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 Education

School — Major — Degree Duration

國立陽明大學 — 微生物免疫研究所(畢) — 博士

Doctorate, Graduate Institute of Microbiology and Immunology, National Yang Ming University

1989/09 — 1996/06

國立陽明大學 — 微生物免疫研究所(畢) — 碩士

Master, Graduate Institute of Microbiology and Immunology, National Yang Ming University

1987/09 — 1989/06

國立陽明大學 — 醫學技術學系(畢) — 學士

Bachelor, Department of Medical Technology, National Yang Ming University

1982/09 — 1986/06

 Intramural Experience

Office/Department/Institute Position Duration
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology   Associate Professor 2021/08/01 —  
生命科學院學士班 Bachelor Program in Life Sciences   Associate Professor 2020/08/01 — 2021/07/31
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology   Associate Professor 2017/02/01 — 2020/07/31
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology   Assistant Professor 2011/08/01 — 2017/01/31
生物科技學系 Department of Biotechnology   Assistant Professor 2011/02/01 — 2011/07/31
生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology   Assistant Professor 2003/08/01 — 2011/01/31
生物學系 Department of Biology   Assistant Professor 1997/08/01 — 2003/07/31

 Extramural Experience

 

 Discipline

NO Discipline Expertise
1 生物醫農類 Biology, Medicine and Agriculture 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology
2 生物醫農類 Biology, Medicine and Agriculture 微生物及免疫學 Microbiology and Immunology

 Research & Technology Platform Open to the Outside

DNA methylation analysis

 Interested Area(s)for Interdisciplinary Research

表觀基因及癌症生物學研究

Epigenetic study and cancer biology

 Area(s) of Expertise & Research

腫瘤生物 病毒學 基因甲基化

cancer biology virology DNA methylation

 Publication

NO Publication
1

微小病毒B19 非結構蛋白質誘發類似類風濕性關節炎之滑膜發炎
顏昌毅, 曾家駿, 林嘉慧, 林原兆, 李瑞年, 王品逸, 陳冠宇, 吳正欽, 歐燦騰, 陳忠仁, 劉于鵬*, 顏正賢* - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2025 15卷(1期):28679頁
(IF: 3.9, 領域排名: 25, 領域期刊數: 136, 領域排名: 18.38%)

Parvovirus B19 NS1 protein induces synovitis mimicking rheumatoid arthritis
Chang-Yi Yen, Chia-Chun Tseng, Chia-Hui Lin, Yuan-Zhao Lin, Ruei-Nian Li, Pin-Yi Wang, Kuan-Yu Chen, Cheng-Chin Wu, Tsan-Teng Ou, Chung-Jen Chen, Yu-Peng Liu*#, Jeng-Hsien Yen* - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2025;15(1):28679
(IF: 3.9, Journal Ranking: 25, Number of Journals of this Field: 136, Ranking: 18.38%)

2

NLRP3 Gene Polymorphisms in Rheumatoid Arthritis and Primary Sjogren's Syndrome Patients.
李瑞年, 歐燦騰#, 林嘉慧, 林原兆, 方姿蓉, 陳怡菁, 曾家駿, 宋婉瑜, 吳正欽, 顏正賢* - - 1 - DIAGNOSTICS (BASEL, SWITZERLAND) - DIAGNOSTICS 2023 13卷(2期):206頁
(IF: 3.6, 領域排名: 64, 領域期刊數: 169, 領域排名: 37.87%)

NLRP3 Gene Polymorphisms in Rheumatoid Arthritis and Primary Sjogren's Syndrome Patients.
Ruei-Nian Li, Tsan-Teng Ou#, Chia-Hui Lin, Yuan-Zhao Lin, Tzu-Jung Fang, Yi-Jing Chen, Chia-Chun Tseng, Wan-Yu Sung, Cheng-Chin Wu, Jeng-Hsien Yen - - 1 - DIAGNOSTICS (BASEL, SWITZERLAND) - DIAGNOSTICS 2023;13(2):206
(IF: 3.6, Journal Ranking: 64, Number of Journals of this Field: 169, Ranking: 37.87%)

3

A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy.
呂迪士, 張文燦, 柯景中, 李瑞年, 楊惠閔, 陳宣佑, 黃琳雅, 張夢揚*, Chang-Yi Wu, 邱建智* - - 1 - LIFE SCIENCES - LIFE SCIENCES 2023 329卷(-期):121835頁
(IF: 6.1, 領域排名: 34, 領域期刊數: 278, 領域排名: 12.23%)

A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy.
Ritesh Urade, Wen-Tsan Chang, Ching-Chung Ko, Ruei-Nian Li, Hui-Min Yang, Hsuan-Yu Chen, Lin-Ya Huang, Meng-Yang Chang*, Chang-Yi Wu*, Chien-Chih Chiu* - - 1 - LIFE SCIENCES - LIFE SCIENCES 2023;329(-):121835
(IF: 6.1, Journal Ranking: 34, Number of Journals of this Field: 278, Ranking: 12.23%)

4

A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage.
鮑永定, 柯景中, 張文燦, 邱逸涵, 洪春姿, 黃昭玲, 曾志華, 陳義龍*, 李瑞年*, 邱建智* - - 1 - CANCER CELL INTERNATIONAL - CANCER CELL INTERNATIONAL 2023 23卷(1期):171頁
(IF: 5.8, 領域排名: 59, 領域期刊數: 241, 領域排名: 24.48%)

A novel quinoline derivative, DFIQ, sensitizes NSCLC cells to ferroptosis by promoting oxidative stress accompanied by autophagic dysfunction and mitochondrial damage.
Yung-Ding Bow, Ching-Chung Ko, Wen-Tsan Chang, Sih-Yan Chou, Chun-Tzu Hung, Jau-Ling Huang, Chih-Hua Tseng, Yeh-Long Chen*, Ruei-Nian Li*, Chien-Chih Chiu* - - 1 - CANCER CELL INTERNATIONAL - CANCER CELL INTERNATIONAL 2023;23(1):171
(IF: 5.8, Journal Ranking: 59, Number of Journals of this Field: 241, Ranking: 24.48%)

5

Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility.
方姿蓉, 林嘉慧, 林原兆, MH Chiu, 李瑞年, 詹華蓁, YT Yeh*, 顏正賢* - - 1 - JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION - JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 2022 121卷(8期):1431-1441頁
(IF: 3.871, 領域排名: 61, 領域期刊數: 172, 領域排名: 35.47%)

Lower HDAC6 mRNA expression and promoter hypomethylation are associated with RA susceptibility.
Tzu-Jung Fang, Chia-Hui Lin, Yuan-Zhao Lin, Min-HSi Chiu, Ruei-Nian Li, Hua-Chen Chan, Yao-Tsung Yeh*, Jeng-Hsien Yen* - - 1 - JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION - JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 2022;121(8):1431-1441
(IF: 3.871, Journal Ranking: 61, Number of Journals of this Field: 172, Ranking: 35.47%)

