Education
| School — Major — Degree | Duration |
|---|---|
|
國立國防醫學院 — 生命科學研究所(畢) — 博士 Doctorate, , |
1999/09 — 2006/05 |
|
國立國防醫學院 — 生理學系(畢) — 碩士 Master, , |
1997/09 — 1999/06 |
|
臺北醫學院 — 公共衛生學系(畢) — 學士 Bachelor, , |
1994/09 — 1997/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 天然藥物研究所碩士班 Master's Program in Natural Products | Director | 2023/08/01 — 2024/07/31 |
| 天然藥物研究所博士班 PhD Program in Natural Products | Director | 2023/08/01 — 2024/07/31 |
| 天然藥物研究所 Graduate Institute of Natural Products | Director | 2021/08/01 — 2024/07/31 |
| 天然藥物研究所 Graduate Institute of Natural Products | Professor | 2017/08/01 — |
| 天然藥物研究所 Graduate Institute of Natural Products | Associate Professor | 2013/08/01 — 2017/07/31 |
| 天然藥物研究所 Graduate Institute of Natural Products | Assistant Professor | 2008/08/01 — 2013/07/31 |
Extramural Experience
Discipline
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
藥物化學、分子流行病學、統計學、ㄧ般外科、放射腫瘤科、血液腫瘤科、內分泌科學
Area(s) of Expertise & Research
抗癌藥物研發、抗發炎藥物研發、代謝性疾病藥物研發、基因損傷修復機制研究、藥物分子生物學研究、基因多型性研究針對基因損傷反應修復與生長因子調控主題探討癌症流行病學、癌症生物學，及抗癌天然藥物研發。
The professional specialties are on topics of DNA damage response and repair, and growth receptor-mediated regulation in cancer epidemiology, biology, and anti-cancer drug discovery.
Publication
| NO | Publication |
|---|---|
| 1 | Severinia buxifolia-isolated acridones inhibit lung cancer invasion and decrease HIFα protein synthesis involving 5'UTR-mediated translation inhibition. Severinia buxifolia-isolated acridones inhibit lung cancer invasion and decrease HIFα protein synthesis involving 5'UTR-mediated translation inhibition. |
| 2 | 附子合併常規心衰竭治療於慢性心臟衰竭病人的效用 The effectiveness of Fuzi in combination with routine heart failure treatment on chronic heart failure patients |
| 3 | 降尿酸治療對心肌梗死後患者的影響：來自基於人群的傾向評分匹配分析的見解 The Impact of Urate-Lowering Therapy in Post-Myocardial Infarction Patients: Insights from a Population-Based, Propensity Score-Matched Analysis. |
| 4 | 3,5,2',4'-Tetramethoxystilbene, a fully methylated resveratrol analog, prevents platelet aggregation and thrombus formation by targeting the protease-activated receptor 4 pathway. 3,5,2',4'-Tetramethoxystilbene, a fully methylated resveratrol analog, prevents platelet aggregation and thrombus formation by targeting the protease-activated receptor 4 pathway. |
| 5 | Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines |
| 6 | Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells. Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells. |
| 7 | 解譯附子及附子複方的現代臨床應用：一個基於市場購物籃分析的全國描述性研究 Uncovering Modern Clinical Applications of Fuzi and Fuzi-Based Formulas: A Nationwide Descriptive Study With Market Basket Analysis |
| 8 | Digoxin的使用與癌症發病率之間的關聯：一個基於競爭風險分析的傾向評分匹配隊列研究 Association Between Digoxin Use and Cancer Incidence: A Propensity Score-Matched Cohort Study With Competing Risk Analysis |
| 9 | Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum |
| 10 | Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes |
| 11 | Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling. Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling. |
| 12 | A functional variant near XCL1 gene improves breast cancer survival via promoting cancer immunity A functional variant near XCL1 gene improves breast cancer survival via promoting cancer immunity |
