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 Education

School — Major — Degree Duration

國立臺灣大學 — 植物科學研究所(畢) — 博士

Doctorate, Institute of Plant Science, National Taiwan University

2000/09 — 2006/06

 Intramural Experience

Office/Department/Institute Position Duration
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology   Chair 2021/08/01 — 2024/07/31
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology   Associate Professor 2015/08/01 —  
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology   Assistant Professor 2010/08/01 — 2015/07/31

 Extramural Experience

 

 Discipline

 

 Research & Technology Platform Open to the Outside

HUVEC

 Interested Area(s)for Interdisciplinary Research

癌症病理機制, 奈米感應器, 巨分子分析, biomarker

 

 Area(s) of Expertise & Research

1. 蛋白質修飾體學 2. 氣體分子生理 3. 心血管疾病機制 4. 粒線體移轉 5. 流體剪力與拉伸力

1. Post-translational modifiomics 2. Gaseous molecules physiology 3. Cardiovascular pathology 4. Mitochondrial transfer 5. Shear force and stretch

 Publication

NO Publication
1

Endothelial Mitochondria Transfer to Melanoma Induces M2-Type Macrophage Polarization and Promotes Tumor Growth by the Nrf2/HO-1-Mediated Pathway.
郭富珍,蔡忻誼,鄭必伶,蔡坤璋,陳品蓁,黃耀斌,劉忠榮,吳登強,吳孟杰,黃斌*,林明瑋* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024 25卷(3期):1857頁
(IF: 5.6, 領域排名: 66, 領域期刊數: 285, 領域排名: 23.16%)

Endothelial Mitochondria Transfer to Melanoma Induces M2-Type Macrophage Polarization and Promotes Tumor Growth by the Nrf2/HO-1-Mediated Pathway.
Fu-Chen Kuo, Hsin-Yi Tsai, Bi-Ling Cheng, Kuen-Jang Tsai, Ping-Chen Chen, Yaw-Bin Huang, Chung-Jung Liu, Deng-Chyang Wu, Meng-Chieh Wu, Bin Huang*, Ming-Wei Lin* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024;25(3):1857
(IF: 5.6, Journal Ranking: 66, Number of Journals of this Field: 285, Ranking: 23.16%)

2

線粒體代謝、AMPK-SIRT 介導的通路、LncRNA 和 MicroRNA 在骨關節炎中的作用
劉皓宇, 張綺芬, 盧政昌, 吳順成, 黃斌, 鄭琮霖, 林松彥, 何承融, 李孟娟, 楊忠達, 王應鈞, 李忠佑, 劉秉政, 魏春旺*, 康琳*, 陳崇桓* - - 1 - Biomedicines - BIOMEDICINES 2022 10卷(7期):1477頁
(IF: 4.757, 領域排名: 86, 領域期刊數: 279, 領域排名: 30.82%)

The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis
Liu, Hao-Yu, Chi-Fen Chang, Cheng-Chang Lu, Shun-Cheng Wu, Bin Huang, Tsung-Lin Cheng, Sung-Yen Lin, Cheng-Jung Ho, Mon-Juan Lee, Chung-Da Yang, Ying-Chun Wang, Jhong-You Li, Ping-Cheng Liu, Chun-Wang Wei*, Lin Kang*, & Chung-Hwan Chen* - - 1 - Biomedicines - BIOMEDICINES 2022;10(7):1477
(IF: 4.757, Journal Ranking: 86, Number of Journals of this Field: 279, Ranking: 30.82%)

3

Novel recombinant keratin degrading subtilisin like serine alkaline protease from Bacillus cereus isolated from marine hydrothermal vent crabs
Gurunathan Revathi, 黃斌, 庫碼, 黃將修*, 譚漢詩* - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2021 11卷(1期):12007頁
(IF: 4.996, 領域排名: 19, 領域期刊數: 73, 領域排名: 26.03%)