6

Genetic and epigenetic alterations of cyclic AMP response element modulator in rheumatoid arthritis.
曾家駿, 林原兆, 林嘉慧,黃道揚,李瑞年, Wen-Chan Tsai, 歐燦騰, 吳正欽, 林育志, 宋婉瑜, 陳冠宇, 章順仁*, 顏正賢* - - 1 - EUROPEAN JOURNAL OF CLINICAL INVESTIGATION - EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2022 52卷(5期):e13715頁
(IF: 5.722, 領域排名: 39, 領域期刊數: 172, 領域排名: 22.67%)

Genetic and epigenetic alterations of cyclic AMP response element modulator in rheumatoid arthritis.
Chia-Chun Tseng, Yuan-Zhao Lin, Chia-Hui Lin, Daw-Yang Hwang, Ruei-Nian Li, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Yu-Chih Lin, Wan-Yu Sung, Kuan-Yu Chen, Shun-Jen Chang*, Jeng-Hsien Yen* - - 1 - EUROPEAN JOURNAL OF CLINICAL INVESTIGATION - EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2022;52(5):e13715
(IF: 5.722, Journal Ranking: 39, Number of Journals of this Field: 172, Ranking: 22.67%)

7

Methylation of TET2 Promoter Is Associated with Global Hypomethylation and Hypohydroxymethylation in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients
宋婉瑜*,林原兆,黃道揚, 林嘉慧,李瑞年,曾家駿,吳正欽,歐燦騰,顏正賢* - - 1 - Diagnostics - DIAGNOSTICS 2022 12卷(12期):3006頁
(IF: 3.992, 領域排名: 60, 領域期刊數: 172, 領域排名: 34.88%)

Methylation of TET2 Promoter Is Associated with Global Hypomethylation and Hypohydroxymethylation in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients
Wan-Yu Sung* ,Yuan-Zhao Lin ,Daw-Yang Hwang, Chia-Hui Lin ,Ruei-Nian Li ,Chia-Chun Tseng,Cheng-Chin Wu ,Tsan-Teng Ou ,Jeng-Hsien Yen* - - 1 - Diagnostics - DIAGNOSTICS 2022;12(12):3006
(IF: 3.992, Journal Ranking: 60, Number of Journals of this Field: 172, Ranking: 34.88%)

8

Vancomycin Functionalization of Gold Nanostars for Sensitive Detection of Foodborne Pathogens through Surface–enhanced Raman Scattering
Dayalan S, Gedda G, 李瑞年, Zulfajri M, 黃俊嬴* - - 1 - Journal of Chinese Chemical Society - JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2022 69卷(12期):2049-2060頁
(IF: 1.753, 領域排名: 135, 領域期刊數: 179, 領域排名: 75.42%)

Vancomycin Functionalization of Gold Nanostars for Sensitive Detection of Foodborne Pathogens through Surface–enhanced Raman Scattering
Sandhiya Dayalan, Gangaraju Gedda, Ruei–Nian Li, Muhammad Zulfajri, Genin Gary Huang* - - 1 - Journal of Chinese Chemical Society - JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2022;69(12):2049-2060
(IF: 1.753, Journal Ranking: 135, Number of Journals of this Field: 179, Ranking: 75.42%)

9

Shotgun proteomic analysis using human serum from type 2 diabetes mellitus patients
李瑞年,沈柏村,林佑賢,梁世欣* - - 1 - International Journal of Diabetes in Developing Countries - INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES 2022 43卷(0期):145-154頁
(IF: 1.013, 領域排名: 140, 領域期刊數: 146, 領域排名: 95.89%)

Shotgun proteomic analysis using human serum from type 2 diabetes mellitus patients
Ruei-Nian Li, Po-Tsun Shen, Hugo You-Hsien Lin, Shih-Shin Liang* - - 1 - International Journal of Diabetes in Developing Countries - INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES 2022;43(0):145-154
(IF: 1.013, Journal Ranking: 140, Number of Journals of this Field: 146, Ranking: 95.89%)

10

A Marine Terpenoid, Heteronemin, Induces Both the Apoptosis and Ferroptosis of Hepatocellular Carcinoma Cells and Involves the ROS and MAPK Pathways.
張文燦, 鮑永定, 傅佩蓉, 李佳陽, 吳長益, 張乙樺, 鄧燕妮, 李瑞年, 呂美津, 劉益昌*, 邱建智* (共同通訊作者) - - 1 - Oxidative medicine and cellular longevity - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2021 2021卷(-期):7689045頁
(IF: 7.31, 領域排名: 55, 領域期刊數: 194, 領域排名: 28.35%)

A Marine Terpenoid, Heteronemin, Induces Both the Apoptosis and Ferroptosis of Hepatocellular Carcinoma Cells and Involves the ROS and MAPK Pathways.
Wen-Tsan Chang, Yung-Ding Bow, Pei-Jung Fu, Chia-Yang Li, Chang-Yi Wu, Yi-Hua Chang, Yen-Ni Teng, Ruei-Nian Li, Mei-Chin Lu, Yi-Chang Liu*, Chien-Chih Chiu* (co-corresponding author) - - 1 - Oxidative medicine and cellular longevity - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2021;2021(-):7689045
(IF: 7.31, Journal Ranking: 55, Number of Journals of this Field: 194, Ranking: 28.35%)

11

Association of F11R polymorphisms and gene expression with primary Sjögren's syndrome patients.
方姿蓉,李瑞年#,林原兆,林嘉慧,曾家駿,宋婉瑜,歐燦騰,吳正欽,顏正賢* - - 1 - International journal of rheumatic diseases - INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 2021 24卷(5期):681-686頁
(IF: 2.454, 領域排名: 28, 領域期刊數: 34, 領域排名: 82.35%)

Association of F11R polymorphisms and gene expression with primary Sjögren's syndrome patients.
Tzu-Jung Fang,Ruei-Nian Li#,Yuan-Zhao Lin,Chia-Hui Lin,Chia-Chun Tseng,Wan-Yu Sung,Tsan-Teng Ou,Cheng-Chin Wu,Jeng-Hsien Yen* - - 1 - International journal of rheumatic diseases - INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 2021;24(5):681-686
(IF: 2.454, Journal Ranking: 28, Number of Journals of this Field: 34, Ranking: 82.35%)

12

A novel CD209 polymorphism is associated with rheumatoid arthritis patients in Taiwan.
詹華蓁,王淑珍#,林嘉慧,林原兆,李瑞年,顏正賢* - - 1 - Journal of clinical laboratory analysis - JOURNAL OF CLINICAL LABORATORY ANALYSIS 2021 35卷(5期):e23751頁
(IF: 2.352, 領域排名: 15, 領域期刊數: 29, 領域排名: 51.72%)