| 13 | 4β-hydroxywithanolide E及withaferin A對人類乳癌細胞Akt signaling pathway的不同作用 human breast cancer cells Different effects of 4β-hydroxywithanolide E and withaferin A, two withanolides from Solanaceae plants, on the Akt signaling pathway in human breast cancer cells |
| 14 | Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging |
| 15 | Ethanol Extracts of Dietary Herb, Alpinia nantoensis, Exhibit Anticancer Potential in Human Breast Cancer Cells Ethanol Extracts of Dietary Herb, Alpinia nantoensis, Exhibit Anticancer Potential in Human Breast Cancer Cells |
| 16 | Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines |
| 17 | Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus |
| 18 | Antiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines Antiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines |
| 19 | Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer. |
| 20 | Secondary Metabolites of the Endophytic Fungus Lachnum abnorme from Ardisia cornudentata Secondary Metabolites of the Endophytic Fungus Lachnum abnorme from Ardisia cornudentata |
| 21 | Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway. Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway. |
| 22 | Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata |
| 23 | Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites. Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites. |
| 24 | CLL2-1,a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-I (CalDAG-GEFI) CLL2-1,a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-I (CalDAG-GEFI) |
| 25 | (-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases. (-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases. |
| 26 | Repairing of N-mustard derivative BO-1055 induced DNA damage requires multiple DNA repair mechanisms Repairing of N-mustard derivative BO-1055 induced DNA damage requires multiple DNA repair mechanisms |
| 27 | Lower antioxidative capacity of multidrug-resistant cancer cells confers collateral sensitivity to protoflavone derivatives. Lower antioxidative capacity of multidrug-resistant cancer cells confers collateral sensitivity to protoflavone derivatives. |
| 28 | Sassarandainol: A new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense Sassarandainol: A new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense |
| 29 | 5-Azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells 5-Azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells |
| 30 | 血小板CalDAG-GEFI為苯氧化砷之作用標的 Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets |
| 31 | Biological Evaluation of Secondary Metabolites from the Roots of Myrica adenophora Biological Evaluation of Secondary Metabolites from the Roots of Myrica adenophora |
| 32 | Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2 Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2 |
| 33 | Anti-proliferation Effect on Human Breast Cancer Cells via Inhibition of pRb Phosphorylation by Taiwanin E Isolated from Eleutherococcustrifoliatus Anti-proliferation Effect on Human Breast Cancer Cells via Inhibition of pRb Phosphorylation by Taiwanin E Isolated from Eleutherococcustrifoliatus |
