Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學院 — 醫學研究所(畢) — 博士 Doctorate, Graduate Institute of Medicine, Kaohsiung Medical College |
1992/09 — 1997/01 |
|
高雄醫學院 — 醫學研究所(畢) — 碩士 Master, Graduate Institute of Medicine, Kaohsiung Medical College |
1988/09 — 1991/06 |
|
高雄醫學院 — 藥學系(畢) — 學士 Bachelor, School of Pharmacy, Kaohsiung Medical College |
1984/09 — 1988/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 藥理學科 Department of Pharmacology | Director | 2023/08/01 — 2024/07/31 |
| 醫學院 College of Medicine | Associate Dean | 2023/08/01 — 2024/07/31 |
| 藥理學科 Department of Pharmacology | Professor | 2008/08/01 — |
| 藥理學科 Department of Pharmacology | Associate Professor | 2007/08/01 — 2008/07/31 |
| 藥理學研究所 Graduate Institute of Pharmacology | Associate Professor | 2005/11/24 — 2007/07/31 |
| 藥理學 Pharmacology | Associate Professor | 2005/02/01 — 2005/11/23 |
| 藥理學 Pharmacology | Assistant Professor | 1997/08/01 — 2005/01/31 |
| 藥理學 Pharmacology | Lecturer | 1992/08/01 — 1997/07/31 |
| 藥理學 Pharmacology | Teaching Assistant | 1989/08/01 — 1992/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 藥理及毒理 Pharmacology and Toxicology |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
減緩神經退化及增加骨骼肌肌肉蛋白質生成之傳統中藥及天然藥物開發
Drug developments for neurodegenerative diseases and skeletal muscle atrophy
Area(s) of Expertise & Research
分子藥理學、神經退化，肌少症、傳統中藥及天然物藥理，開發代謝及粒腺體標的藥物
molecular pharmacology, neurodegeneration, sarcopenia, drug development for traditional Chinese medicine and natural products targeting metabolism and mitochondria
Publication
| NO | Publication |
|---|---|
| 1 | 芳樟醇，一種植物芳香化合物，在帕金森氏症實驗模型中具保護多巴胺神經元及改善運動功能和骨骼肌強度的作用 Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson's Disease. |
| 2 | Guilu Erxian Jiao enhances protein synthesis, glucose homeostasis, mitochondrial biogenesis and slow-twitch fibers in the skeletal muscle Guilu Erxian Jiao enhances protein synthesis, glucose homeostasis, mitochondrial biogenesis and slow-twitch fibers in the skeletal muscle |
| 3 | An efficient cellular image-based platform for high-content screening of neuroprotective agents against chemotherapy-induced neuropathy. An efficient cellular image-based platform for high-content screening of neuroprotective agents against chemotherapy-induced neuropathy. |
| 4 | Guilu Erxian Jiao enhances protein synthesis, glucose homeostasis, mitochondrial biogenesis and slow-twitch fibers in the skeletal muscle. Guilu Erxian Jiao enhances protein synthesis, glucose homeostasis, mitochondrial biogenesis and slow-twitch fibers in the skeletal muscle. |
| 5 | Hyperbaric Oxygen Therapy Improves Parkinson's Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway. Hyperbaric Oxygen Therapy Improves Parkinson's Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway. |
| 6 | 重度憂鬱症患者的新陳代謝症候群成分和白血球端粒長度 Metabolic syndrome components and leukocyte telomere length in patients with major depressive disorder. |
| 7 | Protective Effects of the Chalcone-Based Derivative AN07 on Inflammation-Associated Myotube Atrophy Induced by Lipopolysaccharide. Protective Effects of the Chalcone-Based Derivative AN07 on Inflammation-Associated Myotube Atrophy Induced by Lipopolysaccharide. |
| 8 | 犬尿喹啉酸及其氨基烷基化衍生物可有效活化M型鉀離子通道 Effective Activation by Kynurenic Acid and Its Aminoalkylated Derivatives on M-Type K+ Current |
| 9 | 柚皮素，一種食物中的黃酮類，藉由活化IGF-1R調節抗氧化的防禦作用並改善甲基乙二醛造成的運動神經元損傷 Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death. |
| 10 | 退行性胸腰椎疾病初次手術前主要精神疾病的盛行率和預後 Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease |
