Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學院 — 醫學研究所(畢) — 博士 Doctorate, Graduate Institute of Medicine, Kaohsiung Medical College |
1987/09 — 1991/01 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 生理學科 Department of Physiology | Associate Professor | 2007/08/01 — |
| 生理學 Physiology | Associate Professor | 1991/04/01 — 2007/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 生理 Physiology |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
神經科學、神經毒物學
Area(s) of Expertise & Research
神經生理學、神經科學、突觸可塑性神經生理學、神經科學、神經毒物學
Neurophysiology, Neuroscience, Neurotoxicology
Publication
| NO | Publication |
|---|---|
| 1 | 軟骨細胞之凝血酶調節素可對抗骨關節炎 Chondrocyte Thrombomodulin Protects against Osteoarthritis. |
| 2 | 組蛋白去乙醯化酶抑制劑可減弱 27-羥基膽固醇對大鼠大腦的影響 Histone deacetylase inhibitor attenuates the effects of 27-hydroxycholesterol on the rat brain. |
| 3 | 高油脂飲食減少新奇環境探索誘發之活性調節細胞骨架相關蛋白質表現 High-fat diet reduces novelty-induced expression of activity-regulated cytoskeleton-associated protein |
| 4 | 在大鼠初代腦皮質神經細胞內調節記憶相關蛋白表現的膽鹼性傳訊途徑 The cholinergic signaling responsible for the expression of a memory-related protein in primary rat cortical neurons |
| 5 | 非致死劑量之奈米銀能透過誘發熱休克蛋白70的表現而減少TNF alpha所引起的肝臟上皮細胞凋亡 Non-lethal dose of silver nanoparticles attenuates TNF-α-induced hepatic epithelial cell death through Hsp70 overexpression |
| 6 | PKMzeta和KIBRA與大鼠進行T型迷宮測驗時的參考記憶而非工作記憶密切相關 Both PKMzeta and KIBRA are closely related to reference memory but not working memory in a T-maze task in rats |
| 7 | 哺育期塑化劑暴露大白鼠藉由運動改善下視丘-腦下垂體-腎上腺皮質軸線功能以降低焦慮症狀 Exercise prevents the increased anxiety-like behavior in lactational di-(2-ethylhexyl) phthalate-exposed female rats in late adolescence by improving the regulation of hypothalamus-pituitary-adrenal axis |
| 8 | 動作技巧學習增進小腦Arc蛋白表現 Motor skill learning enhances the expression of activity-regulated cytoskeleton-associated protein in the rat cerebellum |
| 9 | 胰島素於鼠大腦皮質神經元經由增進AMPA受器之胞吞誘發學習蛋白表現 Insulin can induce the expression of a memory-related synaptic protein through facilitating AMPA receptor endocytosis in rat cortical neurons. |
| 10 | Baicalein Inhibits HMGB1 Release and MMP-2/-9 Expression in Lipopolysaccharide-Induced Cardiac Hypertrophy Baicalein Inhibits HMGB1 Release and MMP-2/-9 Expression in Lipopolysaccharide-Induced Cardiac Hypertrophy |
| 11 | Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production, calcium overload and apoptosis via MAPK pathways. Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production, calcium overload and apoptosis via MAPK pathways. |
| 12 | 肌縮蛋白基因缺陷小鼠在國內隻培育與分生學上之應用 Incubation and molecular biology application of dystrophin-deficient MDX mice |
| 13 | 塑化劑DEHP經由減少MyoD與 Myogenin表現抑制肌肉分化 Di-(2-ethylhexyl)-phthalate reduces MyoD and myogenin expression and inhibits myogenic differentiation in C2C12 cells |
