Education
| School — Major — Degree | Duration |
|---|---|
|
國立國防醫學院 — 生命科學研究所(畢) — 博士 Doctorate, , |
2000/09 — 2004/04 |
|
俄亥俄州立大學 — 分子遺傳所(畢) — 碩士 Master, , |
1995/09 — 1998/08 |
|
國立臺灣大學 — 動物學研究所(畢) — 碩士 Master, , |
1991/09 — 1993/06 |
|
國立臺灣大學 — 動物學系(畢) — 學士 Bachelor, , |
1987/09 — 1991/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 生物科技學系 Department of Biotechnology | Professor | 2015/02/01 — |
| 生物科技學系 Department of Biotechnology | Associate Professor | 2010/08/01 — 2015/01/31 |
| 生物科技學系 Department of Biotechnology | Assistant Professor | 2004/08/16 — 2010/07/31 |
Extramural Experience
Discipline
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
化學合成、天然藥物、臨床醫學
Area(s) of Expertise & Research
癌症化療抗藥機轉, 檳榔分子細胞生物學,生物技術實驗,腫瘤基因體學
Publication
| NO | Publication |
|---|---|
| 1 | Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation. Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation. |
| 2 | 老藥新用抗精神病藥物三氟拉嗪透過 ROS/自噬途徑誘導 SLC7A11/GPX4 調控的口腔癌鐵死亡 Repurposing of the Antipsychotic Trifluoperazine Induces SLC7A11/GPX4- Mediated Ferroptosis of Oral Cancer via the ROS/Autophagy Pathway |
| 3 | Resistance to the platinum‑based chemotherapeutic drugs in oral cancer: Focus on the role of p22phox (Review). Resistance to the platinum‑based chemotherapeutic drugs in oral cancer: Focus on the role of p22phox (Review). |
| 4 | 白花丹素藉由ROS調控的內質網壓力和粒線體功能障礙造成抗藥性口腔癌细胞凋亡 Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction |
| 5 | 圓禿的臨床和遺傳：前沿綜述 Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review. |
| 6 | Female Pattern Hair Loss: An Overview with Focus on the Genetics. Female Pattern Hair Loss: An Overview with Focus on the Genetics. |
| 7 | Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells |
| 8 | diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation. diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation. |
| 9 | Second-to-fourth digit ratio and age predicting the severity of androgenetic alopecia: a cross-sectional study Second-to-fourth digit ratio and age predicting the severity of androgenetic alopecia: a cross-sectional study |
| 10 | The Role of Nonapoptotic Programmed Cell Death - Ferroptosis, Necroptosis, and Pyroptosis - in Pancreatic Ductal Adenocarcinoma Treatment. The Role of Nonapoptotic Programmed Cell Death - Ferroptosis, Necroptosis, and Pyroptosis - in Pancreatic Ductal Adenocarcinoma Treatment. |
| 11 | 綠緣酸抑制食道鱗狀細胞癌轉移是經由EGFR/p-Akt/Snail途徑 Chlorogenic acid inhibition Esophageal Squamous Cell Carcinoma metastasis by EGFR/p-Akt/Snail signaling pathways |
| 12 | The Phenoxyphenol Compound diTFPP Mediates Exogenous C2-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells. The Phenoxyphenol Compound diTFPP Mediates Exogenous C2-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells. |