| 11 | 雷公藤內酯透過抑制 NF-κB/TNF-α 和調節蛋白質合成/降解途徑來防止 LPS 誘導的骨骼肌萎縮 Triptolide prevents LPS-induced skeletal muscle atrophy via inhibiting NF-κB/TNF-α and regulating protein synthesis/degradation pathway. |
| 12 | UCL-2077 (3-(三苯基甲基氨基甲基)吡啶)抑制收斂的特性，已知抑制過極化後erg介導的鉀電流和中電導的鈣激活鉀通道 Characterization of Convergent Suppression by UCL-2077 (3-(Triphenylmethylaminomethyl)pyridine), Known to Inhibit Slow Afterhyperpolarization, of erg-Mediated Potassium Currents and Intermediate-Conductance Calcium-Activated Potassium Channels |
| 13 | Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids From Croton tonkinensis Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids From Croton tonkinensis |
| 14 | Characterization in Dual Activation by Oxaliplatin, a Platinum-Based Chemotherapeutic Agent of Hyperpolarization-Activated Cation and Electroporation-Induced Currents Characterization in Dual Activation by Oxaliplatin, a Platinum-Based Chemotherapeutic Agent of Hyperpolarization-Activated Cation and Electroporation-Induced Currents |
| 15 | The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07. The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07. |
| 16 | Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from Magnolia officinalis, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K+ Current. Effectiveness in the Block by Honokiol, a Dimerized Allylphenol from Magnolia officinalis, of Hyperpolarization-Activated Cation Current and Delayed-Rectifier K+ Current. |
| 17 | 六味地黃水萃取物對糖尿病引起肌萎縮的保護作用 Protective effects of Liuwei dihuang water extracts on diabetic muscle atrophy |
| 18 | 2-碘基-4'甲氧基查耳酮透過激活GLP-1受體以增強神經營養因子訊號、抗氧化作用及乙二醛途徑以減輕甲基乙二醛誘導的神經毒性 2-Iodo-4'-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity by Activation of GLP-1 Receptor and Enhancement of Neurotrophic Signal, Antioxidant Defense and Glyoxalase Pathway |
| 19 | loganin對1-甲基-4-苯基吡啶誘導的神經毒性的新保護作用：增強神經營養信號，激活IGF-1R / GLP-1R和抑制RhoA / ROCK途徑 The novel protective effects of loganin against 1-methyl-4-phenylpyridinium-induced neurotoxicity: Enhancement of neurotrophic signaling, activation of IGF-1R/GLP-1R, and inhibition of RhoA/ROCK pathway |
| 20 | 天麻苷元和天麻素對腦下垂體細胞和海馬迴神經元M型鉀離子電流的抑制作用 Characterization of the Inhibitory effect of gastrodigenin and gastrodin on M-type K+ currents in pituitary cells and hippocampal neurons |
| 21 | Evidence for the Capability of Roxadustat (FG-4592), an Oral HIF Prolyl-Hydroxylase Inhibitor, to Perturb Membrane Ionic Currents: An Unidentified Yet Important Action Evidence for the Capability of Roxadustat (FG-4592), an Oral HIF Prolyl-Hydroxylase Inhibitor, to Perturb Membrane Ionic Currents: An Unidentified Yet Important Action |
| 22 | Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by Ganoderma Triterpenoids, the Main Active Constitutents of Ganoderma Spores Evidence for Effective Inhibitory Actions on Hyperpolarization-Activated Cation Current Caused by Ganoderma Triterpenoids, the Main Active Constitutents of Ganoderma Spores |
| 23 | Differential regulation of tefluthrin and telmisartan on the gating charges of INa activation and inactivation as well as on resurgent and persistent INa in a pituitary cell line (GH3) Differential regulation of tefluthrin and telmisartan on the gating charges of INa activation and inactivation as well as on resurgent and persistent INa in a pituitary cell line (GH3) |
| 24 | Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons. Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in olfactory sensory (Rolf B1.T) neurons. |
