Education
School — Major — Degree | Duration |
---|---|
國立臺灣大學 — 植物科學研究所(畢) — 博士 Doctorate, Institute of Plant Science, National Taiwan University |
2000/09 — 2006/06 |
Intramural Experience
Office/Department/Institute | Position | Duration |
---|---|---|
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology | Associate Professor | 2015/08/01 — |
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology | Assistant Professor | 2010/08/01 — 2015/07/31 |
Extramural Experience
Discipline
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
癌症病理機制, 奈米感應器, 巨分子分析, biomarker, 粒線體
Area(s) of Expertise & Research
1. 蛋白質修飾體學 2. 氣體分子生理 3. 心血管疾病機制 4. 粒線體移轉 5. 流體剪力與拉伸力
1. Post-translational modifiomics 2. Gaseous molecules physiology 3. Cardiovascular pathology 4. Mitochondrial transfer 5. Shear force and stretch
Publication
NO | Publication |
---|---|
1 | 血管內皮細胞粒線體移植黑色素細胞瘤誘導 M2-巨噬細胞之極化及藉由Nrf2/HO-1-促進腫瘤生長 Endothelial Mitochondria Transfer to Melanoma Induces M2-Type Macrophage Polarization and Promotes Tumor Growth by the Nrf2/HO-1-Mediated Pathway. |
2 | 胡氏柴胡萃取物調節皮膚角質細胞之氧化逆境與粒線體自噬 The crude extract obtained from Cinnamomum macrostemon Hayata regulates oxidative stress and mitophagy in keratinocytes. |
3 | 機械流體力調節大腸癌細胞惡性度 Mechanical shear flow regulates the malignancy of colorectal cancer cells |
4 | 移殖胃上皮細胞粒線體降低胃癌細胞之惡性度 Transplanting mitochondria from gastric epithelial cells reduces the malignancy of gastric cancer |
5 | 比較不同基質對於內皮細胞在流體剪力下一氧化氮所調控的蛋白質硝基化 Comparison of different coating matrices on cell binding and nitric oxide-mediated protein S-nitrosylation in endothelial cells under shear flow. |
6 | 線粒體代謝、AMPK-SIRT 介導的通路、LncRNA 和 MicroRNA 在骨關節炎中的作用 The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis |
7 | Novel recombinant keratin degrading subtilisin like serine alkaline protease from Bacillus cereus isolated from marine hydrothermal vent crabs Novel recombinant keratin degrading subtilisin like serine alkaline protease from Bacillus cereus isolated from marine hydrothermal vent crabs |
8 | CYP26A1新穎標記與檳榔相關口腔及咽癌 CYP26A1 Is a Novel Biomarker for Betel Quid-Related Oral and Pharyngeal Cancers. |
9 | 檳榔鹼促進血管內皮細胞一氧化氮合成以及蛋白質轉譯後硝基化修飾 Arecoline Increases the Production of Nitric Oxide and Post-Translational S-Nitrosoproteome in Endothelial Cells |
10 | 阿拉比卡咖啡誘導多被體體胚形成與再生 Thidiazuron enhanced somatic embryogenesis from callus lines of arabica coffee and subsequent plant regeneration. |
11 | Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma |
12 | 在化學與生理條件下具生物啟發性的銅一價化合物的NO釋放研究 Nitric oxide-release study of a bio-inspired copper(I)-nitrito complex under chemical and biological conditions |
13 | 喜樹鹼促進內皮細胞一氧化氮合成以及蛋白質硝基化修飾 Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells |
14 | 流體剪力促進內皮細胞中硫化氫生成以及一氧化氮的訊息傳遞 Laminar shear flow increases hydrogen sulfide and activates a nitric oxide producing signaling cascade in endothelial cells |
15 | 硫化氫調控內皮細胞蛋白質硝基化與粒線體型態 Hydrogen sulfide modulates the S-nitrosoproteome and the mitochondrial morphology in endothelial cells |
16 | 若舒伐他汀藥物調控血管內皮細胞的乙醯基化質體 Rosuvastatin modulates the post-translational acetylome in endothelial cells. |
17 | 流體力學又導內皮細胞的機械力傳導:活性氧家族以及一氧化氮的交互關係 Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. |