A novel CD209 polymorphism is associated with rheumatoid arthritis patients in Taiwan.
Hua-Chen Chan, Shu-Chen Wang#, Chia-Hui Lin, Yuan-Zhao Lin, Ruei-Nian Li, Jeng-Hsien Yen* - - 1 - Journal of clinical laboratory analysis - JOURNAL OF CLINICAL LABORATORY ANALYSIS 2021;35(5):e23751
(IF: 2.352, Journal Ranking: 15, Number of Journals of this Field: 29, Ranking: 51.72%)

13

The Phenoxyphenol Compound diTFPP Mediates Exogenous C2-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells.
張文燦, 鮑永定#, 陳讌君, 李佳陽, 陳逸夫, 朱奕靜, 鄧燕妮, 李瑞年, 邱建智* - - 1 - Antioxidants (Basel, Switzerland) - ANTIOXIDANTS 2021 10卷(3期):394頁
(IF: 7.675, 領域排名: 4, 領域期刊數: 63, 領域排名: 6.35%)

The Phenoxyphenol Compound diTFPP Mediates Exogenous C2-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells.
Wen-Tsan Chang, Yung-Ding Bow#, Yen-Chun Chen, Chia-Yang Li, Jeff Yi-Fu Chen, Yi-Ching Chu, Yen-Ni Teng, Ruei-Nian Li, Chien-Chih Chiu* - - 1 - Antioxidants (Basel, Switzerland) - ANTIOXIDANTS 2021;10(3):394
(IF: 7.675, Journal Ranking: 4, Number of Journals of this Field: 63, Ranking: 6.35%)

14

MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner.
汪硯雲,陳玉昆,StevenLo,紀宗辰,陳怡華,胡楚松,陳雅雯,江士昇,蔡芳瑜,劉旺達,李瑞年,謝雅晶,黃志仁,袁行修* - - 1 - Oncogene - ONCOGENE 2021 40卷(20期):3510-3532頁
(IF: 9.867, 領域排名: 29, 領域期刊數: 298, 領域排名: 9.73%)

MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner.
Yen-Yun Wang, Yuk-Kwan Chen, Steven Lo, Tsung-Chen Chi, Yi-Hua Chen, Stephen Chu-Sung Hu, Ya-Wen Chen, Shih Sheng Jiang, Fang-Yu Tsai, Wangta Liu, Ruei-Nian Li, Ya-Ching Hsieh, Chih-Jen Huang, Shyng-Shiou F Yuan* - - 1 - Oncogene - ONCOGENE 2021;40(20):3510-3532
(IF: 9.867, Journal Ranking: 29, Number of Journals of this Field: 298, Ranking: 9.73%)

15

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells.
彭聖堯#, 湯人仰#, 李瑞年, 黃弘文, 吳長益, 邱建智, 張芳榮, Hong-Wei Zhang, 李昀柔, 許志宏*, 張學偉* - - 1 - Cancers - CANCERS 2021 13卷(10期):2450頁
(IF: 6.575, 領域排名: 60, 領域期刊數: 245, 領域排名: 24.49%)

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells.
Sheng-Yao Peng, Jen-Yang Tang, Ruei-Nian Li, Hurng-Wern Huang, Chang-Yi Wu, Chien-Chih Chiu, Fang-Rong Chang, Hong-Wei Zhang,Yun-Jou Lee, Jyh-Horng Sheu*, Hsueh-Wei Chang* - - 1 - Cancers - CANCERS 2021;13(10):2450
(IF: 6.575, Journal Ranking: 60, Number of Journals of this Field: 245, Ranking: 24.49%)

16

Comparison of Antioxidant and Anticancer Properties of Soft Coral-Derived Sinularin and Dihydrosinularin.
王聖傑, 李瑞年, 林立青, 湯人仰, 蘇瑞欣, 許志宏*, 張學偉* - - 1 - Molecules (Basel, Switzerland) - MOLECULES 2021 26卷(13期):3853頁
(IF: 4.927, 領域排名: 65, 領域期刊數: 179, 領域排名: 36.31%)

Comparison of Antioxidant and Anticancer Properties of Soft Coral-Derived Sinularin and Dihydrosinularin.
Sheng-Chieh Wang, Ruei-Nian Li, Li-Ching Lin, Jen-Yang Tang, Jui-Hsin Su, Jyh-Horng Sheu*, Hsueh-Wei Chang* - - 1 - Molecules (Basel, Switzerland) - MOLECULES 2021;26(13):3853
(IF: 4.927, Journal Ranking: 65, Number of Journals of this Field: 179, Ranking: 36.31%)

17

Silencing of FOXA2 decreases E‐cadherin expression and is associated with lymph node metastasis in oral cancer
鮑永定#, 汪硯雲#, 陳玉昆, 蘇昶瑋, 許經偉, 蕭綾儀, 袁行修*, 李瑞年* - - 1 - oral diseases - ORAL DISEASES 2020 26卷(4期):756-765頁
(IF: 2.613, 領域排名: 19, 領域期刊數: 91, 領域排名: 20.88%)

Silencing of FOXA2 decreases E‐cadherin expression and is associated with lymph node metastasis in oral cancer
Yung‐Ding Bow#, Yen‐Yun Wang#, Yuk‐Kwan Chen, Chang‐Wei Su, Ching‐Wei Hsu, Ling‐yi Xiao, Shyng‐Shiou Yuan*, Ruei‐Nian Li* - - 1 - oral diseases - ORAL DISEASES 2020;26(4):756-765
(IF: 2.613, Journal Ranking: 19, Number of Journals of this Field: 91, Ranking: 20.88%)

18

Genetic and Epigenetic Alteration of the Programmed Cell Death 1 (PDCD1) in Rheumatoid Arthritis
曾家駿, 林原兆, 林嘉慧, 李瑞年, 蔡文展, 歐燦騰, 吳正欽, 宋婉瑜, 顏正賢* - - 1 - Eur J Clin Invest - EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2019 49卷(10期):e13094頁
(IF: 2.784, 領域排名: 37, 領域期刊數: 160, 領域排名: 23.13%)

Genetic and Epigenetic Alteration of the Programmed Cell Death 1 (PDCD1) in Rheumatoid Arthritis
Tseng CC, Lin YC, Lin CH, Li RN, Tsai WC, Ou TT, Wu CC, Sung WY, Yen JH* - - 1 - Eur J Clin Invest - EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2019;49(10):e13094
(IF: 2.784, Journal Ranking: 37, Number of Journals of this Field: 160, Ranking: 23.13%)

19

GADD45a and GADD45b Genes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients
李瑞年, 林原兆, Ya-Chun Pan, 林嘉慧, 曾家駿, 宋婉瑜, 吳正欽, 歐燦騰, 蔡文展, 顏正賢* - - 1 - Journal of Clinical Medicine - JOURNAL OF CLINICAL MEDICINE 2019 8卷(6期):801頁
(IF: 5.688, 領域排名: 15, 領域期刊數: 160, 領域排名: 9.38%)