| 25 | Identifying early decline of daily function and its association with physical function in chronic kidney disease: performancebased and self-reported measures Identifying early decline of daily function and its association with physical function in chronic kidney disease: performancebased and self-reported measures |
| 26 | Resveratrol prevents nanoparticles-induced inflammation and oxidative stress via downregulation of PKC-α and NADPH oxidase in lung epithelial A549 cells. Resveratrol prevents nanoparticles-induced inflammation and oxidative stress via downregulation of PKC-α and NADPH oxidase in lung epithelial A549 cells. |
| 27 | Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells |
| 28 | Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. |
| 29 | The water extract of Liuwei dihuang possesses multi-protective properties on neurons and muscle tissue against deficiency of survival motor neuron protein. The water extract of Liuwei dihuang possesses multi-protective properties on neurons and muscle tissue against deficiency of survival motor neuron protein. |
| 30 | 馬錢子苷具神經保護特性,在脊髓性肌肉萎縮症實驗模式中能回復SMN蛋白質並活化蛋白質合成Akt/mTOR Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy |
| 31 | Validation of Taiwan Performance-Based Instrumental Activities of Daily Living (TPIADL), a Performance- Based Measurement of Instrumental Activities of Daily Living for Patients with Vascular Cognitive Impairment Validation of Taiwan Performance-Based Instrumental Activities of Daily Living (TPIADL), a Performance- Based Measurement of Instrumental Activities of Daily Living for Patients with Vascular Cognitive Impairment |
| 32 | 異稟酚在人類肺泡上皮細胞藉由Nrf2/GSH的活化以及抑制NADPH氧化酶的活性降低了內毒素所產生的過氧化物產量 Propofol Attenuates Lipopolysaccharide-Induced Reactive Oxygen Species Production Through Activation of Nrf2/GSH and Suppression of NADPH Oxidase in Human Alveolar Epithelial Cells |
| 33 | Investigations on contribution of glial inwardly-rectifying K(+) current to membrane potential and ion flux: An experimental and theoretical study. Investigations on contribution of glial inwardly-rectifying K(+) current to membrane potential and ion flux: An experimental and theoretical study. |
| 34 | Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury. Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury. |
| 35 | Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumor cells. Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumor cells. |
| 36 | Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia |
| 37 | The Chinese herbal formula Liuwei dihuang protects dopaminergic neurons against Parkinson's toxin through enhancing antioxidative defense and preventing apoptotic death The Chinese herbal formula Liuwei dihuang protects dopaminergic neurons against Parkinson's toxin through enhancing antioxidative defense and preventing apoptotic death |
| 38 | Nanomolar naloxone attenuates neurotoxicity induced by oxidative stress and survival motor neuron protein deficiency Nanomolar naloxone attenuates neurotoxicity induced by oxidative stress and survival motor neuron protein deficiency |
| 39 | The Utilization of a New Immunochromatographic Test in Detection of Helicobacter pylori Antibody from Maternal and Umbilical Cord Serum The Utilization of a New Immunochromatographic Test in Detection of Helicobacter pylori Antibody from Maternal and Umbilical Cord Serum |
| 40 | High effectiveness of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from human glioma cells. High effectiveness of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from human glioma cells. |
