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 Education

School — Major — Degree Duration

國立國防醫學院 — 生命科學研究所(畢) — 博士

Doctorate,  ,  

1999/09 — 2006/05

國立國防醫學院 — 生理學系(畢) — 碩士

Master,  ,  

1997/09 — 1999/06

臺北醫學院 — 公共衛生學系(畢) — 學士

Bachelor,  ,  

1994/09 — 1997/06

 Intramural Experience

Office/Department/Institute Position Duration
環境保護暨職業安全衛生室 Office of Environmental Protection and Occupational Safety and Health   Director 2026/08/01 — 2027/07/31
天然藥物研究所 Graduate Institute of Natural Products   Professor 2017/08/01 —  
天然藥物研究所 Graduate Institute of Natural Products   Associate Professor 2013/08/01 — 2017/07/31
天然藥物研究所 Graduate Institute of Natural Products   Assistant Professor 2008/08/01 — 2013/07/31

 Extramural Experience

 

 Discipline

 

 Research & Technology Platform Open to the Outside

 

 Interested Area(s)for Interdisciplinary Research

藥物化學、分子流行病學、統計學、ㄧ般外科、放射腫瘤科、血液腫瘤科、內分泌科學

 

 Area(s) of Expertise & Research

1. 針對癌症、發炎、代謝相關疾病和症候群的天然產物的研究與開發。2. DNA損傷修復機制研究。3.癌症流行病學、癌症生物學研究。

1. Research and development of natural products for diseases and syndromes related to cancer, inflammation, and metabolism. 2. Research on DNA damage repair mechanisms. 3. Research on cancer epidemiology and cancer biology.

 Publication

NO Publication
1

Bioactivity-guided isolation of alkaloids and chlorophyll-derived, compounds from Murraya koenigii with anti-inflammatory, anti-allergic,, and SARS-CoV-2 entry-inhibitory activities
Faruk Mohamed Abbas Umare, 柯麥可, Shanmuganathan Keerthana, Kulandhaivel Soundar Rajan, 王聖帆, Chu En-Liang, 王惠君* - - 1 - FOOD BIOSCIENCE - FOOD BIOSCIENCE 2026 81卷(-期):109103頁
(IF: 6.2, 領域排名: 37, 領域期刊數: 187, 領域排名: 19.79%)

Bioactivity-guided isolation of alkaloids and chlorophyll-derived, compounds from Murraya koenigii with anti-inflammatory, anti-allergic,, and SARS-CoV-2 entry-inhibitory activities
Faruk Mohamed Abbas Umare, Korinek Michal, Shanmuganathan Keerthana, Kulandhaivel Soundar Rajan, Wang Sheng-Fan, Chu En-Liang, Wang Hui-Chun - - 1 - FOOD BIOSCIENCE - FOOD BIOSCIENCE 2026;81(-):109103
(IF: 6.2, Journal Ranking: 37, Number of Journals of this Field: 187, Ranking: 19.79%)

2

Bischofia javanica as a functional food source: Integrated DNA barcoding and metabolomics reveal multi-target regulation of anti-allergic, anti-inflammatory, and osteogenic activities.
Thiyagarajan Raviraj, Keerthana Shanmuganathan, 魏文琦, 蔡尚廷, 張芳榮, 陳炳宏, 王惠君, 洪子桓*, Aekkhaluck Intharuksa*, 柯麥可* - - 1 - Journal of Functional Foods - 2026 144卷(-期):107423頁
(IF: 0, 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Bischofia javanica as a functional food source: Integrated DNA barcoding and metabolomics reveal multi-target regulation of anti-allergic, anti-inflammatory, and osteogenic activities.
Thiyagarajan Raviraj, Keerthana Shanmuganathan, Wen-Chi Wei, Shang-Ting Tsai, Fang-Rong Chang, Bing-Hung Chen, Hui-Chun Wang, Tzu-Huan Hung*, Aekkhaluck Intharuksa*, Michal Korinek* - - 1 - Journal of Functional Foods - 2026;144(-):107423
(IF: 0, Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

3

The potential of curry leaf extract in controlling SARS-CoV-2 infectious syndromes
Mohamed Abbas Umare Faruk, 柯麥可, 王惠君* - - 1 - Phytochemistry Letters - PHYTOCHEMISTRY LETTERS 2025 69卷(S期):103411頁
(IF: 1.4, 領域排名: 162, 領域期刊數: 273, 領域排名: 59.34%)

The potential of curry leaf extract in controlling SARS-CoV-2 infectious syndromes
Mohamed Abbas Umare Faruk, Michal Korinek, Hui-Chun Wang* - - 1 - Phytochemistry Letters - PHYTOCHEMISTRY LETTERS 2025;69(S):103411
(IF: 1.4, Journal Ranking: 162, Number of Journals of this Field: 273, Ranking: 59.34%)

4

Hybrid Molecules of p53 Activators and Protoflavones to Target Multiple Myeloma
Lopes F, Girst G, Rincón R, Ferreira RJF, Gonçalves LM, Saraiva L, 王惠君, Cuendet M, Hunyadi A, Santos MMM. - - 2 - ChemMedChem - 2025 20卷(21期):e202500600頁
(IF: 0, 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Hybrid Molecules of p53 Activators and Protoflavones to Target Multiple Myeloma
Lopes F, Girst G, Rincón R, Ferreira RJF, Gonçalves LM, Saraiva L, Wang HC, Cuendet M, Hunyadi A, Santos MMM. - - 2 - ChemMedChem - 2025;20(21):e202500600
(IF: 0, Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

5

Isolation of a new natural bromopyrrole alkaloid agenakasine, a biosynthetically related metabolite laughine, and norzooanemonin from a marine sponge Agelas nakamurai
Fu CW, Ahmed AF, Chiang L, Chiou SF, 王惠君, Sheu JH* - - 2 - Phytochemistry Letters - 2025 68卷(-期):102975頁
(IF: 0, 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Isolation of a new natural bromopyrrole alkaloid agenakasine, a biosynthetically related metabolite laughine, and norzooanemonin from a marine sponge Agelas nakamurai
Fu CW, Ahmed AF, Chiang L, Chiou SF, Wang HC, Sheu JH* - - 2 - Phytochemistry Letters - 2025;68(-):102975
(IF: 0, Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

6

Indigofera suffruticosa aerial parts extract induce G2/M arrest and ATR/CHK1 pathway in Jurkat cells.
Hong-Loan Tran, Kuei-Hung Lai, 張訓碩, Yi-Siao Chen, 王惠君, 楊舜心, 張學偉, Chin-Mu Hsu, 顏嘉宏*, 蕭惠樺* - - 1 - BMC COMPLEMENTARY MEDICINE AND THERAPIES - BMC COMPLEMENTARY MEDICINE AND THERAPIES 2024 24卷(1期):28頁
(IF: 3.3, 領域排名: 9, 領域期刊數: 43, 領域排名: 20.93%)

Indigofera suffruticosa aerial parts extract induce G2/M arrest and ATR/CHK1 pathway in Jurkat cells.
Hong-Loan Tran, Kuei-Hung Lai, Hsun-Shuo Chang, Yi-Siao Chen, Hui-Chun Wang, Shuen-Shin Yang, Hsueh-Wei Chang, Chin-Mu Hsu, Chia-Hung Yen, Hui-Hua Hsiao - - 1 - BMC COMPLEMENTARY MEDICINE AND THERAPIES - BMC COMPLEMENTARY MEDICINE AND THERAPIES 2024;24(1):28
(IF: 3.3, Journal Ranking: 9, Number of Journals of this Field: 43, Ranking: 20.93%)

7

Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions.
胡皓竣, 余思穎, 蔡逸宏, Pei-Wen Hsieh, 王惠君, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Hao-Chun Hu, 吳永昌, 張芳榮*, Istvan Szatmari*, Ferenc Fulop - - 1 - ORGANIC & BIOMOLECULAR CHEMISTRY - ORGANIC & BIOMOLECULAR CHEMISTRY 2024 22卷(13期):2620-2629頁
(IF: 2.9, 領域排名: 13, 領域期刊數: 58, 領域排名: 22.41%)

Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions.
Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Pei-Wen Hsieh, Hui-Chun Wang, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Hao-Chun Hu, Yang-Chang Wu, Fang-Rong Chang*, Istvan Szatmari*, Ferenc Fulop - - 1 - ORGANIC & BIOMOLECULAR CHEMISTRY - ORGANIC & BIOMOLECULAR CHEMISTRY 2024;22(13):2620-2629
(IF: 2.9, Journal Ranking: 13, Number of Journals of this Field: 58, Ranking: 22.41%)

8

Preparation of Dearomatized p-Coumaric Acid Derivatives as DNA Damage Response Inhibitors with Potent In Vitro Antitumor Effect.
Laura Fasi, Timea Gonda#, Noemi Toth, Mate Vass, Andras Gyovai, Viktoria Nagy, Imre Ocsovszki, Istvan Zupko, Norbert Kusz, Marta Nove, Gabriella Spengler, Robert Berkecz, 王惠君, 張芳榮*, Attila Hunyadi* - - 1 - CHEMMEDCHEM - CHEMMEDCHEM 2024 19卷(19期):e202300675頁
(IF: 3.6, 領域排名: 94, 領域期刊數: 354, 領域排名: 26.55%)

Preparation of Dearomatized p-Coumaric Acid Derivatives as DNA Damage Response Inhibitors with Potent In Vitro Antitumor Effect.
Laura Fasi, Timea Gonda#, Noemi Toth, Mate Vass, Andras Gyovai, Viktoria Nagy, Imre Ocsovszki, Istvan Zupko, Norbert Kusz, Marta Nove, Gabriella Spengler, Robert Berkecz, Hui-Chun Wang, Fang-Rong Chang*, Attila Hunyadi* - - 1 - CHEMMEDCHEM - CHEMMEDCHEM 2024;19(19):e202300675
(IF: 3.6, Journal Ranking: 94, Number of Journals of this Field: 354, Ranking: 26.55%)

9

Severinia buxifolia-isolated acridones inhibit lung cancer invasion and decrease HIFα protein synthesis involving 5'UTR-mediated translation inhibition.
陳品維, 黃聖凱#, Wen-Cheng Chou, 張芳榮, 鄭源斌, 王惠君* - - 1 - PHYTOMEDICINE : INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY - PHYTOMEDICINE 2023 109卷(-期):154570頁
(IF: 7.9, 領域排名: 1, 領域期刊數: 28, 領域排名: 3.57%)

Severinia buxifolia-isolated acridones inhibit lung cancer invasion and decrease HIFα protein synthesis involving 5'UTR-mediated translation inhibition.
Pin-Wei Chen, Sheng-Kai Huang#, Wen-Cheng Chou, Fang-Rong Chang, Yuan-Bin Cheng, Hui-Chun Wang* - - 1 - PHYTOMEDICINE : INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY - PHYTOMEDICINE 2023;109(-):154570
(IF: 7.9, Journal Ranking: 1, Number of Journals of this Field: 28, Ranking: 3.57%)

10

Flexibanone, the first cembranoid possessing an α-methylene-δ-lactone linking with a tetrahydronfuran ring by C-3/C-4 single bond, from the soft coral Sinularia flexibilis
王惠君, 張學偉, 張芳榮, 宋秉鈞*#, 許志宏* - - 1 - Tetrahedron Letters - TETRAHEDRON LETTERS 2023 129卷(6期):154753頁
(IF: 1.8, 領域排名: 34, 領域期刊數: 52, 領域排名: 65.38%)

Flexibanone, the first cembranoid possessing an α-methylene-δ-lactone linking with a tetrahydronfuran ring by C-3/C-4 single bond, from the soft coral Sinularia flexibilis
Chi-Jen Tai, Hong-Wei Zhang, Hui-Chun Wang, Ya-Ting Chuang, Hsueh-Wei Chang, Fang-Rong Chang, Ping-Jyun Sung, Jyh-Horng Sheu - - 1 - Tetrahedron Letters - TETRAHEDRON LETTERS 2023;129(6):154753
(IF: 1.8, Journal Ranking: 34, Number of Journals of this Field: 52, Ranking: 65.38%)

11

附子合併常規心衰竭治療於慢性心臟衰竭病人的效用
戴志融, Mohamed El-Shazly, 楊奕馨, 蔡逸宏, Dezső Csupor, Judit Hohmann, 吳永昌, 曾子桂, 張芳榮*, 王惠君* - - 1 - Journal of Ethnopharmacology - JOURNAL OF ETHNOPHARMACOLOGY 2022 289卷(-期):115040頁
(IF: 5.195, 領域排名: 4, 領域期刊數: 30, 領域排名: 13.33%)

The effectiveness of Fuzi in combination with routine heart failure treatment on chronic heart failure patients
Chi-Jung Tai, Mohamed El-Shazly, Yi-Hsin Yang, Yi-Hong Tsai, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, Fang-Rong Chang, Hui-Chun Wang - - 1 - Journal of Ethnopharmacology - JOURNAL OF ETHNOPHARMACOLOGY 2022;289(-):115040
(IF: 5.195, Journal Ranking: 4, Number of Journals of this Field: 30, Ranking: 13.33%)

12

降尿酸治療對心肌梗死後患者的影響:來自基於人群的傾向評分匹配分析的見解
戴志融, 吳志中, 李坤泰, 曾子桂, 王惠君, 張芳榮*, 楊奕馨* - - 1 - CLINICAL PHARMACOLOGY AND THERAPEUTICS - CLINICAL PHARMACOLOGY & THERAPEUTICS 2022 111卷(3期):655-663頁
(IF: 6.7, 領域排名: 29, 領域期刊數: 277, 領域排名: 10.47%)

The Impact of Urate-Lowering Therapy in Post-Myocardial Infarction Patients: Insights from a Population-Based, Propensity Score-Matched Analysis.
Chi-Jung Tai, Chin-Chung Wu, Kun-Tai Lee, Tzyy-Guey Tseng, Hui-Chun Wang, Fang-Rong Chang*, Yi-Hsin Yang* - - 1 - CLINICAL PHARMACOLOGY AND THERAPEUTICS - CLINICAL PHARMACOLOGY & THERAPEUTICS 2022;111(3):655-663
(IF: 6.7, Journal Ranking: 29, Number of Journals of this Field: 277, Ranking: 10.47%)

13

3,5,2',4'-Tetramethoxystilbene, a fully methylated resveratrol analog, prevents platelet aggregation and thrombus formation by targeting the protease-activated receptor 4 pathway.
江怡臻, 吳雨珊, 康雅斐, 王惠君, 蔡孟君, 吳志中* - - 1 - CHEMICO-BIOLOGICAL INTERACTIONS - CHEMICO-BIOLOGICAL INTERACTIONS 2022 357卷(4期):109889頁
(IF: 5.194, 領域排名: 15, 領域期刊數: 93, 領域排名: 16.13%)

3,5,2',4'-Tetramethoxystilbene, a fully methylated resveratrol analog, prevents platelet aggregation and thrombus formation by targeting the protease-activated receptor 4 pathway.
Yi-Chun Chiang, Yu-Shan Wu, Ya-Fei Kang, Hui-Chun Wang, Meng-Chun Tsai, Chin-Chung Wu* - - 1 - CHEMICO-BIOLOGICAL INTERACTIONS - CHEMICO-BIOLOGICAL INTERACTIONS 2022;357(4):109889
(IF: 5.194, Journal Ranking: 15, Number of Journals of this Field: 93, Ranking: 16.13%)

14

Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines
Yang SC, Chen HY, Chuang WL, 王惠君, Hsieh CP*, Huang YF* - - 2 - International journal of molecular sciences - INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 2022 23卷(3期):1632頁
(IF: 10.75, 領域排名: 28, 領域期刊數: 297, 領域排名: 9.43%)

Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines
Yang SC, Chen HY, Chuang WL, Wang HC, Hsieh CP*, Huang YF* - - 2 - International journal of molecular sciences - INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 2022;23(3):1632
(IF: 10.75, Journal Ranking: 28, Number of Journals of this Field: 297, Ranking: 9.43%)

15

Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells.
謝侃言, 蔡儒瑩, 林雅函, 張芳榮, 王惠君, 吳志中* - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2021 11卷(1期):4610頁
(IF: 4.996, 領域排名: 19, 領域期刊數: 73, 領域排名: 26.03%)

Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells.
Kan-Yen Hsieh, Ju-Ying Tsai, Ya-Han Lin, Fang-Rong Chang, Hui-Chun Wang, Chin-Chung Wu* - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2021;11(1):4610
(IF: 4.996, Journal Ranking: 19, Number of Journals of this Field: 73, Ranking: 26.03%)

16

解譯附子及附子複方的現代臨床應用:一個基於市場購物籃分析的全國描述性研究
戴志融, Mohamed El-Shazly, 蔡逸宏, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, 張芳榮*, 王惠君* - - 1 - Frontiers in Pharmacology - FRONTIERS IN PHARMACOLOGY 2021 12卷(-期):641530頁
(IF: 5.988, 領域排名: 50, 領域期刊數: 279, 領域排名: 17.92%)

Uncovering Modern Clinical Applications of Fuzi and Fuzi-Based Formulas: A Nationwide Descriptive Study With Market Basket Analysis
Chi-Jung Tai, Mohamed El-Shazly, Yi-Hong Tsai, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, Fang-Rong Chang*, Hui-Chun Wang* - - 1 - Frontiers in Pharmacology - FRONTIERS IN PHARMACOLOGY 2021;12(-):641530
(IF: 5.988, Journal Ranking: 50, Number of Journals of this Field: 279, Ranking: 17.92%)

17

Digoxin的使用與癌症發病率之間的關聯:一個基於競爭風險分析的傾向評分匹配隊列研究
戴志融, 楊奕馨, Tzyy-Guey Tseng, 張芳榮*, 王惠君* - - 1 - Frontiers in Pharmacology - FRONTIERS IN PHARMACOLOGY 2021 12卷(-期):564097頁
(IF: 5.988, 領域排名: 50, 領域期刊數: 279, 領域排名: 17.92%)

Association Between Digoxin Use and Cancer Incidence: A Propensity Score-Matched Cohort Study With Competing Risk Analysis
Chi-Jung Tai, Yi-Hsin Yang, Tzyy-Guey Tseng, Fang-Rong Chang*, Hui-Chun Wang* - - 1 - Frontiers in Pharmacology - FRONTIERS IN PHARMACOLOGY 2021;12(-):564097
(IF: 5.988, Journal Ranking: 50, Number of Journals of this Field: 279, Ranking: 17.92%)

18

Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum
王惠君, Ke TY, Ko YC, Lin JJ, Chang JS, 鄭源斌* - - 1 - Marine drugs - MARINE DRUGS 2021 19卷(10期):529頁
(IF: 6.085, 領域排名: 10, 領域期刊數: 63, 領域排名: 15.87%)

Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum
Wang HC, Ke TY, Ko YC, Lin JJ, Chang JS, Cheng YB* - - 1 - Marine drugs - MARINE DRUGS 2021;19(10):529
(IF: 6.085, Journal Ranking: 10, Number of Journals of this Field: 63, Ranking: 15.87%)

19

Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes
滕暐林, 黃寶��, 王惠君, 曾志華, 顏峰霖* - - 1 - Antioxidants - ANTIOXIDANTS 2021 10卷(10期):1552頁
(IF: 7.675, 領域排名: 4, 領域期刊數: 63, 領域排名: 6.35%)

Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes
Wei-Lin Teng, Pao-Hsien Huang, Hui-Chun Wang, Chih-Hua Tseng, Feng-Lin Yen* - - 1 - Antioxidants - ANTIOXIDANTS 2021;10(10):1552
(IF: 7.675, Journal Ranking: 4, Number of Journals of this Field: 63, Ranking: 6.35%)

20

Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling.
Ahmed Dhahir Latif,Tamas Jernei,Ana Podolski-Renic,Ching-Ying Kuo,Mate Vagvolgyi,Gabor Girst,Istvan Zupko,Sedef Develi,Engin Ulukaya,王惠君,Milica Pecic,Antal Csampai,Attila Hunyadi* - - 1 - Antioxidants (Basel, Switzerland) - ANTIOXIDANTS 2020 9卷(6期):519頁
(IF: 6.312, 領域排名: 60, 領域期刊數: 298, 領域排名: 20.13%)

Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling.
Ahmed Dhahir Latif,Tamas Jernei,Ana Podolski-Renic,Ching-Ying Kuo,Mate Vagvolgyi,Gabor Girst,Istvan Zupko,Sedef Develi,Engin Ulukaya,Hui-Chun Wang,Milica Pecic,Antal Csampai,Attila Hunyadi* - - 1 - Antioxidants (Basel, Switzerland) - ANTIOXIDANTS 2020;9(6):519
(IF: 6.312, Journal Ranking: 60, Number of Journals of this Field: 298, Ranking: 20.13%)

21

A functional variant near XCL1 gene improves breast cancer survival via promoting cancer immunity
ChouWC*,HsiungCN,ChenWT,TsengLM,王惠君,ChuHW,HouMF,YuJC*,沈志陽*. - - 1 - International journal of cancer - INTERNATIONAL JOURNAL OF CANCER 2020 146卷(8期):2182-2193頁
(IF: 7.396, 領域排名: 42, 領域期刊數: 242, 領域排名: 17.36%)

A functional variant near XCL1 gene improves breast cancer survival via promoting cancer immunity
Chou WC*, Hsiung CN, Chen WT, Tseng LM, Wang HC, Chu HW, Hou MF, Yu JC*, Shen CY*. - - 1 - International journal of cancer - INTERNATIONAL JOURNAL OF CANCER 2020;146(8):2182-2193
(IF: 7.396, Journal Ranking: 42, Number of Journals of this Field: 242, Ranking: 17.36%)

22

4β-hydroxywithanolide E及withaferin A對人類乳癌細胞Akt signaling pathway的不同作用 human breast cancer cells
王惠君, 胡皓竣, 張芳榮, Ju-YingTsai, 郭靜頴, 吳永昌, 吳志中* - - 1 - Phytomedicine - PHYTOMEDICINE 2019 53卷(-期):213-222頁
(IF: 4.268, 領域排名: 2, 領域期刊數: 28, 領域排名: 7.14%)

Different effects of 4β-hydroxywithanolide E and withaferin A, two withanolides from Solanaceae plants, on the Akt signaling pathway in human breast cancer cells
Hui-Chun Wang, Hao-Han Hu, Fang-Rong Chang, Ju-YingTsai, Ching-Ying Kuo, Yang-Chang Wu, Chin-Chung Wu* - - 1 - Phytomedicine - PHYTOMEDICINE 2019;53(-):213-222
(IF: 4.268, Journal Ranking: 2, Number of Journals of this Field: 28, Ranking: 7.14%)

23

Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging
Fási L, Di Meo F#, Kuo CY#, Stojkovic Buric S, Martins A, Kúsz N, Béni Z, Dékány M, Balogh GT, Pesic M, 王惠君, Trouillas P, Hunyadi A.* - - 1 - Journal of Medicinal Chemistry - JOURNAL OF MEDICINAL CHEMISTRY 2019 62卷(3期):1657-1668頁
(IF: 6.205, 領域排名: 3, 領域期刊數: 61, 領域排名: 4.92%)

Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging
Fási L, Di Meo F#, Kuo CY#, Stojkovic Buric S, Martins A, Kúsz N, Béni Z, Dékány M, Balogh GT, Pesic M, Wang HC, Trouillas P, Hunyadi A.* - - 1 - Journal of Medicinal Chemistry - JOURNAL OF MEDICINAL CHEMISTRY 2019;62(3):1657-1668
(IF: 6.205, Journal Ranking: 3, Number of Journals of this Field: 61, Ranking: 4.92%)

