Education
School — Major — Degree | Duration |
---|---|
國立成功大學 — 基礎醫學研究所(畢) — 博士 Doctorate, Institute of Basic Medical Sciences, National Cheng Kung University |
2000/09 — 2006/01 |
國立中興大學 — 分子生物學研究所(畢) — 碩士 Master, Institute of molecular biology, National Chung Hsing University |
1993/09 — 1996/06 |
東海大學 — 生物學系(畢) — 學士 Bachelor, Department of life science, Tunghai University |
1989/09 — 1993/06 |
Intramural Experience
Office/Department/Institute | Position | Duration |
---|---|---|
醫學研究所 Graduate Institute of Medicine | Professor | 2019/08/01 — |
醫學研究所 Graduate Institute of Medicine | Associate Professor | 2015/08/01 — 2019/07/31 |
生理學科 Department of Physiology | Associate Professor | 2012/08/01 — 2015/07/31 |
生理學科 Department of Physiology | Assistant Professor | 2007/08/01 — 2012/07/31 |
Extramural Experience
Discipline
NO | Discipline | Expertise |
---|---|---|
1 | 生物醫農類 Biology, Medicine and Agriculture | 生理 Physiology |
2 | 生物醫農類 Biology, Medicine and Agriculture | 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology |
3 | 生物醫農類 Biology, Medicine and Agriculture | 腎臟科、新陳代謝及內分泌 Division of Nephrology, Division of Metabolism & Endocrinology |
4 | 生物醫農類 Biology, Medicine and Agriculture | 骨科 Division of Orthopedics |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
生理,物理治療、醫化、生醫、藥理,,DDR1研究
Area(s) of Expertise & Research
DDR1接受器研究、硬骨與軟骨相關疾病與天然藥物治療研究、幹細胞與醫材結合之再生醫學研究、collagen receptor之訊息傳遞機制研究、Phyical stimulation on myotube and tendon regeneration study
DDR1 receptor research, bone and cartilage related diseases and natural medicine treatment research, regenerative medicine research combining stem cells and medical materials, collagen receptor message transmission mechanism research, Phyical stimulation on myotube and tendon regeneration study
Publication
NO | Publication |
---|---|
1 | Adipose derived stem cells loaded photocurable and bioprintable bioinks composed of GelMA, HAMA and PEGDA crosslinker to differentiate into smooth muscle phenotype. Adipose derived stem cells loaded photocurable and bioprintable bioinks composed of GelMA, HAMA and PEGDA crosslinker to differentiate into smooth muscle phenotype. |
2 | 軟骨細胞之凝血酶調節素可對抗骨關節炎 Chondrocyte Thrombomodulin Protects against Osteoarthritis. |
3 | Exploring the cellular and molecular mechanism of discoidin domain receptors (DDR1 and DDR2) in bone formation, regeneration, and its associated disease conditions. Exploring the cellular and molecular mechanism of discoidin domain receptors (DDR1 and DDR2) in bone formation, regeneration, and its associated disease conditions. |
4 | Ablation of Discoidin Domain Receptor 1 Provokes an Osteopenic Phenotype by Regulating Osteoblast/Osteocyte Autophagy and Apoptosis Ablation of Discoidin Domain Receptor 1 Provokes an Osteopenic Phenotype by Regulating Osteoblast/Osteocyte Autophagy and Apoptosis |
5 | The Essential Role of Stathmin in Myoblast C2C12 for Vertical Vibration-Induced Myotube Formation. The Essential Role of Stathmin in Myoblast C2C12 for Vertical Vibration-Induced Myotube Formation. |
6 | Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes |
7 | Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy. Discoidin Domain Receptors 1 Inhibition Alleviates Osteoarthritis via Enhancing Autophagy. |
8 | Discoidin domain receptor 1 regulates Runx2 during osteogenesis of osteoblasts and promotes bone ossification via phosphorylation of p-38. Discoidin domain receptor 1 regulates Runx2 during osteogenesis of osteoblasts and promotes bone ossification via phosphorylation of p-38. |