| 41 | Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with alpha-hSlo subunit Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with alpha-hSlo subunit |
| 42 | Nrf2-Keap1 Antioxidant Defense and Cell Survival Signaling Are Upregulated by 17β-Estradiol in Homocysteine-Treated Dopaminergic SH-SY5Y Cells Nrf2-Keap1 Antioxidant Defense and Cell Survival Signaling Are Upregulated by 17β-Estradiol in Homocysteine-Treated Dopaminergic SH-SY5Y Cells |
| 43 | Melamine activates NFκB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells. Melamine activates NFκB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells. |
| 44 | Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. |
| 45 | Melamine activates NFκB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells. Melamine activates NFκB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS production in macrophages and human embryonic kidney cells. |
| 46 | 牡丹酚在初代小神經膠細胞及皮質神經細胞降低小神經膠細胞引起的發炎及氧化壓力引起的神經毒性 Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons |
| 47 | 雷公藤甲素增加運動神經存活蛋白表現在人類脊髓萎縮症纖維母細胞及脊髓萎縮症小鼠 Triptolide increases SMN transcript and protein levels in human SMA fibroblasts and improves survival in SMA-like mice. |
| 48 | Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo |
| 49 | Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells |
| 50 | Possible effects of reduced conductance in delayed-rectifier K+ current on neuronal firing Possible effects of reduced conductance in delayed-rectifier K+ current on neuronal firing |
| 51 | Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells |
| 52 | Contribution of blocked potassium current conductance and increased conductance of persistent sodium current to the afterdischarge in myelinated neuron Contribution of blocked potassium current conductance and increased conductance of persistent sodium current to the afterdischarge in myelinated neuron |
| 53 | Verapamil藉由抑制小神經膠細胞活化保護多巴胺神經 Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation |
| 54 | Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells |
| 55 | memantine的抑制反應, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells |
| 56 | Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes |
| 57 | Contribution of non-inactivating Na+ current induced by oxidizing agents to the firing behavior of neuronal action potentials: experimental and theoretical studies from NG108-15 neuronal cells Contribution of non-inactivating Na+ current induced by oxidizing agents to the firing behavior of neuronal action potentials: experimental and theoretical studies from NG108-15 neuronal cells |
| 58 | 三黃瀉心湯保護SH-SY5Y神經細胞減少小神經膠細胞活化及6-OHDA引起的神經毒性 San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells |
| 59 | 6-Hydroxycleroda-3,13-dien-15,16-olide可藉由抑制小神經細胞的活化保護酯多醣體所引起的神經毒性 6-Hydroxycleroda-3,13-dien-15,16-olide protects neuronal cells from lipopolysaccharide-induced neurotoxicity through the inhibition of microglia-mediated inflammation |
| 60 | KMUP-1可藉由 PKG, PI3K/Akt及Bcl-2/Bax的路徑來抑制serum deprivation在SH-SY5Y所引起的神經毒性 KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: Roles of PKG, PI3K/Akt and Bcl-2/Bax pathways |
| 61 | 檳榔之主成分檳榔鹼可藉由增加氧化壓力及抑制抗氧化系統來導致神經毒性 Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protective system |
| 62 | UCHL1調控SMN蛋白質表現量 Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulates the level of SMN expression through ubiquitination in primary spinal muscular atrophy fibroblasts |
| 63 | Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley neuron during exposure to sinusoidal external voltage Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley neuron during exposure to sinusoidal external voltage |