Novel recombinant keratin degrading subtilisin like serine alkaline protease from Bacillus cereus isolated from marine hydrothermal vent crabs
Gurunathan Revathi, Huang Bin, Ponnusamy Vinoth Kumar, Hwang Jiang-Shiou*, Dahms Hans-Uwe* - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2021;11(1):12007
(IF: 4.996, Journal Ranking: 19, Number of Journals of this Field: 73, Ranking: 26.03%)

4

CYP26A1新穎標記與檳榔相關口腔及咽癌
陳丙何, 鍾加明, 汪硯雲, 黃弘文, 黃斌, 李家和, 袁行修, 吳哲維, 林莉萱, 曾良鵬* - - 1 - Diagnostics (Basel, Switzerland) - DIAGNOSTICS 2020 10卷(11期):982頁
(IF: 3.706, 領域排名: 45, 領域期刊數: 169, 領域排名: 26.63%)

CYP26A1 Is a Novel Biomarker for Betel Quid-Related Oral and Pharyngeal Cancers.
Ping-Ho Chen, Chia-Min Chung, Yen-Yun Wang, Hurng-Wern Huang, Bin Huang, Ka-Wo Lee, Shyng-Shiou Yuan, Che-Wei Wu, Lee-Shuan Lin, Leong-Perng Chan* - - 1 - Diagnostics (Basel, Switzerland) - DIAGNOSTICS 2020;10(11):982
(IF: 3.706, Journal Ranking: 45, Number of Journals of this Field: 169, Ranking: 26.63%)

5

檳榔鹼促進血管內皮細胞一氧化氮合成以及蛋白質轉譯後硝基化修飾
Chien-Yi Wu, Wun-Rong Lin, Cherng-Jye Jeng, Chien-Hsing Wu, 黃斌* - - 2 - Current Proteomics - 2020 17卷(3期):172-179頁
(IF: 0, 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Arecoline Increases the Production of Nitric Oxide and Post-Translational S-Nitrosoproteome in Endothelial Cells
Chien-Yi Wu, Wun-Rong Lin, Cherng-Jye Jeng, Chien-Hsing Wu, Bin Huang* - - 2 - Current Proteomics - 2020;17(3):172-179
(IF: 0, Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

6

阿拉比卡咖啡誘導多被體體胚形成與再生
王憶潔, 林孟澤, 黃斌, 鍾曉航, 陳彥澄 - - 1 - ACTA BIOLOGICA CRACOVIENSIA Series Botanica - ACTA BIOLOGICA CRACOVIENSIA SERIES BOTANICA 2019 60卷(2期):35-44頁
(IF: 1.111, 領域排名: 147, 領域期刊數: 228, 領域排名: 64.47%)

Thidiazuron enhanced somatic embryogenesis from callus lines of arabica coffee and subsequent plant regeneration.
YI-CHIEH WANG, MENG-ZE LIN, BIN HUANG, HSIAO-HANG CHUNG, JEN-TSUNG CHEN - - 1 - ACTA BIOLOGICA CRACOVIENSIA Series Botanica - ACTA BIOLOGICA CRACOVIENSIA SERIES BOTANICA 2019;60(2):35-44
(IF: 1.111, Journal Ranking: 147, Number of Journals of this Field: 228, Ranking: 64.47%)

7

Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma
楊明慧,陳宛柔,傅耀賢,黃斌,蔡婉琪,陳宜民,林柏樵,袁景輝,田育彰 - - 1 - Oncotarget - Oncotarget 2018 9卷(1期):442-452頁
(IF: 5.168, 領域排名: 44, 領域期刊數: 217, 領域排名: 20.28%)

Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma
Ming-Hui Yang, Wan-Jou Chen, Yaw-Syan Fu, Bin Huang, Wan-Chi Tsai, Yi- Ming Arthur Chen, Po-Chiao Lin, Cheng-Hui Yuan and Yu-Chang Tyan - - 1 - Oncotarget - Oncotarget 2018;9(1):442-452
(IF: 5.168, Journal Ranking: 44, Number of Journals of this Field: 217, Ranking: 20.28%)

