Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學院 — 醫學研究所(畢) — 博士 Doctorate, Graduate Institute of Medicine, Kaohsiung Medical College |
1990/09 — 1995/06 |
|
高雄醫學院 — 醫學研究所(畢) — 碩士 Master, Graduate Institute of Medicine, Kaohsiung Medical College |
1988/09 — 1990/06 |
|
高雄醫學院 — 藥學系(畢) — 學士 Bachelor, School of Pharmacy, Kaohsiung Medical College |
1983/09 — 1987/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 藥理學科 Department of Pharmacology | Professor | 2007/08/01 — |
| 藥理學研究所 Graduate Institute of Pharmacology | Professor | 2005/08/01 — 2007/07/31 |
| 藥理學 Pharmacology | Associate Professor | 1997/08/01 — 2005/07/31 |
| 藥理學 Pharmacology | Lecturer | 1990/08/01 — 1997/07/31 |
| 藥理學 Pharmacology | Teaching Assistant | 1987/08/01 — 1990/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 藥理及毒理 Pharmacology and Toxicology |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
神經藥理學研究群、心臟血管系統研究群、中樞神經血管性疾病研究群、生命藥學研究群、毒理學研究群
Neuropharmacology, Cardiovascular System, Central Vascular Disease, Life Pharmacy, Toxicology
Area(s) of Expertise & Research
血管電氣生理學、分子藥理學、自主神經藥理學、基礎醫學、心臟電氣生理學、新藥開發研究、中草藥藥理研究
Vascular Electrophysiology, Molecular Pharmacology, Autonomic Pharmacology, Basic Medicine, Cardiac Electrophysiology, New Drug Development, Herbal Pharmacology
Publication
| NO | Publication |
|---|---|
| 1 | Upregulated Small-Conductance Calcium-Activated Potassium Currents Contribute to Atrial Arrhythmogenesis in High-Fat Feeding Mice Upregulated Small-Conductance Calcium-Activated Potassium Currents Contribute to Atrial Arrhythmogenesis in High-Fat Feeding Mice |
| 2 | 茶鹼衍生物KMUP-3透過PI3K/Akt/eNOS增強自噬作用優化心肌細胞保護 Optimizing myocardial cell protection with xanthine derivative KMUP-3 potentiates autophagy through the PI3K/Akt/eNOS axis. |
| 3 | 黃嘌呤衍生物 KMUP-1 抑制低氧誘導 TRPC1 表現及鈣池調控鈣離子流在肺動脈血管平滑肌細胞 The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca Entry in Pulmonary Arterial Smooth Muscle Cells. |
| 4 | Rhopaloic Acid A 透過 JNK/BNIP3/Nix 介導的粒線體自噬觸發口腔癌中線粒體損傷誘導的細胞凋亡 Rhopaloic acid A triggers mitochondria damage-induced apoptosis in oral cancer by JNK/BNIP3/Nix-mediated mitophagy |
| 5 | 老藥新用抗精神病藥物三氟拉嗪透過 ROS/自噬途徑誘導 SLC7A11/GPX4 調控的口腔癌鐵死亡 Repurposing of the Antipsychotic Trifluoperazine Induces SLC7A11/GPX4- Mediated Ferroptosis of Oral Cancer via the ROS/Autophagy Pathway |
| 6 | 第二型鈉葡萄糖轉運蛋白 (SGLT2) 抑制劑改善代謝異常及肥胖綜合症誘導的心肌細胞損傷和粒腺體重塑 Sodium glucose cotransporter 2 (SGLT2) inhibitor ameliorate metabolic disorder and obesity induced cardiomyocyte injury and mitochondrial remodeling |
| 7 | Efficiency comparison of an isoeugenol-derivated compound, eugenosedin-A, with glibenclamide and pioglitazone in protecting cardiovascular dysfunction of diabetic SHR. Efficiency comparison of an isoeugenol-derivated compound, eugenosedin-A, with glibenclamide and pioglitazone in protecting cardiovascular dysfunction of diabetic SHR. |
| 8 | Eugenosedin-A 改善肥胖相關高血糖經由調控 ATP 敏感性鉀通道及胰島素分泌在胰臟乙型細胞 Eugenosedin-A improves obesity-related hyperglycemia by regulating ATP-sensitive K channels and insulin secretion in pancreatic β cells. |
| 9 | 黃芩素在體外和體內預防平滑肌細胞血管鈣化的潛在作用 Potential actions of baicalein for preventing vascular calcification of smooth muscle cells in vitro and in vivo |
| 10 | Clinical Observation of SGLT2 Inhibitor Therapy for Cardiac Arrhythmia and Related Cardiovascular Disease in Diabetic Patients with Controlled Hypertension. Clinical Observation of SGLT2 Inhibitor Therapy for Cardiac Arrhythmia and Related Cardiovascular Disease in Diabetic Patients with Controlled Hypertension. |
| 11 | Unique Pulmonary Hypertension in Young Children: A Case Series Study. Unique Pulmonary Hypertension in Young Children: A Case Series Study. |
| 12 | Long-Term Study on Therapeutic Strategy for Treatment of Eisenmenger Syndrome Patients: A Case Series Study. Long-Term Study on Therapeutic Strategy for Treatment of Eisenmenger Syndrome Patients: A Case Series Study. |