| 64 | 具Piperazine骨架之甲型腎上腺激素阻斷劑KMUP-1及Dodxazosin經由調控雄性素接受器及攝護腺特異性抗原表現抑制LNCaP細胞與免疫缺乏老鼠之癌細胞生長 Piperazine-designed alpha1A/alpha1D-adrenoceptor blocker KMUP-1 and doxazosin provide down-regulation of androgen receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts |
| 65 | In vitro effects of Helicobacter pylori-induced infection in gastric epithelial AGS cells on microglia-mediated toxicity in neuroblastoma SH-SY5Y cells. In vitro effects of Helicobacter pylori-induced infection in gastric epithelial AGS cells on microglia-mediated toxicity in neuroblastoma SH-SY5Y cells. |
| 66 | 分析在分化之NG108-15神經細胞上之inactivating及noninactivating之鈉離子通道 Analytical studies of rapidly inactivating and noninactivating sodium currents in differentiated NG108-15 neuronal cells |
| 67 | 4-t-Butylcatechol之神經作用:含catechol之抗氧化劑 Neuronal effects of 4-t-Butylcatechol: A model for catechol-containing antioxidants |
| 68 | aconitine阻斷分化之NG108-15神經細胞之delayed rectifier K(+) current Characterization of aconitine-induced block of delayed rectifier K(+) current in differentiated NG108-15 neuronal cells |
| 69 | 三黃瀉心湯對於U46619引起之肺動脈高血壓之治療作用 Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure |
| 70 | 蘭嶼肉桂中Isoobtusilactone A的抗癌活性：包含凋亡、細胞週期失調、粒腺體調控和活性氧化物之特性 Anticancer Activity of Isoobtusilactone A from Cinnamomum kotoense: Involvement of Apoptosis, Cell-Cycle Dysregulation, Mitochondria Regulation, and Reactive Oxygen Species |
| 71 | Erroneous result of white blood cell differential count in a patient with mixed hyperlipidemia Erroneous result of white blood cell differential count in a patient with mixed hyperlipidemia |
| 72 | 合成抗血小板凝集2-Benzoylaminobenzoate 衍生物 Synthesis and Anti-platelet Evaluation of 2-Benzoylaminobenzoate Analogs |
| 73 | 三黃瀉心湯抑制幽門螺旋桿菌引起胃上皮細胞之發炎反應 San-Huang-Xie-Xin-Tang inhibits Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells |
| 74 | Evaluation of the two immunochromatographic methods for detecting urine and serum IgG antibodies to Helicobacter pylori and comparison of accuracy and clinical utility. Evaluation of the two immunochromatographic methods for detecting urine and serum IgG antibodies to Helicobacter pylori and comparison of accuracy and clinical utility. |
| 75 | KMUP-1促進攝護腺鬆弛及抗上皮細胞增生經由加強cGMP表現以及甲型-1A/1D腎上腺受體拮抗作用抑制Rho Kinase cGMP-enhancing- and ��1A/��1D-adrenoceptor blockade-derived inhibition of Rho-kinase by KMUP-1 provides optimal prostate relaxation and epithelial cell anti-proliferation efficacy |
| 76 | GLNVA對於小神經膠細胞及因神經毒素所導致的神經細胞毒性之神經保護作用 Neuroprotective Effects of GLNVA against Microglia-like Cells and 6-OHDA-Induced Neurotoxicity in SH-SY5Y Human Dopaminergic Neuroblastoma Cells |
| 77 | 黃嘌呤結構的上皮相依呼吸道鬆弛劑KMUP-3能促進呼吸系統的表現和保護對抗TNF-a 誘發的氣管收縮是透過一氧化氮釋放和cGMP與蛋白激酶G的表現 A xanthine-based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving nitric oxide release and expression of cGMP and protein kinase G. |
| 78 | The clinical applications and accuracy of 2 rapid near-patient tests in detecting Helicobacter pylori infection. The clinical applications and accuracy of 2 rapid near-patient tests in detecting Helicobacter pylori infection. |
| 79 | MCPT引起之內皮相關及不相關之血管鬆弛作用: 經由cyclic nucleotides, 鉀通道打開, 磷酸二酯酶抑制作用 Endothelium-dependent and -independent vasorelaxation by atheophylline derivative MCPT: Roles of cyclic nucleotidespotassium channel opening and phosphodiesterase inhibition, |
| 80 | chromanol 293B 抑制心臟H9c2 cells的 delayed-rectifier K+ current Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells |
| 81 | 三黃瀉心湯降低LPS引起之低血壓與發炎因子 San-Huang-Xie-Xin-Tang reduces lipopolysaccharides-induced |
| 82 | The best method of detecting prior Helicobacter pylori infection The best method of detecting prior Helicobacter pylori infection |
| 83 | Effects of arecoline in relaxing human umbilical vessels and inhibiting endothelial cell growth Effects of arecoline in relaxing human umbilical vessels and inhibiting endothelial cell growth |
| 84 | 抗氧化劑 eugenosedin-A,保護內毒素對大鼠與小鼠所引起低血壓,高血糖與細胞激素免疫作用之機轉 Antioxidant eugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice |
| 85 | 三黃瀉心湯會減弱在大鼠肺中由 Lipopolysaccharide 所誘導的發炎反應 San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs |
| 86 | Capsaicin-induced cell death in a human gastric adenocarcinoma cell line. Capsaicin-induced cell death in a human gastric adenocarcinoma cell line. |
| 87 | KMUP-1引起天竺鼠氣管鬆弛，其中內皮角色，環化腺苷及鉀離子通道 KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K channels |
| 88 | Urgosedin抑制內毒素引起的低血壓, 低血糖及發炎相關介質 Urgosedin inhibits hypotension, hypoglycemia and pro-inflammatory mediators induced by lipopolysaccharide |
| 89 | 非侵襲性經線掛膠囊檢測在診斷幽門螺旋桿菌感染之臨床應用 The clinical utility of string-PCR test in diagnosing Helicobacter pylori infection |
| 90 | 一個新發展以糞便檢測幽門螺旋桿菌感染測試法的評估:一展望性研究 Evaluation of a newly developed office-based stool test for detecting Helicobacter pylori: an extensive pilot study |
| 91 | 非侵襲性經線掛膠囊檢測在診斷幽門螺旋桿菌感染之臨床應用 The Clinical Utility of String-PCR Test in Diagnosing Helicobacter pylori Infection |
| 92 | 一個最新發展以糞便檢測幽門螺旋桿菌感染檢測法的評估:一展望性研究 Evaluation of a newly developed office-based stool test for detecting Helicobacter pylori: an extensive pilot study |
| 93 | ICI-182,780,動情激素受體拮抗劑,對人類冠狀內皮細胞大型鈣離子活化鉀離子通道的抑制性作用 Inhibitory Action of ICI-182,780, an Estrogen Receptor Antagonist, on BKCa Channel Activity in Cultured Endothelial Cells of Human Coronary Artery |
| 94 | 番椒晶素衍生物VOA經由CGRP, NO, cGMP及血管內皮相關作用引起大白鼠腸繫膜動脈及主動脈之鬆弛作用 A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP and endothelium-dependent activities |
| 95 | 番椒晶素衍生物VOA經由CGRP, NO, cGMP及血管內皮相關作用引起大白鼠腸繫膜動脈及主動脈之鬆弛作用 A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP and endothelium-dependent activities |
| 96 | 香夾蘭胺為骨架的丙醇胺衍生物具有腎上腺素甲/乙型受體阻斷和血管鬆弛特性 A Vanillylamide-Based Propanolamine Derivative Displays alpha/beta-Adrenoceptor Blocking and Vasodilating Properties |
| 97 | KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K+ channels. KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K+ channels. |
| 98 | 香夾蘭胺為骨架的丙醇胺衍生物具有腎上腺素甲/乙型受體阻斷和血管鬆弛特性 A Vanillylamide-Based Propanolamine Derivative Displays alpha/beta-Adrenoceptor Blocking and Vasodilating Properties |
| 99 | 在蜘蛛膜下腔出血的實驗模式下探討番椒晶素衍生物glycenyl nonivamide 之預防腦血管痙攣作用 Prevention of cerebral vasospasm by a capsaicin derivative, glyceryl nonivamide, in an experimental model of subarachnoid hemorrhage. |
| 100 | 服用辣椒素預防實驗性蜘蛛膜下腔出血引發的血管痙攣 Prevention of cerebral vasospasm by a capsaicin derivative, glyceryl nonivamide, in an experimental model of subarachnoid hemorrhage |
| 101 | 血管擴張性乙型阻斷劑脂溶性對於乙型受體之功能與結合活性影響 Lipid solubility of vasodilatory vanilloid type beta-blockers on the functional and binding activities of beta-adrenoceptor subtypes |
| 102 | Lipid solubility of vasodilatory vanilloid-type beta-blockers on the functional and binding activities of beta-adrenoceptor subtypes Lipid solubility of vasodilatory vanilloid-type beta-blockers on the functional and binding activities of beta-adrenoceptor subtypes |
| 103 | Ferulidilol:兼具有乙二型腎上腺激性致效劑作用之血管鬆弛及抗氧化作用之腎上腺激性及鈣離子通道阻斷劑 Ferulidilol: A vasodilatory and antioxidant adrenoceptor and calcium entry blocker, with ancillary b2-agonist activity |
