Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學大學 — 醫學研究所(畢) — 博士 Doctorate, , |
1994/09 — 2003/06 |
|
美國阿肯色大學醫學院 — 生物化學(畢) — 碩士 Master, Department of Biochemistry, University of Arkansa for Medical Science |
1987/09 — 1989/12 |
|
中興大學 — 植物病理學系(畢) — 學士 Bachelor, , |
1981/09 — 1985/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology | Associate Professor | 2012/05/01 — |
| 生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology | Assistant Professor | 2003/08/01 — 2012/04/30 |
| 生物學系 Department of Biology | Lecturer | 1991/08/01 — 2003/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 生物學之生化及分子生物 Biochemistry and Molecular Biology |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
抗纖維化藥物篩選及訊息傳遞路徑之探討
screening of anti fibrosis drug, signal transduction of inflammatory diseases
Area(s) of Expertise & Research
Asthma,inflammatory lung disease,Environmental pollutant and lung diseases生物化學 細胞生物學 分子生物學
Biochemistry Cell Biology Molecular Biology
Publication
| NO | Publication |
|---|---|
| 1 | 空氣污染物質丙烯醯胺可透過第2型先天淋巴球增強過敏原誘發之嗜酸性肺部發炎 Acrylamide, an air pollutant, enhances allergen-induced eosinophilic, lung inflammation via group 2 innate lymphoid cells |
| 2 | A rapid and sensitive analytical methodology for the simultaneous biomonitoring of two direct oral anticoagulant drugs and their major metabolites in thromboembolic disordered patients samples for clinical evaluations. A rapid and sensitive analytical methodology for the simultaneous biomonitoring of two direct oral anticoagulant drugs and their major metabolites in thromboembolic disordered patients samples for clinical evaluations. |
| 3 | 鐮狀細胞貧血小鼠中風後側支循環受損之研究 Impaired post-stroke collateral circulation in sickle cell anemia mice |
| 4 | 芳香烃受體活化影響巨噬細胞中的 發炎反應及肺上皮細胞之間質化 AhR Mediated Activation of Pro-Inflammatory Response of RAW 264.7 Cells Modulate the Epithelial-Mesenchymal Transition |
| 5 | Pomegranate extract inhibits migration and invasion of oral cancer cells by downregulating matrix metalloproteinase-2/9 and epithelial-mesenchymal transition Pomegranate extract inhibits migration and invasion of oral cancer cells by downregulating matrix metalloproteinase-2/9 and epithelial-mesenchymal transition |
| 6 | 胃酸逆流對於肺部纖維母細胞分化之影響 Stimulatory effect of gastroesophageal reflux disease (GERD) on pulmonary fibroblast differentiation |
| 7 | 組合式照護對於急性呼吸衰竭病人的影響 Outcome of improved care bundle in acute respiratory failure patients |
| 8 | Unfolded Prrotein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells Unfolded Prrotein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells |
| 9 | Discovery of pyrazolo[4,3-c]quinolines derivatives as potential anti-inflammatory agents through inhibiting of NO production Discovery of pyrazolo[4,3-c]quinolines derivatives as potential anti-inflammatory agents through inhibiting of NO production |
| 10 | Discovery of Pyrazolo[4,3-c]quinolines Derivatives as Potential Anti-Inflammatory Agents through Inhibiting of NO Production. Discovery of Pyrazolo[4,3-c]quinolines Derivatives as Potential Anti-Inflammatory Agents through Inhibiting of NO Production. |