| 13 | 馬錢子環烯醚萜苷調控自噬流作用於慢性神經壓迫損傷誘發神經性疼痛 The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain |
| 14 | 血管緊張素轉換酶2激活劑可減輕左肺切除與VEGF抑制的大鼠模型中的嚴重肺動脈高壓 Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition |
| 15 | KMUP-1恢復周邊神經損傷誘發背根神經節BKCa 通道抑制作用 BKCa channel inhibition by peripheral nerve injury is restored by the xanthine derivative KMUP-1 in dorsal root ganglia |
| 16 | In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis |
| 17 | Empagliflozin 治療代謝症候群小鼠心室電生理基質的特徵 Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin. |
| 18 | Cinaciguat 通過血管舒張和抗重塑預防新生大鼠出生後動脈導管關閉 Cinaciguat Prevents Postnatal Closure of Ductus Arteriosus by Vasodilation and Anti-remodeling in Neonatal Rats |
| 19 | Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial |
| 20 | 低能量體外震波療法作為壓力性尿失禁的新療法：一項隨機對照臨床研究 Low Intensity Extracorporeal Shock Wave Therapy as a Novel Treatment for Stress Urinary Incontinence: A Randomized-Controlled Clinical Study |
| 21 | The effectiveness comparisons of eugenosedin-A, glibenclamide and pioglitazone on diabetes mellitus induced by STZ/NA and high-fat diet in SHR. The effectiveness comparisons of eugenosedin-A, glibenclamide and pioglitazone on diabetes mellitus induced by STZ/NA and high-fat diet in SHR. |
| 22 | Loganin 預防 CXCL12/CXCR4 調控神經性疼痛透過 NLRP3發炎體在神經損傷的大鼠 Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via the NLRP3 inflammasome axis in nerve-injured rats. |
| 23 | Loganin 改善痛性糖尿病神經病變透過調控氧化壓力、發炎及胰島素抗性在Streptozotocin-Nicotinamide誘導之糖尿病鼠 Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats |
| 24 | Loganin 預防慢性神經壓迫損傷引發神經性疼痛透過降低 TNF-α/IL-1β 誘發NF-κB 活化及許旺細胞之去髓鞘化 Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-α/IL-1β-mediated NF-κB activation and Schwann cell demyelination |
| 25 | Trans, Trans-2,4- decadienal 對於心肌細胞離子電流之影響 Effects of Trans, Trans-2,4- decadienal on the Ions Currents of Cardiomyocytes: Possible Mechanisms of Arrhythmogenesis Induced by Cooking-oil Fumes |
| 26 | Vasculoprotective effects of Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats Vasculoprotective effects of Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats |
| 27 | Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation. Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation. |
| 28 | 脂肪組織分泌體對於心肌細胞離子通道的調控 Effects of Secretome from Fat Tissues on Ion Currents of Cardiomyocyte Modulated by Sodium-Glucose Transporter 2 Inhibitor |
| 29 | 黃腐醇防止維生素D3和尼古丁誘導之血管鈣化 The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D Plus Nicotine. |
| 30 | The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction. The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction. |
| 31 | KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO-cGMP-MAPK Signaling Pathways KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO-cGMP-MAPK Signaling Pathways |
| 32 | Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages Decreased Ambient Oxygen Tension Alters the Expression of Endothelin-1, iNOS and cGMP in Rat Alveolar Macrophages |
| 33 | 極低密度脂蛋白調節鈣離子感測蛋白STIM1抑制SOCE造成心房心肌肌蛋白失序 Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes |
| 34 | 黃嘌呤衍生KMUP-1反轉高糖毒性活化之Kv通道經由cAMP/PKA訊息路徑於大鼠胰島乙型細胞 Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells |
| 35 | Eugenosedin-A改善葡萄糖代謝及抑制MAPK表現在streptozotocin/nicotinamide誘導的糖尿病鼠 Eugenosedin-A improves glucose metabolism and inhibits MAPKs expression in streptozotocin/nicotinamide-induced diabetic rats. |
| 36 | KMUP-1保護streptozotocin引起腸系膜動脈功能障礙藉由活化ATP敏感性之鉀離子通道 KMUP-1 protects against streptozotocin-induced mesenteric artery dysfunction via activation of ATP-sensitive potassium channels |