24

Ethanol Extracts of Dietary Herb, Alpinia nantoensis, Exhibit Anticancer Potential in Human Breast Cancer Cells
Kuo CY, Weng TS, Kumar KJS, Tseng YH, Tung TW, Wang SY*, 王惠君* - - 1 - Integrative Cancer Therapies - INTEGRATIVE CANCER THERAPIES 2019 18卷(-期):UNSP 1534735419866924頁
(IF: 2.634, 領域排名: 7, 領域期刊數: 27, 領域排名: 25.93%)

Ethanol Extracts of Dietary Herb, Alpinia nantoensis, Exhibit Anticancer Potential in Human Breast Cancer Cells
Kuo CY, Weng TS, Kumar KJS, Tseng YH, Tung TW, Wang SY*, Wang HC* - - 1 - Integrative Cancer Therapies - INTEGRATIVE CANCER THERAPIES 2019;18(-):UNSP 1534735419866924
(IF: 2.634, Journal Ranking: 7, Number of Journals of this Field: 27, Ranking: 25.93%)

25

Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines
Kuo CY, Schelz Z, Tóth B, Vasas A, Ocsovszki I, 張芳榮, Hohmann J, Zupkó I*, 王惠君* - - 1 - Phytomedicine - PHYTOMEDICINE 2019 58卷(-期):152770頁
(IF: 4.268, 領域排名: 2, 領域期刊數: 28, 領域排名: 7.14%)

Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines
Kuo CY, Schelz Z, Tóth B, Vasas A, Ocsovszki I Chang FR, Hohmann J, Zupkó I*, Wang HC* - - 1 - Phytomedicine - PHYTOMEDICINE 2019;58(-):152770
(IF: 4.268, Journal Ranking: 2, Number of Journals of this Field: 28, Ranking: 7.14%)

26

Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus
鄭源斌, Fan-Jin Liu, Chih-Hsin Wang, Tsong-Long Hwang,Yung-Fong Tsai,顏嘉宏,王惠君,Yen-Hsueh Tseng,Ching-Te Chien, 陳宜民, 張芳榮*, 吳永昌* - - 1 - PLANTA MEDICA - PLANTA MEDICA 2018 84卷(1期):49-58頁
(IF: 2.494, 領域排名: 58, 領域期刊數: 226, 領域排名: 25.66%)

Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus
5. Yuan-Bin Cheng?, Fan-Jin Liu?, Chih-Hsin Wang, Tsong-Long Hwang, YungFong Tsai, Chia-Hung Yen, Hui-Chun Wang, Yen-Hsueh Tseng, Ching-Te Chien, Yi-Ming Arthur Chen, Fang-Rong Chang*, Yang-Chang Wu* - - 1 - PLANTA MEDICA - PLANTA MEDICA 2018;84(1):49-58
(IF: 2.494, Journal Ranking: 58, Number of Journals of this Field: 226, Ranking: 25.66%)

27

Antiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines
Sinka I, Kiss A, Mernyák E, Wölfling J, Schneider G, Ocsovszki I, Kuo CY, 王惠君, Zupkó I* - - 1 - European journal of pharmaceutical sciences - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2018 123卷(-期):362-370頁
(IF: 3.466, 領域排名: 68, 領域期刊數: 261, 領域排名: 26.05%)

Antiproliferative and antimetastatic properties of 3-benzyloxy-16-hydroxymethylene-estradiol analogs against breast cancer cell lines
Sinka I, Kiss A, Mernyák E, Wölfling J, Schneider G, Ocsovszki I, Kuo CY, Wang HC, Zupkó I* - - 1 - European journal of pharmaceutical sciences - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2018;123(-):362-370
(IF: 3.466, Journal Ranking: 68, Number of Journals of this Field: 261, Ranking: 26.05%)

28

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer
Cheng AN, Fan CC, Lo YK, Kuo CL, 王惠君, Lien IH, Lin SY, Chen CH, Jiang SS, Chang IS, Juan HF, Lyu PC, Lee AY* - - 1 - Scientific reports - Sci Rep 2017 7卷(1期):17024頁
(IF: 4.122, 領域排名: 12, 領域期刊數: 64, 領域排名: 18.75%)

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer.
Cheng AN, Fan CC, Lo YK, Kuo CL, Wang HC, Lien IH, Lin SY, Chen CH, Jiang SS, Chang IS, Juan HF, Lyu PC, Lee AY* - - 1 - Scientific reports - Sci Rep 2017;7(1):17024
(IF: 4.122, Journal Ranking: 12, Number of Journals of this Field: 64, Ranking: 18.75%)

29

Secondary Metabolites of the Endophytic Fungus Lachnum abnorme from Ardisia cornudentata
張訓碩, Chu-Hung Lin, Yi-Shuan Chen, 王惠君, Hing-Yuen Chan, Sung-Yuan Hsieh, 吳和澄, Ming-Jen Cheng*, Gwo-Fang Yuan, Shan-Yu Lin, Yue-Jin Lin, 陳益昇* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INT J MOL SCI 2016 17卷(9期):1512頁
(IF: 3.257, 領域排名: 52, 領域期刊數: 163, 領域排名: 31.90%)

Secondary Metabolites of the Endophytic Fungus Lachnum abnorme from Ardisia cornudentata
Hsun-Shuo Chang, Chu-Hung Lin, Yi-Shuan Chen, Hui-Chun Wang, Hing-Yuen Chan, Sung-Yuan Hsieh, Ho-Cheng Wu, Ming-Jen Cheng*, Gwo-Fang Yuan, Shan-Yu Lin, Yue-Jin Lin, Ih-Sheng Chen* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INT J MOL SCI 2016;17(9):1512
(IF: 3.257, Journal Ranking: 52, Number of Journals of this Field: 163, Ranking: 31.90%)

30

Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway.
郭靜穎, István Zupkó, 張芳榮, Attila Hunyadi, 吳志中, 翁騰崧, 王惠君* - - 1 - Toxicology and Applied Pharmacology - Toxicol. Appl. Pharmacol. 2016 311卷(0期):99–105頁
(IF: 3.791, 領域排名: 15, 領域期刊數: 92, 領域排名: 16.30%)

Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway.
Ching-Ying Kuo, István Zupkó, Fang-Rong Chang, Attila Hunyadi, Chin-Chung Wu, Teng-Song Weng, Hui-Chun Wang - - 1 - Toxicology and Applied Pharmacology - Toxicol. Appl. Pharmacol. 2016;311(0):99–105
(IF: 3.791, Journal Ranking: 15, Number of Journals of this Field: 92, Ranking: 16.30%)

31

Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata
趙子華, 吳佳芸, 黃瓊瑤, 王惠君, 戴昌鳳, 吳永昌, 許志宏* - - 1 - Marine drugs - Mar. Drugs 2016 14卷(8期):150頁
(IF: 3.503, 領域排名: 13, 領域期刊數: 60, 領域排名: 21.67%)

Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata
Chao, C.-H.; Wu, C.-Y.; Huang, C.-Y.; Wang, H.-C.; Dai, C.-F.; Wu, Y.-C.; Sheu, J.-H.* - - 1 - Marine drugs - Mar. Drugs 2016;14(8):150
(IF: 3.503, Journal Ranking: 13, Number of Journals of this Field: 60, Ranking: 21.67%)

32

Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites.
黃瓊瑤, 張哲偉, 曾彥儒, Lee, J., 宋秉鈞, 蘇瑞欣, 黃聰龍, 戴昌鳳, 王惠君, 許志宏* - - 1 - Marine drugs - Mar. Drugs 2016 14卷(10期):E180頁
(IF: 3.503, 領域排名: 13, 領域期刊數: 60, 領域排名: 21.67%)

Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites.
Huang, C.-Y.; Chang, C.-W.; Tseng, Y.-J.; Lee, J.; Sung, P.-J.; Su, J.-H.; Hwang, T.-L.; Dai, C.-F.; Wang, H.-C.; Sheu, J.-H.* - - 1 - Marine drugs - Mar. Drugs 2016;14(10):E180
(IF: 3.503, Journal Ranking: 13, Number of Journals of this Field: 60, Ranking: 21.67%)