| 104 | 硝基化蕃椒晶素重新考量氫質子酸於蕃椒晶素誘發之感覺神經活性之角色 Nitrated nonivamide displaying a drawback of proton’s role in capsaicin associated sensory and neuronal activities |
| 105 | Isoeugenolol一個具有氣管及血管平滑肌鬆弛特性的乙一型腎上腺素拮抗劑 Isoeugenolol：A selective beta1-adrenergic antagonist with tracheal and vascular smooth muscle relaxant properties |
| 106 | Selective block by glycerol nonivamide of inwardly rectifying k+ current in rat anterior pituitary GH3 cells |
| 107 | Glyceryl nonivamide, a non pungent analogue of capsaicin, enhances substance P release and real function in rats 待補 |
| 108 | The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonivamide 待補 |
| 109 | Capsazocaine : a capsaicin-sensitivity functional antagonist displays an argument on sensory capsaicin receptor 待補 |
| 110 | Capsinolol: the first β-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart |
| 111 | Glyceryl nonivamide : A capsaicin derivative with cardiac calcitonin gene-related peptide releasing, K+ channel opening, and vasorelaxant properties 待補 |
| 112 | Capsinolol: the first β-adrenoceptor block with an associated calcitonin gene-related peptide releasing activity in the heart Capsinolol: the first β-adrenoceptor block with an associated calcitonin gene-related peptide releasing activity in the heart |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
113 — N 國科會(原科技部) — MOST111-2320-B-037-018-MY3 — 1 個人型
開發具調節PGC-1 alpha 訊息相關的粒線體生合成、代謝和肌肉激素分泌作用的傳統中藥和天然物以改善骨骼肌和其他器官的功能(3/3)( )
|
2024/08/01 ~ 2025/07/31 |
| 2 |
112 — N 國科會(原科技部) — MOST111-2320-B-037-018-MY3 — 1 個人型
開發具調節PGC-1 alpha 訊息相關的粒線體生合成、代謝和肌肉激素分泌作用的傳統中藥和天然物以改善骨骼肌和其他器官的功能(2/3)( )
|
2023/08/01 ~ 2025/07/31 |
| 3 |
112 — Z 大專學生研究計畫及博士後 — NSTC112-2811-B-037-022 — 9 博士後研究員
博士級研究人員--莊雨凡( )
|
2023/08/01 ~ 2024/07/31 |
| 4 |
111 — N 國科會(原科技部) — MOST111-2320-B-037-018-MY3 — 1 個人型
開發具調節PGC-1 alpha 訊息相關的粒線體生合成、代謝和肌肉激素分泌作用的傳統中藥和天然物以改善骨骼肌和其他器官的功能(1/3)( )
|
2022/08/01 ~ 2025/07/31 |
| 5 |
111 — Z 大專學生研究計畫及博士後 — MOST111-2811-B-037-005 — 9 博士後研究員
博士級研究人員--方偉宇( )
|
2022/08/01 ~ 2023/07/31 |
| 6 |
111 — Z 大專學生研究計畫及博士後 — NSTC111-2811-B-037-028 — 9 博士後研究員
博士級研究人員--陳心穎( )
|
2022/11/15 ~ 2023/07/31 |
| 7 |
110 — N 國科會(原科技部) — MOST108-2320-B-037-019-MY3 — 1 個人型
研發可改善骨骼肌質量，肌力及運動功能之傳統中藥及天然物: 針對高糖、發炎及老化之實驗疾病模式(3/3)( )
|
2021/08/01 ~ 2022/10/31 |
| 8 |
110 — Z 大專學生研究計畫及博士後 — MOST110-2811-B-037-507 — 9 博士後研究員
博士後研究員--方偉宇( )
|
2021/08/01 ~ 2022/07/31 |
| 9 |
109 — N 國科會(原科技部) — MOST108-2320-B-037-019-MY3 — 1 個人型
研發可改善骨骼肌質量，肌力及運動功能之傳統中藥及天然物: 針對高糖、發炎及老化之實驗疾病模式(2/3)( )
|
2020/08/01 ~ 2022/10/31 |
| 10 |
109 — Z 大專學生研究計畫及博士後 — MOST109-2811-B-037-520 — 9 博士後研究員
博士後研究員--方偉宇( )
|
2020/08/01 ~ 2021/07/31 |
| 11 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-019-MY3 — 1 個人型
研發可改善骨骼肌質量，肌力及運動功能之傳統中藥及天然物: 針對高糖、發炎及老化之實驗疾病模式(1/3)( )
|
2019/08/01 ~ 2022/10/31 |
| 12 |
108 — Z 大專學生研究計畫及博士後 — MOST108-2811-B-037-528 — 9 博士後研究員
博士後研究員--方偉宇( )
|
2019/09/01 ~ 2020/07/31 |
| 13 |
107 — N 國科會(原科技部) — MOST105-2320-B-037-013-MY3 — 1 個人型
減緩神經退化及增加骨骼肌肌肉蛋白質生成之傳統中藥及天然藥物開發(3/3)( )
|
2018/08/01 ~ 2019/10/31 |
| 14 |
107 — Z 大專學生研究計畫及博士後 — MOST107-2811-B-037-507 — 9 博士後研究員
博士後研究員--李姿瑩( )
|
2018/08/01 ~ 2019/07/31 |
| 15 |
106 — N 國科會(原科技部) — MOST105-2320-B-037-013-MY3 — 1 個人型
減緩神經退化及增加骨骼肌肌肉蛋白質生成之傳統中藥及天然藥物開發(2/3)( )
|
2017/08/01 ~ 2019/10/31 |
| 16 |
106 — Z 大專學生研究計畫及博士後 — MOST106-2811-B-037-010 — 9 博士後研究員
博士後研究員--曾于庭( )
|
2017/08/01 ~ 2018/07/31 |
| 17 |
105 — N 國科會(原科技部) — MOST105-2320-B-037-013-MY3 — 1 個人型
減緩神經退化及增加骨骼肌肌肉蛋白質生成之傳統中藥及天然藥物開發(1/3)( )
|