| 11 | Aryl hydrocarbon receptor–ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism Aryl hydrocarbon receptor–ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism |
| 12 | 探索3-phenylquinolinylchalcone衍生物具有選擇性抗乳癌之潛力藥物 Discovery of 3-phenylquinolinylchalcone derivatives as potent and selective anticancer agents against breast cancers |
| 13 | 合成3-phenylquinolinylchalcone 衍生物並評估其抗肺癌與抗乳癌活性 Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers |
| 14 | 合成β-lapachone 衍生物並評估其抗發炎活性 Synthesis and anti-inflammatory evaluations of β-lapachone derivatives |
| 15 | 2,3-Diarylquinoline 衍生物的合成與抗增生活性 Synthesis and antiproliferative evaluation of 2,3-diarylquinoline derivatives |
| 16 | 確認furo[3', 2':3,4]naphtho[1,2-d]imidazole 衍生物為口服mPGES-1抑制劑 Identification of furo[3', 2':3,4]naphtho[1,2-d]imidazole derivatives as orally active and selective inhibitors of microsomal prostaglandin E(2) synthase-1 (mPGES-1) |
| 17 | 合成6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one為具有潛力之抗癌試劑 Synthesis of 6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one derivatives as potential anticancer agents |
| 18 | 2,3-diarylquinoline 衍生物之合成以及抗腫瘤增生之研究 Synthesis and antiproliferative evaluation of 2,3-diarylquinoline derivatives |
| 19 | 胃酸誘發氣道平滑肌細胞釋放細胞激素與氣到重槊之研究 Study of gastric fluid induced cytokine and chemokine expression in airway smooth muscle cells and airway remodeling. |
| 20 | vitamin D 對於 大鼠bilateral femoral vessels局部缺氧之改善效用 Pretreatment of Vitamin D3 ameliorates lung and muscle injury induced by reperfusion of bilateral femoral vessels in a rat model |
| 21 | 6-Aryl-11-iminoindeno[1,2-c]quinoline衍生物的合成及抗增生活性評估 Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives |
| 22 | 2,3-Diarylquinoline 衍生物的合成與抗增生活性 Synthesis and antiproliferative evaluation of 2,3-diarylquinoline derivatives |
| 23 | 2,3-diarylquinoline 衍生物之合成以及抗增生之研究 Synthesis and antiproliferative evaluation of 2,3-diarylquinoline derivatives |
| 24 | 6-aryl-11-iminoindeno[1,2-c]quinoline 衍生物合成與抗增生活性評估 Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives |
| 25 | 胃酸逆流誘發小鼠巨噬細胞之MMP表現以及其對肺部疾病之影響 Macrophage activation by gastric fluid suggests MMP involvement in aspiration-induced lung disease |
| 26 | Iminonaphtho[2,3-b]furan類衍生物之合成與抗增生活性評估 Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3-b]furan derivatives |
| 27 | 6-arylindeno[1,2-c]quinoline derivatives 之合成以及其對於抑制腫瘤細胞株增生之研究 Synthesis and antiproliferative evaluation of 6-arylindeno[1,2-c]quinoline derivatives |
| 28 | Furo[3',2':3,4]naphtho[1,2-d]imidazole 衍生物之抗發炎研究 Furo[3',2':3,4]naphtho[1,2-d]imidazole derivatives as potential inhibitors of inflammatory factors in sepsis |
| 29 | Furo[3',2':3,4]naphtho[1,2-d]imidazole衍生物為敗血症抗發炎抑制劑 Furo[3',2':3,4]naphtho[1,2-d]imidazole derivatives as potential inhibitors of inflammatory factors in sepsis. |
| 30 | 6-arylindeno[1,2-c]quinoline衍生物的合成與抗增生活性評估 Synthesis and antiproliferative evaluation of 6-arylindeno[1,2-c]quinoline derivatives |
| 31 | 無 Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity |
| 32 | A membrane antibody receptor for noninvasive imaging of gene expression. A membrane antibody receptor for noninvasive imaging of gene expression. |
| 33 | The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination |
| 34 | 病毒凋亡蛋白Apoptin和細胞內Hippi蛋白的結合作用 The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin interacting protein 1 |
| 35 | Sequence of a Human E2F-4 Pseudogene with Shortened AGC Trinucleotide Repeats 待補 |
| 36 | Overexpression of E2F-1 mRNA and failure to detet mutations in the retinoblastoma protein-binding domain of E2F-1 in human leukemias 待補 |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
114 — NK 高醫-中山合作計畫 — — 1 個人型
高血壓引發中風病理機轉：內皮保護與微神經膠活化的治療研究(Targeting Hypertension-Induced Stroke Pathology: Therapeutic Potential on Endothelial Protection and Microglia Activation)
|
2025/01/01 ~ 2025/12/31 |
| 2 |
113 — M 高醫(種子計畫) — KMU-M114016 —
腫瘤微環境中芳香烴受體的活化對於調控腫瘤相關纖維母細胞的分化所扮演之角色( )
|
2025/01/01 ~ 2025/12/31 |
| 3 |
112 — NK 高醫-中山合作計畫 — — 1 個人型
誘導內皮一氧化氮合成酶於地中海型貧血小鼠中風保護之研究(Endothelial nitric oxide synthase (eNOS) induction for the post-stroke protection in thalassemia mice)
|
2023/01/01 ~ 2023/12/31 |
| 4 |
111 — NK 高醫-中山合作計畫 — — 1 個人型
探討巨噬細胞中芳香烴受體誘發之Integrin V 及 Integrin 1如何影響巨噬細胞極化，肺上皮細胞間質化，以及肺纖維化(Studies of Aryl hydrocarbon receptor induced Integrin V and Integrin 1 in macrophage polarization, epithelial to mesenchymal transition and pulmonary fibrosis)
|
2022/01/01 ~ 2022/12/31 |
| 5 |
109 — M 高醫(種子計畫) — KMU-M110001 —
芳香烃受體的活化對於巨噬細胞的極化，金屬蛋白酶的表現以及對於肺部上皮細胞間質化和肺纖維化的影響( )
|
2021/01/01 ~ 2021/12/31 |
| 6 |
108 — N 國科會(原科技部) — MOST108-2635-B-037-003 — 1 個人型
芳香烴受體與花生四烯酸在肺部纖維化的疾病中對於巨噬細胞的極化及MMP表現的影響( )
|
2019/08/01 ~ 2020/07/31 |
| 7 |
107 — X 高奇合作計畫 — 108CM-KMU-01 —
芳香烃受體的活化與花生四烯酸之代謝對於肺部上皮細胞間質化之影響( )
|
2019/05/01 ~ 2020/04/30 |
| 8 |
106 — X 高奇合作計畫 — 107CM-KMU-04 —
芳香烃受體的活化對於肺部巨噬細胞的極化以及金屬蛋白酶MMP的表現及肺部上皮細胞間質化的影響( )
|
2018/05/01 ~ 2019/04/30 |
| 9 |
105 — M 高醫(種子計畫) — KMU-M106026 —
芳香烃受體之活化與花生四烯酸之代謝對於肺部上皮細胞間質化以及肺部纖維化之影響( )
|
2017/01/01 ~ 2017/12/31 |
| 10 |
105 — TP 頂尖計畫(高醫) — KMU-TP105PR01 —
芳香烴受體之活化與花生四烯酸之代謝對於廢不尚皮細胞間質化以及肺部纖維化之影響( )
|
2016/11/01 ~ 2017/10/31 |
| 11 |
104 — M 高醫(種子計畫) — KMU-M105013 —
芳香烃受體之活化及下游花生四烯酸代謝物對於肺部上皮細胞轉換為間葉細胞之研究( )
|
2016/01/01 ~ 2016/12/31 |
| 12 |
104 — TP 頂尖計畫(高醫) — KMU-TP104PR01 —
Axis pertaing AhR induced arachidonic acid in epithelial to mesenchyma transition in pulmonary epithelial cells( )
|
2015/11/01 ~ 2016/09/30 |
| 13 |
103 — TP 頂尖計畫(高醫) — KMU-TP103A05 —
研究芳香烴受體在氣喘免疫調控之關鍵角色(Study on the Critical Link between Ligand-AhR Axis and Asthma)
|
2014/08/01 ~ 2015/07/31 |
| 14 |
102 — M 高醫(種子計畫) — KMU-M103002 —
芳香烴受體(Aryl hydrocarbon receptor)與肺纖維母細胞分化之研究( )
|
2014/01/01 ~ 2014/12/31 |
| 15 |
101 — N 國科會(原科技部) — NSC99-2320-B-037-027-MY3 — 1 個人型
胃酸逆流對於氣道結構改變以及誘發氣喘所扮演之角色(3/3)( )
|
2012/08/01 ~ 2013/07/31 |
| 16 |
100 — N 國科會(原科技部) — NSC99-2320-B-037-027-MY3 — 1 個人型
胃酸逆流對於氣道結構改變以及誘發氣喘所扮演之角色(2/3)( )
|
2011/08/01 ~ 2013/07/31 |
| 17 |
099 — N 國科會(原科技部) — NSC99-2320-B-037-027-MY3 — 1 個人型
胃酸逆流對於氣道結構改變以及誘發氣喘所扮演之角色(1/3)( )
|
2010/08/01 ~ 2013/07/31 |
| 18 |
096 — Y 高醫-彰基合作計畫 — 97-CCH-KMU-017 — 1 個人型
胃酸及LPS對於氣管平滑肌細胞病變之研究( )
|
2008/01/01 ~ 2008/12/31 |
| 19 |
093 — Q 新聘教師計畫(校內) — Q094002 — 1 個人型
DED(DEATH EFFECTOR DOMAIN)蛋白參與在雞貧血病毒蛋白所誘發細胞凋亡機制之研究( )
|
2004/11/01 ~ 2005/07/31 |
| 20 |
092 — M 高醫(種子計畫) — — 1 個人型
APAP1以及APAP4對於斑馬魚胚胎發育之研究( )
|
2003/11/01 ~ 2004/07/31 |