GADD45a and GADD45b Genes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients
Ruei-Nian Li, Yuan-Zhao Lin, Ya-Chun Pan, Chia-Hui Lin, Chia-Chun Tseng, Wan-Yu Sung, Cheng-Chin Wu, Tsan-Teng Ou, Wen-Chan Tsai and Jeng-Hsien Yen* - - 1 - Journal of Clinical Medicine - JOURNAL OF CLINICAL MEDICINE 2019;8(6):801
(IF: 5.688, Journal Ranking: 15, Number of Journals of this Field: 160, Ranking: 9.38%)

20

Combination Therapy of Chloroquine and C2-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells
周翰林,林逸翔,劉旺達,吳長益,李瑞年,黃弘文,周季賢,邱顯肇,邱建智* - - 1 - Cancers - CANCERS 2019 11卷(3期):370頁
(IF: 6.126, 領域排名: 37, 領域期刊數: 244, 領域排名: 15.16%)

Combination Therapy of Chloroquine and C2-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells
Han-Lin Chou†, Yi-Hsiung Lin†, Wangta Liu, Chang-Yi Wu, Ruei-Nian Li, Hurng-Wern Huang, Chi-Hsien Chou, Shean-Jaw Chiou, Chien-Chih Chiu* - - 1 - Cancers - CANCERS 2019;11(3):370
(IF: 6.126, Journal Ranking: 37, Number of Journals of this Field: 244, Ranking: 15.16%)

21

Next-Generation Sequencing Profiles of the Methylome and Transcriptome in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis.
曾家駿, 林原兆, 林嘉慧, 李瑞年, Yen CY, 詹華蓁, 蔡文展, 歐燦騰, 吳正欽, 宋婉瑜, 顏正賢* - - 1 - J Clin Med - JOURNAL OF CLINICAL MEDICINE 2019 8卷(9期):1284頁
(IF: 5.688, 領域排名: 15, 領域期刊數: 160, 領域排名: 9.38%)

Next-Generation Sequencing Profiles of the Methylome and Transcriptome in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis.
Tseng CC, Lin YC, Lin CH, Li RN, Yen CY, Chan HC, Tsai WC, Ou TT, Wu CC, Sung WY, Yen JH*. - - 1 - J Clin Med - JOURNAL OF CLINICAL MEDICINE 2019;8(9):1284
(IF: 5.688, Journal Ranking: 15, Number of Journals of this Field: 160, Ranking: 9.38%)

22

Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells
Yung-Ting Chang#, Chiung-Yao Huang#, 李瑞年, 廖志中, 劉靜如, 許志宏*, 張學偉* - - 1 - Onco Targets Ther - 2017 10卷(1期):3289-3297頁
(IF: 2.612, 領域排名: 61, 領域期刊數: 160, 領域排名: 38.13%)

Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells
Yung-Ting Chang#, Chiung-Yao Huang#, Ruei-Nian Li, Chih-Chuang Liaw, Jing-Ru Liu, Jyh-Horng Sheu*, Hsueh-Wei Chang* - - 1 - Onco Targets Ther - 2017;10(1):3289-3297
(IF: 2.612, Journal Ranking: 61, Number of Journals of this Field: 160, Ranking: 38.13%)

23

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells.
張學偉,李瑞年, 王慧如, 劉靜如,湯人仰, 黃弘文,詹雨璇, Ching-Yu Yen* - - 1 - Frontiers in Physiology - FRONT PHYSIOL 2017 8卷(1期):643頁
(IF: 4.134, 領域排名: 15, 領域期刊數: 84, 領域排名: 17.86%)

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells.
Hsueh-Wei Chang, Ruei-Nian Li, Hui-Ru Wang, Jing-Ru Liu, Jen-Yang Tang, Hurng-Wern Huang, Yu-Hsuan Chan, Ching-Yu Yen* - - 1 - Frontiers in Physiology - FRONT PHYSIOL 2017;8(1):643
(IF: 4.134, Journal Ranking: 15, Number of Journals of this Field: 84, Ranking: 17.86%)

24

Promoter methylation status of tumor suppressor genes p16 and CDH1 in cervical intraepithelial Neoplasia.
李瑞年, Li CY, 李建宏,彭瓊瑜, 吳明蒼* - - 1 - Oncology Letters - Oncol Lett 2017 13卷(6期):4397-4401頁
(IF: 1.39, 領域排名: 192, 領域期刊數: 217, 領域排名: 88.48%)

Promoter methylation status of tumor suppressor genes p16 and CDH1 in cervical intraepithelial Neoplasia.
Li RN, Li CY, Lee CH, Peng CY, Wu MT* - - 1 - Oncology Letters - Oncol Lett 2017;13(6):4397-4401
(IF: 1.39, Journal Ranking: 192, Number of Journals of this Field: 217, Ranking: 88.48%)

25

類風溼性關節炎病人之F11R 基因表現及基因多形性
方姿蓉, 林嘉慧, 林原兆, 李瑞年, 歐燦騰, 吳正欽, 蔡文展, 顏正賢* - - 1 - International Journal of Rheumatic Diseases - INT J RHEUM DIS 2016 19卷(2期):127-133頁
(IF: 1.914, 領域排名: 21, 領域期刊數: 32, 領域排名: 65.63%)

F11R mRNA expression and promoter polymorphisms in pateints with rheumatoid arthritis.
Tzu-Jung Fang, Chia-hui Lin, Yuan-Zhao Lin, Ruei-Nian Li, Tsan-Teng Ou, Cheng-Chin Wu, Wen-Chan Tsai and Jeng-Hsien Yen*. - - 1 - International Journal of Rheumatic Diseases - INT J RHEUM DIS 2016;19(2):127-133
(IF: 1.914, Journal Ranking: 21, Number of Journals of this Field: 32, Ranking: 65.63%)

26

Methylation and gene expression of histone deacetylases 6 in systemic lupus erythematosus.
方姿蓉, 林原兆, 劉靜菁, 林嘉慧, 李瑞年, 吳正欽, 歐燦騰, 蔡文展, 顏正賢* - - 1 - International Journal of Rheumatic Diseases - INT J RHEUM DIS 2016 19卷(10期):968-973頁
(IF: 1.914, 領域排名: 21, 領域期刊數: 32, 領域排名: 65.63%)

Methylation and gene expression of histone deacetylases 6 in systemic lupus erythematosus.
Tzu-Jung Fang, Yuan-Zhao Lin, Ching-Ching Liu, Chia-Hui Lin, Reui-Nian Li, Cheng-Chin Wu, Tsan-Teng Ou, Wen-Chan Tsai and Jeng-Hsien Yen* - - 1 - International Journal of Rheumatic Diseases - INT J RHEUM DIS 2016;19(10):968-973
(IF: 1.914, Journal Ranking: 21, Number of Journals of this Field: 32, Ranking: 65.63%)