| 37 | Exogenous heat shock Cognate protein 70 suppresses LPS-induced inflammation by down-regulating NF-κB through MAPK and MMP-2/-9 pathways in macrophages Exogenous heat shock Cognate protein 70 suppresses LPS-induced inflammation by down-regulating NF-κB through MAPK and MMP-2/-9 pathways in macrophages |
| 38 | B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats |
| 39 | GPCR 調控物質KMUP-1減少三酸甘油脂蓄積包含MAPKs/Akt/PPARγ及PKA/PKG/HSL訊息在3T3-L1前脂肪細胞 KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes |
| 40 | Valproate 減少神經性發炎及神經死亡在大鼠慢性神經壓迫損傷模式 Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model |
| 41 | Statins Ameliorate Pulmonary Hypertension Secondary to Left Ventricular Dysfunction Through the Rho-Kinase Pathway and NADPH Oxidase Statins Ameliorate Pulmonary Hypertension Secondary to Left Ventricular Dysfunction Through the Rho-Kinase Pathway and NADPH Oxidase |
| 42 | 代謝症候群之極低密度脂蛋白調節間隙連接與延緩心臟內電傳導 Very-low-density lipoprotein of metabolic syndrome modulates gap junctions and slows cardiac conduction |
| 43 | Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model |
| 44 | Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model. Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model. |
| 45 | Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization |
| 46 | 黃嘌呤衍生物可藉由活化內皮細胞一氧化氮合酶以減少內皮前驅細胞在缺氧情況下所誘導的細胞凋亡現象 Activation of endothelial NO synthase by a xanthine derivative ameliorates hypoxia-induced apoptosis in endothelial progenitor cells. |
| 47 | Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway |
| 48 | 茶鹼衍生物KMUP-1改善肥胖型小鼠脂肪性肝炎透過 MMP-9/IL-10 及促進脂肪溶解經由 HSL/p-HSL Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice |
| 49 | 代謝症候群中的非常低密度脂蛋白造成心房脂質沉積與心房顫動 的發生有關 VLDL from metabolic syndrome individuals enhanced lipid accumulation in atria with association of susceptibility to atrial fibrillation |
| 50 | NO活化劑 KMUP-1恢復UTP抑制延遲性整流鉀電流包含RhoA/Rho kinase訊息在肺動脈平滑肌細胞 Restoration of uridine 5-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cells |
| 51 | Xanthine 衍生物 KMUP-1 減弱 Serotonin 引起肺動脈血管狹窄及鉀離子通道抑制活性透過 PKC 路徑 The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K+-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries |
| 52 | 糙米預防高脂飼料誘導高血糖經由升高胰島素分泌及葡萄糖代謝路徑在C57BL/6J小鼠 Pre-germinated brown rice prevents high-fat diet induced hyperglycemia through elevated insulin secretion and glucose metabolism pathway in C57BL/6J strain mice |
| 53 | L-ascorbic acid 結合KMUP-1 或 sildenafil 降低血管內皮生長因子及恢復一氧化氮酶在缺氧肺動脈 Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery |
| 54 | Atorvastatin 阻止慢性神經性損傷引起之發炎透過 NFκB 向下調節在大鼠背根神經節及脊髓 Atorvastatin Prevents Neuroinflammation in Chronic Constriction Injury Rats through Nuclear NFκB Downregulation in the Dorsal Root Ganglion and Spinal Cord |
| 55 | 黃嘌呤衍生物KMUP-1 改善 HDL via PPARγ/SR-B1, LDL via LDLRs 及HSL via PKA/PKG 造成肝臟脂肪流失 Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss |
| 56 | Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumor cells. Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumor cells. |
| 57 | Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia |
| 58 | Eugenosedin-A 改善高脂血症誘發血管內皮功能障礙透過抑制 α1-adrenoceptor/5-HT 活性及 NADPH 氧化酶表現 Eugenosedin-A ameliorates hyperlipidemia-induced vascular endothelial dysfunction via inhibition of α1-adrenoceptor/5-HT activity and NADPH oxidase expression |
| 59 | Xanthine衍生之鉀離子通道開啟者保護血清素引起心肌肥大透過調控蛋白激酶 A Xanthine-Derivative K+-Channel Opener Protects against Serotonin-Induced Cardiomyocyte Hypertrophy via the Modulation of Protein Kinases |
| 60 | Xanthine Derivative KMUP-1 Reduces Inflammation and Hyperalgesia in a Bilateral Chronic Constriction Injury Model by Suppressing MAPK and NFκB Activation. Xanthine Derivative KMUP-1 Reduces Inflammation and Hyperalgesia in a Bilateral Chronic Constriction Injury Model by Suppressing MAPK and NFκB Activation. |