9 | (-)-Epigallocatechin-3-gallate (EGCG) enhances healing of femoral bone defect (-)-Epigallocatechin-3-gallate (EGCG) enhances healing of femoral bone defect |
10 | (-)-Epigallocatechin-3-Gallate Decrease Osteoclastogenesis via Modulation of RANKL and Osteoprotegrin (-)-Epigallocatechin-3-Gallate Decrease Osteoclastogenesis via Modulation of RANKL and Osteoprotegrin |
11 | Alpha-5 Integrin Mediates Simvastatin-Induced Osteogenesis of Bone Marrow Mesenchymal Stem Cells Alpha-5 Integrin Mediates Simvastatin-Induced Osteogenesis of Bone Marrow Mesenchymal Stem Cells |
12 | Enhancement of chondrogenesis of adipose-derived stem cells in HA-PNIPAAm-CL hydrogel for cartilage regeneration in rabbits. Enhancement of chondrogenesis of adipose-derived stem cells in HA-PNIPAAm-CL hydrogel for cartilage regeneration in rabbits. |
13 | Transforming growth factor beta 1 mediates the low-frequency vertical vibration enhanced production of tenomodulin and type I collagen in rat Achilles tendon. Transforming growth factor beta 1 mediates the low-frequency vertical vibration enhanced production of tenomodulin and type I collagen in rat Achilles tendon. |
14 | (-)-Epigallocatechin-3-Gallate (EGCG) Enhances Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells. (-)-Epigallocatechin-3-Gallate (EGCG) Enhances Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells. |
15 | Combination of a bioceramic scaffold and simvastatin nanoparticles as a synthetic alternative to autologous bone grafting Combination of a bioceramic scaffold and simvastatin nanoparticles as a synthetic alternative to autologous bone grafting |
16 | Enhancement of Bone Marrow-Derived Mesenchymal Stem Cell Osteogenesis and New Bone Formation in Rats by Obtusilactone A Enhancement of Bone Marrow-Derived Mesenchymal Stem Cell Osteogenesis and New Bone Formation in Rats by Obtusilactone A |
17 | 髓系凝血酶調節素類凝集素功能區抑制食骨細胞生成作用與發炎性骨質流失 Myeloid thrombomodulin lectin-like domain inhibits osteoclastogenesis and inflammatory bone loss |
18 | Suppression of discoidin domain receptor 1 expression enhances the chondrogenesis of adipose-derived stem cells Suppression of discoidin domain receptor 1 expression enhances the chondrogenesis of adipose-derived stem cells |
19 | 低能量雷射治療於背根神經節壓迫之效益 Effect of low level laser therapy on chronic compression of the dorsal root ganglion |
20 | 合成陽離子高分子奈米粒子為simvastatin藥物載體對其促進骨髓間質幹細胞成骨化之特性研究 Synthesis and characterization of cationic polymeric nanoparticles as simvastatin carriers for enhancing the osteogenesis of bone marrow mesenchymal stem cells |
21 | 低能量雷射治療改善坐骨神經壓迫損傷後之功能回復與神經再生 Low-level laser irradiation improves functional recovery and nerve regeneration in sciatic nerve crush rat injury model |
22 | 低能雷射經由表觀基因對單核球第一型巨噬細胞相關細胞激素表達之影響 Effects of low-level laser therapy on M1-related cytokine expression in monocytes via histone modification |
23 | 人類脂肪幹細胞在支架無懸浮培養生長分化能力的表徵和評估 Characterization and evaluation of the differentiation ability of human adipose-derived stem cells growing in scaffold-free suspension culture. |
24 | Effects of Low-Level Laser Therapy on M1-Related Cytokine Expression in Monocytes via Histone Modification Effects of Low-Level Laser Therapy on M1-Related Cytokine Expression in Monocytes via Histone Modification |
25 | Electromagnetic fields enhance chondrogenesis of human adipose-derived stem cells in a chondrogenic microenvironment in vitro. Electromagnetic fields enhance chondrogenesis of human adipose-derived stem cells in a chondrogenic microenvironment in vitro. |
26 | 負溫感水膠製備多孔性生物陶瓷結合控制釋放rhBMP-2載體:體外與體內研究 Preparation of Porous Bioceramics Using Reverse Thermo-Responsive Hydrogels in Combination with rhBMP-2 Carriers: In Vitro and In Vivo Evaluation |