8

在化學與生理條件下具生物啟發性的銅一價化合物的NO釋放研究
莊宛蓉, Manmath Narwane, 陳信允, 高佳麟, 黃斌, 許冠美, 王雲銘*, 許智能* - - 1 - Dalton Trans. - DALTON TRANSACTIONS 2018 47卷(47期):13151-13157頁
(IF: 4.099, 領域排名: 6, 領域期刊數: 45, 領域排名: 13.33%)

Nitric oxide-release study of a bio-inspired copper(I)-nitrito complex under chemical and biological conditions
Wan-Jung Chuang, Manmath Narwane, Hsing-Yin Chen, Chai-Lin Kao, Bin Huang, Kuang-Mei Hsu, Yun-Ming Wang* and Sodio C. N. Hsu * - - 1 - Dalton Trans. - DALTON TRANSACTIONS 2018;47(47):13151-13157
(IF: 4.099, Journal Ranking: 6, Number of Journals of this Field: 45, Ranking: 13.33%)

9

喜樹鹼促進內皮細胞一氧化氮合成以及蛋白質硝基化修飾
黃斌*, 鄭仁坤, 吳建儀, 陳丙何, 涂柏澍, 傅耀賢*, 吳建興* - - 1 - Vascular Pharmacology - Vasc Pharmacol 2017 90卷(0期):27-35頁
(IF: 3.607, 領域排名: 59, 領域期刊數: 261, 領域排名: 22.61%)

Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells
Bin Huang, Jen-Kun Cheng, Chien-Yi Wug, Ping-Ho Chen, Po-Shu Tu, Yaw-Syan Fu, Chien-Hsing Wu - - 1 - Vascular Pharmacology - Vasc Pharmacol 2017;90(0):27-35
(IF: 3.607, Journal Ranking: 59, Number of Journals of this Field: 261, Ranking: 22.61%)

10

流體剪力促進內皮細胞中硫化氫生成以及一氧化氮的訊息傳遞
黃斌,陳長廷,陳綺霞,王雲銘,謝學真*,王寧* - - 1 - Biochemical and Biophysical Research Communications - Biochem Biophys Res Commun 2015 464卷(4期):1254-9頁
(IF: 2.297, 領域排名: 41, 領域期刊數: 73, 領域排名: 56.16%)

Laminar shear flow increases hydrogen sulfide and activates a nitric oxide producing signaling cascade in endothelial cells
Bin Huang,Chang-Ting Chen,Chi-Shia Chen,Yun-Ming Wang,Hsyue-Jen Hsiehe*,Danny Ling Wang* - - 1 - Biochemical and Biophysical Research Communications - Biochem Biophys Res Commun 2015;464(4):1254-9
(IF: 2.297, Journal Ranking: 41, Number of Journals of this Field: 73, Ranking: 56.16%)

11

硫化氫調控內皮細胞蛋白質硝基化與粒線體型態
邱讚旺,陳應龍,吳建儀,余培泠,謝瀛華,黃斌* - - 1 - Acta Cardiologica Sinica - Acta Cardiologica Sinica 2015 In press卷(in press期):in press頁
(IF: 0.331, 領域排名: 121, 領域期刊數: 123, 領域排名: 98.37%)

Hydrogen sulfide modulates the S-nitrosoproteome and the mitochondrial morphology in endothelial cells
Tsan-Wan Chiu,Ying-Lun Chen,Chien-Yi Wu,Pei-Ling Yu,Ying-Hua Shieh,Bin Huang* - - 1 - Acta Cardiologica Sinica - Acta Cardiologica Sinica 2015;In press(in press):in press
(IF: 0.331, Journal Ranking: 121, Number of Journals of this Field: 123, Ranking: 98.37%)

12

若舒伐他汀藥物調控血管內皮細胞的乙醯基化質體
林明忠, 邢中熹, 李福安,吳建興,傅耀賢,鄭仁坤, 黃斌* - - 1 - Acta Cardiologica Sinica - Acta Cardiologica Sinica 2014 30卷(1期):67-73頁
(IF: 0.331, 領域排名: 121, 領域期刊數: 123, 領域排名: 98.37%)