33

CLL2-1,a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-I (CalDAG-GEFI)
Chieh-Yu Liao, 李家琳, 王惠君, Shih-Shin Liang, Po-Hsiung Kung, 吳永昌, 張芳榮, 吳志中* - - 1 - Free Radical Biology and Medicine - 2015 78卷(-期):101-110頁
(IF: 5.736, 領域排名: 16, 領域期刊數: 128, 領域排名: 12.50%)

CLL2-1,a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-I (CalDAG-GEFI)
Chieh-Yu Liao, Chia-Lin Lee, Hui-Chun Wang, Shih-Shin Liang, Po-Hsiung Kung, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung Wu* - - 1 - Free Radical Biology and Medicine - 2015;78(-):101-110
(IF: 5.736, Journal Ranking: 16, Number of Journals of this Field: 128, Ranking: 12.50%)

34

(-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases.
王惠君*, 張芳榮, 黃姿蓉, 郭靖穎, 蔡聿奇, 吳志中* - - 1 - Chemical Research in Toxicology - Chem Res Toxicol. 2015 28卷(5期):897-906頁
(IF: 4.19, 領域排名: 5, 領域期刊數: 58, 領域排名: 8.62%)

(-)-Liriopein B Suppresses Breast Cancer Progression via Inhibition of Multiple Kinases.
Wang HC*, Chang FR, Huang TJ, Kuo CY, Tsai YC, Wu CC*. - - 1 - Chemical Research in Toxicology - Chem Res Toxicol. 2015;28(5):897-906
(IF: 4.19, Journal Ranking: 5, Number of Journals of this Field: 58, Ranking: 8.62%)

35

Repairing of N-mustard derivative BO-1055 induced DNA damage requires multiple DNA repair mechanisms
郭靖穎, 周文城, 吳志中, 翁藤松, Kakadiya R, 蘇燦隆*, 王惠君* - - 1 - Ocotarget - Oncotarget 2015 0卷(0期):0頁
(IF: 6.359, 領域排名: 21, 領域期刊數: 211, 領域排名: 9.95%)

Repairing of N-mustard derivative BO-1055 induced DNA damage requires multiple DNA repair mechanisms
Kuo CY, Chou WC, Wu CC, Wong TS, Kakadiya R, Lee TC, Su TS*, Wang HC*. - - 1 - Ocotarget - Oncotarget 2015;0(0):0
(IF: 6.359, Journal Ranking: 21, Number of Journals of this Field: 211, Ranking: 9.95%)

36

Lower antioxidative capacity of multidrug-resistant cancer cells confers collateral sensitivity to protoflavone derivatives.
5Stanković T, Dankó B, Martins A, Dragoj M, Stojković S, Isaković A, 王惠君, 吳永昌, Hunyadi A, Pešić M* - - 1 - Cancer Chemother Pharmacol. - Cancer Chemother Pharmacol. 2015 76卷(3期):555-565頁
(IF: 2.769, 領域排名: 98, 領域期刊數: 255, 領域排名: 38.43%)

Lower antioxidative capacity of multidrug-resistant cancer cells confers collateral sensitivity to protoflavone derivatives.
Stanković T, Dankó B, Martins A, Dragoj M, Stojković S, Isaković A, Wang HC, Wu YC, Hunyadi A, Pešić M* - - 1 - Cancer Chemother Pharmacol. - Cancer Chemother Pharmacol. 2015;76(3):555-565
(IF: 2.769, Journal Ranking: 98, Number of Journals of this Field: 255, Ranking: 38.43%)

37

Sassarandainol: A new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense
Hou YL, 張訓碩,王惠君, Wang SY, Chen TY, Lin CH,陳益昇* - - 1 - Natural product research - Nat Prod Res 2015 299卷(824期):827-832頁
(IF: 0.919, 領域排名: 46, 領域期刊數: 72, 領域排名: 63.89%)

Sassarandainol: A new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense
Hou YL, Chang HS, Wang HC, Wang SY, Chen TY, Lin CH, Chen IS* - - 1 - Natural product research - Nat Prod Res 2015;299(824):827-832
(IF: 0.919, Journal Ranking: 46, Number of Journals of this Field: 72, Ranking: 63.89%)

38

5-Azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells
張學偉, 王惠君, Chiau-Yi Chen, Ting-Wei Hung, 侯明鋒, 袁行修, 黃志仁*, 曾昭能* - - 1 - MOLECULES - MOLECULES 2014 19卷(3期):3149-3159頁
(IF: 2.095, 領域排名: 30, 領域期刊數: 58, 領域排名: 51.72%)

5-Azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells
Hsueh-Wei Chang, Hui-Jun Wang, Chiau-Yi Chen, Ting-Wei Hung, Ming-Feng Hou, Shyng-Shiou F. Yuan, Chih-Jen Huang*, Chao-Neng Tseng* - - 1 - MOLECULES - MOLECULES 2014;19(3):3149-3159
(IF: 2.095, Journal Ranking: 30, Number of Journals of this Field: 58, Ranking: 51.72%)

39

血小板CalDAG-GEFI為苯氧化砷之作用標的
郭芷芸,王惠君,孔柏雄,呂濟宇,廖婕羽,吳明蒼,吳志中* - - 1 - Thrombosis and Haemostasis - THROMB HAEMOSTASIS 2014 111卷(5期):892-901頁
(IF: 5.76, 領域排名: 6, 領域期刊數: 68, 領域排名: 8.82%)

Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets
Kuo CY, Wang HC, Kung PH, Lu CY, Liao CY, Wu MT, Wu CC - - 1 - Thrombosis and Haemostasis - THROMB HAEMOSTASIS 2014;111(5):892-901
(IF: 5.76, Journal Ranking: 6, Number of Journals of this Field: 68, Ranking: 8.82%)

40

Biological Evaluation of Secondary Metabolites from the Roots of Myrica adenophora
丁雅智, 柯宏慧, 王惠君, 彭健芳, 張訓碩, 謝沛宸, 陳益昇* - - 1 - Phytochemistry - Phytochemistry 2014 103卷(-期):89-98頁
(IF: 3.35, 領域排名: 28, 領域期刊數: 199, 領域排名: 14.07%)

Biological Evaluation of Secondary Metabolites from the Roots of Myrica adenophora
Ya-Chih Ting, Horng-Huey Ko, Hui-Chun Wang, Chien-Fang Peng, Hsun-Shuo Chang, Pei-Chen Hsieh, Ih-Sheng Chen* - - 1 - Phytochemistry - Phytochemistry 2014;103(-):89-98
(IF: 3.35, Journal Ranking: 28, Number of Journals of this Field: 199, Ranking: 14.07%)

41

Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2
鄭源斌, 簡怡亭, 李景欽, 曾敬凱, 王惠君, 羅宜雯, 吳羿鴻, 王升陽, 吳永昌*, 張芳榮* - - 1 - Journal of Natural Products - 2014 2014卷(77期):2367-2374頁
(IF: 3.947, 領域排名: 8, 領域期刊數: 58, 領域排名: 13.79%)

Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2
Yuan-Bin Cheng, Yi-Ting Chien, Jin-Ching Lee, Chin-Kai Tseng, Hui-Chun Wang, I-Wen Lo, Yi-Hung Wu, Sheng-Yang Wang, Yang-Chang Wu and Fang-Rong Chang - - 1 - Journal of Natural Products - 2014;2014(77):2367-2374
(IF: 3.947, Journal Ranking: 8, Number of Journals of this Field: 58, Ranking: 13.79%)

42

Anti-proliferation Effect on Human Breast Cancer Cells via Inhibition of pRb Phosphorylation by Taiwanin E Isolated from Eleutherococcustrifoliatus
王惠君, Tseng YH, Wu HR, Chu FH, Yueh-Hsiung Kuo YH* and Wang SY* - - 1 - Natural product communications - Nat Prod Commun 2014 9卷(9期):1303-1306頁
(IF: 0.924, 領域排名: 76, 領域期刊數: 123, 領域排名: 61.79%)

