Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學大學 — 藥學研究所(畢) — 博士 Doctorate, Graduate Institute of Pharmaceutical Science, Kaohsiung Medical University |
1997/09 — 2002/06 |
|
高雄醫學大學 — 藥學系(畢) — 學士 Bachelor, School of Pharmacy, Kaohsiung Medical University |
1993/09 — 1997/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 香粧品學系 Department of Fragrance and Cosmetic Science | Professor | 2015/02/01 — |
| 香粧品學系 Department of Fragrance and Cosmetic Science | Associate Professor | 2010/08/01 — 2015/01/31 |
| 香粧品學系 Department of Fragrance and Cosmetic Science | Assistant Professor | 2007/08/01 — 2010/07/31 |
Extramural Experience
| DEPNO | Position- Office/Department/Institute | Duration |
|---|---|---|
| 中台科技大學放射技術系 | 助理教授 | 0930801 — 0960731 |
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy |
| 2 | 自然科學類 Natural Sciences | 化學 Chemistry |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
需要分析技術的單位
Anyone who needs analytical technology
Area(s) of Expertise & Research
生物分析方法開發、藥物、食品及粧品中有效與有害成分分析、樣品前處理、液相及氣相層析、質譜分析
Bioanalytical method development; Analysis of active or harmful compounds in drugs, food, and cosmetics; Sample pretreatment; Liquid and gas chromatography; Mass spectrometry
Publication
| NO | Publication |
|---|---|
| 1 | Molecularly imprinted dispersive micro solid-phase extraction and tandem derivatization for the determination of histamine in fermented wines. Molecularly imprinted dispersive micro solid-phase extraction and tandem derivatization for the determination of histamine in fermented wines. |
| 2 | A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells. A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells. |
| 3 | Fluorescence detection of apolipoprotein E gene polymorphisms based on oligonucleotide ligation and magnetic separation. Fluorescence detection of apolipoprotein E gene polymorphisms based on oligonucleotide ligation and magnetic separation. |
| 4 | 使用揮發性衍生試劑快速甲基化人血漿中的纈沙坦，以提高其在 MALDI-TOF 質譜分析中的靈敏度 Rapid methylation of valsartan in human plasma using evaporative derivatization reagent to improve its sensitivity in MALDI-TOF mass spectrometry |
| 5 | A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl-1 downregulation in human breast cancer cells. A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl-1 downregulation in human breast cancer cells. |
| 6 | Antitumor Effects of a Sesquiterpene Derivative from Marine Sponge in Human Breast Cancer Cells. Antitumor Effects of a Sesquiterpene Derivative from Marine Sponge in Human Breast Cancer Cells. |
| 7 | 食品中六種生物胺之同時衍生化及液固相變微萃取法搭配窄管液相層析-紫外光偵測 Simultaneous derivatization and liquid-solid phase transition microextraction of six biogenic amines in foods followed by narrowbore liquid chromatography-ultraviolet detection |