| 13 | 鼻腔灌洗液外泌體中粘蛋白 5AC 顯著上調，可能促進 COX-2、VEGF 和 MMP-9 的表達：對鼻息肉發病機制的影響 Mucin 5AC is significantly upregulated in exosomes from the nasal lavage fluid and may promote the expression of COX-2, VEGF and MMP-9: an implication in nasal polyp pathogenesis |
| 14 | Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases. Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases. |
| 15 | Autophagy Is Deficient and May be Negatively Regulated by SERPINB3 in,Middle Ear Cholesteatoma Autophagy Is Deficient and May be Negatively Regulated by SERPINB3 in,Middle Ear Cholesteatoma |
| 16 | 細胞自噬在中耳膽脂瘤中缺乏並可能被SERPINB3負面調控 Autophagy Is Deficient and May be Negatively Regulated by SERPINB3 in Middle Ear Cholesteatoma |
| 17 | 內質網膜蛋白p22phox透過與順鉑直接結合造成口腔癌順鉑抗藥性 Direct Binding of Cisplatin to p22phox, an Endoplasmic Reticulum (ER) Membrane Protein, Contributes to Cisplatin Resistance in Oral Squamous Cell Carcinoma (OSCC) Cells |
| 18 | Human non‑small cell lung cancer cells can be sensitized to camptothecin by modulating autophagy Human non‑small cell lung cancer cells can be sensitized to camptothecin by modulating autophagy |
| 19 | A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling. A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling. |
| 20 | An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation |
| 21 | An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation |
| 22 | An Iron-Catalyzed Cascade Approach to Benzo[b]carbazole Synthesis Followed by 1,4-Sulfonyl Migration An Iron-Catalyzed Cascade Approach to Benzo[b]carbazole Synthesis Followed by 1,4-Sulfonyl Migration |
| 23 | Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps |
| 24 | Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis. Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis. |
| 25 | Autophagy is deficient in nasal polyps: implications for the pathogenesis of the disease. Autophagy is deficient in nasal polyps: implications for the pathogenesis of the disease. |
| 26 | BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9 BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9 |
| 27 | 種系動態重建柯薩奇 B2病毒之時空散佈和族群變化歷程 Phylodynamic reconstruction of the spatiotemporal transmission and demographic history of coxsackievirus B2 |
| 28 | Autophagy is deficient and inversely correlated with COX-2 expression in nasal polyps: a novel insight into the inflammation mechanism. Autophagy is deficient and inversely correlated with COX-2 expression in nasal polyps: a novel insight into the inflammation mechanism. |
| 29 | Serine protease inhibitor-1 (SERPIN) B1 promotes oral cancer cell mobility and is over-expressed in invasive squamous cell carcinoma Serine protease inhibitor-1 (SERPIN) B1 promotes oral cancer cell mobility and is over-expressed in invasive squamous cell carcinoma |