Anti-proliferation Effect on Human Breast Cancer Cells via Inhibition of pRb Phosphorylation by Taiwanin E Isolated from Eleutherococcustrifoliatus
Wang HC, Tseng YH, Wu HR, Chu FH, Yueh-Hsiung Kuo YH* and Wang SY* - - 1 - Natural product communications - Nat Prod Commun 2014;9(9):1303-1306
(IF: 0.924, Journal Ranking: 76, Number of Journals of this Field: 123, Ranking: 61.79%)

43

A method to identify RNA A-to-I editing targets using I-specific cleavage and exon array analysis
曾昭能*, 張學偉, Joel Stocker,王惠君, Chiu-Chin Lu, Cheng-Hsuan Wu, Jyuer-Ger Yang, Chung-Lung Cho, Hurng-Wern Huang* - - 1 - Molecular Cellular Probes - MOL CELL PROBE 2013 27卷(1期):38-45頁
(IF: 1.873, 領域排名: 89, 領域期刊數: 160, 領域排名: 55.63%)

A method to identify RNA A-to-I editing targets using I-specific cleavage and exon array analysis
Chao-Neng Tseng*, Hsueh-Wei Chang, Joel Stocker, Hui-Chun Wang, Chiu-Chin Lu, Cheng-Hsuan Wu, Jyuer-Ger Yang, Chung-Lung Cho, Hurng-Wern Huang* - - 1 - Molecular Cellular Probes - MOL CELL PROBE 2013;27(1):38-45
(IF: 1.873, Journal Ranking: 89, Number of Journals of this Field: 160, Ranking: 55.63%)

44

Lucidone Suppresses Hepatitis C Virus Replication by Nrf2-Mediated Heme Oxygenase-1 Induction
陳威均,王昇陽,邱建智,曾敬凱,林俊光,王惠君,李景欽* - - 1 - Antimicrobial Agents and Chemotherapy - ANTIMICROB AGENTS CH 2013 57卷(3期):1180-1191頁
(IF: 4.451, 領域排名: 27, 領域期刊數: 254, 領域排名: 10.63%)

Lucidone Suppresses Hepatitis C Virus Replication by Nrf2-Mediated Heme Oxygenase-1 Induction
Wei-Chun Chen,Sheng-Yang Wang, Chien-Chih Chiu, Chin-Kai Tseng, Chun-Kuang Lin, Hui-Chun Wang,Jin-Ching Lee - - 1 - Antimicrobial Agents and Chemotherapy - ANTIMICROB AGENTS CH 2013;57(3):1180-1191
(IF: 4.451, Journal Ranking: 27, Number of Journals of this Field: 254, Ranking: 10.63%)

45

Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro
王惠君*, 吳志中, 鄭迪升, 郭靜穎, 蔡聿奇, 江尚育, 翁騰崧, 吳永昌, 張芳榮* - - 1 - Evidence-Based Complementary and Alternative Medicine - EVID-BASED COMPL ALT 2013 2013卷(857929期):1-10頁
(IF: 2.175, 領域排名: 6, 領域期刊數: 22, 領域排名: 27.27%)

Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro
Hui-Chun Wang*, Chin-Chung Wu, Ti-Sheng Cheng, Ching-Ying Kuo, Yu-Chi Tsai, Shang-Yu Chiang, Teng-Song Wong, Yang-Chang Wu, and Fang-Rong Chang* - - 1 - Evidence-Based Complementary and Alternative Medicine - EVID-BASED COMPL ALT 2013;2013(857929):1-10
(IF: 2.175, Journal Ranking: 6, Number of Journals of this Field: 22, Ranking: 27.27%)

46

Establishment of metabolite profile for an Antrodia cinnamomea health food product and investigation of its chemoprevention activity
王惠君, Chu FH, Chien SC, Liao JW, Hsieh HW, Li WH, Lin CC, Shaw JF, Kuo YH*, Wang SY* - - 1 - J. Agric. Food Chem. - J AGR FOOD CHEM 2013 66卷(36期):8556–8564頁
(IF: 2.906, 領域排名: 1, 領域期刊數: 57, 領域排名: 1.75%)

Establishment of metabolite profile for an Antrodia cinnamomea health food product and investigation of its chemoprevention activity
Wang HC, Chu FH, Chien SC, Liao JW, Hsieh HW, Li WH, Lin CC, Shaw JF, Kuo YH*, Wang SY* - - 1 - J. Agric. Food Chem. - J AGR FOOD CHEM 2013;66(36):8556–8564
(IF: 2.906, Journal Ranking: 1, Number of Journals of this Field: 57, Ranking: 1.75%)

47

Inhibition of ATR-dependent dignaling by protoapigenone and its derivative sensitizes cancer cells to interstrand cross-link-generating agents in vitro and in vivo.
王惠君*,李岳倫,周文城,吳志中,曾昭能,劉彥廷,林紋璉,張芳榮,莊大偉,Hunyadi A,吳永昌* - - 1 - molecular cancer therapeutics - MOL CANCER THER 2012 11卷(7期):1443-1453頁
(IF: 5.225, 領域排名: 28, 領域期刊數: 182, 領域排名: 15.38%)

Inhibition of ATR-dependent dignaling by protoapigenone and its derivative sensitizes cancer cells to interstrand cross-link-generating agents in vitro and in vivo.
Wang HC*,Lee AY,Chou WC,Wu CC,Tseng CN,Liu KY,Lin WL,Chang FR,Chuang DW,Hunyadi A,Wu YC* - - 1 - molecular cancer therapeutics - MOL CANCER THER 2012;11(7):1443-1453
(IF: 5.225, Journal Ranking: 28, Number of Journals of this Field: 182, Ranking: 15.38%)

48

Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90
王惠君, 蔡宜伶, 吳永昌, 張芳榮, 劉玫杏, Wen-Ying Chen, 吳志中* - - 1 - PLoS One - PLOS ONE 2012 7卷(5期):e37764頁
(IF: 4.092, 領域排名: 12, 領域期刊數: 85, 領域排名: 14.12%)

Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90
Hui-Chun Wang, Yi-Ling Tsai, Yang-Chang Wu, Fang-Rong Chang, Mei-Hsin Liu, Wen-Ying Chen, Chin-Chung Wu* - - 1 - PLoS One - PLOS ONE 2012;7(5):e37764
(IF: 4.092, Journal Ranking: 12, Number of Journals of this Field: 85, Ranking: 14.12%)

49

In Vitro Cytotoxic Activity of Novel Protoflavone Analogs-Selectivity Against A Multi-Drug Resistant Cancer Cell Line
Attila Hunyadi, 莊大緯, 王惠君, 張芳榮, 吳永昌* - - 1 - Planta Medica - PLANTA MED 2012 78卷(78期):1079PD30頁
(IF: 2.369, 領域排名: 45, 領域期刊數: 185, 領域排名: 24.32%)

In Vitro Cytotoxic Activity of Novel Protoflavone Analogs-Selectivity Against A Multi-Drug Resistant Cancer Cell Line
Attila Hunyadi, Da-Wei Chuang, Hui-Chun Wang, Fang-Rong Chang, Yang-Chang Wu* - - 1 - Planta Medica - PLANTA MED 2012;78(78):1079PD30
(IF: 2.369, Journal Ranking: 45, Number of Journals of this Field: 185, Ranking: 24.32%)

50

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents
李家琳, Chi-Huan Huang, 王惠君, 莊大緯, 吳明忠, Sheng-Yang Wang, 黃聰龍, 吳志中, 陳義龍, 張芳榮*, 吳永昌* - - 1 - Organic & Biomolecular Chemistry - ORG BIOMOL CHEM 2011 9卷(0期):70-73頁
(IF: 3.762, 領域排名: 10, 領域期刊數: 57, 領域排名: 17.54%)