| 14 | 非致死劑量鋁暴露會在SH-SY5Y細胞藉由干擾ERK傳訊途徑降低腦泌神經滋養素誘發Arc蛋白的表現 Nonlethal aluminum maltolate can reduce brain-derived neurotrophic factor-induced Arc expression through interrupting the ERK signaling in SH-SY5Y neuroblastoma cells. |
| 15 | PPARγ 活化 Trim17 參與鄰苯二甲酸雙(2-乙基己酯)誘發之Neuro-2a細胞凋亡 Activation of Trim17 by PPARγ is involved in Di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells |
| 16 | Rho關連激酶抑制劑對鋁在大鼠腦皮質神經細胞造成神經毒性的保護效應 The protective effect of Rho-associated kinase inhibitor on aluminum-induced neurotoxicity in rat cortical neurons |
| 17 | 以電氣生理學模式探討二氧化鍺暴露造成之大鼠上行性聽覺路徑功能性改變 Functional changes on ascending auditory pathway in rats caused by germanium dioxide exposure: an electrophysiological study |
| 18 | 乙型類澱粉蛋白會阻礙大鼠腦皮質神經細胞涉及BDNF誘發Arc蛋白表現的PI3K-Akt-mTOR途徑之傳訊 Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons. |
| 19 | 非致死劑量乙型類澱粉體會損壞大腦神經元內BDNF所誘發的arc蛋白表現 Amyloid-beta at sublethal level impairs BDNF-induced arc expression in cortical neurons |
| 20 | Cdc42會參與BDNF調節ADF/cofilin和視網膜神經細胞生長錐絲狀假足的過程 Cdc42 participates in the regulation of ADF/cofilin and retinal growth cone filopodia by Brain Derived Neurotrophic Factor. |
| 21 | 二氧化鍺誘發Neuro-2A細胞產生粒線體媒介之細胞凋亡 Germanium dioxide induces mitochondria-mediated apoptosis in Neuro-2A cells |
| 22 | 細胞黏附修飾物(MOCA)會調節由N-cadherin控制的細胞間黏附和神經突向外生長 Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth. |
| 23 | 建立一個新的神經肌肉細胞共同培養模式並證實神經性一氧化氮合成酶參與乙醯膽鹼受器聚集增大的過程而與聚集的初始形成無關 Implication of nNOS in the enlargement of AChR aggregates but not the initial aggregate formation in a novel coculture model. |
| 24 | 台灣鉛暴露工人的神經行為變化 Neurobehavioral changes in Taiwanese lead-exposed workers. |
| 25 | 鉛暴露會造成神經肌肉接合處形成時乙醯膽鹼受器聚集減少 Lead-induced attenuation in the aggregation of acetylcholine receptors during the neuromuscular junction formation. |
| 26 | 耳蝸摘除術誘導耳蝸神經核內的神經細胞同時表現生長相關蛋白質GAP-43和神經性一氧化氮合成酶 Co-induction of growth-associated protein GAP-43 and neuronal nitric oxide synthase in the cochlear nucleus following cochleotomy |
| 27 | mdx小鼠的聽覺系統較易受到噪音暴露之損害 Increased vulnerability of auditory system to noise exposure in mdx mice |
| 28 | 投與中藥會增加缺乏肌縮蛋白小鼠之行為活動 Administration of Chinese Herbal Medicines Facilitates the Locomotor Activity in Dystrophin-Deficient Mice |
| 29 | 藉由Fos蛋白免疫組織化學染色評估大鼠橄欖耳蝸神經束在噪音暴露下的保護作用 Evaluating the protective role of the olivocochlear bundle against acoustic overexposure in rats by using Fos immunohistochemistry |
| 30 | 二氧化鍺在大鼠體內之動力學研究 Kinetics of germanium dioxide in rats |
| 31 | The suppressive effect of the olivocochlear bundle in rats studied by brainstem auditory evoked potentials following brainstem lesion |
| 32 | Effect of olivocochlear bundle lesion on locomotor activity in rats |
| 33 | Synergetic effects of noise and aminoglycoside antibiotic (gentamicin) on auditory function in the gerbil |
