Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學大學 — 醫學研究所(畢) — 博士 Doctorate, Graduate Institute of Medicine, Kaohsiung Medical University |
1997/09 — 2006/06 |
|
高雄醫學院 — 生物化學研究所(畢) — 碩士 Master, Graduate Institute of Biochemistry, Kaohsiung Medical University (former Kaohsiung Medical College) |
1995/09 — 1997/06 |
|
東海大學 — 生物學系(畢) — 學士 Bachelor, Department of Biology, Tunghai University |
1982/09 — 1986/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology | Associate Professor | 2014/08/01 — |
| 生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology | Assistant Professor | 2006/08/01 — 2014/07/31 |
| 生物醫學暨環境生物學系 Department of Biomedical Science and Environmental Biology | Lecturer | 2003/08/01 — 2006/07/31 |
| 生物學系 Department of Biology | Lecturer | 1997/08/01 — 2003/07/31 |
| 生物學系 Department of Biology | Teaching Assistant | 1990/08/01 — 1997/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 生物學之生化及分子生物 Biochemistry and Molecular Biology |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
建立細胞及動物模式之生物相關領域
Area(s) of Expertise & Research
生物醫學,分子生物學,生物化學,細胞生物學,
molecular and cell biology, biochemistry
Publication
| NO | Publication |
|---|---|
| 1 | The Controversial Roles of Areca Nut: Medicine or Toxin The Controversial Roles of Areca Nut: Medicine or Toxin |
| 2 | TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer TMEM211 Promotes Tumor Progression and Metastasis in Colon Cancer |
| 3 | N-acetyl cysteine prevents arecoline-inhibited C2C12 myoblast differentiation through ERK1/2 phosphorylation N-acetyl cysteine prevents arecoline-inhibited C2C12 myoblast differentiation through ERK1/2 phosphorylation |
| 4 | Effects of areca nut consumption on cell differentiation of osteoblasts, myoblasts, and fibroblasts Effects of areca nut consumption on cell differentiation of osteoblasts, myoblasts, and fibroblasts |
| 5 | Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice |
| 6 | Brefeldin A effectively inhibits cancer stem cell-like properties and MMP-9 activity in human colorectal cancer Colo 205 cells Brefeldin A effectively inhibits cancer stem cell-like properties and MMP-9 activity in human colorectal cancer Colo 205 cells |
| 7 | Arecoline inhibits and destabilizes agrin-induced acetylcholine receptor cluster formation in C2C12 myotubes Arecoline inhibits and destabilizes agrin-induced acetylcholine receptor cluster formation in C2C12 myotubes |
| 8 | Brefeldin A Inhibits Cancer Stem Cell Properties in Human Lung Cancer Cells Brefeldin A Inhibits Cancer Stem Cell Properties in Human Lung Cancer Cells |
| 9 | Arecoline inhibits myogenic differentiation of C2C12 myoblasts by reducing STAT3 phosphorylation Arecoline inhibits myogenic differentiation of C2C12 myoblasts by reducing STAT3 phosphorylation |
| 10 | Agrin induces association of Chrna1 mRNA and nicotinic acetylcholine receptor in C2C12 myotubes Agrin induces association of Chrna1 mRNA and nicotinic acetylcholine receptor in C2C12 myotubes |