First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents
Chia-Lin Lee, Chi-Huan Huang, Hui-Chun Wang, Da-Wei Chuang, Ming-Jung Wu, Sheng-Yang Wang,Tsong-Long Hwang, Chin-Chung Wu,Yeh-Long Chen, Fang-Rong Chang* and Yang-Chang Wu* - - 1 - Organic & Biomolecular Chemistry - ORG BIOMOL CHEM 2011;9(0):70-73
(IF: 3.762, Journal Ranking: 10, Number of Journals of this Field: 57, Ranking: 17.54%)

51

Antioxidant and Tyrosinase Inhibitory Constituents from the Desugared Sugarcane Extract, a By-Product of Sugar Production
鐘鈺旻, 王惠君, Mohamed El-Shazly, Yann-Lii Leu, Ming-Ching Cheng , 李家琳, 張芳榮*, 吳永昌* - - 1 - Journal of Agricultural and Food Chemistry - J AGR FOOD CHEM 2011 17卷(59期):9219-9225頁
(IF: 2.816, 領域排名: 2, 領域期刊數: 55, 領域排名: 3.64%)

Antioxidant and Tyrosinase Inhibitory Constituents from the Desugared Sugar cane Extract, a By-Product of Sugar Production
Yu-Ming Chung, Hui-Chun Wang, Mohamed El-Shazly, Yann-Lii Leu, Ming-Ching Cheng , Chia-Lin Lee, Fang-Rong Chang*, and Yang-Chang Wu* - - 1 - Journal of Agricultural and Food Chemistry - J AGR FOOD CHEM 2011;17(59):9219-9225
(IF: 2.816, Journal Ranking: 2, Number of Journals of this Field: 55, Ranking: 3.64%)

52

Using the pER8:GUS Reporter System to Screen for Phytoestrogens from Caesalpinia sappan
賴宛君, 王惠君, 陳冠宇, 楊顓丞, Michal Korinek, Chia-Jung Hsieh, Hiroshi Nozaki, Ken-Ichiro Hayashi, 吳志中, 吳永昌, 張芳榮* - - 1 - Journal of Natural Products - J NAT PROD 2011 8卷(74期):1698-1706頁
(IF: 2.872, 領域排名: 28, 領域期刊數: 185, 領域排名: 15.14%)

Using the pER8:GUS Reporter System to Screen for Phytoestrogens from Caesalpinia sappan
Wan-Chun Lai, Hui-Chun Wang, Guan-Yu Chen, Juan-Cheng Yang, Michal Korinek, Chia-Jung Hsieh, Hiroshi Nozaki, Ken-Ichiro Hayashi, Chih-Chung Wu, Yang-Chang Wu, and Fang-Rong Chang* - - 1 - Journal of Natural Products - J NAT PROD 2011;8(74):1698-1706
(IF: 2.872, Journal Ranking: 28, Number of Journals of this Field: 185, Ranking: 15.14%)

53

Direct Semi-synthesis of the Anticancer Lead-drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives
Attila Hunyadi, 莊大緯, Balazs Danko, Michael Y. Chiang, 李家琳, 王惠君, 吳志中, 張芳榮*, 吳永昌* - - 1 - PLoS ONE - PLOS ONE 2011 6卷(8期):e23922頁
(IF: 4.411, 領域排名: 12, 領域期刊數: 85, 領域排名: 14.12%)

Direct Semi-synthesis of the Anticancer Lead-drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives
Attila Hunyadi, Da-Wei Chuang, Balazs Danko, Michael Y. Chiang, Chia-Lin Lee, Hui-Chun Wang, Chin-Chung Wu, Fang-Rong Chang*, and Yang-Chang Wu* - - 1 - PLoS ONE - PLOS ONE 2011;6(8):e23922
(IF: 4.411, Journal Ranking: 12, Number of Journals of this Field: 85, Ranking: 14.12%)

54

FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.
Udler MS, 王惠君, Easton DF* - - 1 - Hum Mol Genet - HUM MOL GENET 2009 8卷(9期):1692-1703頁
(IF: 7.249, 領域排名: 13, 領域期刊數: 138, 領域排名: 9.42%)

FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.
Udler MS et al. (Wang HC is listed as the 25th among 35 authors). - - 1 - Hum Mol Genet - HUM MOL GENET 2009;8(9):1692-1703
(IF: 7.249, Journal Ranking: 13, Number of Journals of this Field: 138, Ranking: 9.42%)

55

Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.
Gaudet MM, 王惠君, Garcia-Closas M* - - 1 - Cancer Epidemiol Biomarkers Prev - CANCER EPIDEM BIOMAR 2009 18卷(5期):1610-1616頁
(IF: 4.77, 領域排名: 29, 領域期刊數: 141, 領域排名: 20.57%)

Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium.
Gaudet MM et al. (Wang HC is listed as the 96th among 119 authors) - - 1 - Cancer Epidemiol Biomarkers Prev - CANCER EPIDEM BIOMAR 2009;18(5):1610-1616
(IF: 4.77, Journal Ranking: 29, Number of Journals of this Field: 141, Ranking: 20.57%)

56

Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
Milne RL, 王惠君, Easton DF* - - 1 - J Natl Cancer Inst - J NATL CANCER I 2009 101卷(14期):1012-1018頁
(IF: 14.933, 領域排名: 5, 領域期刊數: 141, 領域排名: 3.55%)

Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
Milne RL et al. (Wang HC is listed as the 86th among 95 authors). - - 1 - J Natl Cancer Inst - J NATL CANCER I 2009;101(14):1012-1018
(IF: 14.933, Journal Ranking: 5, Number of Journals of this Field: 141, Ranking: 3.55%)

57

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
周文城, 王惠君, 翁芬華, 丁先玲, 吳佩怡, 謝小燕*, 沈志陽* - - 1 - EMBO Journal - EMBO J 2008 27卷(23期):3140-3150頁
(IF: 8.295, 領域排名: 20, 領域期刊數: 276, 領域排名: 7.25%)

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, Shieh SY*, Shen CY*. - - 1 - EMBO Journal - EMBO J 2008;27(23):3140-3150
(IF: 8.295, Journal Ranking: 20, Number of Journals of this Field: 276, Ranking: 7.25%)

58

Genome-wide association study identifies novel breast cancer susceptibility loci.
Easton DF, 王惠君, Ponder BA* - - 1 - Nature - NATURE 2007 447卷(7148期):1087-93頁
(IF: 31.434, 領域排名: 1, 領域期刊數: 42, 領域排名: 2.38%)

Genome-wide association study identifies novel breast cancer susceptibility loci.
Easton DF et al. (Wang HC is listed as the 27th among 105 authors). - - 1 - Nature - NATURE 2007;447(7148):1087-93
(IF: 31.434, Journal Ranking: 1, Number of Journals of this Field: 42, Ranking: 2.38%)

59

Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.
許桓明, 王惠君, 沈志陽, 余志成* - - 1 - Cancer Epidemiol Biomarkers Prev. - CANCER EPIDEM BIOMAR 2007 16卷(10期):2024-2032頁
(IF: 4.77, 領域排名: 29, 領域期刊數: 141, 領域排名: 20.57%)

Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.
Hsu HM, Wang HC, Chen ST, Hsu GC, Shen CY, Yu JC. - - 1 - Cancer Epidemiol Biomarkers Prev. - CANCER EPIDEM BIOMAR 2007;16(10):2024-2032
(IF: 4.77, Journal Ranking: 29, Number of Journals of this Field: 141, Ranking: 20.57%)

60

Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
王惠君, 周文城, 謝小燕, 沈志陽* - - 1 - Cancer Research - CANCER RES 2006 66卷(3期):1391-1400頁
(IF: 7.514, 領域排名: 12, 領域期刊數: 141, 領域排名: 8.51%)

Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
Wang HC, Chou WC, Shieh SY, Shen CY. - - 1 - Cancer Research - CANCER RES 2006;66(3):1391-1400
(IF: 7.514, Journal Ranking: 12, Number of Journals of this Field: 141, Ranking: 8.51%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
115 — KP 高醫屏科大 — NPUSTKMU-115-P004 — 1 個人型
毛喉鞘蕊花枝葉之雙萜類化合物之生物活性研究( )
2026/01/01 ~ 2026/12/31
2
115 — N 國科會(原科技部) — NSTC113-2320-B-037-016-MY3 — 1 個人型
中藥緩解癌症引起的免疫抑制(3/3)( )
2026/08/01 ~ 2027/07/31
3
114 — G 農業部(原農委會) — 1141A046 —  
山村森林產物深度開發及最適化計畫( )
2025/06/12 ~ 2025/12/31
4
114 — G 農業部(原農委會) — 1151A016 —  
山村森林產物深度開發及最適化計畫2( )
2026/04/08 ~ 2026/12/31
5
114 — N 國科會(原科技部) — NSTC113-2320-B-037-016-MY3 — 1 個人型
中藥緩解癌症引起的免疫抑制(2/3)( )
2025/08/01 ~ 2027/07/31
6
113 — N 國科會(原科技部) — NSTC113-2320-B-037-016-MY3 — 1 個人型
中藥緩解癌症引起的免疫抑制(1/3)( )
2024/08/01 ~ 2027/07/31
7
112 — N 國科會(原科技部) — NSTC112-2320-B-037-015 — 1 個人型
探索小分子的DDR靶標及其潛在利用( )
2023/08/01 ~ 2024/08/31
8
111 — NK 高醫-中山合作計畫 —   — 2 整合型
海洋天然物在細胞激素活化細胞發炎與纖維化路徑之作用( )
2022/01/01 ~ 2022/12/31
9
111 — T 其他政府單位 —   —  
阿里山十大功勞植物成分分析、功效評估及衍生產品開發( )
2022/11/12 ~ 2024/09/30
10
110 — NK 高醫-中山合作計畫 —   — 2 整合型
以粒線體代謝酵素為標靶開發治療抗藥性癌症之海洋天然物研究( )
2021/01/01 ~ 2021/12/31
11
109 — N 國科會(原科技部) — MOST107-2320-B-037-008-MY3 — 1 個人型
探討植物來源的阿啶酮生物鹼抑制肺癌轉移的分子作用機轉 (2)(3/3)( )
2020/08/01 ~ 2021/12/31
12
109 — NK 高醫-中山合作計畫 — NSYSUKMU109-I005-3 — 2 整合型
以粒線體膜訊息傳遞靶位開發治療抗藥性癌症之海洋天然物研究( )
2020/01/01 ~ 2020/12/31
13
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-140-B — 8 大專學生研究計畫
110年度大專學生研究計畫-林原志(藥學2)( )
2021/07/01 ~ 2022/02/28
14
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-141-B — 8 大專學生研究計畫
110年度大專學生研究計畫-林�q安(香��3)( )
2021/07/01 ~ 2022/02/28
15
108 — N 國科會(原科技部) — MOST107-2320-B-037-008-MY3 — 1 個人型
探討植物來源的阿啶酮生物鹼抑制肺癌轉移的分子作用機轉 (2)(2/3)( )
2019/08/01 ~ 2021/12/31
16
108 — NK 高醫-中山合作計畫 — NSYSUKMU108-I006-2 — 2 整合型
抗癌與抗發炎海洋天然物研究( )
2019/01/01 ~ 2019/12/31
17
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-006-B — 8 大專學生研究計畫
109年度大專學生研究計畫-陳品維(藥學3)( )
2020/07/01 ~ 2021/02/28
18
107 — NK 高醫-中山合作計畫 — NSYSUKMU107-I003-2 — 2 整合型
從海洋天然物篩選能逆轉臨床上肺癌惡化相關基因表現的潛力藥物( )
2018/01/01 ~ 2018/12/31
19
107 — N 國科會(原科技部) — MOST107-2320-B-037-008-MY3 — 1 個人型
探討植物來源的阿啶酮生物鹼抑制肺癌轉移的分子作用機轉 (2)(1/3)( )
2018/08/01 ~ 2021/12/31
20
107 — Y 高醫-彰基合作計畫 — 108-CCH-KMU-004 — 1 個人型
Zoledronic acid 影響 gamma H2AX所媒介的基因修復功能( )
2019/01/01 ~ 2019/12/31
21
106 — N 國科會(原科技部) — MOST106-2320-B-037-011 — 1 個人型
探討植物來源的阿啶酮生物鹼抑制肺癌轉移的分子作用機轉( )
2017/08/01 ~ 2018/10/31
22
105 — N 國科會(原科技部) — MOST103-2320-B-037-007-MY3 — 1 個人型
以多功能測試平台結合分子藥理機轉研究開發天然物萃取物有效成份(3/3)( )
2016/08/01 ~ 2017/09/30
23
105 — TP 頂尖計畫(高醫) — KMU-TP105H04 —  
子計畫四、調控基因IRES轉錄機制抑制癌症幹細胞( )
2016/11/01 ~ 2017/10/31
24
104 — N 國科會(原科技部) — MOST103-2320-B-037-007-MY3 — 1 個人型
以多功能測試平台結合分子藥理機轉研究開發天然物萃取物有效成份(2/3)( )
2015/08/01 ~ 2017/07/31
25
104 — TP 頂尖計畫(高醫) — KMU-TP104H04 —  
子計畫四、建立小鼠模式研究天然物對抗癌幹細胞( )
2015/10/01 ~ 2016/09/30
26
103 — N 國科會(原科技部) — MOST103-2320-B-037-007-MY3 — 1 個人型
以多功能測試平台結合分子藥理機轉研究開發天然物萃取物有效成份(1/3)( )
2014/08/01 ~ 2017/09/30
27
102 — N 國科會(原科技部) — NSC102-2313-B-037-002 — 1 個人型
南投月桃抗癌與抑制體脂細胞生成活性成分探索( )
2013/08/01 ~ 2014/07/31
28
101 — M 高醫(種子計畫) — KMU-M102005(獲其他補助) —  
黃酮化合物調控細胞週期監測點臨床應用之評估( )
2012/12/01 ~ 2013/12/31
29
101 — N 國科會(原科技部) — NSC101-2314-B-037-071 — 1 個人型
黃酮化合物調控細胞週期監測點臨床應用之評估( )
2012/08/01 ~ 2013/07/31
30
100 — M 高醫(種子計畫) — KMU-M110002 —  
探討新合成氨芥衍生物之抗癌藥理機轉( )
2011/12/15 ~ 2012/12/31
31
099 — N 國科會(原科技部) — NSC99-2320-B-037-008 — 1 個人型
專利天然化合物調控細胞周期監測點之機制探討( )
2010/08/01 ~ 2011/07/31
32
098 — N 國科會(原科技部) — NSC98-2320-B-037-011 — 1 個人型
以細胞活性快速篩選法從天然物中尋找能調控缺氧誘導因子-1的化合物來治療缺血疾病與癌症( )
2009/08/01 ~ 2010/07/31
33
098 — Q 新聘教師計畫(校內) — KMU-Q099006 —  
Phenanthrens類化合物調節代謝症候群活性之開發( )
2010/02/01 ~ 2010/12/31
34
097 — N 國科會(原科技部) — NSC97-2314-B-037-051 — 1 個人型
天然萃取物protoapigenone於乳癌細胞株之DNA損傷反應( )
2008/10/01 ~ 2009/07/31
35
097 — Q 新聘教師計畫(校內) — KUM-Q098021 —  
探討Protoapigenone是否與DNA損傷反應有關( )
2009/01/01 ~ 2009/12/31

 Patent

NO Patent Name Country Certified Date Patent No
1 抑制ATR與FANCD2激活之組成物與方法 中華民國 2015/06/01 I486341
2 五味子甲素之用途 中華民國 2016/08/11 I544918
3 抑制ATR與FANCD2激活之組成物與方法 美國 2018/03/20 9,918,962
4 五味子素之用途 中華民國 2017/02/01 I568437
5 赤芝酮之用途 中華民國 2017/02/11 I569796
6 抑制ATR與FANCD2激活之組成物與方法 美國 2019/02/05 10,195,176
7 抑制ATR與FANCD2激活之組成物與方法 美國 2022/08/16 11,413,267