| 30 | 13-Acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression 13-Acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression |
| 31 | CYP26B1的差異表現與檳榔引起口腔癌的關係 Expression of a Splice Variant of CYP26B1 in Betel Quid-Related Oral Cancer |
| 32 | Calreticulin,一個內質網蛋白,高度表現並對於口腔癌細胞生長與移轉扮演重要角色 Calreticulin, an endoplasmic reticulum-resident protein, is highly expressed and essential for cell proliferation and migration in oral squamous cell carcinoma. |
| 33 | Serum 25-hydroxyvitamin D levels are lower in chronic rhinosinusitis with nasal polyposis and are correlated with disease severity in Taiwanese patients. Serum 25-hydroxyvitamin D levels are lower in chronic rhinosinusitis with nasal polyposis and are correlated with disease severity in Taiwanese patients. |
| 34 | 檳榔子萃取液透過增加活性氧分子與抑制GSK3β誘發血清飢餓口腔癌細胞固縮壞死 Areca nut extract induces pyknotic necrosis in serum-starved oral cells via increasing reactive oxygen species and inhibiting GSK3β: an implication for cytopathic effects in betel quid chewers |
| 35 | Anti-allergic activity of grape seed extract (GSE) on RBL-2H3 mast cells Anti-allergic activity of grape seed extract (GSE) on RBL-2H3 mast cells |
| 36 | 咖啡酸對於太平洋紫杉醇抑制生長能透過NF-κB路徑對肺癌細胞提供保護作用 Protective Effect of Caffeic Acid on Paclitaxel Induced Anti-Proliferation and Apoptosis of Lung Cancer Cells Involves NF-κB Pathway |
| 37 | 細胞自噬與活性氧化物能調節因抑制ATM激酶所引起之頭頸癌細胞的死亡 Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells |
| 38 | 檳榔鹼透過活性氧/mTOR complex 1途徑下調控p21及p27並可能造成口腔上皮鱗狀細胞癌 Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex1 pathway and may contribute to oral squamous cell carcinoma |
| 39 | Reversine 透過細胞週期停滯與伴隨發生之細胞凋亡及自噬抑制口腔鱗狀細胞癌 Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy |
| 40 | 11-Dehydrosinulariolide 透過粒線體失調與內質網壓力誘發人類黑色素細胞癌凋亡 Induction of apoptosis by 11-Dehydrosinulariolide via mitochondrial dysregulation and ER stress pathways in human melanoma cells |
| 41 | 利用蛋白體探討sinularin對黑色素細胞瘤A2058的抗癌活性 Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells |
| 42 | 紫錐菊萃取物誘導大腸癌細胞之凋亡 Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis |
| 43 | RhoGDP 分離抑制因子過度表現可以預測口腔上皮鱗狀細胞癌的低存活率 Overexpression of Rho GDP-dissociation inhibitor alpha predicts poor survival in oral squamous cell carcinoma |
| 44 | 利用蛋白體分析11-Dehydrosinulariolide 在CAL-27細胞的抗癌效果 Proteomic Analysis of Anti-Tumor Effects of 11-Dehydrosinulariolide on CAL-27 Cells |
| 45 | 利用弱陰離子交換層析法純化尿液蛋白體有助鑑定出低量蛋白 Identification of low-abundance proteins via fractionation of the urine proteome with weak anion exchange chromatography |
