Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學大學 — 醫學研究所(畢) — 博士 Doctorate, Graduate Institute of Medicine, Kaohsiung Medical University |
2008/08 — 2016/06 |
|
高雄醫學大學 — 醫學研究所(畢) — 碩士 Master, Graduate Institute of Medicine, Kaohsiung Medical University |
— 2005/06 |
|
高雄醫學院 — 醫學系(畢) — 學士 Bachelor, School of Medicine, Kaohsiung Medical College |
— 1999/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 內科部 | Visiting Staff | — |
| 內科學科 Department of Internal Medicine | Professor | 2023/02/01 — |
| 內科學科 Department of Internal Medicine | Associate Professor | 2019/08/01 — 2023/01/31 |
| 內科學科 Department of Internal Medicine | Assistant Professor | 2014/02/01 — 2019/07/31 |
Extramural Experience
Discipline
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
所有相關領域
all related topics with potential and impact.
Area(s) of Expertise & Research
臨床方面: 成人心臟科疾病包括冠狀動脈疾病、心律不整、瓣膜心臟病、心衰竭、心肌病變等診斷、治療與預防、心臟急重症醫療、心臟超音波操作與診斷。 研究方面: 脂質致病機轉研究、心臟電生理相關研究、離子通道、心律不整機轉探討、心臟電生理模型模擬。
Clinical aspect: adult cardiologist; diagnosis, treatment and prevention of arrhythmia, coronary artery disease, valvular heart disease, heart failure, and cardiomyopathy; critical medicine for acute coronary syndrome and acute decompensated heart failure; echocardiography. Research aspect: lipid science and cardiac lipotoxicity, cardiac electrophysiology, ion channels study, mechanisms of arrhythmias, computational simulation of cardiac electrophysiology.
Publication
| NO | Publication |
|---|---|
| 1 | Female showed favorable left ventricle hypertrophy regression during post-TAVR follow-up. Female showed favorable left ventricle hypertrophy regression during post-TAVR follow-up. |
| 2 | 心臟衰竭患者生命最後一個月在重症監護使用的趨勢和變化 Trends and Changes in Intensive Care Use for Patients With Heart Failure in the Last Month of Life |
| 3 | Upregulated Small-Conductance Calcium-Activated Potassium Currents Contribute to Atrial Arrhythmogenesis in High-Fat Feeding Mice Upregulated Small-Conductance Calcium-Activated Potassium Currents Contribute to Atrial Arrhythmogenesis in High-Fat Feeding Mice |
| 4 | Spondyloarthritis and nonbacterial thrombotic endocarditis as paraneoplastic manifestations in treatment-naive Burkitt lymphoma. Spondyloarthritis and nonbacterial thrombotic endocarditis as paraneoplastic manifestations in treatment-naive Burkitt lymphoma. |
| 5 | 極低密度脂蛋白脂質組成及不飽和脂肪酸與代謝症候群心房重塑的關聯 Association of lipid composition and unsaturated fatty acids of VLDL with atrial remodeling in metabolic syndrome |
| 6 | An open-label randomized non-inferior study of generic-name and brand-name of propafenone for rhythm control in patients with paroxysmal atrial fibrillation. An open-label randomized non-inferior study of generic-name and brand-name of propafenone for rhythm control in patients with paroxysmal atrial fibrillation. |
| 7 | Mitochondrial Oxidative Stress Mediates Bradyarrhythmia in Leigh Syndrome Mitochondrial Disease Mice. Mitochondrial Oxidative Stress Mediates Bradyarrhythmia in Leigh Syndrome Mitochondrial Disease Mice. |