| 61 | Alteration of Basilar Artery Rho-Kinase and Soluble Guanylyl Cyclase Protein Expression in a Rat Model of Cerebral Vasospasm following Subarachnoid Hemorrhage Alteration of Basilar Artery Rho-Kinase and Soluble Guanylyl Cyclase Protein Expression in a Rat Model of Cerebral Vasospasm following Subarachnoid Hemorrhage |
| 62 | B型利鈉鉎肽於肺血管平滑肌細胞之抗增生與抗遷徙作用 B-type Natriuretic Peptide Inhibits Angiotensin Ⅱ-induced Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells |
| 63 | Dual ELE/NEP抑制可改善主動脈縮窄狀況造成心室失常之舒張功能失常及心室再模化 Dual ELE/NEP inhibition improved diastolic function and ameliorated cardiac remodeling in rats with myocardial dysfunction secondary to pressure overload by aortic banding |
| 64 | KMUP-1 PROTECTS KIDNEY FROM STREPTOZOTOCIN-INDUCED PROINFLAMMATION IN EARLY DIABETIC NEPHROPATHY BY RESTORING eNOS/PPAR gamma AND INHIBITING MMP-9 KMUP-1 PROTECTS KIDNEY FROM STREPTOZOTOCIN-INDUCED PROINFLAMMATION IN EARLY DIABETIC NEPHROPATHY BY RESTORING eNOS/PPAR gamma AND INHIBITING MMP-9 |
| 65 | 內皮一氧化氮合成酶促進G蛋白結合受體拮抗劑抑制肺動脈高血壓在野百荷鹼模式是藉由ET-1相關及ET-1不相關的路進 Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model. |
| 66 | Eugenosedin-A 預防高脂飲食增加細胞粘附分子經由抑制 MAPK及p65之NF-κB路徑在大鼠動物模式 Eugenosedin-A prevents high-fat diet increased adhesion molecules through inhibition of MAPK- and p65-mediated NF-κB pathway in rat model |
| 67 | No donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling. No donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling. |
| 68 | 中央與周邊脂肪組織對於心肌細胞延遲整流性鉀離子電流之不同影響 Differential effects of central and peripheral fat tissues on the delayed rectifier k outward currents in cardiac myocytes |
| 69 | Atorvastatin之神經保護及抗發炎作用在大鼠慢性神經損傷動物模式 Neuroprotective and anti-inflammatory activities of atorvastatin in a rat chronic constriction injury model |
| 70 | 鉀離子通道活化劑KMUP-1 and Pinacidil 防止蜘蛛膜下腔出血引起之血管攣縮經由恢復 BKCa通道活性 Potassium-Channel Openers KMUP-1 and Pinacidil Prevent Subarachnoid Hemorrhage-Induced Vasospasm by Restoring the BKCa-Channel Activity |
| 71 | 蛋白激酶調節肺動脈平滑肌細胞之鈣池調控鈣離子通道 Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells |
| 72 | Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil |
| 73 | Eugenosedin-A抑制高血脂小鼠之發炎反應及降低內皮一氧化氮酶 Suppression of inflammatory response and endothelial nitric oxide synthase downregulation in hyperlipidaemic C57BL/6J mice by eugenosedin-A |
| 74 | KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance |
| 75 | Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kB and AP-1 through inhibition of MAPKs and Akt/IkBa signaling pathways in macrophages Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kB and AP-1 through inhibition of MAPKs and Akt/IkBa signaling pathways in macrophages |
| 76 | Baicalein分離來自黃芩，具有保護內皮素誘導肺動脈血管平滑肌細胞增生經由抑制TRPC1通道表現 Baicalein, isolated from Scutellaria baicalensis, protects against endothelin-1-induced pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression. |
| 77 | KMUP-1 抑制大鼠基底動脈細胞 L-型鈣離子通道關連蛋白激酶C KMUP-1 inhibits L-type Ca2+ channels involved the protein kinase C in rat basilar artery myocytes |
| 78 | KMUP-1抑制H441 肺上皮細胞生長轉移透過增加NO/cGMP 及抑制Rho kinase/VEGF 路徑 KMUP-1 INHIBITS H441 LUNG EPITHELIAL CELL GROWTH, MIGRATION AND PROINFLAMMATION VIA INCREASED NO/CGMP AND INHIBITED RHO KINASE/VEGF SIGNALING PATHWAYS |
| 79 | KMUP-1經由NO/cGMP/PKG和ERK1/2/calcineurin A路徑減低isoprenaline誘導大鼠的心肌肥厚 KMUP-1 attenuates isoproterenol-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways |
| 80 | KMUP-1改善 monocrotaline 引起肺動脈高壓經由調控鈣離子敏感性及鉀離子通道 KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca(2+) sensitization and K(+)-channel. |
| 81 | 茶鹼衍生物KMUP-1經由NO/cGMP依賴性抑制RhoA/Rho kinase 表現治療肺高壓 The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase |
| 82 | 黃芩之成分Baicalin活化大傳導性鈣離子活化鉀離子通道由 cyclic nucleotide依賴型蛋白激酶 Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca(2+)-activated K(+) channels via cyclic nucleotide-dependent protein kinases in mesenteric artery |