| 46 | 4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest 4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest |
| 47 | 靈芝萃取物協同增強抗癌藥物毒殺具抗藥性之泌尿上皮癌細胞 Ling-Zhi Polysaccharides Potentiates Cytotoxic Effects of Anticancer Drugs Against Drug-Resistant Urothelial Carcinoma Cells |
| 48 | Additive effects of C2-ceramide on Paclitaxel-induced premature senescence of human lung cancer cells Additive effects of C2-ceramide on Paclitaxel-induced premature senescence of human lung cancer cells |
| 49 | Betel quid extract promotes oral cancer cell migration by activating a muscarinic M4 receptor-mediated signaling cascade involving SFKs and ERK1/2 Betel quid extract promotes oral cancer cell migration by activating a muscarinic M4 receptor-mediated signaling cascade involving SFKs and ERK1/2 |
| 50 | Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan |
| 51 | p38 MAPK and NF-κB pathways are involved in naphtho[1,2-b]furan-4,5-dione induced anti-proliferation and apoptosisof human hepatoma cells p38 MAPK and NF-κB pathways are involved in naphtho[1,2-b]furan-4,5-dione induced anti-proliferation and apoptosisof human hepatoma cells |
| 52 | 食道癌細胞株侵犯次族群分子功能分析 Molecular characterization of invasive subpopulations fro esophageal squamous cell carcinomam an cell line. |
| 53 | 蕨類萃取化合物 protoapigenone 誘導肺癌細胞H1299的DNA損壞及細胞週期G2/M期停滯 Fern plant-derived protoapigenone leads to DNA damage, apoptosis and G2/M arrest in lung cancer cell line H1299 |
| 54 | SERPINB1 促進口腔癌細胞移轉並過度表現於侵犯性口腔鱗狀細胞癌 Serine Protease Inhibitor (SERPIN) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma |
| 55 | MAP2 參與口腔癌細胞移轉: 一個MAP2在非神經細胞的新穎功能 Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: A novel biological function of MAP2 in non-neuronal cells |
| 56 | Src家族激脢媒介檳榔液誘發之口腔癌細胞移轉且可能成為口腔癌早期侵犯作用之生物標記 Src Family Kinases Mediate Betel Quid–Induced Oral Cancer Cell Motility and Could Be a Biomarker for Early Invasion in Oral Squamous Cell Carcinoma |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
112 — M 高醫(種子計畫) — KMU-M113017 —
建立以酵母菌雙雜交系統為基礎的新冠肺炎藥物篩選平台:以新型冠狀病毒(SARS-CoV-2)核殼蛋白自我結合為藥物標靶及範例( )
|
2024/01/01 ~ 2024/12/31 |
| 2 |
111 — M 高醫(種子計畫) — KMU-M12010 —
內質網蛋白p22phox透過轉譯層面調控誘導口腔癌癌症幹細胞特性相關研究( )
|
2023/01/01 ~ 2023/12/31 |
| 3 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-032-B — 8 大專學生研究計畫
112年度大專學生研究計畫-李靚(生技3)( )
|
2023/07/01 ~ 2024/02/29 |
| 4 |
109 — N 國科會(原科技部) — MOST109-2311-B-037-001 — 1 個人型
p22phox促進口腔癌癌症幹細胞特性及其相關分子機轉探討( )
|
2020/08/01 ~ 2021/07/31 |
| 5 |
108 — N 國科會(原科技部) — MOST107-2320-B-037-020-MY2 — 1 個人型
p22phox 與順鉑結合及胞外體在p22phox主導口腔鱗狀上皮細胞癌順鉑抗藥性之角色(2/2)( )
|
2019/08/01 ~ 2020/07/31 |
| 6 |
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-020-B — 8 大專學生研究計畫
109年度大專學生研究計畫-楊瑞德(醫技3)( )
|
2020/07/01 ~ 2021/02/28 |