| 8 | Long-term High-fat Diet Consumption Depletes Glial Cells and Tyrosine Hydroxylase–containing Neurons in the Brain of Middle-aged Rats Long-term High-fat Diet Consumption Depletes Glial Cells and Tyrosine Hydroxylase–containing Neurons in the Brain of Middle-aged Rats |
| 9 | 極低密度脂蛋白致病角色的新證據 Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL) |
| 10 | 利用運動心電圖通過深度學習神經網絡改善心房顫動的早期診斷 Exploiting exercise electrocardiography to improve early diagnosis of atrial fibrillation with deep learning neural networks. |
| 11 | Skin sympathetic nerve activity and ventricular arrhythmias in acute coronary syndrome Skin sympathetic nerve activity and ventricular arrhythmias in acute coronary syndrome |
| 12 | QTc 期間與代謝症候群個體的心房顫動有關 QTc Interval is Associated with Atrial Fibrillation in Individuals with Metabolic Syndrome Phenotype |
| 13 | An artificial intelligence approach for predicting cardiotoxicity in breast cancer patients receiving anthracycline. An artificial intelligence approach for predicting cardiotoxicity in breast cancer patients receiving anthracycline. |
| 14 | 關注極低密度脂蛋白於代謝性心臟病的致病角色：疾病與機轉 Spotlight on very-low-density lipoprotein as a driver of cardiometabolic disorders: Implications for disease progression and mechanistic insights. |
| 15 | 1-磷酸鞘氨醇增強內鈣對嗜鉻細胞大電導鈣激活鉀通道之控制 Permissive Modulation of Sphingosine-1-Phosphate-Enhanced Intracellular Calcium on BKCa Channel of Chromaffin Cells |
| 16 | 陰電性極低密度脂蛋白誘發小鼠腦部發炎和認知功能障礙 Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice |
| 17 | 在疫情大流行時執行冠狀動脈介入治療？心導管室因應武漢肺炎之可行模式 Performing a percutaneous coronary intervention in the Pandemic?A paradigm for a Catheterization Laboratory responding to Covid-19 |
| 18 | High Skin Sympathetic Nerve Activity in Patients with Recurrent Syncope High Skin Sympathetic Nerve Activity in Patients with Recurrent Syncope |
| 19 | 極低密度脂蛋白在代謝症候群的心房病變的致病角色 The Pathogenic Role of Very Low Density Lipoprotein on Atrial Remodeling in the Metabolic Syndrome |
| 20 | Role of low-density lipoprotein in early vascular aging associated with systemic lupus erythematosus Role of low-density lipoprotein in early vascular aging associated with systemic lupus erythematosus |
| 21 | 脂質和脂蛋白對用於心臟組織再生的間質幹細胞的影響 Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration |
| 22 | 餐後極低密度脂蛋白在代謝症候群之心房重構發展中的作用 The role of postprandial very-low-density lipoprotein in the development of atrial remodeling in metabolic syndrome |
| 23 | 在疫情大流行時執行冠狀動脈介入治療？ 心導管室因應新冠肺炎之可行模式 Performing a Percutaneous Coronary Intervention in the Pandemic? A Paradigm for a Catheterization Laboratory Responding to Covid-19 |
| 24 | 鈉－葡萄糖共同轉運蛋白2抑制劑 empagliflozin 減緩高血壓心衰竭大鼠的心臟纖維化與改善血型動力學 The Sodium-Glucose Co-transporter 2 Inhibitor Empagliflozin Attenuates Cardiac Fibrosis and Improves Ventricular Hemodynamics in Hypertensive Heart Failure Rats |
| 25 | 同步心電圖與侵入性動脈血壓紀錄 Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats |
| 26 | adipoectin T94G 多型性與年輕型頑固性高血壓病人相關性之探討 Association between adiponectin T94G polymorphism and resistant T hypertension in young-onset Taiwanese patients |
| 27 | 極低密度脂蛋白調節鈣離子感測蛋白STIM1抑制SOCE造成心房心肌肌蛋白失序 Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes |
| 28 | Immunoregulatory effects of very low density lipoprotein from healthy individuals and metabolic syndrome patients on glial cells Immunoregulatory effects of very low density lipoprotein from healthy individuals and metabolic syndrome patients on glial cells |
| 29 | 黃嘌呤衍生KMUP-1反轉高糖毒性活化之Kv通道經由cAMP/PKA訊息路徑於大鼠胰島乙型細胞 Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells |
| 30 | 高脂飲食惡化年長高血壓鼠之左心房與心室重塑 High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats |
| 31 | Association between modified CHA2DS2-VASc Score with Ankle-Brachial index < 0.9. Association between modified CHA2DS2-VASc Score with Ankle-Brachial index < 0.9. |
| 32 | Range of L5 LDL levels in healthy adults and L5’s predictive power in patients with hyperlipidemia or coronary artery disease Range of L5 LDL levels in healthy adults and L5’s predictive power in patients with hyperlipidemia or coronary artery disease |
| 33 | V141M KCNQ1基因突變造成短ＱＴ症候群之機轉探討- 電腦模型模擬研究 Pro-arrhythmogenic effects of the V141M KCNQ1 mutation in short QT syndrome and its potential therapeutic targets - insights from modeling |
| 34 | 代謝症候群之極低密度脂蛋白調節間隙連接與延緩心臟內電傳導 Very-low-density lipoprotein of metabolic syndrome modulates gap junctions and slows cardiac conduction |
| 35 | 陰電性低密度脂蛋白誘發代謝症候群脂肪組織發炎反應 Electronegative Low-density Lipoprotein L5 Induces Adipose Tissue Inflammation Associated with Metabolic Syndrome |
| 36 | 空氣污染PM與動脈硬化 Air Pollution Particular Matter and Atherosclerosis |
| 37 | 右心房鉀離子通道KCNQ1基因在術後心房顫動的調控 Modulation of Potassium Channel KCNQ1 Transcript in Right Atrial Appendage of Patients with Postoperative Atrial Fibrillation |
| 38 | 代謝症候群中的非常低密度脂蛋白造成心房脂質沉積與心房顫動 的發生有關 VLDL from metabolic syndrome individuals enhanced lipid accumulation in atria with association of susceptibility to atrial fibrillation |
| 39 | Areca Nut Chewing Complicated with Non-Obstructive and Obstructive ST Elevation Myocardial Infarction Areca Nut Chewing Complicated with Non-Obstructive and Obstructive ST Elevation Myocardial Infarction |
| 40 | 美國2013年新版膽固醇治療指引中的四大他汀類降膽固醇藥物受惠者血漿中有較高濃度的陰電性低密度脂蛋白膽固醇 Four Statin Benefit Groups Defined by The 2013 ACC/AHA New Cholesterol Guideline are Characterized by Increased Plasma Level of Electronegative LDL |
| 41 | 登革熱併發猛爆性心肌炎與休克經主動脈氣球幫浦支持 Fulminant dengue myocarditis complicated with profound shock and fatal outcome under intra-aortic balloon pumping support |
| 42 | 冠狀動脈側枝循環在有顯著冠狀動脈疾病之血管擴張症患者身上 Coronary Collateral Circulation in Patients of Coronary Ectasia with Significant Coronary Artery Disease |
| 43 | KCNQ1選擇性剪接的改變調節心臟IKs電流與動作電位在極化 Modulation of KCNQ1 Alternative Splicing Regulates Cardiac IKs and Action Potential Repolarization |