| 83 | Isoeugenol-based chlorophenylpiperazine 衍生物對於 serotonergic/adrenergic 受體, 血小板凝集及脂質過氧化之結構活性關連性 Structure-activity relationships of isoeugenol-based chlorophenylpiperazine derivatives on serotonergic/adrenergic receptor, platelet aggregation, and lipid peroxidation |
| 84 | KMUP-1 經由 serotonin 受體/transporter 與 NO synthase 及 抑制 RhoA 與 AKT/ERK 磷酸化降低肺動脈增生 KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation |
| 85 | Protective effects if a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat Protective effects if a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat |
| 86 | Protective effects of a dual endothelin converting enzyme/neutral endothpeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat Protective effects of a dual endothelin converting enzyme/neutral endothpeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat |
| 87 | Eugenosedin-A預防小鼠餵食高脂飼料造成之高血醣,高脂血症及脂質過氧化 Eugenosedin-A prevents hyperglycaemia, hyperlipidaemia and lipid peroxidation in C57BL/6J mice fed a high-fat diet |
| 88 | 具Piperazine骨架之甲型腎上腺激素阻斷劑KMUP-1及Dodxazosin經由調控雄性素接受器及攝護腺特異性抗原表現抑制LNCaP細胞與免疫缺乏老鼠之癌細胞生長 Piperazine-designed alpha1A/alpha1D-adrenoceptor blocker KMUP-1 and doxazosin provide down-regulation of androgen receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts |
| 89 | labedipinedilol-A抑制大鼠腦血管平滑肌細胞電位相關性 L型鈣離子通道牽涉蛋白激𡓨C Inhibition of voltage-gated L-type calcium channels by labedipinedilol-A involves protein kinase C in rat cerebrovascular smooth muscle cells |
| 90 | 以活體大鼠與離體人類血小板為實驗模式證明eugenosedin-B具交感神經與血清素接受體抑制作用 Hypotensive and Antiaggregative Effects of Eugenosedin-B With Serotonin and a/b-Adrenoceptor Antagonistic Activities in Rats and Human Platelets |
| 91 | Isoeugenodilol抑制血管平滑肌細胞增生和氣球擴張術新生內層經由ERK1/2去活化作用 Isoeugenodilol inhibits smooth muscle cell proliferation and neointimal thickening after balloon injury via inactivation of ERK1/2 pathway |
| 92 | 蘭嶼肉桂中Isoobtusilactone A的抗癌活性：包含凋亡、細胞週期失調、粒腺體調控和活性氧化物之特性 Anticancer Activity of Isoobtusilactone A from Cinnamomum kotoense: Involvement of Apoptosis, Cell-Cycle Dysregulation, Mitochondria Regulation, and Reactive Oxygen Species |
| 93 | 腦血管平滑肌細胞給予低滲透壓處理抑制內流整流性鉀離子通道 Hyposmotic challenge inhibits inward rectifying K+ channels in cerebral arterial smooth muscle cells |
| 94 | Eugenosedin-A改善內毒素引起p38 MAPK, 誘導型一氧化氮及環氧酶之向上調節 Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2 |
| 95 | Eugenose-A活化BKCa 通道藉由cAMP及cGMP相依性之蛋白激酶在大鼠基底動脈細胞 Activation of BKCa channels via cyclic AMP- and cyclic GMP-dependent protein kinases by eugenosedin-A in rat basilar artery myocytes |
| 96 | KMUP-1促進攝護腺鬆弛及抗上皮細胞增生經由加強cGMP表現以及甲型-1A/1D腎上腺受體拮抗作用抑制Rho Kinase cGMP-enhancing- and ��1A/��1D-adrenoceptor blockade-derived inhibition of Rho-kinase by KMUP-1 provides optimal prostate relaxation and epithelial cell anti-proliferation efficacy |
| 97 | 黃嘌呤結構的上皮相依呼吸道鬆弛劑KMUP-3能促進呼吸系統的表現和保護對抗TNF-a 誘發的氣管收縮是透過一氧化氮釋放和cGMP與蛋白激酶G的表現 A xanthine-based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving nitric oxide release and expression of cGMP and protein kinase G. |
| 98 | 黃嘌呤衍生物KMUP-1及KMUP-3抑制大鼠氣管前,發炎物質TNF-a引發誘導型一氧化氮酶,關連於溶解型鳥糞嘌呤環化酶及G蛋白激酶 Inhibition of Proinflammatory Tumor Necrosis Factor--Induced Inducible Nitric-Oxide Synthase by Xanthine-Based 7-[2-[4- (2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in Rat Trachea: The Involvement of Soluble Guanylate Cyclase and Protein Kinase G |
| 99 | MCPT引起之內皮相關及不相關之血管鬆弛作用: 經由cyclic nucleotides, 鉀通道打開, 磷酸二酯酶抑制作用 Endothelium-dependent and -independent vasorelaxation by atheophylline derivative MCPT: Roles of cyclic nucleotidespotassium channel opening and phosphodiesterase inhibition, |
| 100 | 動脈平滑肌鬆弛劑KMUP-3 和 KMUP-4 皆為茶鹼 nitrophenylpiperazine 衍生物,顯示具有增加cGMP活性之作用 Aortic smooth muscle relaxants KMUP-3 and KMUP-4, two nitrophenylpiperazine derivatives of xanthine, display cGMP-enhancing activity: roles of endothelium, phosphodiesterase, and K+ channel. |