| 8 | 熱損傷患者之慢性腎臟疾病的風險：一項台灣縱貫性世代研究 Risk of chronic kidney disease in patients with heat injury: A nationwide longitudinal cohort study in Taiwan |
| 9 | 配合超聲渦流輔助分散液液微萃取與高效液相層析-二極管陣列偵測器檢測化粧品和人體角質層中的紫外線過濾劑 Ultrasound-Vortex-Assisted Dispersive Liquid-Liquid Microextraction Combined with High Performance Liquid Chromatography-Diode Array Detection for Determining UV Filters in Cosmetics and the Human Stratum Corneum |
| 10 | 心臟糖苷αlDiginoside通過調節人類口腔鱗狀癌細胞中Mcl-1的抗腫瘤活性 Antitumor Activity of the Cardiac Glycoside αlDiginoside by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells |
| 11 | 微波輔助衍生反應結合凝聚提取法並配合毛細管液相層析法測定生物基質樣品中的穀胱甘肽 Microwave-assisted derivatization combined with coacervative extraction for determining glutathione in biomatrix samples, followed by capillary liquid chromatography |
| 12 | 利用兩種微萃取法配合毛細管液相層析儀-紫外光偵測器測定對羥基苯甲酸酯 Determination of parabens using two microextraction methods coupled with capillary liquid chromatography-UV detection |
| 13 | 超音波輔助衍生反應合併毛細管電泳測量生物樣品中天冬氨酸和谷氨酸之對掌異構物與阿滋海默症進展之關係 Enantioselective determination of aspartate and glutamate in biological samples by ultrasonic-assisted derivatization coupled with capillary electrophoresis and linked to Alzheimer’s disease progression |
| 14 | 軟珊瑚之Sterol類化合物誘導MCF-7乳腺癌細胞之細胞凋亡與自噬作用 A Sterol from Soft Coral Induces Apoptosis and Autophagy in MCF-7 Breast Cancer Cells |
| 15 | 以質譜儀分析對羥基苯甲酸酯及其代謝物 Derivatization-Enhanced Detection Strategy in Mass Spectrometry: Analyze 4-Hydroxybenzoate and Survey their Metabolites after Human Keratinocytes Exposed to UV Radiation |
| 16 | 以氣相層析質譜儀搭配串聯式衍生法及鹽析輔助液液微萃取法分析尿液中的生物硫醇 Tandem derivatization combined with salting-out assisted liquid–liquid microextraction for determination of biothiols in urine by gas chromatography–mass spectrometry |
| 17 | 螢光衍生合併水溶性溶媒分散液液微萃取法分析人體血漿中之butyrobetaine, l-carnitine和acetyl-l-carnitine Fluorescent derivatization combined with aqueous solvent-based dispersive liquid-liquid microextraction for determination of butyrobetaine, l-carnitine and acetyl-l-carnitine in human plasma |
| 18 | 利用微波輔助衍生配合分散液液微萃取法分析不同樣品基質中之傳明酸 Determination of tranexamic acid in various matrices using microwave-assisted derivatization followed by dispersive liquid-liquid microextraction |
| 19 | 利用微胞崩解毛細管電泳線上濃縮技術分析防曬產品中的紫外光吸收劑 Determining ultraviolet absorbents in sunscreen products bycombining direct injection with micelle collapse on-linepreconcentration capillary electrophoresis |
| 20 | 以GC/MS分析精油中之phenylpropenes成分 Dual dispersive liquid–liquid microextraction for determination of phenylpropenes in oils by gas chromatography–mass spectrometry |
| 21 | Application of Central Composite Design for the Determination of Exfoliating Agents in Cosmetics by Capillary Electrophoresis with Electroosmotic Flow Modulation Application of Central Composite Design for the Determination of Exfoliating Agents in Cosmetics by Capillary Electrophoresis with Electroosmotic Flow Modulation |