| 11 | A preliminary report on the toxicity of arecoline on early pregnancy in mice. A preliminary report on the toxicity of arecoline on early pregnancy in mice. |
| 12 | 過氧化氫降低被穩定減弱SMN蛋白質的HeLa細胞的存活率 Hydrogen peroxide decreases the survival rate of HeLa cells with stable knockdown of survival motor neuron protein |
| 13 | Inhibition of the Epstein-Barr virus lytic cycle by moronic acid Inhibition of the Epstein-Barr virus lytic cycle by moronic acid |
| 14 | hydroxyurea對脊髓性肌肉性萎縮症病人及細胞之影響 The effect of hydroxyurea in spinal muscular atrophy cells and patients. |
| 15 | 利用毛細管電泳定量SMN1和SMN2用於診斷脊髓肌肉萎縮症 Quantification of SMN1 and SMN2 genes by capillary electrophoresis for diagnosis of spinal muscular atrophy |
| 16 | 無 Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity |
| 17 | The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination |
| 18 | cIAP1結合蛋白質及cIAP1泛素化之研究 The studies on the cIAP1-associated proteins and cIAP1 ubiquitination |
| 19 | 病毒凋亡蛋白Apoptin和細胞內Hippi蛋白的結合作用 The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin interacting protein 1 |
| 20 | 無 Identification of a CArG-independent region of the cysteine-rich protein 2 promoter that directs expression in the developing vasculature |
| 21 | Sequence of a Human E2F-4 Pseudogene with Shortened AGC Trinucleotide Repeats 待補 |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
113 — M 高醫(種子計畫) — KMU-M114011 —
探討IFI6調控口腔鳞状细胞癌發展之分子機制( )
|
2025/01/01 ~ 2025/12/31 |
| 2 |
112 — M 高醫(種子計畫) — KMU-M113025 —
化學合成物質對神經纖維延長之研究( )
|
2024/01/01 ~ 2024/12/31 |
| 3 |
108 — N 國科會(原科技部) — MOST108-2314-B-037-075 — 1 個人型
檳榔鹼對骨母細胞分化影響之研究( )
|
2019/08/01 ~ 2020/07/31 |
| 4 |
104 — TP 頂尖計畫(高醫) — KMU-TP104PR16 —
以蛋白質體學方法篩選淋巴結中調節癌細胞轉移之分子( )
|
2016/02/04 ~ 2016/09/30 |
| 5 |
103 — M 高醫(種子計畫) — KMU-M104003 —
檳榔鹼對肌肉發育機制及類成骨細胞分化影響之研究( )
|
2015/01/01 ~ 2015/12/31 |
| 6 |
102 — M 高醫(種子計畫) — KMU-M103001 —
篩選脊髓肌肉萎縮症(SMA)的運動神元經纖維增長之藥物( )
|
2014/01/01 ~ 2014/12/31 |
| 7 |
101 — M 高醫(種子計畫) — KMU-M102002 —
檳榔鹼對肌肉發育及成骨細胞分化影響之研究( )
|
2012/12/01 ~ 2013/12/31 |
| 8 |
098 — N 國科會(原科技部) — NSC96-2314-B-037-035-MY3 — 2 整合型
脊髓肌肉萎縮症:從生物標記到治療對策-以基因剔除及RNA干擾方法研究hnRNP A1和SPRK2對SMN缺陷之影響(3/3)( )
|
2009/08/01 ~ 2010/07/31 |
| 9 |
097 — N 國科會(原科技部) — NSC96-2314-B-037-035-MY3 — 2 整合型
脊髓肌肉萎縮症:從生物標記到治療對策-以基因剔除及RNA干擾方法研究hnRNP A1和SPRK2對SMN缺陷之影響(2/3)( )
|
2008/08/01 ~ 2010/07/31 |
| 10 |
096 — N 國科會(原科技部) — NSC96-2314-B-037-035-MY3 — 2 整合型
脊髓肌肉萎縮症:從生物標記到治療對策-以基因剔除及RNA干擾方法研究hnRNP A1和SPRK2對SMN缺陷之影響(1/3)( )
|
2007/08/01 ~ 2010/07/31 |
| 11 |
088 — M 高醫(種子計畫) — KMC89-A-03 —
人類乳癌細胞株MCF7中與果蠅細胞凋亡蛋白質REAPER結的蛋白質之基因選殖( )
|
1999/08/01 ~ 1999/07/31 |
| 12 |
087 — M 高醫(種子計畫) — KMC88-A-07 —
選殖與果蠅細胞凋亡蛋白質REAPER結合之人類基因( )
|
1998/11/15 ~ 1999/07/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | hnRNP A1 基因剔除之動物模式及其用途 | 美國 | 2015/02/03 | 8,946,503 |