| 34 | A method to identify RNA A-to-I editing targets using I-specific cleavage and exon array analysis A method to identify RNA A-to-I editing targets using I-specific cleavage and exon array analysis |
| 35 | Lucidone Suppresses Hepatitis C Virus Replication by Nrf2-Mediated Heme Oxygenase-1 Induction Lucidone Suppresses Hepatitis C Virus Replication by Nrf2-Mediated Heme Oxygenase-1 Induction |
| 36 | Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro |
| 37 | Establishment of metabolite profile for an Antrodia cinnamomea health food product and investigation of its chemoprevention activity Establishment of metabolite profile for an Antrodia cinnamomea health food product and investigation of its chemoprevention activity |
| 38 | Inhibition of ATR-dependent dignaling by protoapigenone and its derivative sensitizes cancer cells to interstrand cross-link-generating agents in vitro and in vivo. Inhibition of ATR-dependent dignaling by protoapigenone and its derivative sensitizes cancer cells to interstrand cross-link-generating agents in vitro and in vivo. |
| 39 | Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90 Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90 |
| 40 | In Vitro Cytotoxic Activity of Novel Protoflavone Analogs-Selectivity Against A Multi-Drug Resistant Cancer Cell Line In Vitro Cytotoxic Activity of Novel Protoflavone Analogs-Selectivity Against A Multi-Drug Resistant Cancer Cell Line |
| 41 | First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents |
| 42 | Antioxidant and Tyrosinase Inhibitory Constituents from the Desugared Sugarcane Extract, a By-Product of Sugar Production Antioxidant and Tyrosinase Inhibitory Constituents from the Desugared Sugar cane Extract, a By-Product of Sugar Production |
| 43 | Using the pER8:GUS Reporter System to Screen for Phytoestrogens from Caesalpinia sappan Using the pER8:GUS Reporter System to Screen for Phytoestrogens from Caesalpinia sappan |
| 44 | Direct Semi-synthesis of the Anticancer Lead-drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives Direct Semi-synthesis of the Anticancer Lead-drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives |
| 45 | FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation. FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation. |
| 46 | Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. |
| 47 | Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. |
| 48 | Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. |
| 49 | Genome-wide association study identifies novel breast cancer susceptibility loci. Genome-wide association study identifies novel breast cancer susceptibility loci. |
| 50 | Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. |
| 51 | Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
112 — N 國科會(原科技部) — NSTC112-2320-B-037-015 — 1 個人型
探索小分子的DDR靶標及其潛在利用( )
|
2023/08/01 ~ 2024/07/31 |
| 2 |
111 — NK 高醫-中山合作計畫 — — 2 整合型
海洋天然物在細胞激素活化細胞發炎與纖維化路徑之作用( )
|
2022/01/01 ~ 2022/12/31 |
| 3 |
111 — T 其他政府單位 — —
阿里山十大功勞植物成分分析、功效評估及衍生產品開發( )
|
2022/11/12 ~ 2024/06/30 |
| 4 |
110 — NK 高醫-中山合作計畫 — — 2 整合型
以粒線體代謝酵素為標靶開發治療抗藥性癌症之海洋天然物研究( )
|
2021/01/01 ~ 2021/12/31 |
| 5 |
109 — N 國科會(原科技部) — MOST107-2320-B-037-008-MY3 — 1 個人型
探討植物來源的阿啶酮生物鹼抑制肺癌轉移的分子作用機轉 (2)(3/3)( )
