: 27, Number of Journals of this Field: 161, Ranking: 16.77%)

2

A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Shanshan Li, 謝侃言#, Chiao-I Kuo, Tzu-Chi Lin, Szu-Hui Lee, Yi-Ru Chen, Chun-Hsiung Wang, Meng-Ru Ho, See-Yeun Ting, Kaiming Zhang, Chung-I Chang - - 1 - NATURE COMMUNICATIONS - NATURE COMMUNICATIONS 2023 14卷(1期):7340頁
(IF: 14.7, 領域排名: 8, 領域期刊數: 134, 領域排名: 5.97%)

A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Shanshan Li, Kan-Yen Hsieh, Chiao-I Kuo, Tzu-Chi Lin, Szu-Hui Lee, Yi-Ru Chen, Chun-Hsiung Wang, Meng-Ru Ho, See-Yeun Ting, Kaiming Zhang, Chung-I Chang - - 1 - NATURE COMMUNICATIONS - NATURE COMMUNICATIONS 2023;14(1):7340
(IF: 14.7, Journal Ranking: 8, Number of Journals of this Field: 134, Ranking: 5.97%)

3

Structural Basis for the Peptidoglycan-Editing Activity of YfiH
Lee Meng-Sheng, 謝侃言, Kuo Chiao- I, Lee Szu-Hui, Garde Shambhavi, Reddy Manjula, Chang Chung- I - - 1 - MBIO - MBIO 2022 13卷(1期):e03646-21頁
(IF: 5.1, 領域排名: 27, 領域期刊數: 161, 領域排名: 16.77%)

Structural Basis for the Peptidoglycan-Editing Activity of YfiH
Lee Meng-Sheng, Hsieh Kan-Yen, Kuo Chiao- I, Lee Szu-Hui, Garde Shambhavi, Reddy Manjula, Chang Chung- I - - 1 - MBIO - MBIO 2022;13(1):e03646-21
(IF: 5.1, Journal Ranking: 27, Number of Journals of this Field: 161, Ranking: 16.77%)

4

Complete three-dimensional structures of the Lon protease translocating, a protein substrate
Li Shanshan, 謝侃言#, Kuo Chiao- I, Lee Szu-Hui, Pintilie Grigore D., Zhang Kaiming, Chang Chung- I - - 1 - SCIENCE ADVANCES - SCIENCE ADVANCES 2021 7卷(42期):eabj7835頁
(IF: 11.7, 領域排名: 11, 領域期刊數: 134, 領域排名: 8.21%)

Complete three-dimensional structures of the Lon protease translocating, a protein substrate
Li Shanshan, Hsieh Kan-Yen, Kuo Chiao- I, Lee Szu-Hui, Pintilie Grigore D., Zhang Kaiming, Chang Chung- I - - 1 - SCIENCE ADVANCES - SCIENCE ADVANCES 2021;7(42):eabj7835
(IF: 11.7, Journal Ranking: 11, Number of Journals of this Field: 134, Ranking: 8.21%)

5

Molecular basis for ATPase-powered substrate translocation by the Lon, AAA plus protease
Li Shanshan, 謝侃言, Su Shih-Chieh, Pintilie Grigore D., Zhang Kaiming, Chang Chung- I - - 1 - JOURNAL OF BIOLOGICAL CHEMISTRY - JOURNAL OF BIOLOGICAL CHEMISTRY 2021 297卷(4期):101239頁
(IF: 4, 領域排名: 100, 領域期刊數: 313, 領域排名: 31.95%)

Molecular basis for ATPase-powered substrate translocation by the Lon, AAA plus protease
Li Shanshan, Hsieh Kan-Yen, Su Shih-Chieh, Pintilie Grigore D., Zhang Kaiming, Chang Chung- I - - 1 - JOURNAL OF BIOLOGICAL CHEMISTRY - JOURNAL OF BIOLOGICAL CHEMISTRY 2021;297(4):101239
(IF: 4, Journal Ranking: 100, Number of Journals of this Field: 313, Ranking: 31.95%)

6

Processive cleavage of substrate at individual proteolytic active sites, of the Lon protease complex
Li Shanshan, 謝侃言#, Kuo Chiao- I, Su Shih-Chieh, Huang Kai-Fa, Zhang Kaiming, Chang Chung- I - - 1 - SCIENCE ADVANCES - SCIENCE ADVANCES 2021 7卷(46期):eabj9537頁
(IF: 11.7, 領域排名: 11, 領域期刊數: 134, 領域排名: 8.21%)