27

Risk evaluation for the development of cervical intraepithelial neoplasia: Development and validation of risk-scoring schemes.
李建宏,彭瓊瑜,李瑞年,陳渝潔,蔡秀婷,洪于琇, 詹德富, Huang HL,賴泰丞 ,吳明蒼* - - 1 - INTERNATIONAL JOURNAL OF CANCER - INT J CANCER 2015 136卷(2期):340-349頁
(IF: 5.085, 領域排名: 31, 領域期刊數: 211, 領域排名: 14.69%)

Risk evaluation for the development of cervical intraepithelial neoplasia: Development and validation of risk-scoring schemes.
Chien-Hung Lee, Chiung-Yu Peng, Ruei-Nian Li, Yu-Chieh Chen, Hsiu-Ting Tsai, Yu-Hsiu Hung, Te-Fu Chan, Hsiao-Ling Huang, Tai-Cheng Lai, Ming-Tsang Wu* - - 1 - INTERNATIONAL JOURNAL OF CANCER - INT J CANCER 2015;136(2):340-349
(IF: 5.085, Journal Ranking: 31, Number of Journals of this Field: 211, Ranking: 14.69%)

28

Activation and inhibition of ATM by phytochemicals: awakening and sleeping the guardian angel naturally
Ammad Ahmad Farooqi, 吳世忠, 張詠婷, 湯人仰, 李�i慈, Muhammad Ismail, Chih-Chuang Liaw, 李瑞年*, 張學偉* - - 1 - ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS - ARCH IMMUNOL THER EX 2015 63卷(5期):357-366頁
(IF: 3.176, 領域排名: 60, 領域期刊數: 148, 領域排名: 40.54%)

Activation and inhibition of ATM by phytochemicals: awakening and sleeping the guardian angel naturally
Ammad Ahmad Farooqi, Shyh-Jong Wu, Yung-Ting Chang, Jen-Yang Tang, Kun-Tzu Li, Muhammad Ismail, Chih-Chuang Liaw, Ruei-Nian Li*, Hsueh-Wei Chang* - - 1 - ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS - ARCH IMMUNOL THER EX 2015;63(5):357-366
(IF: 3.176, Journal Ranking: 60, Number of Journals of this Field: 148, Ranking: 40.54%)

29

Natural products mediated regulation of oxidative stress and DNA damage in ultraviolet exposed skin cells
Ammad Ahmad Farooqi, 李瑞年, Hurng-Wern Huang, Muhammad Ismail, 袁行修, 王惠民, 劉靜如, 湯人仰*, 張學偉* - - 1 - CURRENT PHARMACEUTICAL BIOTECHNOLOGY - CURR PHARM BIOTECHNO 2015 16卷(12期):1078-1084頁
(IF: 1.95, 領域排名: 152, 領域期刊數: 255, 領域排名: 59.61%)

Natural products mediated regulation of oxidative stress and DNA damage in ultraviolet exposed skin cells
Ammad Ahmad Farooqi, Ruei-Nian Li, Hurng-Wern Huang, Muhammad Ismail, Shyng-Shiou F. Yuan, Hui-Min David Wang, Jing-Ru Liu, Jen-Yang Tang*, Hsueh-Wei Chang* - - 1 - CURRENT PHARMACEUTICAL BIOTECHNOLOGY - CURR PHARM BIOTECHNO 2015;16(12):1078-1084
(IF: 1.95, Journal Ranking: 152, Number of Journals of this Field: 255, Ranking: 59.61%)

30

Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers
Ammad Ahmad Farooqi, 湯人仰, 李瑞年, Muhammad Ismail, 張詠婷, Chih-Wen Shu, 袁行修, 劉靜如, 黃志仁*, 張學偉* - - 1 - International Journal of Nanomedicine - INT J NANOMED 2015 10卷(-期):3183-3191頁
(IF: 4.383, 領域排名: 30, 領域期刊數: 255, 領域排名: 11.76%)

Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers
Ammad Ahmad Farooqi, Jen-Yang Tang, Ruei-Nian Li, Muhammad Ismail, Yung-Ting Chang, Chih-Wen Shu, Shyng-Shiou F. Yuan, Jing-Ru Liu, Chih-Jen Huang*, Hsueh-Wei Chang* - - 1 - International Journal of Nanomedicine - INT J NANOMED 2015;10(-):3183-3191
(IF: 4.383, Journal Ranking: 30, Number of Journals of this Field: 255, Ranking: 11.76%)

31

Alternative splicing, DNA damage, and modulating drugs in radiation therapy for cancer
湯人仰, 李瑞年, 陳丙何, Hurng-Wern Huang, 侯明鋒*, 張學偉* - - 1 - Anti-Cancer Agents in Medicinal Chemistry - ANTI-CANCER AGENT ME 2015 15卷(6期):674-680頁
(IF: 2.469, 領域排名: 29, 領域期刊數: 59, 領域排名: 49.15%)

Alternative splicing, DNA damage, and modulating drugs in radiation therapy for cancer
Jen-Yang Tang, Ruei-Nian Li, Ping-Ho Chen, Hurng-Wern Huang, Ming-Feng Hou*, Hsueh-Wei Chang* - - 1 - Anti-Cancer Agents in Medicinal Chemistry - ANTI-CANCER AGENT ME 2015;15(6):674-680
(IF: 2.469, Journal Ranking: 29, Number of Journals of this Field: 59, Ranking: 49.15%)

32

iridium(III) 複合物抗菌及抗癌活性研究
Lihua Lu, Li-Juan Liu, Wei-chieh Chao, Hai-Jing Zhong, Modi Wang, Xiu-Ping Chen, Jin-Jian Lu, Ruei-nian Li*, 李瑞年*, Dik-Lung Ma, Chung-Hang Leung - - 1 - Scientific Reports - SCI REP-UK 2015 5卷(9期):14544頁
(IF: 5.578, 領域排名: 5, 領域期刊數: 57, 領域排名: 8.77%)

Identification of an iridium (III) complesx with anti-bacterial and anti-cancer activity
Lihua Lu, Li-Juan Liu, Wei-chieh Chao, Hai-Jing Zhong, Modi Wang, Xiu-Ping Chen, Jin-Jian Lu, Ruei-nian Li*, Dik-Lung Ma and Chung-Hang Leung - - 1 - Scientific Reports - SCI REP-UK 2015;5(9):14544
(IF: 5.578, Journal Ranking: 5, Number of Journals of this Field: 57, Ranking: 8.77%)

33

類風濕性關節炎和全身性紅斑性狼瘡的OSMR基因多型性
林原兆, 李瑞年(共同第一), 林嘉慧, 歐燦騰, 吳正欽(1), 蔡文展, 劉宏文, 顏正賢* - - 1 - AUTOIMMUNITY - AUTOIMMUNITY 2014 47卷(1期):23-26頁
(IF: 2.754, 領域排名: 71, 領域期刊數: 144, 領域排名: 49.31%)

Association of OSMR Gene Polymorphisms with Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients.
Lin YZ, Li RN, Lin CH, Ou TT, Wu CC, Tsai WC, Liu HW, Yen JH* - - 1 - AUTOIMMUNITY - AUTOIMMUNITY 2014;47(1):23-26
(IF: 2.754, Journal Ranking: 71, Number of Journals of this Field: 144, Ranking: 49.31%)