| 44 | 短時間投予N-acetylcysteine, probucol, ascorbic acid在顯影劑細胞毒性的影響 Impact of short-duration administration of n-acetylcysteine, probucol and ascorbic acid on contrast-induced cytotoxicity. |
| 45 | 離子性照影劑比非離子性照影劑在糖尿病腎臟引起更明顯的凋亡 Ionic contrast media induced more apoptosis in diabetic kidney than nonionic contrast media. |
| 46 | JNK/ATF2途徑與顯影劑造成之細胞凋亡有關 JNK/ATF2 Pathway Is Involved in Iodinated Contrast Media-Induced Apoptosis |
| 47 | 急性一氧化碳中毒造成ST 段上升之心肌梗塞 —罕見的病歷報告 Acute carbon monoxide poisoning resulting in ST elevation myocardial infarction: a rare case report. |
| 48 | Mismatch between arterial stiffness increase and left ventricular diastolic dysfunction Mismatch between arterial stiffness increase and left ventricular diastolic dysfunction |
| 49 | 以舒張中期二尖瓣環的運動型態來分辨左心室的舒張功能 Differentiation of left ventricular diastolic function by mid-diastolic mitral annular motion patterns. |
| 50 | 感染性心內膜炎與葡萄膜炎-病歷報告 Infective endocarditis with uveitis |
| 51 | 抗氧化劑Acetylcysteine 及probucol對STZ誘發糖尿病鼠內生性腎glutathione peroxidase的作用 Effects of acetylcysteine and probucol on contrast medium-induced depression of intrinsic renal glutathione peroxidase activity in diabetic rats |
| 52 | 感染性心內膜炎與葡萄膜炎--病歷報告 Infective endocarditis with uveitis: a rare case report |
| 53 | 顯影劑對心肌旋轉蛋白I免疫分析測定的偽陽性干擾 Positive interference from contrast media in cardiac troponin I immunoassays |
| 54 | 不同的顯影劑對正常鼠和糖尿病鼠心臟和腎臟抗氧化酵素活性的影響 Effects of different contrast media on glutathione peroxidase and superoxide dismutase activities in the heart and kidneys of normal and streptozotocin-induced diabetic rats. |
| 55 | 高滲透壓離子顯影劑對Streptozotocin 誘發的糖尿病鼠腎抗氧化活性的急性作用 Acute effect of ionic high osmolar contrast medium on renal antioxidant enzyme activity in streptozotocin-induced diabetic rats |
| 56 | Terlipressin 引起之急性心肌梗塞- 一病例報告及文獻回顧 Terlipressin-related acute myocardial infarction: a case report and literature review |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
113 — KT 高醫清大 — KT113P012 — 1 個人型
開發預測新型口服抗凝血劑之藥效與出血副作用之基因標記檢測平台(Development a diagnosis platform for predicting the efficacy and bleeding adverse events of direct oral anticoagulants (DOACs))
|
2024/01/01 ~ 2024/12/31 |
| 2 |
113 — N 國科會(原科技部) — NSTC113-2314-B-037-055 — 1 個人型
極低密度脂蛋白接受器和脂蛋白脂肪?的相互作用對心房肌病之影響( )
|
2024/08/01 ~ 2025/07/31 |
| 3 |
112 — N 國科會(原科技部) — NSTC112-2314-B-037-069 — 1 個人型
極低密度脂蛋白接受器的選擇性剪接變異型於調控心臟脂質利用之角色( )
|
2023/08/01 ~ 2024/07/31 |
| 4 |
112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-028-B — 8 大專學生研究計畫
113年度大專學生研究計畫-張仁懷(藥學3)( )
|
2024/07/01 ~ 2025/02/28 |
| 5 |
112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-030-B — 8 大專學生研究計畫
113年度大專學生研究計畫-邱亭維(醫學4)( )
|
2024/07/01 ~ 2025/02/28 |
| 6 |
111 — KK 高科大高醫產學合作補助 — —
網球選手的人工智慧心臟評估系統( )
|
2022/11/01 ~ 2023/10/31 |
| 7 |
111 — N 國科會(原科技部) — MOST109-2314-B-037-111-MY3 — 1 個人型
極低密度脂蛋白/接受器訊息調控心臟自律神經支配對心律不整發生的影響(3/3)( )
|
2022/08/01 ~ 2023/07/31 |
| 8 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-060-B — 8 大專學生研究計畫
112年度大專學生研究計畫-黃加佳(醫學2)( )
|
2023/07/01 ~ 2024/02/29 |
| 9 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-061-B — 8 大專學生研究計畫