2016/08/01 ~ 2019/10/31 |
| 18 |
105 — Z 大專學生研究計畫及博士後 — MOST105-2811-B-037-022 — 9 博士後研究員
博士後研究員--曾于庭( )
|
2016/08/01 ~ 2017/07/31 |
| 19 |
104 — N 國科會(原科技部) — NSC102-2628-B-037-001-MY3 — 1 個人型
神經退化性疾病之多重標的治療藥物開發:傳統中藥、天然物及化學合成物(3/3)( )
|
2015/08/01 ~ 2016/07/31 |
| 20 |
103 — N 國科會(原科技部) — NSC102-2628-B-037-001-MY3 — 1 個人型
神經退化性疾病之多重標的治療藥物開發:傳統中藥、天然物及化學合成物(2/3)( )
|
2014/08/01 ~ 2016/07/31 |
| 21 |
102 — N 國科會(原科技部) — NSC102-2628-B-037-001-MY3 — 1 個人型
神經退化性疾病之多重標的治療藥物開發:傳統中藥、天然物及化學合成物(1/3)( )
|
2013/08/01 ~ 2016/07/31 |
| 22 |
101 — N 國科會(原科技部) — NSC99-2320-B-037-023-MY3 — 1 個人型
地黃丸之神經保護作用及機轉探討:建立治療神經發炎及神經退化的傳統中藥開發平台(3/3)( )
|
2012/08/01 ~ 2013/07/31 |
| 23 |
100 — N 國科會(原科技部) — NSC99-2320-B-037-023-MY3 — 1 個人型
地黃丸之神經保護作用及機轉探討:建立治療神經發炎及神經退化的傳統中藥開發平台(2/3)( )
|
2011/08/01 ~ 2013/07/31 |
| 24 |
099 — N 國科會(原科技部) — NSC99-2320-B-037-023-MY3 — 1 個人型
地黃丸之神經保護作用及機轉探討:建立治療神經發炎及神經退化的傳統中藥開發平台(1/3)( )
|
2010/08/01 ~ 2013/07/31 |
| 25 |
098 — N 國科會(原科技部) — NSC96-2320-B-037-039-MY3 — 1 個人型
三黃瀉心湯對於小神經膠細胞及神經毒素引起的神經退化之保護作用:抗發炎,抗氧化壓力及抗細胞凋亡(3/3)( )
|
2009/08/01 ~ 2010/07/31 |
| 26 |
097 — N 國科會(原科技部) — NSC96-2320-B-037-039-MY3 — 1 個人型
三黃瀉心湯對於小神經膠細胞及神經毒素引起的神經退化之保護作用:抗發炎,抗氧化壓力及抗細胞凋亡(2/3)( )
|
2008/08/01 ~ 2010/07/31 |
| 27 |
096 — N 國科會(原科技部) — NSC96-2320-B-037-039-MY3 — 1 個人型
三黃瀉心湯對於小神經膠細胞及神經毒素引起的神經退化之保護作用:抗發炎,抗氧化壓力及抗細胞凋亡(1/3)( )
|
2007/08/01 ~ 2010/07/31 |
| 28 |
095 — N 國科會(原科技部) — NSC95-2320-B-037-042- — 1 個人型
三黃瀉心湯抑制內毒素及血栓素A2引起肺高壓之作用及機轉( )
|
2006/08/01 ~ 2007/07/31 |
| 29 |
095 — QA 出國進修返校服務計畫 — — 1 個人型
神經保護劑之新藥研發：台灣垂枝長葉暗羅樹萃取之具有抗發炎作用之雙萜類(Development of Neuroprotective Agents: Antiinflammatory Diterpenes from Formosa Polyathia longifolia var. pendula)
|
2006/12/01 ~ 2007/07/31 |
| 30 |
094 — N 國科會(原科技部) — NSC94-2320-B-037-032- — 1 個人型
腦缺血及發炎之藥理研究：抗發炎及神經血管保護之新藥研發( )
|
2005/08/01 ~ 2006/07/31 |
| 31 |
091 — N 國科會(原科技部) — NSC91-2320-B-037-063 — 1 個人型
KMUPs其血管擴張及抑制血小板凝集作用：經由增加環化糞嘌呤核甘 單磷酸及打開鉀通道( )
|
2002/08/01 ~ 2003/07/31 |
| 32 |
090 — N 國科會(原科技部) — NSC90-2315-B-037-003 — 1 個人型
新系列兼具有拮抗甲型腎上腺性受體及釋放一氧化氮之血管擴張劑之機轉及應用(Mechanisms and applications of a series new type vas-odilators with thier unique alpha-adrenoceptor blockad-e activity combined with nitric oxide releasing)
|
2001/08/01 ~ 2002/07/31 |
| 33 |
089 — N 國科會(原科技部) — NSC 89-2320-B-037-046- — 1 個人型
新系列具有釋放CALCITONIN GENE RELATED PEPTIDE或一氧化氮的血 管擴張劑之作用及應用(Effects and applications of a series new type vasodilators with their unique calcitonin gene related peptide or combined with nitric oxide releasing properties)
|
2000/08/01 ~ 2001/07/31 |
| 34 |
088 — N 國科會(原科技部) — NSC 89-2320-B-037-007- — 1 個人型
新系列具有釋放CALCITONIN GENE RELATED PEPTIDE或一氧化氮的血 管擴張劑之作用及應用(1/3)(Effects and applications of a series new type vasodilators with their unique calcitonin gene related peptide or combin-ed with nitric oxide releasing properties)
|
1999/08/01 ~ 2000/07/31 |
| 35 |
087 — N 國科會(原科技部) — NSC88-2314-B-037-012- — 1 個人型
新的番椒晶素衍生物NITROGLYCERYL NONIVAMIDE:兼具有似硝酸鹽作 用及鉀離子通道打開之血管擴張劑(Nitroglyceryl nonivamide : A new capsicin analogue with its unique vasodilator properties attributable to a combination of nitrate-like and potassium channel activation)
|
1998/08/01 ~ 1999/07/31 |
| 36 |
086 — N 國科會(原科技部) — NSC87-2314-B037-096 —
番椒晶素衍生物對於大白鼠三叉神經節及背根誰神經節之神經元細胞的影響(Effects of capsaicin derivatives on rattrigeminal ganglion and dorsal root ganglion neurons)
|
1997/08/01 ~ 1998/07/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 雷公藤甲素用於製備治療與運動神經元存活蛋白質表現相關之疾病的藥物的用途 | 中華民國 | 2015/04/11 | I480040 |
| 2 | 查耳酮衍生物的用途 | 中華民國 | 2021/01/01 | I714812 |
| 3 | Linalool乳液製劑 | 中華民國 | 2019/10/21 | I674892 |