| 34 | Auditory effects of aircraft noise on people living near an airport |
| 35 | 肌縮蛋白缺乏小鼠之動作行為觀察 Locomotion of Dystrophin-deficient mice |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-009 — 1 個人型
以囓齒動物模式探討組織蛋白去乙醯酶在27-羥基膽固醇減損學習記憶能力過程中的角色( )
|
2019/08/01 ~ 2020/07/31 |
| 2 |
107 — M 高醫(種子計畫) — KMU-M108015 —
膽固醇代謝產物27-OHC藉由影響組脂蛋白去乙醯酶及beta-類澱粉蛋白質而導致記憶相關蛋白質表現缺損之探討( )
|
2019/01/01 ~ 2019/12/31 |
| 3 |
106 — M 高醫(種子計畫) — KMU-M107006 —
探討高膽固醇血症對神經元活性的影響－膽固醇代謝產物27-OH影響記憶相關蛋白質Arc表現量之表觀遺傳學研究( )
|
2018/01/01 ~ 2018/12/31 |
| 4 |
105 — N 國科會(原科技部) — MOST105-2320-B-037-018 — 1 個人型
瘦素於大腦調節母性行為之研究( )
|
2016/08/01 ~ 2017/07/31 |
| 5 |
105 — Z 大專學生研究計畫及博士後 — MOST106-2813-C-037-025-B — 8 大專學生研究計畫
106年度大專學生研究計畫-于先甫(運醫3)( )
|
2017/07/01 ~ 2018/02/28 |
| 6 |
102 — M 高醫(種子計畫) — KMU-M103010 —
探討在胰島素作用下阻斷Arc蛋白形成對AMPA受器內吞的影響 Evaluating the effect of blocking insulin-induced Arc expression insulin-stimulated AMPA receptor endocytosis( )
|
2014/01/01 ~ 2014/12/31 |
| 7 |
101 — N 國科會(原科技部) — NSC101-2320-B-037-025 — 1 個人型
以大鼠大腦皮質神經元初級培養探討PKMζ在BDNF誘發Arc蛋白表現的角色及其作用機轉( )
|
2012/08/01 ~ 2013/07/31 |
| 8 |
100 — M 高醫(種子計畫) — KMU-M110003 —
探討PKMzeta與KIBRA記憶相關蛋白在正常大鼠的前額葉皮質工作記憶之角色( )
|
2011/12/15 ~ 2012/12/31 |
| 9 |
099 — N 國科會(原科技部) — NSC97-2320-B-037-017-MY3 —
探討腦內胰島素傳訊途徑誘發早期基因蛋白Arc表現的可能調控或干擾因素(3/3)( )
|
2010/08/01 ~ 2011/07/31 |
| 10 |
098 — N 國科會(原科技部) — NSC97-2320-B-037-017-MY3 — 1 個人型
探討腦內胰島素傳訊途徑誘發早期基因蛋白Arc表現的可能調控或干擾因素(2/3)( )
|
2009/08/01 ~ 2011/07/31 |
| 11 |
097 — N 國科會(原科技部) — NSC97-2320-B-037-017-MY3 — 1 個人型
探討腦內胰島素傳訊途徑誘發早期基因蛋白Arc表現的可能調控或干擾因素(1/3)( )
|
2008/08/01 ~ 2011/07/31 |
| 12 |
096 — N 國科會(原科技部) — NSC96-2320-B-037-029 — 1 個人型
探討乙型類澱粉體干擾腦內胰島素調節突觸可塑性之可能機轉( )
|
2007/08/01 ~ 2008/07/31 |
| 13 |
095 — M 高醫(種子計畫) — — 1 個人型
探討鋁暴露對BDNF誘導Arc蛋白表現之影響及可能被干擾的訊息傳遞路徑(Investigating the effect of aluminum exposure on BDNF-induced Arc expression and the possible involved signsling pathway.)
|
2006/12/01 ~ 2007/07/31 |
| 14 |
094 — N 國科會(原科技部) — NSC94-2320-B-037-019- — 1 個人型
探討鋁暴露下促進beta澱粉樣蛋白形成及斑塊沉積的作用與Rho-ROCK訊息傳遞路徑之相關( )
|
2005/08/01 ~ 2006/07/31 |
| 15 |
092 — N 國科會(原科技部) — NSC92-2320-B-037-023- — 1 個人型
探討脂蛋白本體E(Apo E)參與耳蝸摘除誘使耳蝸神經核突觸重塑之可能性( )
|
2003/08/01 ~ 2004/07/31 |
| 16 |
091 — N 國科會(原科技部) — NSC91-2320-B-037-021 — 1 個人型
耳蝸摘除誘使腦幹聽覺神經網路發生重塑現象之探討:neurotrophins的角色( )
|
2002/08/01 ~ 2003/07/31 |
| 17 |
090 — N 國科會(原科技部) — NSC90-2320-B-037-031 — 1 個人型
利用耳蝸損害模式探討neurotrophins重整腦幹聽覺神經網路之機轉(Neurotrophins-modulated reorganization of auditory brainstem neuronal network following cochlear injury)
|
2001/08/01 ~ 2002/07/31 |
| 18 |
089 — N 國科會(原科技部) — NSC 89-2320-B-037-050- — 1 個人型
以突觸重塑之模式探討細胞骨骼蛋白DYSTROPHIN在腦幹聽覺神經核之生理角色(Investigating the physiological role of dystrophin in audi- tory brainstem by using synaptic remodeling model)
|
2000/08/01 ~ 2001/07/31 |