| 22 | 化學衍生配合毛細管液相層析或基質輔助雷射脫附游離-飛行時間質譜法微量分析化粧品中硫辛酸並整合人類角質細胞蛋白質表現 Chemical derivatization combined with capillary LC or MALDI-TOF MS for trace determination of lipoic acid in cosmetics and integrated protein expression profiling in human keratinocytes |
| 23 | 分散液液微萃取法合併微波輔助衍生反應測量尿液中硫辛酸及其代謝物 Dispersive liquid-liquid microextraction combined with microwave-assisted derivatization for determining lipoic acid and its metabolites in human urine |
| 24 | 利用環糊精修飾毛細管電泳法結合實驗設計法以偵測化粧品中多種羥基酸 Determination of hydroxy acids in cosmetics by chemometric experimental design and cyclodextrin-modified capillary electrophoresis |
| 25 | 利用毛細管液相層析法配合紫外光偵測器微小化定量水樣品及化粧品中十種鄰苯二甲酸酯類:有效減少有機廢液之策略 Micro-scale quantitation of ten phthalate esters in water samples and cosmetics using capillary liquid chromatography coupled to UV detection: effective strategies to reduce the production of organic waste |
| 26 | 利用奈米液相層析配合串聯式質譜儀初步篩選acrylamide和glycidamide之主要血漿蛋白質修飾 Modification of major plasma proteins by acrylamide and glycidamide: Preliminary screening by nano liquid chromatography with tandem mass spectrometry |
| 27 | 利用質譜配合飛行時間分析器定量人體血漿中irbesartan及主要蛋白質 Quantitation of irbesartan and major proteins in human plasma by mass spectrometry with time-of-flight analyzer |
| 28 | 利用奈米化液相層析串聯質譜儀鑑定MES-13細胞中ANGIOTENSIN II (1-8)代謝物:初步平台 IDENTIFICATION OF THE METABOLITES OF ANGIOTENSIN II (1-8) IN MES-13 CELLS BY A SIMPLE NANOLC-MS-MS SYSTEM: A PRELIMINARY PLATFORM |
| 29 | 利用基質輔助雷射脫附飛行時間質譜法配合quinolone基質添加劑定量分析人體血漿中quinapril Quantitation of quinapril in human plasma by matrix-assisted laser desorption ionization time-of-flight mass spectrometry with quinolone matrix additives |
| 30 | 利用基質輔助雷射脫附飛行時間質譜法配合微小化衍生反應定量分析人體周邊血液之glutathione Quantitation of the glutathione in human peripheral blood by matrix-assisted laser desorption ionization time-of-flight mass spectrometry coupled with micro-scale derivatization |
| 31 | 利用二種節省溶媒方式分析Quinapril:應用毛細管高壓液相層析法配合紫外光偵測器及LDI-TOF-MS Analysis of Quinapril by Two Solvent-Saving Methods: Application of Capillary Column High-Performance Liquid Chromatography with Ultraviolet Absorbance Detection and LDI-TOF-MS |
| 32 | 以微米等級模式偵測血管收縮素轉換酵素抑制劑投藥前後人體尿液中主要蛋白質的變化 A Micro-Scale Model to Monitor the Major Proteins in Human Urine Before and After Medication with Angiotensin-Converting Enzyme Inhibitor: A Preliminary Study |
| 33 | 利用二維電泳配合ZipTip及自行組裝之奈米流體系統做蛋白質鑑定 Protein identification from two-dimensional gel electrophoresis by connecting ZipTip with a home-assembled nanoflow system |
| 34 | 利用液相層析-串聯式質譜儀在微升等級血漿中分析血管收縮素接受體拮抗劑及蛋白質標記 Analysis of angiotensin II receptor antagonist and protein markers at microliter level plasma by LC–MS/MS |