| 101 | 抗氧化劑 eugenosedin-A,保護內毒素對大鼠與小鼠所引起低血壓,高血糖與細胞激素免疫作用之機轉 Antioxidant eugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice |
| 102 | KMUP-1活化基底動脈細胞大傳導性鈣離子相依性鉀通道藉由環化核苷酸相關性蛋白激酶 KMUP-1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide-dependent protein kinases |
| 103 | KMUP-1引起天竺鼠氣管鬆弛，其中內皮角色，環化腺苷及鉀離子通道 KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K channels |
| 104 | Eugenosedin-A具有血清素，甲型及乙型拮抗活性之降血壓作用，比較自發性高血壓鼠及正常鼠 Hypotensive Effects of Eugenosedin-A with Serotonin, Alpha- and Beta-Adrenoceptor Antagonistic Activities in Spontaneously Hypertensive and Normotensive Rats |
| 105 | Pyrimidine nucleotides 抑制鉀電流及去極化大鼠腦血管經由活化 Rho 激酶 Pyrimidine nucleotides suppress KDR currents and depolarize rat cerebral arteries by activating Rho kinase |
| 106 | Urgosedin抑制內毒素引起的低血壓, 低血糖及發炎相關介質 Urgosedin inhibits hypotension, hypoglycemia and pro-inflammatory mediators induced by lipopolysaccharide |
| 107 | KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K+ channels. KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K+ channels. |
| 108 | 黃漂呤衍生物,kmup-2,在兔子的胸主動脈及陰莖海綿體能增加cGMP及鉀離子通道活性,並具有勃起功能 Xanthine-analog, KMUP-2, enhances cyclic GMP and K+ channel activities in rabbit aorta and corpus cavernosum with associated penile erection |
| 109 | 黃漂呤衍生物kmup-2,在兔子的胸主動脈及陰莖海綿體能增加cGMP及鉀離子通道活性, 並具有勃起功能 Xanthine-analog, KMUP-2, enhances cyclic GMP and K+ channel activities in rabbit aorta and corpus cavernosum with associated penile erection |
| 110 | Xanthine衍生KMCP-98活化腺甘酸受體亞型(英) A unique xanthine derivative KMCP-98 with activation of adenosine receptor subtypes |
| 111 | 一個奇特黃嘌呤衍生物KMCP-98具有活化腺甘亞型接受體特性 A Unique Xanthine Derivative KMCP-98 With Activation of Adenosine Receptor |
| 112 | 由茶鹼衍生在大鼠胸主動脈具鉀離子通道開啟,磷酸二酯酶抑制、環化鳥糞嘌呤單磷酸增加之作用 A xanthine-based KMUP-1 with cyclic GMP enhancing and K+ channels opening activities in rat aortic smooth muscle |
| 113 | Xanthine衍生KMUP-1促大白鼠主動脈平滑肌表現cGMP和開鉀通道(英) A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle. |
| 114 | 台灣眼鏡蛇 long neurotoxin 構造與功能之研究 Structure-function studies on Taiwan cobra long neurotoxin homolog |
| 115 | 血管擴張性乙型阻斷劑脂溶性對於乙型受體之功能與結合活性影響 Lipid solubility of vasodilatory vanilloid type beta-blockers on the functional and binding activities of beta-adrenoceptor subtypes |
| 116 | 在分節型尋常性白斑患者之病灶發現局部有皮表血流量增加及交感神經接受器反應提高現象 Cutaneous blood flood flow and adrenoceptor response increase in segmental-type vitiligo lesions |
| 117 | Lipid solubility of vasodilatory vanilloid-type beta-blockers on the functional and binding activities of beta-adrenoceptor subtypes Lipid solubility of vasodilatory vanilloid-type beta-blockers on the functional and binding activities of beta-adrenoceptor subtypes |
| 118 | 台灣眼鏡蛇毒類神經毒素結構與功能之研究 Structure-function studies on Taiwan cobra long neurotoxin homolog |
| 119 | Ferulidilol:兼具有乙二型腎上腺激性致效劑作用之血管鬆弛及抗氧化作用之腎上腺激性及鈣離子通道阻斷劑 Ferulidilol: A vasodilatory and antioxidant adrenoceptor and calcium entry blocker, with ancillary b2-agonist activity |
| 120 | 臺灣眼鏡蛇Corba Toxin之表現及突變之探討 Expression and mutagenesis studies of cobrotoxin from Taiwan cobra |
| 121 | 硝基化蕃椒晶素重新考量氫質子酸於蕃椒晶素誘發之感覺神經活性之角色 Nitrated nonivamide displaying a drawback of proton’s role in capsaicin associated sensory and neuronal activities |
| 122 | Isoeugenolol一個具有氣管及血管平滑肌鬆弛特性的乙一型腎上腺素拮抗劑 Isoeugenolol：A selective beta1-adrenergic antagonist with tracheal and vascular smooth muscle relaxant properties |
| 123 | Eugenodilol: 第三代丁香油酚衍生之兼具有甲型腎上腺激性阻斷及乙二型腎上腺激性致效劑相關血管鬆弛作用之腎上腺激性乙型阻斷劑 Eugenodilol：A third generation b-adrenoceptor blocker, derived from eugenol, with b-blocking and b2-agonist associated vasorelaxant activities. |
| 124 | A highly selective b1-adrenergic blocker with partial b2 agonist activity derived from ferulic acid, an active component of Ligusticum wallichii FRANCH |