Rosuvastatin modulates the post-translational acetylome in endothelial cells.
Ming Chung Lin, Chung Hsi Hsing, Fu An Li, Chien Hsing Wu, Yaw Syan Fu , Jen Kun Cheng, Bin Huang* - - 1 - Acta Cardiologica Sinica - Acta Cardiologica Sinica 2014;30(1):67-73
(IF: 0.331, Journal Ranking: 121, Number of Journals of this Field: 123, Ranking: 98.37%)

13

流體力學又導內皮細胞的機械力傳導:活性氧家族以及一氧化氮的交互關係
謝學真, 劉靜安, 黃斌, 曾曉慧, 王寧* - - 1 - Journal of Biomedical Science - J BIOMED SCI 2014 21卷(-期):3頁
(IF: 2.736, 領域排名: 49, 領域期刊數: 124, 領域排名: 39.52%)

Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications.
Hsyue-Jen Hsieh, Ching-Ann Liu, Bin Huang, Anne H.H. Tseng and Danny Ling Wang. - - 1 - Journal of Biomedical Science - J BIOMED SCI 2014;21(-):3
(IF: 2.736, Journal Ranking: 49, Number of Journals of this Field: 124, Ranking: 39.52%)

14

20(S)-protopanaxadiol人蔘皂苷調控的內皮蛋白質體
謝瀛華,陳健全, 李福安, 鄭仁坤, 林明忠, 黃斌* - - 1 - Acta Cardiologica Sinica - Acta Cardiologica Sinica 2014 4卷(1期):23頁
(IF: 0.331, 領域排名: 121, 領域期刊數: 123, 領域排名: 98.37%)

The translational proteome modulated by 20(S)-protopanaxadiol in endothelial cells
Ying Hua Shieh, Chien Chuan Chen, Fu An Li, Jen Kun Cheng, Ming Chung Lin, Bin Huang* - - 1 - Acta Cardiologica Sinica - Acta Cardiologica Sinica 2014;4(1):23
(IF: 0.331, Journal Ranking: 121, Number of Journals of this Field: 123, Ranking: 98.37%)

15

Leucine rich domain 與 NT2/D1細胞中 LRWD1 蛋白質穩定度的相互關係
蔡永杰, 鄧燕妮, 洪瑞祥, 吳健興, 郭昱廷, 郭保麟, 邱建智, 黃斌* - - 1 - Advances in Medical Sciences - Adv Med Sci 2014 59卷(2期):266-272頁
(IF: 1.105, 領域排名: 102, 領域期刊數: 123, 領域排名: 82.93%)

Correlation between leucine rich domain and the stability of LRWD1 protein in human NT2/D1 cells
Yung Chieh Tsai, Yen Ni Teng, Jui Hsiang Hung, Chien Hsing Wu, Yu Ting Kuo, Pao Lin Kuo, Chien Chih Chiu, Bin Huang* - - 1 - Advances in Medical Sciences - Adv Med Sci 2014;59(2):266-272
(IF: 1.105, Journal Ranking: 102, Number of Journals of this Field: 123, Ranking: 82.93%)

16

Arsenic Modulates Posttranslational S-Nitrosylation and Translational Proteome in Keratinocytes
黃斌, 江國豪, 余幸司, 陳應龍, 尤慧玲, 廖偉廷* - - 1 - Scientific World Journal - SCI WORLD J 2014 2014卷(-期):360153頁
(IF: 1.219, 領域排名: 16, 領域期刊數: 55, 領域排名: 29.09%)

Arsenic Modulates Posttranslational S-Nitrosylation and Translational Proteome in Keratinocytes
Bin Huang, Kuo-Hao Chiang, Hsin-Su Yu, Ying-Lun Chen, Huey-Ling You, Wei-Ting Liao* - - 1 - Scientific World Journal - SCI WORLD J 2014;2014(-):360153
(IF: 1.219, Journal Ranking: 16, Number of Journals of this Field: 55, Ranking: 29.09%)