18 | 20(S)-protopanaxadiol人蔘皂苷調控的內皮蛋白質體 The translational proteome modulated by 20(S)-protopanaxadiol in endothelial cells |
19 | Leucine rich domain 與 NT2/D1細胞中 LRWD1 蛋白質穩定度的相互關係 Correlation between leucine rich domain and the stability of LRWD1 protein in human NT2/D1 cells |
20 | Arsenic Modulates Posttranslational S-Nitrosylation and Translational Proteome in Keratinocytes Arsenic Modulates Posttranslational S-Nitrosylation and Translational Proteome in Keratinocytes |
21 | CYP26B1的差異表現與檳榔引起口腔癌的關係 Expression of a Splice Variant of CYP26B1 in Betel Quid-Related Oral Cancer |
22 | 若舒伐他汀藥物調控血管內皮細胞的磷酸化質體 Rosuvastatin-regulated post-translational phosphoproteome in human umbilical vein endothelial cells |
23 | 血管內皮細胞中一氧化氮調控若舒伐他汀藥物所調控的硝基化與蛋白質體 The role of nitric oxide on rosuvastatin-mediated S-nitrosylation and translational proteomes in human umbilical vein endothelial cells. |
24 | 香茹的粗萃取物對血管內皮細胞的蛋白質體及轉譯後硝酸化蛋白質體之研究 Glossogyne tenuifolia Enhances Posttranslational S-Nitrosylation of Proteins in Vascular Endothelial Cells |
25 | 單蔘酚酸抑制謝館內皮細胞中IFN-γ所誘導的JAK/STAT1 表現 Salvianolic Acid B Suppresses IFN-γ-Induced JAK/STAT1 Activation in Endothelial Cells |
Project
NO |
YEAR — Source — No — Type
Project Name
|
Duration |
---|---|---|
1 |
114 — KP 高醫屏科大 — NPUST-KMU-114-P004 — 1 個人型
探討粒線體移植的胃癌細胞中外源性粒線體與內生性粒線體之競合關係與辨識機制( )
|
2025/01/01 ~ 2025/12/31 |
2 |
111 — N 國科會(原科技部) — MOST111-2314-B-037-008 — 2 整合型
微生態、粒線體移植及Helicobacter pylori致病株改變胃癌細胞惡性度-探討胃癌細胞與周邊細胞間之粒線體供需平衡機制(3/3)( )
|
2022/08/01 ~ 2023/07/31 |
3 |
110 — N 國科會(原科技部) — MOST110-2314-B-037-140 — 2 整合型
微生態、粒線體移植及Helicobacter pylori致病株改變胃癌細胞惡性度-探討胃癌細胞與周邊細胞間之粒線體供需平衡機制(2/3)( )
|
2021/08/01 ~ 2022/07/31 |
4 |
109 — N 國科會(原科技部) — MOST109-2314-B-037-118 — 2 整合型
微生態、粒線體移植及Helicobacter pylori致病株改變胃癌細胞惡性度-探討胃癌細胞與周邊細胞間之粒線體供需平衡機制(1/3)( )
|
2020/08/01 ~ 2021/07/31 |
5 |
106 — NK 高醫-中山合作計畫 — NSYSKMU106P009 — 1 個人型
從冰凍中復活:盤古蟾蜍之蛋白質體及生理表現研究( )
|
2017/01/01 ~ 2017/12/31 |
6 |
105 — NK 高醫-中山合作計畫 — — 1 個人型
從冰凍 中復活:盤古蟾蜍之蛋白質體及生理表現研究( )
|
2016/01/01 ~ 2016/12/31 |
7 |
105 — TP 頂尖計畫(高醫) — KMU-TP105E13 —
子計畫十三、GNMT基因突變之肝癌母鼠中四號染色體NKX1與X染色體PTCHD1遺失蛋白質之功能研究( )
|
2016/11/01 ~ 2017/10/31 |
8 |
104 — TP 頂尖計畫(高醫) — KMU-TP104E13 —
子計畫十三、肝癌疾病鼠之遺失蛋白質鑑定與功能分析( )
|
2015/10/01 ~ 2016/09/30 |
9 |
103 — TP 頂尖計畫(高醫) — KMU-TP103C08 —
Posttranslational modified mitochondrial proteins used as an early diagnostic biomarker in colorectal cancer(Posttranslational modified mitochondrial proteins used as an early diagnostic biomarker in colorectal cancer)
|
2014/08/01 ~ 2015/07/31 |
10 |
103 — Z 大專學生研究計畫及博士後 — 104-2815-C-037-021-B — 8 大專學生研究計畫
104年度大專學生研究計畫-高靖傑(生物3)( )
|
2015/07/01 ~ 2016/02/29 |
11 |
101 — N 國科會(原科技部) — NSC101-2320-B-037-041 — 1 個人型
大鼠頸動脈限流所引起的缺氧逆境對內皮細胞磷酸化蛋白質體學之研究( )
|
2012/08/01 ~ 2013/07/31 |
12 |
100 — Q 新聘教師計畫(校內) — KMU-Q110003 —
以新型同位素標定法鑑定血管內皮細胞中半胱胺酸硝基化修飾與定量蛋白質體學( )
|
2011/12/15 ~ 2012/12/31 |
13 |
100 — X 高奇合作計畫 — 101CM-KMU-01 —
硫化氫與一氧化氮對血管內皮細胞之交互蛋白質體研究( )
|
2012/05/01 ~ 2013/04/30 |
14 |
099 — N 國科會(原科技部) — NSC100-2320-B-037-001 — 1 個人型
瑞舒伐他汀藥物誘導血管內皮細胞蛋白質的動態磷酸化質體研究( )
|
2011/01/01 ~ 2011/10/31 |
15 |
099 — Q 新聘教師計畫(校內) — Q100003 —
瑞舒伐他汀降血脂藥物誘導血管內皮細胞蛋白質半胱胺酸硝基化的位置鑑定( )
|
2011/01/01 ~ 2011/12/31 |
16 |
099 — X 高奇合作計畫 — 100CM-KMU-01 —
若舒伐他汀藥物誘導血管內皮細胞之轉譯後乙醯基化質體研究( )
|
2011/05/01 ~ 2012/04/30 |