Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學大學 — 天然藥物研究所(畢) — 博士 Doctorate, Graduate Institute of Natural Products, Kaohsiung Medical University |
2012/09 — 2019/06 |
|
高雄醫學大學 — 天然藥物研究所(畢) — 碩士 Master, Graduate Institute of Natural Products, Kaohsiung Medical University |
2010/09 — 2012/06 |
|
高雄醫學大學 — 藥學系(畢) — 學士 Bachelor, School of Pharmacy, Kaohsiung Medical University |
2006/09 — 2010/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 藥學系 School of Pharmacy | Assistant Professor | 2024/08/01 — |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 生物學之生化及分子生物 Biochemistry and Molecular Biology |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 藥理及毒理 Pharmacology and Toxicology |
| 3 | 生物醫農類 Biology, Medicine and Agriculture | 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
天然產物化學、藥物化學、和 藥物劑型和遞送系統的設計
Natural product chemistry, Medicinal chemistry, and Design of drug dosage form and delivery system
Area(s) of Expertise & Research
抗凝血劑和抗癌藥物開發、蛋白質藥物開發、結構生物學、冷凍電顯（單粒子分析）和 X 射線蛋白質晶體學
Discovery of anticoagulants and anti-cancer drugs, protein drug development, structural biology, cryo-electron microscopy (single particle analysis), and protein crystallography.
Publication
| NO | Publication |
|---|---|
| 1 | Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun's lipoprotein from peptidoglycan. Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun's lipoprotein from peptidoglycan. |
| 2 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. |
| 3 | Structural Basis for the Peptidoglycan-Editing Activity of YfiH Structural Basis for the Peptidoglycan-Editing Activity of YfiH |
| 4 | Complete three-dimensional structures of the Lon protease translocating, a protein substrate Complete three-dimensional structures of the Lon protease translocating, a protein substrate |
| 5 | Molecular basis for ATPase-powered substrate translocation by the Lon, AAA plus protease Molecular basis for ATPase-powered substrate translocation by the Lon, AAA plus protease |
| 6 | Processive cleavage of substrate at individual proteolytic active sites, of the Lon protease complex Processive cleavage of substrate at individual proteolytic active sites, of the Lon protease complex |
| 7 | Design, synthesis and evaluation of antiproliferative activity of, fluorinated betulinic acid Design, synthesis and evaluation of antiproliferative activity of, fluorinated betulinic acid |
| 8 | Design, synthesis and potent cytotoxic activity of novel, 7-(<i>N</i>-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin, derivatives Design, synthesis and potent cytotoxic activity of novel, 7-(<i>N</i>-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin, derivatives |
| 9 | Design, synthesis, and cytotoxic activity of novel 7-substituted, camptothecin derivatives incorporating piperazinyl-sulfonylamidine, moieties Design, synthesis, and cytotoxic activity of novel 7-substituted, camptothecin derivatives incorporating piperazinyl-sulfonylamidine, moieties |
| 10 | Design, synthesis and structure-activity relationships of, (±)-isochaihulactone derivatives Design, synthesis and structure-activity relationships of, (±)-isochaihulactone derivatives |
| 11 | Alkaloids from <i>Oxytropis ochrocephala</i> and antiproliferative, activity of sophoridine derivatives against cancer cell lines Alkaloids from <i>Oxytropis ochrocephala</i> and antiproliferative, activity of sophoridine derivatives against cancer cell lines |
| 12 | Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors. Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors. |
| 13 | Selective cytotoxic eremophilane-type sesquiterpenes from <i>Penicillium, citreonigrum</i> Selective cytotoxic eremophilane-type sesquiterpenes from <i>Penicillium, citreonigrum</i> |
| 14 | Multidrug resistance-selective antiproliferative activity of, <i>Piper</i> amide alkaloids and synthetic analogues Multidrug resistance-selective antiproliferative activity of, <i>Piper</i> amide alkaloids and synthetic analogues |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
114 — KK 高科大高醫產學合作補助 — — 3 產學合作
新型單原子 Cu –N–C 觸媒之開發：高效合成吲哚骨架並應用於細胞毒殺與抗癌藥理活性之研究( )
|
2026/01/01 ~ 2026/12/31 |
| 2 |
113 — KK 高科大高醫產學合作補助 — — 3 產學合作
高效能單金屬催化劑同時於電催化高產量過氧化氫並應用於水質抑菌之處理( )
|
2025/01/01 ~ 2025/12/31 |
| 3 |
113 — N 國科會(原科技部) — NSTC114-2320-B-037-004 — 1 個人型
以Tissue factor-FVIIa-FXa三元複合體結構為基礎的藥物開發( )
|
2025/01/01 ~ 2026/07/31 |
| 4 |
113 — Q 新聘教師計畫(校內) — KMU-Q114001 —
Tissue factor複合體形成分子機制之探討以及tissue factor抑制劑的開發( )
|
2025/01/01 ~ 2025/12/31 |