Processive cleavage of substrate at individual proteolytic active sites, of the Lon protease complex
Li Shanshan, Hsieh Kan-Yen, Kuo Chiao- I, Su Shih-Chieh, Huang Kai-Fa, Zhang Kaiming, Chang Chung- I - - 1 - SCIENCE ADVANCES - SCIENCE ADVANCES 2021;7(46):eabj9537
(IF: 11.7, Journal Ranking: 11, Number of Journals of this Field: 134, Ranking: 8.21%)

7

Design, synthesis and evaluation of antiproliferative activity of, fluorinated betulinic acid
Li Jizhen, Chang Ling-Chu, 謝侃言, Hsu Pei-Ling, Capuzzi Stephen J., Zhang Ying-Chao, Li Kang-Po, Morris-Natschke Susan L., Goto Masuo, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY - BIOORGANIC & MEDICINAL CHEMISTRY 2019 27卷(13期):2871-2882頁
(IF: 3.3, 領域排名: 10, 領域期刊數: 58, 領域排名: 17.24%)

Design, synthesis and evaluation of antiproliferative activity of, fluorinated betulinic acid
Li Jizhen, Chang Ling-Chu, Hsieh Kan-Yen, Hsu Pei-Ling, Capuzzi Stephen J., Zhang Ying-Chao, Li Kang-Po, Morris-Natschke Susan L., Goto Masuo, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY - BIOORGANIC & MEDICINAL CHEMISTRY 2019;27(13):2871-2882
(IF: 3.3, Journal Ranking: 10, Number of Journals of this Field: 58, Ranking: 17.24%)

8

Design, synthesis and potent cytotoxic activity of novel, 7-(<i>N</i>-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin, derivatives
Zhu Gao-Xiang, Cheng Pi-Le, Goto Masuo, Zhang Na, Morris-Natschke Susan L., 謝侃言, Yang Guan-Zhou, Yang Qian-Ru, Liu Ying-Qian, Chen Hai-Le, Zhang Xiao-Shuai, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2017 27卷(8期):1750-1753頁
(IF: 2.5, 領域排名: 16, 領域期刊數: 58, 領域排名: 27.59%)

Design, synthesis and potent cytotoxic activity of novel, 7-(<i>N</i>-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin, derivatives
Zhu Gao-Xiang, Cheng Pi-Le, Goto Masuo, Zhang Na, Morris-Natschke Susan L., Hsieh Kan-Yen, Yang Guan-Zhou, Yang Qian-Ru, Liu Ying-Qian, Chen Hai-Le, Zhang Xiao-Shuai, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2017;27(8):1750-1753
(IF: 2.5, Journal Ranking: 16, Number of Journals of this Field: 58, Ranking: 27.59%)

9

Design, synthesis, and cytotoxic activity of novel 7-substituted, camptothecin derivatives incorporating piperazinyl-sulfonylamidine, moieties
Yang Cheng-Jie, Song Zi-Long, Goto Masuo, Liu Ying-Qian, 謝侃言, Morris-Natschke Susan L., Zhao Yong-Long, Zhang Jun-Xiang, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2017 27卷(17期):3959-3962頁
(IF: 2.5, 領域排名: 16, 領域期刊數: 58, 領域排名: 27.59%)

Design, synthesis, and cytotoxic activity of novel 7-substituted, camptothecin derivatives incorporating piperazinyl-sulfonylamidine, moieties
Yang Cheng-Jie, Song Zi-Long, Goto Masuo, Liu Ying-Qian, Hsieh Kan-Yen, Morris-Natschke Susan L., Zhao Yong-Long, Zhang Jun-Xiang, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2017;27(17):3959-3962
(IF: 2.5, Journal Ranking: 16, Number of Journals of this Field: 58, Ranking: 27.59%)

10

Design, synthesis and structure-activity relationships of, (±)-isochaihulactone derivatives
Zhao Yu, Liu Po-Yen, 謝侃言, Hsu Pei-Ling, Goto Masuo, Morris-Natschke Susan L., Harn Horng-Jyh, Lee Kuo-Hsiung - - 1 - MEDCHEMCOMM - MEDCHEMCOMM 2017 8卷(11期):2040-2049頁
(IF: 5.121, 領域排名: 18, 領域期刊數: 63, 領域排名: 28.57%)