112年度大專學生研究計畫-周亮宜(醫學3)( )
|
2023/07/01 ~ 2024/02/29 |
| 10 |
110 — N 國科會(原科技部) — MOST109-2314-B-037-111-MY3 — 1 個人型
極低密度脂蛋白/接受器訊息調控心臟自律神經支配對心律不整發生的影響(2/3)( )
|
2021/08/01 ~ 2023/07/31 |
| 11 |
110 — Z 大專學生研究計畫及博士後 — MOST111-2813-C-037-080-B — 8 大專學生研究計畫
111年度大專學生研究計畫-陳漢宜(醫學3)( )
|
2022/07/01 ~ 2023/02/28 |
| 12 |
109 — I 國衛院 — NHRI-EX110-10724SC —
脂蛋白血脂於早期心房心肌病變與心房顫動發生的轉譯醫學研究( )
|
2021/01/01 ~ 2021/12/31 |
| 13 |
109 — KP 高醫屏科大 — NPUST-KMU-109-P005 — 1 個人型
脂質毒性導致心房心肌病變之豬模式轉譯研究( )
|
2020/01/01 ~ 2020/12/31 |
| 14 |
109 — N 國科會(原科技部) — MOST109-2314-B-037-111-MY3 — 1 個人型
極低密度脂蛋白/接受器訊息調控心臟自律神經支配對心律不整發生的影響(1/3)( )
|
2020/08/01 ~ 2023/07/31 |
| 15 |
109 — X 高奇合作計畫 — 110CM-KMU-01 —
透過基因多型性探討抗癌藥物對於女性乳癌患者所造成心臟毒性之精準醫學研究( )
|
2021/08/01 ~ 2022/07/31 |
| 16 |
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-165-B — 8 大專學生研究計畫
110年度大專學生研究計畫-才芷伶(醫學3)( )
|
2021/07/01 ~ 2022/02/28 |
| 17 |
108 — I 國衛院 — NHRI-EX109-10724SC —
脂蛋白血脂於早期心房心肌病變與心房顫動發生的轉譯醫學研究( )
|
2020/01/01 ~ 2020/12/31 |
| 18 |
108 — N 國科會(原科技部) — MOST108-2314-B-037-098 — 1 個人型
極低密度脂蛋白相關分子訊號於心房病變中之致病角色( )
|
2019/08/01 ~ 2020/07/31 |
| 19 |
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-044-B — 8 大專學生研究計畫
109年度大專學生研究計畫-黃日楷(醫學5)( )
|
2020/07/01 ~ 2021/02/28 |
| 20 |
107 — I 國衛院 — NHRI-EX108-10724SC —
脂蛋白血脂於早期心房心肌病變與心房顫動發生的轉譯醫學研究(The Alliance of Lipoproteins-Lipids with Early Atrial Myopathy and Atrial Fibrillation)
|
2019/01/01 ~ 2019/12/31 |
| 21 |
107 — N 國科會(原科技部) — MOST107-2314-B-037-110 — 1 個人型
極低密度脂蛋白在心房病變中的代謝異常之致病角色( )
|
2018/08/01 ~ 2019/07/31 |
| 22 |
107 — X 高奇合作計畫 — 108CM-KMU-09 —
探討極低密度脂蛋白接受體於代謝症候群患者心臟重塑之角色( )
|
2019/05/01 ~ 2020/04/30 |
| 23 |
106 — I 國衛院 — NHRI-EX107-10724SC —
脂蛋白血脂於早期心房心肌病變與心房顫動發生的轉譯醫學研究( )
|
2018/01/01 ~ 2018/12/31 |
| 24 |
106 — N 國科會(原科技部) — MOST104-2314-B-037-080-MY3 — 1 個人型
極低密度脂蛋白在代謝症候群中發展心房顫動扮演的角色(3/3)( )
|
2017/08/01 ~ 2018/07/31 |
| 25 |
105 — N 國科會(原科技部) — MOST104-2314-B-037-080-MY3 — 1 個人型
極低密度脂蛋白在代謝症候群中發展心房顫動扮演的角色(2/3)( )
|
2016/08/01 ~ 2018/07/31 |
| 26 |
105 — TP 頂尖計畫(高醫) — KMU-TP105D08 —
子計畫八、極低密度脂蛋白干擾心房肌細胞粒線體功能-代謝症候群影響心房顫動發生的可能機轉( )
|
2016/11/01 ~ 2017/10/31 |
| 27 |
104 — NK 高醫-中山合作計畫 — NSYSUKMU104-P027 — 1 個人型
心臟電生理模型模擬平台( )
|
2015/01/01 ~ 2015/12/31 |
| 28 |
104 — N 國科會(原科技部) — MOST104-2314-B-037-080-MY3 — 1 個人型
極低密度脂蛋白在代謝症候群中發展心房顫動扮演的角色(1/3)( )
|
2015/08/01 ~ 2018/07/31 |
| 29 |
104 — TP 頂尖計畫(高醫) — KMU-TP104D10 —
子計畫十、代謝症候群中非常低密度脂蛋白對心房間隙連接的調控( )
|
2015/10/01 ~ 2016/09/30 |
| 30 |
103 — N 國科會(原科技部) — MOST103-2314-B-037-053 — 1 個人型
選擇性剪接為造成心房顫動的電氣重構之新致病機轉( )
|
2014/08/01 ~ 2015/07/31 |
| 31 |
103 — TP 頂尖計畫(高醫) — KMU-TP103D05 —
微小核醣核酸在代謝症候群合併脂肪肝發生心房顫動的關鍵角色( )
|
2014/08/01 ~ 2015/07/31 |
| 32 |
102 — N 國科會(原科技部) — NSC102-2314-B-037-041 — 1 個人型
解析基因選擇性剪接與心律不整的關係( )
|
2013/08/01 ~ 2014/07/31 |
| 33 |
099 — N 國科會(原科技部) — NSC99-2221-E-037-001 — 1 個人型
運用基因轉殖與電氣生理技術探討選擇性剪接在鉀離子通道KCNQ1之調控機制( )
|
2010/08/01 ~ 2011/07/31 |
| 34 |
097 — M 高醫(種子計畫) — KMU-M098027 —
糖尿病心肌病變之預後相關因子及基因多形變化( )
|
2009/01/01 ~ 2009/12/31 |