34

Methylation status of retinoic acid receptor beta2 promoter and global DNA in esophageal squamous cell carcinoma
李瑞年,余方榮,吳俊杰,陳玉桂,余俊杰, 周世華,李瑞英,鄭裕仁,吳明蒼,吳宜珍* - - 1 - Journal of Surgical Oncology - J SURG ONCOL 2014 109卷(6期):623-627頁
(IF: 2.843, 領域排名: 34, 領域期刊數: 204, 領域排名: 16.67%)

Methylation status of retinoic acid receptor beta2 promoter and global DNA in esophageal squamous cell carcinoma
Li RN, Yu FJ, Wu CC, Chen YK, Yu CC, Chou SH, Lee JY, Cheng YJ, Wu MT, Wu IC* - - 1 - Journal of Surgical Oncology - J SURG ONCOL 2014;109(6):623-627
(IF: 2.843, Journal Ranking: 34, Number of Journals of this Field: 204, Ranking: 16.67%)

35

Multiple single nucleotide polymorphisms associated with the susceptibility of pre-Diabetes Mellitus in a Taiwanese population(under review).
林秋菊,李瑞年 - - 0 - Disease marker American Journal of Medical Genetics. - 0 2014 0卷(0期):0頁
(IF: 0, 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Multiple single nucleotide polymorphisms associated with the susceptibility of pre-Diabetes Mellitus in a Taiwanese population(under review).
Lin, C.C., Lee, R. N* - - 0 - Disease marker American Journal of Medical Genetics. - 0 2014;0(0):0
(IF: 0, Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

36

Networks development between nicotinic chemical probes and Ca9-22 oral cancer cells by general proteomics analyses
李瑞年, Chin-Jen Wu, Zong-Jing Yu, 張學偉*,梁世欣* - - 1 - Electrophoresis - ELECTROPHORESIS 2014 35卷(15期):2213-2221頁
(IF: 3.161, 領域排名: 16, 領域期刊數: 76, 領域排名: 21.05%)

Networks development between nicotinic chemical probes and Ca9-22 oral cancer cells by general proteomics analyses
Ruei-Nian Li, Chin-Jen Wu, Zong-Jing Yu, Hsueh-Wei Chang*, Shih-Shin Liang* - - 1 - Electrophoresis - ELECTROPHORESIS 2014;35(15):2213-2221
(IF: 3.161, Journal Ranking: 16, Number of Journals of this Field: 76, Ranking: 21.05%)

37

單核球與 SLC11A1 多形性在披衣菌所引起的反應性關節炎之致病機轉上所扮演的角色
陳怡菁, 李瑞年, 林嘉慧, 顏正賢* - - 1 - SCANDINAVIAN JOURNAL OF RHEUMATOLOGY - SCAND J RHEUMATOL 2013 42卷(2期):146-149頁
(IF: 2.607, 領域排名: 14, 領域期刊數: 30, 領域排名: 46.67%)

The role of monocytes and SLC11A1 polymorphisms in the pathogenesis of Chlamydia-induced reactive arthritis.
Chen YJ, Li RN, Lin CH, Yen JH. - - 1 - SCANDINAVIAN JOURNAL OF RHEUMATOLOGY - SCAND J RHEUMATOL 2013;42(2):146-149
(IF: 2.607, Journal Ranking: 14, Number of Journals of this Field: 30, Ranking: 46.67%)

38

Global DNA Methylation, DNMT1, and MBD2 in Patients with Rheumatoid Arthritis
方姿蓉,劉靜菁(共同第一), 歐燦騰,吳正欽,李瑞年,林原兆,林嘉慧,蔡文展,劉宏文,顏正賢* - - 1 - Immunology Letters - IMMUNOL LETT 2011 135卷(1-2期):96-99頁
(IF: 2.511, 領域排名: 77, 領域期刊數: 134, 領域排名: 57.46%)

Global DNA Methylation, DNMT1, and MBD2 in Patients with Rheumatoid Arthritis
Liu CC, Fang TJ, Ou TT, Wu CC, Li RN, Lin YC, Lin CH, Tsai WC, Liu HW, Yen JH* - - 1 - Immunology Letters - IMMUNOL LETT 2011;135(1-2):96-99
(IF: 2.511, Journal Ranking: 77, Number of Journals of this Field: 134, Ranking: 57.46%)

39

Global DNA methylation, DNMT1, and MBD2 in patients with systemic lupus erythematosus
劉靜菁, 歐燦騰,吳正欽,李瑞年,林原兆,林嘉慧,蔡文展,劉宏文,顏正賢* - - 1 - Lupus - LUPUS 2011 20卷(2期):131-136頁
(IF: 2.6, 領域排名: 14, 領域期刊數: 29, 領域排名: 48.28%)

Global DNA methylation, DNMT1, and MBD2 in patients with systemic lupus erythematosus
Liu CC, Ou TT, Wu CC, Li RN, Lin YC, Lin CH, Tsai WC, Liu HW, Yen JH* - - 1 - Lupus - LUPUS 2011;20(2):131-136
(IF: 2.6, Journal Ranking: 14, Number of Journals of this Field: 29, Ranking: 48.28%)

40

Simultaneous Detection of Multiple Single Nucleotide Polymorphisms by a Simple Membrane Chip
Yu-Hsiang Yanga#, Ruei-Nian Lib#, Shey-Cherng Tzouh, Jaw-Yuan Wangc, Hsin-Pai Leed, Hsien-Chung Wangd, Fang-Ming Chenc, Yung-Hsin Wanga, Ming-Chia Hsieha, Ming-Yii Huange, Wei-Lung Tsengf, g, Shiu-Ru Linh, and Tian-Lu Cheng - - 1 - Genetic Testing and Molecular Biomarkers - GENET TEST MOL BIOMA 2011 14卷(5期):653-659頁
(IF: 0.879, 領域排名: 135, 領域期刊數: 156, 領域排名: 86.54%)

Simultaneous Detection of Multiple Single Nucleotide Polymorphisms by a Simple Membrane Chip
Yu-Hsiang Yanga#, Ruei-Nian Lib#, Shey-Cherng Tzouh, Jaw-Yuan Wangc, Hsin-Pai Leed, Hsien-Chung Wangd, Fang-Ming Chenc, Yung-Hsin Wanga, Ming-Chia Hsieha, Ming-Yii Huange, Wei-Lung Tsengf, g, Shiu-Ru Linh, and Tian-Lu Cheng - - 1 - Genetic Testing and Molecular Biomarkers - GENET TEST MOL BIOMA 2011;14(5):653-659
(IF: 0.879, Journal Ranking: 135, Number of Journals of this Field: 156, Ranking: 86.54%)