Design, synthesis and structure-activity relationships of, (±)-isochaihulactone derivatives
Zhao Yu, Liu Po-Yen, Hsieh Kan-Yen, Hsu Pei-Ling, Goto Masuo, Morris-Natschke Susan L., Harn Horng-Jyh, Lee Kuo-Hsiung - - 1 - MEDCHEMCOMM - MEDCHEMCOMM 2017;8(11):2040-2049
(IF: 5.121, Journal Ranking: 18, Number of Journals of this Field: 63, Ranking: 28.57%)

11

Alkaloids from <i>Oxytropis ochrocephala</i> and antiproliferative, activity of sophoridine derivatives against cancer cell lines
Tan Cheng-jian, Zhao Yu, Goto Masuo, 謝侃言, Yang Xiao-ming, Morris-Natschke Susan L., Liu Li-na, Zhao Bao-yu, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2016 26卷(5期):1495-1497頁
(IF: 2.5, 領域排名: 16, 領域期刊數: 58, 領域排名: 27.59%)

Alkaloids from <i>Oxytropis ochrocephala</i> and antiproliferative, activity of sophoridine derivatives against cancer cell lines
Tan Cheng-jian, Zhao Yu, Goto Masuo, Hsieh Kan-Yen, Yang Xiao-ming, Morris-Natschke Susan L., Liu Li-na, Zhao Bao-yu, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2016;26(5):1495-1497
(IF: 2.5, Journal Ranking: 16, Number of Journals of this Field: 58, Ranking: 27.59%)

12

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.
Sheng-Biao Wang, Xiao-Feng Wang, Bingjie Qin, Emika Ohkoshi, 謝侃言, Ernest Hamel, Mu-Tian Cui, Dong-Qing Zhu, Masuo Goto, Susan L Morris-Natschke, Kuo-Hsiung Lee, Lan Xie - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY - BIOORGANIC & MEDICINAL CHEMISTRY 2015 23卷(17期):5740-7頁
(IF: 3.3, 領域排名: 10, 領域期刊數: 58, 領域排名: 17.24%)

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.
Sheng-Biao Wang, Xiao-Feng Wang, Bingjie Qin, Emika Ohkoshi, Kan-Yen Hsieh, Ernest Hamel, Mu-Tian Cui, Dong-Qing Zhu, Masuo Goto, Susan L Morris-Natschke, Kuo-Hsiung Lee, Lan Xie - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY - BIOORGANIC & MEDICINAL CHEMISTRY 2015;23(17):5740-7
(IF: 3.3, Journal Ranking: 10, Number of Journals of this Field: 58, Ranking: 17.24%)

13

Selective cytotoxic eremophilane-type sesquiterpenes from <i>Penicillium, citreonigrum</i>
Yuan Wei-Hua, Goto Masuo, 謝侃言, Yuan Bo, Zhao Yu, Morris-Natschke Susan. L., Lee Kuo-Hsiung - - 1 - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2015 17卷(12期):1239-1244頁
(IF: 1.3, 領域排名: 166, 領域期刊數: 265, 領域排名: 62.64%)

Selective cytotoxic eremophilane-type sesquiterpenes from <i>Penicillium, citreonigrum</i>
Yuan Wei-Hua, Goto Masuo, Hsieh Kan-Yen, Yuan Bo, Zhao Yu, Morris-Natschke Susan. L., Lee Kuo-Hsiung - - 1 - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2015;17(12):1239-1244
(IF: 1.3, Journal Ranking: 166, Number of Journals of this Field: 265, Ranking: 62.64%)

14

Multidrug resistance-selective antiproliferative activity of, <i>Piper</i> amide alkaloids and synthetic analogues
Wang Yue-Hu, Goto Masuo, Wang Li-Ting, 謝侃言, Morris-Natschke Susan L., Tang Gui-Hua, Long Chun-Lin, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2014 24卷(20期):4818-4821頁
(IF: 2.5, 領域排名: 16, 領域期刊數: 58, 領域排名: 27.59%)

Multidrug resistance-selective antiproliferative activity of, <i>Piper</i> amide alkaloids and synthetic analogues
Wang Yue-Hu, Goto Masuo, Wang Li-Ting, Hsieh Kan-Yen, Morris-Natschke Susan L., Tang Gui-Hua, Long Chun-Lin, Lee Kuo-Hsiung - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2014;24(20):4818-4821
(IF: 2.5, Journal Ranking: 16, Number of Journals of this Field: 58, Ranking: 27.59%)

 Project

 

 Patent