| 35 | 開發低分子量化合物基質並應用於利用基質輔助雷射脫附離子化-飛行時間質譜儀分析致癌檳榔鹼 A New Matrix for Analyzing Low Molecular Mass Compounds and Its Application for Determination of Carcinogenic Areca Alkaloids by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry |
| 36 | 利用質譜儀在微升等級分析人體血漿中Glyclazide Trace Analysis of Glyclazide in Human Plasma at Microscale Level by Mass Spectrometry |
| 37 | 利用奈米等級液相層析及串聯式質譜儀分析臨床鹼性化合物 Determination of Clinically Very Basic Compounds by Nanoscale Liquid Chromatography with Tandem Mass Spectrometry |
| 38 | 人體血漿中Methylxanthines之快速分析 Rapid simultaneous determination of three methylxanthines in human plasma by capillary electrophoresis |
| 39 | 衍生化高壓液相層析對tobramycin於血漿中之微量分析研究 trace analysis of tobramycin in human plasma by derivatization and high-performance liquid chromatography with ultraviolet detection |
| 40 | 衍生化液相層析對amikacin之微量分析 Trace analysis of amikacin by derivatization and high performance liquid chromatography |
| 41 | 高效能液相層析法對人體血漿中amikacin之微量分析 Trace analysis of amikacin in human plasma by high performance liquid chromatography |
| 42 | 衍生化液相層析對市售amikacin製劑之微量分析 Trace analysis of amikacin in commercial preparation by derivatization and HPLC |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
113 — NK 高醫-中山合作計畫 — NK113P15 — 1 個人型
前列腺癌細胞以葫蘆烷三萜類化合物有無搭配異硫氰酸酯共同治療的抗癌活性探討及分析(Discovery and analysis of antitumor activity of the cucurbitane triterpenoid in prostate cancer cells co-treatment with and without isothiocyanates)
|
2024/01/01 ~ 2024/12/31 |
| 2 |
112 — N 國科會(原科技部) — NSTC112-2113-M-037-018 — 1 個人型
可切換分子液體微萃取法結合快速衍生反應進行微量分析(1/3)( )
|
2023/08/01 ~ 2024/07/31 |
| 3 |
112 — NK 高醫-中山合作計畫 — — 1 個人型
探討固醇類天然物的抗胃癌細胞活性及其生物標誌物分析(Discovery of antitumor activity of the sterol in gastric cancer cells and biomarker analysis)
|
2023/01/01 ~ 2023/12/31 |
| 4 |
111 — N 國科會(原科技部) — MOST111-2113-M-037-018 — 1 個人型
發展智能聚合物及綠色衍生法於微量分析之應用(3/3)( )
|
2022/08/01 ~ 2023/07/31 |
| 5 |
110 — N 國科會(原科技部) — MOST110-2113-M-037-020 — 1 個人型
發展智能聚合物及綠色衍生法於微量分析之應用(2/3)( )
|
2021/08/01 ~ 2022/07/31 |
| 6 |
110 — NK 高醫-中山合作計畫 — — 1 個人型
探討一個海綿之倍半萜類似物的抗肝癌細胞活性及其微量分析法開發( )
|
2021/01/01 ~ 2021/12/31 |
| 7 |
109 — N 國科會(原科技部) — MOST109-2113-M-037-010 — 1 個人型
發展智能聚合物及綠色衍生法於微量分析之應用(1/3)( )
|
2020/08/01 ~ 2021/07/31 |
| 8 |
109 — NK 高醫-中山合作計畫 — NSYSUKMU109-P004 — 1 個人型
探討一個鏈黴菌屬之大環內酯類似物的抗乳癌細胞活性及其微定量分析( )
|
2020/01/01 ~ 2020/12/31 |
| 9 |
108 — N 國科會(原科技部) — MOST108-2113-M-037-003 — 1 個人型
發展專一性之固相微萃取暨較環保衍生技術(2/2)( )
|
2019/08/01 ~ 2020/07/31 |
| 10 |
108 — NK 高醫-中山合作計畫 — NSYSUKMU108-P008 — 1 個人型
強心配醣體divaricoside 作為口腔癌治療標靶之探究及其與多胺生物標誌物的微量分析( )
|
2019/01/01 ~ 2019/12/31 |
| 11 |
107 — NK 高醫-中山合作計畫 — NSYSUKMU107-P011 — 1 個人型
"G 蛋白質耦合受體30，一個膜動情素受體作為胃癌治療標靶之探究及其 微小化定量分析研究"( )
|
2018/01/01 ~ 2018/12/31 |
| 12 |
107 — N 國科會(原科技部) — MOST107-2113-M-037-011 — 1 個人型
發展專一性之固相微萃取暨較環保衍生技術(1/2)( )
|
2018/08/01 ~ 2019/07/31 |
| 13 |
106 — NK 高醫-中山合作計畫 — NSYSKMU106P005 — 1 個人型
BI-D1870 調控胰臟癌細胞凋亡及其微小化定量分析研究( )