|
2020/08/01 ~ 2021/12/31 |
| 6 |
109 — NK 高醫-中山合作計畫 — NSYSUKMU109-I005-3 — 2 整合型
以粒線體膜訊息傳遞靶位開發治療抗藥性癌症之海洋天然物研究( )
|
2020/01/01 ~ 2020/12/31 |
| 7 |
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-140-B — 8 大專學生研究計畫
110年度大專學生研究計畫-林原志(藥學2)( )
|
2021/07/01 ~ 2022/02/28 |
| 8 |
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-141-B — 8 大專學生研究計畫
110年度大專學生研究計畫-林兪安(香粧3)( )
|
2021/07/01 ~ 2022/02/28 |
| 9 |
108 — N 國科會(原科技部) — MOST107-2320-B-037-008-MY3 — 1 個人型
探討植物來源的阿啶酮生物鹼抑制肺癌轉移的分子作用機轉 (2)(2/3)( )
|
2019/08/01 ~ 2021/12/31 |
| 10 |
108 — NK 高醫-中山合作計畫 — NSYSUKMU108-I006-2 — 2 整合型
抗癌與抗發炎海洋天然物研究( )
|
2019/01/01 ~ 2019/12/31 |
| 11 |
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-006-B — 8 大專學生研究計畫
109年度大專學生研究計畫-陳品維(藥學3)( )
|
2020/07/01 ~ 2021/02/28 |
| 12 |
107 — NK 高醫-中山合作計畫 — NSYSUKMU107-I003-2 — 2 整合型
從海洋天然物篩選能逆轉臨床上肺癌惡化相關基因表現的潛力藥物( )
|
2018/01/01 ~ 2018/12/31 |
| 13 |
107 — N 國科會(原科技部) — MOST107-2320-B-037-008-MY3 — 1 個人型
探討植物來源的阿啶酮生物鹼抑制肺癌轉移的分子作用機轉 (2)(1/3)( )
|
2018/08/01 ~ 2021/12/31 |
| 14 |
107 — Y 高醫-彰基合作計畫 — 108-CCH-KMU-004 — 1 個人型
Zoledronic acid 影響 gamma H2AX所媒介的基因修復功能( )
|
2019/01/01 ~ 2019/12/31 |
| 15 |
106 — N 國科會(原科技部) — MOST106-2320-B-037-011 — 1 個人型
探討植物來源的阿啶酮生物鹼抑制肺癌轉移的分子作用機轉( )
|
2017/08/01 ~ 2018/10/31 |
| 16 |
105 — N 國科會(原科技部) — MOST103-2320-B-037-007-MY3 — 1 個人型
以多功能測試平台結合分子藥理機轉研究開發天然物萃取物有效成份(3/3)( )
|
2016/08/01 ~ 2017/09/30 |
| 17 |
105 — TP 頂尖計畫(高醫) — KMU-TP105H04 —
子計畫四、調控基因IRES轉錄機制抑制癌症幹細胞( )
|
2016/11/01 ~ 2017/10/31 |
| 18 |
104 — N 國科會(原科技部) — MOST103-2320-B-037-007-MY3 — 1 個人型
以多功能測試平台結合分子藥理機轉研究開發天然物萃取物有效成份(2/3)( )
|
2015/08/01 ~ 2017/07/31 |
| 19 |
104 — TP 頂尖計畫(高醫) — KMU-TP104H04 —
子計畫四、建立小鼠模式研究天然物對抗癌幹細胞( )
|
2015/10/01 ~ 2016/09/30 |
| 20 |
103 — N 國科會(原科技部) — MOST103-2320-B-037-007-MY3 — 1 個人型
以多功能測試平台結合分子藥理機轉研究開發天然物萃取物有效成份(1/3)( )
|
2014/08/01 ~ 2017/09/30 |
| 21 |
102 — N 國科會(原科技部) — NSC102-2313-B-037-002 — 1 個人型
南投月桃抗癌與抑制體脂細胞生成活性成分探索( )
|
2013/08/01 ~ 2014/07/31 |
| 22 |
101 — M 高醫(種子計畫) — KMU-M102005(獲其他補助) —
黃酮化合物調控細胞週期監測點臨床應用之評估( )
|
2012/12/01 ~ 2013/12/31 |
| 23 |
101 — N 國科會(原科技部) — NSC101-2314-B-037-071 — 1 個人型
黃酮化合物調控細胞週期監測點臨床應用之評估( )
|
2012/08/01 ~ 2013/07/31 |
| 24 |
100 — M 高醫(種子計畫) — KMU-M110002 —
探討新合成氨芥衍生物之抗癌藥理機轉( )
|
2011/12/15 ~ 2012/12/31 |
| 25 |
099 — N 國科會(原科技部) — NSC99-2320-B-037-008 — 1 個人型
專利天然化合物調控細胞周期監測點之機制探討( )
|
2010/08/01 ~ 2011/07/31 |
| 26 |
098 — N 國科會(原科技部) — NSC98-2320-B-037-011 — 1 個人型
以細胞活性快速篩選法從天然物中尋找能調控缺氧誘導因子-1的化合物來治療缺血疾病與癌症( )
|
2009/08/01 ~ 2010/07/31 |
| 27 |
098 — Q 新聘教師計畫(校內) — KMU-Q099006 —
Phenanthrens類化合物調節代謝症候群活性之開發( )
|
2010/02/01 ~ 2010/12/31 |
| 28 |
097 — N 國科會(原科技部) — NSC97-2314-B-037-051 — 1 個人型
天然萃取物protoapigenone於乳癌細胞株之DNA損傷反應( )
|
2008/10/01 ~ 2009/07/31 |
| 29 |
097 — Q 新聘教師計畫(校內) — KUM-Q098021 —
探討Protoapigenone是否與DNA損傷反應有關( )
|
2009/01/01 ~ 2009/12/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 抑制ATR與FANCD2激活之組成物與方法 | 中華民國 | 2015/06/01 | I486341 |
| 2 | 五味子甲素之用途 | 中華民國 | 2016/08/11 | I544918 |
| 3 | 抑制ATR與FANCD2激活之組成物與方法 | 美國 | 2018/03/20 | 9,918,962 |
| 4 | 五味子素之用途 | 中華民國 | 2017/02/01 | I568437 |
| 5 | 赤芝酮之用途 | 中華民國 | 2017/02/11 | I569796 |
| 6 | 抑制ATR與FANCD2激活之組成物與方法 | 美國 | 2019/02/05 | 10,195,176 |
| 7 | 抑制ATR與FANCD2激活之組成物與方法 | 美國 | 2022/08/16 | 11,413,267 |