17

CYP26B1的差異表現與檳榔引起口腔癌的關係
陳丙何,李家和,許正傑,陳逸夫,王彥雄,陳克恭,王惠民,黃弘文*,黃耀斌*,黃斌 - - 1 - Scientific World Journal - SCI WORLD J 2014 2014卷(-期):810561頁
(IF: 1.219, 領域排名: 16, 領域期刊數: 55, 領域排名: 29.09%)

Expression of a Splice Variant of CYP26B1 in Betel Quid-Related Oral Cancer
Ping-Ho Chen, Ka-Wo Lee, Cheng-Chieh Hsu, Jeff Yi-Fu Chen, Yan-Hsiung Wang, Ker-Kong Chen, Hui-Min David Wang, Hurng-Wern Huang*, Bin Huang* - - 1 - Scientific World Journal - SCI WORLD J 2014;2014(-):810561
(IF: 1.219, Journal Ranking: 16, Number of Journals of this Field: 55, Ranking: 29.09%)

18

若舒伐他汀藥物調控血管內皮細胞的磷酸化質體
黃斌, 吳建興, 李福安, 梁世欣, 謝瀛華, 王寧* - - 1 - Kaohsiung Journal of Medical Sciences - Kaohsiung J Med Sci 2013 29卷(7期):347-352頁
(IF: 0.805, 領域排名: 101, 領域期刊數: 122, 領域排名: 82.79%)

Rosuvastatin-regulated post-translational phosphoproteome in human umbilical vein endothelial cells
Bin Huang, Chien-Hsing Wu, Fu-An Li, Shih-Shin Liang, Ying-Hua Shieh, Ling Danny Wang - - 1 - Kaohsiung Journal of Medical Sciences - Kaohsiung J Med Sci 2013;29(7):347-352
(IF: 0.805, Journal Ranking: 101, Number of Journals of this Field: 122, Ranking: 82.79%)

19

血管內皮細胞中一氧化氮調控若舒伐他汀藥物所調控的硝基化與蛋白質體
黃斌,李福安, 吳建興,王寧 - - 1 - Proteome Science - Proteome Sci 2012 10卷(1期):43頁
(IF: 2.42, 領域排名: 37, 領域期刊數: 75, 領域排名: 49.33%)

The role of nitric oxide on rosuvastatin-mediated S-nitrosylation and translational proteomes in human umbilical vein endothelial cells.
Bin Huang, Fu An Li, Chien Hsing Wu, Danny Ling Wang - - 1 - Proteome Science - Proteome Sci 2012;10(1):43
(IF: 2.42, Journal Ranking: 37, Number of Journals of this Field: 75, Ranking: 49.33%)

20

香茹的粗萃取物對血管內皮細胞的蛋白質體及轉譯後硝酸化蛋白質體之研究
王朝平, 洪哲穎, 許夏芬, 陳翰容, 黃斌, 洪尉欽, 尤登弘, 邱正安, 盧麗芬, 許家彰* - - 9 - Taiwania - 2011 56卷(2期):97-104頁
(IF: 0, 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Glossogyne tenuifolia Enhances Posttranslational S-Nitrosylation of Proteins in Vascular Endothelial Cells
Chao-Ping Wang, Jer-Yiing Houng, Hsia-Fen Hsu, Han-Jung Chen, Bin Huang, Wei-Chin Hung, Teng-Hung Yu, Cheng-An Chiu, Li-Fen Lu, Chia-Chang Hsu* - - 9 - Taiwania - 2011;56(2):97-104
(IF: 0, Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

21

單蔘酚酸抑制謝館內皮細胞中IFN-γ所誘導的JAK/STAT1 表現
陳識中, 林雲蓮, 黃斌, 王寧, 鄭靜枝* - - 1 - Thrombosis Research - THROMB RES 2011 128卷(6期):560-564頁
(IF: 2.372, 領域排名: 30, 領域期刊數: 66, 領域排名: 45.45%)