27 | 四級胺鹽官能基分子修飾 PLGA-PEG高分子成陽離子奈米粒子在基因轉殖研究 Cationic nanoparticles with quaternary ammonium functionalized PLGA-PEG-based copolymers for potent gene transfection |
28 | 低能量雷射照射促進幹細胞經由IGF1 and BMP 造成骨化 Low-Power GaAlAs Laser Irradiation Promotes the Proliferation and Osteogenic Differentiation of Stem Cells via IGF1 and BMP2. |
29 | Characterization and enhancement of chondrogenesis in porous hyaluronic acid-modified scaffolds made of PLGA(75/25) blended with PEI-grafted PLGA(50/50). Characterization and enhancement of chondrogenesis in porous hyaluronic acid-modified scaffolds made of PLGA(75/25) blended with PEI-grafted PLGA(50/50). |
30 | The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration |
31 | Contributions of active site residues to cofactor binding and catalysis of 3α-hydroxysteroid dehydrogenase/carbonyl reductase. Contributions of active site residues to cofactor binding and catalysis of 3α-hydroxysteroid dehydrogenase/carbonyl reductase. |
32 | Preparation and Characterization of Calcium Phosphate Deposited on Gold Nanoparticles Preparation and Characterization of Calcium Phosphate Deposited on Gold Nanoparticles |
33 | DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation. DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation. |
34 | 低振幅垂直振動促進肌母細胞肌束形成 Low-magnitude vertical vibration enhances myotube formation in C2C12 myoblasts. |
35 | (-)-N-Formylanonaine from Michelia alba as human tyrosinase inhibitor and antioxidant (-)-N-Formylanonaine from Michelia alba as human tyrosinase inhibitor and antioxidant |
36 | The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration |
37 | DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation. DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation. |
38 | Discoidin domain receptor 1 activation suppressed alpha2beta1 integrin-dependent cell spreading through inhibition of Cdc42 activity. Discoidin domain receptor 1 activation suppressed alpha2beta1 integrin-dependent cell spreading through inhibition of Cdc42 activity. |
39 | DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading. DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading. |
40 | Contributions of Active Site Residues to Cofactor Binding and Catalysis of 3α-Hydroxysteroid Dehydrogenase/Carbonyl Reductase. Contributions of Active Site Residues to Cofactor Binding and Catalysis of 3α-Hydroxysteroid Dehydrogenase/Carbonyl Reductase. |
41 | Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration |
42 | A discoidin domain receptor 1/SHP-2 signaling complex inhibits a2b1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. A discoidin domain receptor 1/SHP-2 signaling complex inhibits a2b1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. |
43 | Function of discoidin domain receptor I in HGF-induced branching tubulogenesis of MDCK cells in collagen gel. Function of discoidin domain receptor I in HGF-induced branching tubulogenesis of MDCK cells in collagen gel. |
44 | Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by alpha2beta1 integrin. Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by alpha2beta1 integrin. |
Project
NO |
YEAR — Source — No — Type
Project Name
|
Duration |
---|---|---|
1 |
112 — N 國科會(原科技部) — MOST111-2320-B-037-008-MY2 — 1 個人型
皮膚角質細胞特異性基因轉殖鼠研究:盤基蛋白受體1型的功能評估 (II)(2/2)( )
|
2023/08/01 ~ 2024/07/31 |
2 |
112 — Z 大專學生研究計畫及博士後 — NSTC112-2811-B-037-013 — 9 博士後研究員
博士級研究人員--Arokia Vijaya Anand( )
|
2023/08/01 ~ 2024/07/31 |
3 |
111 — N 國科會(原科技部) — MOST111-2320-B-037-008-MY2 — 1 個人型
皮膚角質細胞特異性基因轉殖鼠研究:盤基蛋白受體1型的功能評估 (II)(1/2)( )
|
2022/08/01 ~ 2024/07/31 |