41

全身性紅斑性狼瘡病人之SOCS1基因表現和基因多形性
詹華蓁, 柯良胤, 張玲麗, 劉靜菁, 洪毓鴻, 林嘉慧, 李瑞年, 蔡文展, 劉宏文, 顏正賢* - - 1 - Lupus - LUPUS 2010 19卷(6期):696-702頁
(IF: 2.586, 領域排名: 13, 領域期刊數: 26, 領域排名: 50.00%)

Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus
HC Chan, LY Ke, LL Chang, CC Liu, YH Hung, CH Lin, RN Li, WC Tsai, HW Liu, JH Yen* - - 1 - Lupus - LUPUS 2010;19(6):696-702
(IF: 2.586, Journal Ranking: 13, Number of Journals of this Field: 26, Ranking: 50.00%)

42

貝賽特氏症候群病人IkBα基因的多形性
洪毓鴻, 吳正欽, 歐燦騰, 林嘉慧, 李瑞年, 林育志, 蔡文展, 劉宏文, 顏正賢* - - 1 - Dis Markets. - DIS MARKERS 2010 28卷(1期):55-62頁
(IF: 2.026, 領域排名: 70, 領域期刊數: 150, 領域排名: 46.67%)

IkappaBalpha promoter polymorphisms in patients with Behçet’s disease
Hung YH, Wu CC, Ou TT, Lin CH, Li RN, Lin YC, Tsai WC, Liu HW, Yen JH*. - - 1 - Dis Markets. - DIS MARKERS 2010;28(1):55-62
(IF: 2.026, Journal Ranking: 70, Number of Journals of this Field: 150, Ranking: 46.67%)

43

類風濕性關節炎病人之IkBalpha promoter功能多形性
李瑞年, 洪毓鴻, 林嘉慧, 陳彥旭, 顏正賢* - - 1 - Journal of Clinical Immunology - J CLIN IMMUNOL 2010 30卷(5期):676-680頁
(IF: 3.326, 領域排名: 48, 領域期刊數: 134, 領域排名: 35.82%)

Inhibitor IkappaBalpha Promoter Functional Polymorphisms in Patients with Rheumatoid Arthritis
Li RN, Hung YH, Lin CH, Chen YH, Yen JH* - - 1 - Journal of Clinical Immunology - J CLIN IMMUNOL 2010;30(5):676-680
(IF: 3.326, Journal Ranking: 48, Number of Journals of this Field: 134, Ranking: 35.82%)

44

僵直性脊椎炎病人之IkBalpha基因多形性
洪毓鴻, 歐燦騰, 林嘉慧, 李瑞年, 林育志, 蔡文展, 劉宏文, 顏正賢* - - 1 - Rheunatol Int. - RHEUMATOL INT 2009 30卷(4期):93-97頁
(IF: 1.327, 領域排名: 19, 領域期刊數: 22, 領域排名: 86.36%)

IkBalpha promoter polymorphisms in patients with ankylosing spondylitis
Hung YH, Ou TT, Lin CH, Li RN, Lin YC, Tsai WC, Liu HW, Yen JH* - - 1 - Rheunatol Int. - RHEUMATOL INT 2009;30(4):93-97
(IF: 1.327, Journal Ranking: 19, Number of Journals of this Field: 22, Ranking: 86.36%)

45

紅斑性狼瘡病人之IkB alpha基因多形性
林嘉慧, 王淑珍, 歐燦騰, 李瑞年, 蔡文展, 劉宏文, 顏正賢* - - 1 - J Clin Immunol - J CLIN IMMUNOL 2008 28卷(3期):207-213頁
(IF: 3.248, 領域排名: 44, 領域期刊數: 121, 領域排名: 36.36%)

IkappaBalpha Promoter Polymorphisms in Patients with Systemic Lupus Erythematosus
Lin CH, Wang SC, Ou TT, Li RN, Tsai WC, Liu HW, Yen JH* - - 1 - J Clin Immunol - J CLIN IMMUNOL 2008;28(3):207-213
(IF: 3.248, Journal Ranking: 44, Number of Journals of this Field: 121, Ranking: 36.36%)

46

原發性乾燥症病人之IkB alpha基因多形性
歐燦騰, 林嘉慧, 林育志, 李瑞年, 蔡文展, 劉宏文, 顏正賢* - - 1 - J Clin Immunol - J CLIN IMMUNOL 2008 28卷(5期):440-444頁
(IF: 3.248, 領域排名: 44, 領域期刊數: 121, 領域排名: 36.36%)

IkBalpha Promoter Polymorphisms in Patients with Primary Sjögren's Syndrome
Ou TT, Lin CH, Lin YC, Li RN, Tsai WC, Liu HW, Yen JH* - - 1 - J Clin Immunol - J CLIN IMMUNOL 2008;28(5):440-444
(IF: 3.248, Journal Ranking: 44, Number of Journals of this Field: 121, Ranking: 36.36%)

47

類風濕性關節炎病人之PD1-Ligand基因多形性
王淑珍, 林嘉慧, 李瑞年,歐燦騰, 吳正欽, 蔡文展, 劉宏文, 顏正賢* - - 1 - J Clin Immunol. - J CLIN IMMUNOL 2007 27卷(6期):563-7頁
(IF: 2.886, 領域排名: 53, 領域期刊數: 119, 領域排名: 44.54%)

Polymorphisms of Genes for Programmed Cell Death 1 Ligands in Patients with Rheumatoid Arthritis
Wang SC, Lin CH, Li RN, Ou TT, Wu CC, Tsai WC, Liu HW, Yen JH* - - 1 - J Clin Immunol. - J CLIN IMMUNOL 2007;27(6):563-7
(IF: 2.886, Journal Ranking: 53, Number of Journals of this Field: 119, Ranking: 44.54%)

48

紅斑性狼瘡病人之IkB alpha promoter多形性
林嘉慧,王淑珍,歐燦騰,李瑞年,蔡文展,劉宏文,顏正賢* - - 1 - J Clin Immunol - J CLIN IMMUNOL 2007 x卷(x期):x-x頁
(IF: 2.886, 領域排名: 53, 領域期刊數: 119, 領域排名: 44.54%)

IκBα Promoter Polymorphisms in Patients with Systemic Lupus Erythematosus
Chia-Hui Lin, Shu-Chen Wang, Tsan-Teng Ou, Ruei-Nian Li, Wen-Chan Tsai, Hong-Wen Liu, Jeng-Hsien Yen* - - 1 - J Clin Immunol - J CLIN IMMUNOL 2007;x(x):x-x
(IF: 2.886, Journal Ranking: 53, Number of Journals of this Field: 119, Ranking: 44.54%)

49

風濕性關節炎病人Parvovirus B19之 感染
陳躍升, 周伯禧, 李瑞年, 蔡文展, 林貴香, 蔡坤寶, 顏正賢*, 劉宏文 - - 1 - JOURNAL OF RHEUMATOLOGY - J RHEUMATOL 2006 33卷(5期):887-891頁
(IF: 2.94, 領域排名: 8, 領域期刊數: 23, 領域排名: 34.78%)