|
2017/01/01 ~ 2017/12/31 |
| 14 |
106 — N 國科會(原科技部) — MOST106-2113-M-037-006 — 1 個人型
微量分析用快速衍生暨微萃取法開發(2/2)( )
|
2017/08/01 ~ 2018/07/31 |
| 15 |
106 — Z 大專學生研究計畫及博士後 — MOST106-2811-M-037-003 — 9 博士後研究員
博士後研究員--徐文展( )
|
2017/08/01 ~ 2018/07/31 |
| 16 |
105 — N 國科會(原科技部) — MOST105-2113-M-037-015 — 1 個人型
微量分析用快速衍生暨微萃取法開發(1/2)( )
|
2016/08/01 ~ 2017/07/31 |
| 17 |
105 — TP 頂尖計畫(高醫) — KMU-TP105PR05 —
小分子極性化合物衍生物鑑定暨分析方法開發( )
|
2016/12/01 ~ 2017/10/31 |
| 18 |
105 — Z 大專學生研究計畫及博士後 — MOST105-2811-M-037-007 — 9 博士後研究員
博士後研究員--徐文展( )
|
2016/10/12 ~ 2017/07/31 |
| 19 |
105 — Z 大專學生研究計畫及博士後 — MOST106-2813-C-037-011-M — 8 大專學生研究計畫
106年度大專學生研究計畫-蘇祐麟(香粧3)( )
|
2017/07/01 ~ 2018/02/28 |
| 20 |
104 — N 國科會(原科技部) — MOST104-2113-M-037-009 — 1 個人型
發展較綠色衍生反應及微小化萃取法應用於胺基酸硫醇分析( )
|
2015/08/01 ~ 2016/07/31 |
| 21 |
104 — TP 頂尖計畫(高醫) — KMU-TP104PR07 —
發展環保且快速之分析方法應用於肉鹼及其相關化合物的檢測( )
|
2015/12/01 ~ 2016/09/30 |
| 22 |
103 — N 國科會(原科技部) — MOST103-2113-M-037-002 — 1 個人型
利用微萃取技術及衍生反應微小化分析功能性胺基酸及其活性類似物( )
|
2014/08/01 ~ 2015/07/31 |
| 23 |
102 — N 國科會(原科技部) — NSC102-2113-M-037-012 — 1 個人型
微小化分析導向之前處理及衍生方法在生物檢品之應用( )
|
2013/08/01 ~ 2014/07/31 |
| 24 |
101 — N 國科會(原科技部) — NSC101-2113-M-037-002 — 1 個人型
發展微小化分析方法合併衍生反應偵測老化相關疾病之代謝調節劑( )
|
2012/08/01 ~ 2013/07/31 |
| 25 |
100 — N 國科會(原科技部) — NSC100-2113-M-037-003 — 1 個人型
利用節省溶媒前處理方式配合微小化分析法測定心血管代謝疾病患者體內藥物及抗氧化物質( )
|
2011/08/01 ~ 2012/07/31 |
| 26 |
099 — N 國科會(原科技部) — NSC99-2113-M-037-004 — 1 個人型
糖尿病合併高血壓患者體內血管收縮素II接受體拮抗劑及其相關生理活性物質分析( )
|
2010/08/01 ~ 2011/07/31 |
| 27 |
098 — N 國科會(原科技部) — NSC97-2113-M-037-008-MY2 — 1 個人型
利用毛細管液相層析法分析血管緊縮素轉換酵素抑制劑及其相關代謝物質(2/2)( )
|
2009/08/01 ~ 2010/07/31 |
| 28 |
097 — N 國科會(原科技部) — NSC97-2113-M-037-008-MY2 — 1 個人型
利用毛細管液相層析法分析血管緊縮素轉換酵素抑制劑及其相關代謝物質(1/2)( )
|
2008/08/01 ~ 2010/07/31 |
| 29 |
097 — Q 新聘教師計畫(校內) — KMU-Q098002 —
在微升等級利用毛細管液相層析分析( )
|
2009/01/01 ~ 2009/12/31 |
| 30 |
096 — N 國科會(原科技部) — NSC95-2113-M-037-025 — 1 個人型
利用毛細管電泳和毛細管液相層析法分析臨床生物檢體中糖尿病用藥之研究( )
|
2006/08/01 ~ 2007/12/31 |
| 31 |
096 — N 國科會(原科技部) — NSC96-2113-M-037-016 — 1 個人型
利用微小化綠色分析化學技術監測降血壓藥與腎素-血管收縮素系統中的血管收縮素胜肽( )
|
2007/08/01 ~ 2008/07/31 |
| 32 |
096 — Q 新聘教師計畫(校內) — —
利用微量級液相層析分析Sulfonylurea類藥物( )
|
2007/11/01 ~ 2008/07/31 |
| 33 |
096 — Y 高醫-彰基合作計畫 — 97-CCH-KMU-009 — 1 個人型
微量分析生物檢體中之AT1接受體拮抗劑( )
|
2008/01/01 ~ 2008/12/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 鄰苯二甲酸酯類之分析方法 | 中華民國 | 2014/07/01 | I443323 |
| 2 | 磷苯二甲酸酯類的萃取方法 | 中華民國 | 2018/11/11 | I640758 |
| 3 | 針對羧酸基團的快速衍生方法及肉鹼類化合物的分析方法 | 中華民國 | 2017/06/01 | I585067 |
| 4 | 針對低分子量及高極性之四級胺化合物之水性溶劑分散液液微萃取法 | 中華民國 | 2017/05/21 | I583659 |
| 5 | 具γ-羧酸基之四級銨化合物的檢測方法、肉鹼缺乏症的診斷方法及用以檢測具γ-羧酸基之四級銨化合物的套組 | 中華民國 | 2018/07/21 | I630387 |
| 6 | 具γ-羧酸基之四級銨化合物的檢測方法 | 美國 | 2020/07/07 | 10,703,969 |
| 7 | 穀胱甘?的檢測方法及其套組 | 中華民國 | 2018/07/01 | I628435 |
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