4 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2811-B-037-001 — 9 博士後研究員
博士級研究人員--Arokia Vijaya Anand( )
|
2023/04/01 ~ 2023/07/31 |
5 |
110 — N 國科會(原科技部) — MOST110-2320-B-037-003 — 1 個人型
皮膚角質細胞特異性基因轉殖鼠研究:盤基蛋白受體1型的功能評估( )
|
2021/08/01 ~ 2022/07/31 |
6 |
109 — N 國科會(原科技部) — MOST109-2320-B-037-005 — 1 個人型
DDR1於角質形成細胞促進傷口癒合之研究( )
|
2020/08/01 ~ 2021/07/31 |
7 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-008 — 1 個人型
研究軟骨細胞盤基蛋白結構域受體1在骨骼發育過程中調節軟骨內骨化的功能( )
|
2019/08/01 ~ 2020/07/31 |
8 |
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-091-B — 8 大專學生研究計畫
109年度大專學生研究計畫-李金美(生物3)( )
|
2020/07/01 ~ 2021/02/28 |
9 |
107 — N 國科會(原科技部) — MOST105-2320-B-037-017-MY3 — 1 個人型
Discoidin domain receptor 1在骨骼發育異常及骨缺損再生功能之研究(3/3)( )
|
2018/08/01 ~ 2019/07/31 |
10 |
107 — Z 大專學生研究計畫及博士後 — MOST107-2811-B-037-511 — 9 博士後研究員
博士後研究員--林逸翔( )
|
2018/08/01 ~ 2019/07/31 |
11 |
106 — N 國科會(原科技部) — MOST105-2320-B-037-017-MY3 — 1 個人型
Discoidin domain receptor 1在骨骼發育異常及骨缺損再生功能之研究(2/3)( )
|
2017/08/01 ~ 2019/07/31 |
12 |
106 — Z 大專學生研究計畫及博士後 — MOST106-2811-B-037-013 — 9 博士後研究員
博士後研究員--林逸翔( )
|
2017/08/01 ~ 2018/07/31 |
13 |
105 — N 國科會(原科技部) — MOST105-2320-B-037-017-MY3 — 1 個人型
Discoidin domain receptor 1在骨骼發育異常及骨缺損再生功能之研究(1/3)( )
|
2016/08/01 ~ 2019/07/31 |
14 |
105 — TP 頂尖計畫(高醫) — KMU-TP105B13 —
子計畫十三、以基因轉殖鼠模式探討Discoidin domain receptor 1 於骨質疏鬆症過程中的分子生物學機制( )
|
2016/11/01 ~ 2017/10/31 |
15 |
105 — Z 大專學生研究計畫及博士後 — MOST105-2811-B-037-033 — 9 博士後研究員
博士後研究員--林逸翔( )
|
2016/12/01 ~ 2017/07/31 |
16 |
104 — N 國科會(原科技部) — MOST104-2320-B-037-034 — 1 個人型
Discoidin domain receptor-1 (DDR1)基因在骨骼發育,骨質疏鬆症及退化性關節炎模式之角色探討: 骨母細胞特異性Ddr1基因剔除鼠及軟骨細胞特異性Ddr1基因剔除鼠研究( )
|
2015/08/01 ~ 2016/07/31 |
17 |
104 — TP 頂尖計畫(高醫) — KMU-TP104B12 —
子計畫十二、以基因轉殖鼠模式探討Discoidin domain receptor-1 於骨與軟骨之發育與退化之分子生物學機制( )
|
2015/10/01 ~ 2016/09/30 |
18 |
103 — N 國科會(原科技部) — NSC101-2320-B-037-035-MY3 — 1 個人型
肌母細胞中Stathmin與Phosphoinositide 3-kinase在垂向震動促進肌管生成之機轉研究(3/3)( )
|
2014/08/01 ~ 2015/07/31 |
19 |
103 — TP 頂尖計畫(高醫) — KMU-TP103B09 —
以基因轉殖鼠模式探討 Discoidin domain receptor-1 於骨與軟骨之發育與退化之分子生物學機制(Using transgenic mice model for studying the molecular mechanisms of Discoidin domain receptor-1 in the development and degeneration of bone and cartilage)
|
2014/08/01 ~ 2015/07/31 |
20 |
102 — N 國科會(原科技部) — NSC101-2320-B-037-035-MY3 — 1 個人型
肌母細胞中Stathmin與Phosphoinositide 3-kinase在垂向震動促進肌管生成之機轉研究(2/3)( )
|
2013/08/01 ~ 2015/07/31 |
21 |
101 — N 國科會(原科技部) — NSC101-2320-B-037-035-MY3 — 1 個人型
肌母細胞中Stathmin與Phosphoinositide 3-kinase在垂向震動促進肌管生成之機轉研究(1/3)( )
|
2012/08/01 ~ 2015/07/31 |
22 |
100 — M 高醫(種子計畫) — KMU-M110006 —
體外3D培養模式與裸鼠及兔子關節軟骨缺損模式-探討膠原蛋白接受體Discoidin domail receptors在脂肪幹細胞軟骨分化機轉之角色與關節軟骨再生研究( )
|
2011/12/15 ~ 2012/12/31 |
23 |
099 — M 高醫(種子計畫) — KMU-M100013 —
膠原蛋白接受體Discoidin domain receptor(DDR)調控人類脂肪幹細胞軟骨分化之機制與關節軟骨組織工程研究( )
|
2011/01/01 ~ 2011/12/31 |
24 |
098 — N 國科會(原科技部) — NSC98-2320-B-037-021 — 1 個人型
DDR1/E-cadherin複合體之功能性研究( )
|
2009/08/01 ~ 2010/07/31 |
25 |
097 — N 國科會(原科技部) — NSC97-2314-B-037-050 — 1 個人型
Discoidin domain receptor 1 與 E-cadherin結合與交互調節之研究( )
|
2008/10/01 ~ 2009/07/31 |
26 |
097 — Q 新聘教師計畫(校內) — KMU-Q098005 —
膠原蛋白接受體(Discoidin domain receptor)對脂肪幹細胞之促軟骨分化哼的軟骨新生之細胞訊息傳遞研究( )
|
2009/01/01 ~ 2009/12/31 |
27 |
096 — Q 新聘教師計畫(校內) — —
雙林酸鹽類(Alendronate)藥物,對骨隨幹細胞之促骨分化後的骨質新生之細胞訊息傳遞研究( )
|
2007/11/01 ~ 2008/07/31 |
Patent
NO | Patent Name | Country | Certified Date | Patent No |
---|---|---|---|---|
1 | 盤基蛋白結構域受體1的抑制劑及活化劑及其用途 | 中華民國 | 2019/11/11 | I676482 |
2 | 促骨新生及骨缺損修復藥物Obtusilactone A之用途 | 中華民國 | 2019/07/21 | I666017 |
3 | 盤基蛋白結構域受體1的抑制劑及活化劑及其用途 | 世界專利(美國) | 2021/03/16 | 10,946,021 |