| 125 | A novel neurotoxin, cobrotoxin B, from Naja Naja Atra (Taiwan cobra) venom: purification, characterization and gene organization 待補 |
| 126 | Eugenolol: an eugenol-derived β-adrenoceptor blocker with partial β2-agonist and calcium mobilization inhibition associated vasorelaxant activities 待補 |
| 127 | Capsazocaine : a capsaicin-sensitivity functional antagonist displays an argument on sensory capsaicin receptor 待補 |
| 128 | Vanidilol : a vanilloid type vasorlaxant and ocular hypotensive β-adrenoceptor blocker with partial β2 agonist activity |
| 129 | Comparative study on the pharmacokinetic bioequivalence of two intravascular ceftriazone preparations |
| 130 | Vanidilol: a vanilloid type vasorlaxant and ocular hypotensive β-adrenoceptor block with partial β2 agonist activity Vanidilol: a vanilloid type vasorlaxant and ocular hypotensive β-adrenceptor block with partial β2 agonist activity |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
114 — N 國科會(原科技部) — NSTC112-2320-B-037-020-MY3 — 1 個人型
梔子苷及其環烯醚萜同類物調控P2嘌呤受體改善第二型糖尿病小鼠誘發神經性疼痛之分子及離子機制研究(3/3)( )
|
2025/08/01 ~ 2026/07/31 |
| 2 |
113 — N 國科會(原科技部) — NSTC112-2320-B-037-020-MY3 — 1 個人型
梔子苷及其環烯醚萜同類物調控P2嘌呤受體改善第二型糖尿病小鼠誘發神經性疼痛之分子及離子機制研究(2/3)( )
|
2024/08/01 ~ 2026/07/31 |
| 3 |
113 — Z 大專學生研究計畫及博士後 — NSTC113-2811-B-037-010 — 9 博士後研究員
博士級研究人員--王亮鈞( )
|
2024/08/01 ~ 2025/07/31 |
| 4 |
112 — KP 高醫屏科大 — NPUST-KMU-112-P003 —
探討銀耳（Tremella fuciformis）預防代謝症候群之功效與藥理機制( )
|
2023/01/01 ~ 2023/12/31 |
| 5 |
112 — N 國科會(原科技部) — NSTC112-2320-B-037-020-MY3 — 1 個人型
梔子苷及其環烯醚萜同類物調控P2嘌呤受體改善第二型糖尿病小鼠誘發神經性疼痛之分子及離子機制研究(1/3)( )
|
2023/08/01 ~ 2026/07/31 |
| 6 |
112 — Z 大專學生研究計畫及博士後 — NSTC112-2811-B-037-007 — 9 博士後研究員
博士級研究人員--王亮鈞( )
|
2023/08/01 ~ 2024/07/31 |
| 7 |
111 — N 國科會(原科技部) — MOST109-2320-B-037-023-MY3 — 1 個人型
山茱萸環烯醚萜苷改善糖尿病鼠痛性神經病變之分子機制及離子通道研究(3/3)( )
|
2022/08/01 ~ 2023/08/31 |
| 8 |
111 — Z 大專學生研究計畫及博士後 — NSTC111-2811-B-037-023 — 9 博士後研究員
博士級研究人員--王亮鈞( )
|
2022/09/01 ~ 2023/07/31 |
| 9 |
110 — N 國科會(原科技部) — MOST109-2320-B-037-023-MY3 — 1 個人型
山茱萸環烯醚萜苷改善糖尿病鼠痛性神經病變之分子機制及離子通道研究(2/3)( )
|
2021/08/01 ~ 2023/08/31 |
| 10 |
110 — Z 大專學生研究計畫及博士後 — MOST110-2811-B-037-506 — 9 博士後研究員
博士後研究員--鄭玉琪( )
|
2021/08/01 ~ 2022/07/31 |
| 11 |
110 — Z 大專學生研究計畫及博士後 — MOST111-2811-B-037-006 — 9 博士後研究員
博士後研究員--周亮吟( )
|
2022/05/01 ~ 2022/07/31 |
| 12 |
109 — N 國科會(原科技部) — MOST109-2320-B-037-023-MY3 — 1 個人型
山茱萸環烯醚萜苷改善糖尿病鼠痛性神經病變之分子機制及離子通道研究(1/3)( )
|
2020/08/01 ~ 2023/08/31 |
| 13 |
109 — Z 大專學生研究計畫及博士後 — MOST109-2811-B-037-514 — 9 博士後研究員
博士後研究員--鄭玉琪( )
|
2020/08/01 ~ 2021/07/31 |
| 14 |
108 — N 國科會(原科技部) — MOST106-2320-B-037-009-MY3 — 1 個人型
馬錢子苷及其同類物改善慢性神經壓迫損傷誘發神經性疼痛之分子機制及離子通道研究(3/3)( )
|
2019/08/01 ~ 2020/10/31 |
| 15 |
108 — Z 大專學生研究計畫及博士後 — MOST108-2811-B-037-509 — 9 博士後研究員
博士後研究員-鄭玉琪( )
|
2019/08/01 ~ 2020/07/31 |
| 16 |
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-024-B — 8 大專學生研究計畫
109年度大專學生研究計畫-廖婉岑(醫學3)( )
|
2020/07/01 ~ 2021/02/28 |
| 17 |
107 — N 國科會(原科技部) — MOST106-2320-B-037-009-MY3 — 1 個人型
馬錢子苷及其同類物改善慢性神經壓迫損傷誘發神經性疼痛之分子機制及離子通道研究(2/3)( )
|
2018/08/01 ~ 2020/10/31 |
| 18 |
107 — Z 大專學生研究計畫及博士後 — MOST107-2811-B-037-503 — 9 博士後研究員
博士後研究員--朱立雯( )
|
2018/08/01 ~ 2019/07/31 |
| 19 |
107 — Z 大專學生研究計畫及博士後 — MOST107-2811-B-037-515 — 9 博士後研究員
博士後研究員--鄭玉琪( )
|
2018/08/01 ~ 2019/07/31 |
| 20 |
107 — Z 大專學生研究計畫及博士後 — MOST108-2813-C-037-053-B — 8 大專學生研究計畫
108年度大專學生研究計畫-吳林學(公衛3)( )
|
2019/07/01 ~ 2020/02/29 |
| 21 |
106 — N 國科會(原科技部) — MOST106-2320-B-037-009-MY3 — 1 個人型
馬錢子苷及其同類物改善慢性神經壓迫損傷誘發神經性疼痛之分子機制及離子通道研究(1/3)( )
|
2017/08/01 ~ 2020/10/31 |
| 22 |
106 — Z 大專學生研究計畫及博士後 — MOST106-2811-B-037-014 — 9 博士後研究員
博士後研究員--朱立雯( )
|
2017/08/01 ~ 2018/07/31 |
| 23 |
105 — M 高醫(種子計畫) — KMU-M106002 —
KMUP-1類似動物保護糖尿病大鼠與db/db小鼠分子機轉研究( )
|
2017/01/01 ~ 2017/12/31 |
| 24 |
105 — TP 頂尖計畫(高醫) — KMU-TP105D03 —
子計畫三、核苷酸活化劑保護HFD/STZ誘導之血管功能障礙及胰島乙型細胞損傷( )
|