Parvovirus B19 infection in patients with rheumatoid arthritis in Taiwan
Chen YS, Chou PH, Li SN, Tsai WC, Lin KH, Tsai KB, Yen JH*, Liu HW - - 1 - JOURNAL OF RHEUMATOLOGY - J RHEUMATOL 2006;33(5):887-891
(IF: 2.94, Journal Ranking: 8, Number of Journals of this Field: 23, Ranking: 34.78%)

50

子宮內腫瘤與人類papillomvirus病毒DNA的定量關係
蔡秀婷, 吳鏡瑚, 賴曉鈴, 李瑞年, et. al. - - 1 - Cancer Epidemiology, Biomarkers & Prevention - CANCER EPIDEM BIOMAR 2005 14卷(11期):2544-2549頁
(IF: 4.46, 領域排名: 5, 領域期刊數: 99, 領域排名: 5.05%)

Association between quantitative high-risk human papillomavirus DNA load and cervical intraepithelial neoplasm risk
Hsiu-ting Tasi, Ching-hu Wu, Hsiao-ling Lai, Ruei-nian Li, Yi-ching Tung, Hung-yi Chuang, Trong-neng Wu, Li-jen Lin, Chi-kung Ho, Hon-wein Liu, Ming-tsang Wu - - 1 - Cancer Epidemiology, Biomarkers & Prevention - CANCER EPIDEM BIOMAR 2005;14(11):2544-2549
(IF: 4.46, Journal Ranking: 5, Number of Journals of this Field: 99, Ranking: 5.05%)

51

服用乳酸桿菌及比菲德氏菌之優酪乳對幽門桿旋桿菌繁殖之影響
王冠元, 李瑞年, 劉景勳, 彭道雄, 蘇育正, 吳登強, 詹昌明, 賴俊煌, 王姿乃, 王文明* - - 1 - Am J Clin Nutr - 2004 80卷(3期):737-41頁
(IF: , 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori.
Wang KY, Li SN, Liu CS, Perng DS, Su YC, Wu DC, Jan CM, Lai CH, Wang TN, Wang WM*. - - 1 - Am J Clin Nutr - 2004;80(3):737-41
(IF: , Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

52

服用乳酸桿菌及比菲德氏菌之優酪乳對幽門桿旋桿菌繁殖之影響
王冠元, 李瑞年, 劉景勳, 彭道雄, 蘇育正, 吳登強, 詹昌明, 賴俊煌, 王姿乃, 王文明* - - 1 - Am J Clin Nutr - AM J CLIN NUTR 2004 80卷(3期):737-741頁
(IF: 5.433, 領域排名: 3, 領域期刊數: 53, 領域排名: 5.66%)

Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori.
Wang KY, Li SN, Liu CS, Perng DS, Su YC, Wu DC, Jan CM, Lai CH, Wang TN, Wang WM*. - - 1 - Am J Clin Nutr - AM J CLIN NUTR 2004;80(3):737-741
(IF: 5.433, Journal Ranking: 3, Number of Journals of this Field: 53, Ranking: 5.66%)

53

兩個致命性中線肉芽腫病例 : 鼻部T/NK細胞淋巴瘤合併Epstein-Barr病毒感染
邱慧嫻,黃柏翰,黃秀鈺,李瑞年,何宜承 - - 0 - Dermatol Sinica - 2000 18卷(0期):88-94頁
(IF: , 領域排名: , 領域期刊數: , 領域排名: %)

Nasal T/NK cell lymphoma associated with virus infection in two cases of lethal midline granuloma
Hui-Hsien Chiu, Po-Han Huang, Hsiu-Yu Huang, Shui-Nin, Li and Ji-Chen Ho - - 0 - Dermatol Sinica - 2000;18(0):88-94
(IF: , Journal Ranking: , Number of Journals of this Field: , Ranking: %)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
112 — M 高醫(種子計畫) — KMU-M113015 —  
PKCβ:口腔上皮鱗狀細胞癌中適應微環境改變的司令官( )
2024/01/01 ~ 2024/12/31
2
110 — M 高醫(種子計畫) — KMU-M111023 —  
探討專一性DNA甲基化調控機制:以PRKCB基因於口腔麟狀上皮細胞癌化機制為例( )
2022/01/01 ~ 2022/12/31
3
110 — NK 高醫-中山合作計畫 —   — 1 個人型
探討二芳基烯烴基類化合物促進於肝癌細胞中誘導細胞程序性死亡之機制( )
2021/01/01 ~ 2021/12/31
4
109 — M 高醫(種子計畫) — KMU-M110009 —  
探討受DNA甲基化調控之蛋白激酶Cβ對口腔癌細胞癌化的影響( )
2021/01/01 ~ 2021/12/31
5
109 — NK 高醫-中山合作計畫 — NSYSUKMU109-I002-1 — 2 整合型
分離軟珊瑚與海綿海洋天然物與合成相關衍生物( )
2020/01/01 ~ 2020/12/31
6
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-021-B — 8 大專學生研究計畫
110年度大專學生研究計畫-李旻諭(生物3)( )
2021/07/01 ~ 2022/02/28
7
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-022-B — 8 大專學生研究計畫
110年度大專學生研究計畫-江定祐(生物2)( )
2021/07/01 ~ 2022/02/28
8
105 — M 高醫(種子計畫) — KMU-M106036 —  
探討RARβ和CDH1基因甲基化與口腔癌細胞遷移能力的相關機制( )
2017/01/01 ~ 2017/12/31
9
104 — TP 頂尖計畫(高醫) — KMU-TP104E28 —  
子計畫二十八、探討基因甲基化與口腔癌細胞遷移的相關機制( )
2015/10/01 ~ 2016/09/30
10
103 — M 高醫(種子計畫) — KMU-M104013 —  
探討RARβ2調控FOXA2基因甲基化與入侵性食道鱗狀細胞癌的相關性( )
2015/01/01 ~ 2015/12/31
11
102 — M 高醫(種子計畫) — KMU-M103016 —  
探討RARβ2基因甲基化與入侵性食道鱗狀細胞癌的相關性( )
2014/01/01 ~ 2014/12/31
12
094 — Z 大專學生研究計畫及博士後 — NSC95-2815-C-037-006-B — 8 大專學生研究計畫
大專暑期計畫--鐘純珊( )
2006/07/01 ~ 2007/02/28
13
088 — N 國科會(原科技部) — NSC 89-2320-B-037-012- — 1 個人型
EB病毒第一型潛伏性膜蛋白對細胞轉形之研究(Study of latent membrane proteinl of Epstein-Barr virus in transformed Balb/c 3T3 cell)
1999/08/01 ~ 2000/07/31
14
087 — N 國科會(原科技部) — NSC88-2314-B-037-099- — 1 個人型
EB病毒早期基因BSLF1啟動子之研究(Study of the promoter of an early gene BSLF in Epstein-Barr virus)
1998/08/01 ~ 1999/07/31

 Patent