| 19 |
088 — N 國科會(原科技部) — NSC 89-2320-B-037-017- — 1 個人型
利用一氧化氮合成脢(NOS)在神經組織之表現探討細胞骨骼蛋白DYSTROPHIN在聽覺神經核發展過程的角色(The Role of Dystrophin in the Development of Auditory Nuclei Evaluated by the nNOS Expression)
|
1999/08/01 ~ 2000/07/31 |
| 20 |
087 — N 國科會(原科技部) — NSC88-2314-B-037-064- — 1 個人型
以音誘早期基因表現探討橄欖耳蝸神經束在噪音性失聽之保護角色(The role of the olivocochlear bundle in protection against noise-induced heaaring loss-investigated by inducing early gene expression in the auditory pathway)
|
1998/08/01 ~ 1999/07/31 |
| 21 |
086 — N 國科會(原科技部) — NSC87-2314-B037-092 —
細胞內骨骼蛋白DYSTROPHIN 在聽覺傳導的角:以聲音刺激誘出聽覺徑路早期基因標記進行探討(Investigation of dystrophin in the function of auditory pathways by inducing early gene marker)
|
1997/08/01 ~ 1998/07/31 |
| 22 |
085 — N 國科會(原科技部) — NSC86-2314-B037-076 —
細胞內骨骼蛋白DYSTROPHIN在視覺與聽覺傳導徑路功能之研究(The study of dystrophin in the function of visual and auditory pathways)
|
1996/08/01 ~ 1997/07/31 |
| 23 |
084 — N 國科會(原科技部) — NSC85-2331-B037-044 —
探討下行抑制性橄欖耳蝸神經束之耳鳴發生機轉與活動行為之影響(Investigation of the inhinbitory olivocochlear bundle in tinnitus mechanism)
|
1995/08/01 ~ 1996/07/31 |
| 24 |
083 — N 國科會(原科技部) — NSC84-2331-B037-021 —
近場性活體電學記錄探討下行性聽覺抑制徑路─耳嗚發生機轉動物模式之前驅研究(Investigation of descending auditory inhibitory pathway by near-field extra-cellular recording─pilot study in mechanismof tinnitus by ani-mal model)
|
1994/08/01 ~ 1995/07/31 |
| 25 |
082 — N 國科會(原科技部) — NSC83-0412-B037-081 —
近場性活體電學記錄探討下行性聽覺抑制徑路─耳嗚發生機轉動物模式之前驅研究(Investigation of descending auditory inhibitory inhibitory pathway by near-field extra-cellular recording ─ pilot study in mechanism of ti-nnitus by animal model)
|
1994/02/01 ~ 1994/07/31 |
| 26 |
082 — N 國科會(原科技部) — NSC83-0421-B037-002Z —
機場高頻率噪音對聽神經功能和行為反應之影響:Ⅲ、附近居民之研 究Ⅳ、以大白鼠模式研究高音頻噪音聽功能損害機轉(The Influence of Aircraft Noise on the Auditory Function)
|
1994/02/01 ~ 1995/07/31 |
| 27 |
081 — N 國科會(原科技部) — NSC82-0420-B037-44-M10 —
以腦幹聽覺誘發電位配合聽覺徑路之破壞探討大鼠聽覺系統中下行性抑制性徑路(Study of the descending inhibition tracts of auditory pathway in rats by BAEPs and discrete lesions of the brainstem auditory pathway.)
|
1992/08/01 ~ 1993/07/31 |
| 28 |
081 — N 國科會(原科技部) — NSC82-0421-B037-055-Z —
南台灣環境與工業危害性神經疾病之登錄及使用神經電生理學生物偵測之研究(A Registration and Electrophysiological Monitoring of Industrial and Environmental Hazard-induced Neurological Disorders in Southern Taiwan)
|
1992/08/01 ~ 1993/07/31 |
| 29 |
080 — N 國科會(原科技部) — NSC81-0412-B037-10 —
氨基配糖體對耳蝸毛細胞細胞電位及腦幹聽覺誘發電位影響之研究(Effects of the aminoglycoside on the cell potential of hair cells and brainstem auditory evoked potential)
|
1991/08/01 ~ 1992/07/31 |
| 30 |
080 — N 國科會(原科技部) — NSC81-0421-B037-01z —
機場高頻率噪音對聽神經功能和行為反應之影響-II.國小學童之研究(The Influence of High-frequency Noise on the Auditory Function and Behavioral Response of the School Children.(2) Study of the School Children)
|
1991/08/01 ~ 1992/07/31 |