Salvianolic Acid B Suppresses IFN-γ-Induced JAK/STAT1 Activation in Endothelial Cells
Shih Chung Chen, Yun Lian Lin, Bin Huang, Danny Ling Wang, Jing Jy Cheng* - - 1 - Thrombosis Research - THROMB RES 2011;128(6):560-564
(IF: 2.372, Journal Ranking: 30, Number of Journals of this Field: 66, Ranking: 45.45%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
111 — N 國科會(原科技部) — MOST111-2314-B-037-008 — 2 整合型
微生態、粒線體移植及Helicobacter pylori致病株改變胃癌細胞惡性度-探討胃癌細胞與周邊細胞間之粒線體供需平衡機制(3/3)( )
2022/08/01 ~ 2023/07/31
2
110 — N 國科會(原科技部) — MOST110-2314-B-037-140 — 2 整合型
微生態、粒線體移植及Helicobacter pylori致病株改變胃癌細胞惡性度-探討胃癌細胞與周邊細胞間之粒線體供需平衡機制(2/3)( )
2021/08/01 ~ 2022/07/31
3
109 — N 國科會(原科技部) — MOST109-2314-B-037-118 — 2 整合型
微生態、粒線體移植及Helicobacter pylori致病株改變胃癌細胞惡性度-探討胃癌細胞與周邊細胞間之粒線體供需平衡機制(1/3)( )
2020/08/01 ~ 2021/07/31
4
106 — NK 高醫-中山合作計畫 — NSYSKMU106P009 — 1 個人型
從冰凍中復活:盤古蟾蜍之蛋白質體及生理表現研究( )
2017/01/01 ~ 2017/12/31
5
105 — NK 高醫-中山合作計畫 —   — 1 個人型
從冰凍 中復活:盤古蟾蜍之蛋白質體及生理表現研究( )
2016/01/01 ~ 2016/12/31
6
105 — TP 頂尖計畫(高醫) — KMU-TP105E13 —  
子計畫十三、GNMT基因突變之肝癌母鼠中四號染色體NKX1與X染色體PTCHD1遺失蛋白質之功能研究( )
2016/11/01 ~ 2017/10/31
7
104 — TP 頂尖計畫(高醫) — KMU-TP104E13 —  
子計畫十三、肝癌疾病鼠之遺失蛋白質鑑定與功能分析( )
2015/10/01 ~ 2016/09/30
8
103 — TP 頂尖計畫(高醫) — KMU-TP103C08 —  
Posttranslational modified mitochondrial proteins used as an early diagnostic biomarker in colorectal cancer(Posttranslational modified mitochondrial proteins used as an early diagnostic biomarker in colorectal cancer)
2014/08/01 ~ 2015/07/31
9
103 — Z 大專學生研究計畫及博士後 — 104-2815-C-037-021-B — 8 大專學生研究計畫
104年度大專學生研究計畫-高靖傑(生物3)( )
2015/07/01 ~ 2016/02/29
10
101 — N 國科會(原科技部) — NSC101-2320-B-037-041 — 1 個人型
大鼠頸動脈限流所引起的缺氧逆境對內皮細胞磷酸化蛋白質體學之研究( )
2012/08/01 ~ 2013/07/31
11
100 — Q 新聘教師計畫(校內) — KMU-Q110003 —  
以新型同位素標定法鑑定血管內皮細胞中半胱胺酸硝基化修飾與定量蛋白質體學( )
2011/12/15 ~ 2012/12/31
12
100 — X 高奇合作計畫 — 101CM-KMU-01 —  
硫化氫與一氧化氮對血管內皮細胞之交互蛋白質體研究( )
2012/05/01 ~ 2013/04/30
13
099 — N 國科會(原科技部) — NSC100-2320-B-037-001 — 1 個人型
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2011/01/01 ~ 2011/10/31
14
099 — Q 新聘教師計畫(校內) — Q100003 —  
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2011/01/01 ~ 2011/12/31
15
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2011/05/01 ~ 2012/04/30

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