| 7 |
107 — N 國科會(原科技部) — MOST107-2320-B-037-020-MY2 — 1 個人型
p22phox 與順鉑結合及胞外體在p22phox主導口腔鱗狀上皮細胞癌順鉑抗藥性之角色(1/2)( )
|
2018/08/01 ~ 2020/07/31 |
| 8 |
106 — N 國科會(原科技部) — MOST106-2320-B-037-027 — 1 個人型
p22phox誘發口腔癌順鉑抗藥性分子機制及其臨床應用( )
|
2017/08/01 ~ 2018/07/31 |
| 9 |
105 — N 國科會(原科技部) — MOST105-2320-B-037-016 — 1 個人型
過度表現p22phox造成口腔癌順鉑抗藥性分子機轉:強調聚二磷酸腺苷核糖及類壓力顆粒複合體的角色( )
|
2016/08/01 ~ 2017/07/31 |
| 10 |
105 — TP 頂尖計畫(高醫) — KMU-TP105A13 —
子計畫5-3、檳榔成癮分子機制及化學預防(2)( )
|
2016/11/01 ~ 2017/10/31 |
| 11 |
105 — Z 大專學生研究計畫及博士後 — MOST106-2813-C-037-020-B — 8 大專學生研究計畫
106年度大專學生研究計畫-包鈺玄(生技3)( )
|
2017/07/01 ~ 2018/02/28 |
| 12 |
104 — N 國科會(原科技部) — MOST104-2320-B-037-021 — 1 個人型
p22phox參與口腔癌順鉑抗藥性之相關機轉研究( )
|
2015/08/01 ~ 2016/07/31 |
| 13 |
104 — TP 頂尖計畫(高醫) — KMU-TP104A15 —
子計畫6-3、檳榔成癮分子機制及化學預防( )
|
2015/10/01 ~ 2016/09/30 |
| 14 |
102 — N 國科會(原科技部) — NSC102-2320-B-037-016 — 1 個人型
探討Chloride intracellular channel 3 (CLIC3) 在口腔癌細胞之功能並評估成為診斷或預後生物標記之可行性( )
|
2013/08/01 ~ 2014/07/31 |
| 15 |
102 — NK 高醫-中山合作計畫 — NSYSUKMU102-P021 — 1 個人型
藥物合成以及其抗癌效果之評估(Drug synthesis and the screening of their anti-cancer potentials)
|
2013/01/01 ~ 2013/12/31 |
| 16 |
101 — X 高奇合作計畫 — 102CM-KMU-03 —
p22phox表現在口腔癌對cisplatin抗藥性中所扮演角色( )
|
2013/05/01 ~ 2014/04/30 |
| 17 |
100 — N 國科會(原科技部) — NSC98-2311-B-037-002-MY3 — 1 個人型
研究蕈毒鹼受體在檳榔液誘發口腔癌細胞移轉與侵犯作用中所扮演之角色(3/3)( )
|
2011/08/01 ~ 2012/08/31 |
| 18 |
100 — X 高奇合作計畫 — 101CM-KMU-03 —
利用微型核醣核酸陣列研究calreticulin在口腔癌所扮演之角色( )
|
2012/05/01 ~ 2013/04/30 |
| 19 |
099 — N 國科會(原科技部) — NSC98-2311-B-037-002-MY3 — 1 個人型
研究蕈毒鹼受體在檳榔液誘發口腔癌細胞移轉與侵犯作用中所扮演之角色(2/3)( )
|
2010/08/01 ~ 2012/08/31 |
| 20 |
099 — X 高奇合作計畫 — 100CM-KMU-05 —
本土性口腔癌細胞株之建立與其特性之分析( )
|
2011/05/01 ~ 2012/04/30 |
| 21 |
098 — N 國科會(原科技部) — NSC98-2311-B-037-002-MY3 — 1 個人型
研究蕈毒鹼受體在檳榔液誘發口腔癌細胞移轉與侵犯作用中所扮演之角色(1/3)( )
|
2009/08/01 ~ 2012/08/31 |
| 22 |
098 — X 高奇合作計畫 — 99CM-KMU-04 —
探討Rho-GDIα在口腔癌細胞所扮演之角色( )
|
2010/05/01 ~ 2011/04/30 |
| 23 |
097 — X 高奇合作計畫 — 98CM-KMU-02 —
探討蕈毒鹼受體在檳榔液誘發口腔癌細胞訊息傳遞中所扮演之角色( )
|
2009/05/01 ~ 2010/04/30 |
| 24 |
096 — N 國科會(原科技部) — NSC95-2311-B-037-004-MY2 — 1 個人型
Src相關激酶參與檳榔液所誘發口腔癌轉移現象之探討(2/2)( )
|
2007/08/01 ~ 2008/07/31 |
| 25 |
095 — N 國科會(原科技部) — NSC95-2311-B-037-004-MY2 — 1 個人型
SRC 相關激𡓨參與檳榔液所誘發口腔癌轉移現象之探討(1/2)( )
|
2006/08/01 ~ 2008/07/31 |
| 26 |
094 — N 國科會(原科技部) — NSC94-2320-B-037-047- — 1 個人型
探討MAP2在口腔癌轉移作用上可能扮演之角色( )
|
2005/08/01 ~ 2006/07/31 |
| 27 |
093 — N 國科會(原科技部) — NSC 94-2320-B-037-013- — 1 個人型
探討MICROTUBULE-ASSOCIATED PROTEIN 2 (MAP2)在檳榔誘發口腔鱗狀細胞癌分子機轉上所扮演之角色( )
|
2005/01/01 ~ 2005/07/31 |
| 28 |
093 — Z 大專學生研究計畫及博士後 — NSC94-2815-C-037-008 — 8 大專學生研究計畫
( )
|
2005/07/01 ~ 2006/02/28 |
| 29 |
093 — Z 大專學生研究計畫及博士後 — NSC94-2815-C-037-009-B — 8 大專學生研究計畫
( )
|
2005/07/01 ~ 2006/02/28 |