2016/11/01 ~ 2017/10/31 |
| 25 |
105 — TP 頂尖計畫(高醫) — KMU-TP105D15 —
平台二、建構脂質誘發神經退化性疾病相關研究以及評估L5毒性成分清除裝置之實驗動物平台( )
|
2016/11/01 ~ 2017/10/31 |
| 26 |
104 — NK 高醫-中山合作計畫 — NSYSUKMU104-P008 — 1 個人型
探討茶鹼衍生物對於慢性神經損傷誘發背根神經元BKCa 電流之影響( )
|
2015/01/01 ~ 2015/12/31 |
| 27 |
103 — N 國科會(原科技部) — NSC101-2320-B-037-032-MY3 — 1 個人型
NOS調節保護慢性神經損傷誘發神經性疼痛及發炎之分子及細胞機制研究(3/3)( )
|
2014/08/01 ~ 2015/07/31 |
| 28 |
102 — N 國科會(原科技部) — NSC101-2320-B-037-032-MY3 — 1 個人型
NOS調節保護慢性神經損傷誘發神經性疼痛及發炎之分子及細胞機制研究(2/3)( )
|
2013/08/01 ~ 2015/07/31 |
| 29 |
102 — NK 高醫-中山合作計畫 — NSYSUKMU102-P005 — 1 個人型
具有生物活性之wogonin預防缺氧性肺動脈鉀通道失能(Prevention of (K+)-channelopathy by bioactive wogonin in hypoxic pulmonary artery)
|
2013/01/01 ~ 2013/12/31 |
| 30 |
101 — N 國科會(原科技部) — NSC101-2320-B-037-032-MY3 — 1 個人型
NOS調節保護慢性神經損傷誘發神經性疼痛及發炎之分子及細胞機制研究(1/3)( )
|
2012/08/01 ~ 2015/07/31 |
| 31 |
101 — NK 高醫-中山合作計畫 — NSYSUKMU101-026 — 1 個人型
以坐骨神經損傷後的動物模式探討valproic acid抑制神經性疼痛之效果(Studies on the effect of valproic acid for attenuation of neuropathic pain in an animal model of sciatic nerve injury)
|
2012/01/01 ~ 2012/12/31 |
| 32 |
100 — N 國科會(原科技部) — NSC98-2320-B-037-017-MY3 — 1 個人型
天然黃芩類黃酮對抗低氧誘發肺血管功能及離子通道異常研究(3/3)( )
|
2011/08/01 ~ 2012/07/31 |
| 33 |
099 — N 國科會(原科技部) — NSC97-2320-B-037-006-MY3 — 1 個人型
新型Rho kinase抑制劑對抗野百合鹼、血清素及缺氧誘導肺高壓之分子機制研究(3/3)( )
|
2010/08/01 ~ 2011/07/31 |
| 34 |
099 — N 國科會(原科技部) — NSC98-2320-B-037-017-MY3 — 1 個人型
天然黃芩類黃酮對抗低氧誘發肺血管功能及離子通道異常研究(2/3)( )
|
2010/08/01 ~ 2012/07/31 |
| 35 |
098 — N 國科會(原科技部) — NSC97-2320-B-037-006-MY3 — 1 個人型
新型Rho kinase抑制劑對抗野百合鹼、血清素及缺氧誘導肺高壓之分子機制研究(2/3)( )
|
2009/08/01 ~ 2011/07/31 |
| 36 |
098 — N 國科會(原科技部) — NSC98-2320-B-037-017-MY3 — 1 個人型
天然黃芩類黃酮對抗低氧誘發肺血管功能及離子通道異常研究(1/3)( )
|
2009/08/01 ~ 2012/07/31 |
| 37 |
097 — N 國科會(原科技部) — NSC97-2320-B-037-006-MY3 — 1 個人型
新型Rho kinase抑制劑對抗野百合鹼、血清素及缺氧誘導肺高壓之分子機制研究(1/3)( )
|
2008/08/01 ~ 2011/07/31 |
| 38 |
096 — N 國科會(原科技部) — NSC95-2320-B-037-038-MY2 — 1 個人型
黃芩及其成分對於內毒素誘發大鼠休克在動脈平滑肌細胞離子通道研究(2/2)( )
|
2007/08/01 ~ 2008/07/31 |
| 39 |
095 — N 國科會(原科技部) — NSC95-2320-B-037-038-MY2 — 1 個人型
黃芩及其成分對於內毒素誘發大鼠休克在動脈平滑肌細胞離子通道研究(1/2)( )
|
2006/08/01 ~ 2008/07/31 |
| 40 |
094 — M 高醫(種子計畫) — — 1 個人型
KUMPS於蜘蛛膜下出血模式引發腦血管痙攣之電生理研究( )
|
2005/10/01 ~ 2006/07/31 |
| 41 |
093 — N 國科會(原科技部) — NSC93-2320-B-037-035- — 1 個人型
KMUPs對於中樞基底動脈平滑肌細胞鈣離子相依性鉀電流之機轉研究( )
|
2004/08/01 ~ 2005/07/31 |
| 42 |
093 — Z 大專學生研究計畫及博士後 — NSC94-2815-C-037-016-B — 8 大專學生研究計畫
( )
|
2005/07/01 ~ 2006/02/28 |
| 43 |
092 — N 國科會(原科技部) — NSC92-2320-B-037-025- — 1 個人型
KMUPs在大鼠腦動脈平滑肌細胞相關蛋白激脢表現及鉀離子電流之研究( )
|
2003/08/01 ~ 2004/07/31 |
| 44 |
091 — N 國科會(原科技部) — NSC91-2320-B-037-060 — 1 個人型
KMUP-1對於溶解型鳥糞嘌呤環化脢及鉀離子通道開啟之藥理及電生理研究( )
|
2002/08/01 ~ 2003/07/31 |
| 45 |
090 — N 國科會(原科技部) — NSC90-2315-B-037-002 — 1 個人型
Xanthine衍生具cGMP增加、鉀離子通道開啟及磷酸二酯抑制作用之藥理研究(Pharmacological investigation of xanthine derivatives with cGMP enhancing,potassium channels opening and phosphodiesterase inhibition activities)
|
2001/08/01 ~ 2002/07/31 |
| 46 |
089 — N 國科會(原科技部) — NSC 89-2320-B-037-081- — 1 個人型
XANTHINE衍生腺甘酸致效及拮抗劑之藥理研究(Pharmacological study of adenosine agonists and antagonists derived from xanthine nucleus)
|
2000/08/01 ~ 2001/07/31 |
| 47 |
088 — N 國科會(原科技部) — NSC 89-2320-B-037-008- — 1 個人型
Xanthine核衍生腺甘酸致效及拮抗劑之藥理研究(1/3)(Pharmacological study of adenosine agonists and antagonists derived from xanthine nucleus)
|
1999/08/01 ~ 2000/07/31 |
| 48 |
087 — N 國科會(原科技部) — NSC88-2314-B-037-011- — 1 個人型
探討VANILLOID衍生物之乙三型致效劑及拮抗劑藥理活性(Pharmacological study of vanilloid-based beta 3 agonists and antagonists)
|
1998/08/01 ~ 1999/07/31 |
| 49 |
086 — N 國科會(原科技部) — NSC87-2314-B037-097 —
VANILLOID型乙型阻斷劑:對於乙三型拮抗劑及乙三型作用劑之活性研究(An approach to vaniloid-based 3 adrenergic antagonists andpartial agonists)
|
1997/08/01 ~ 1998/07/31 |
| 50 |
085 — N 國科會(原科技部) — NSC86-2745-B037-003 —
由川芎活性成分阿魏酸衍生生乙型腎上腺激性阻斷之藥理研究(A new β-adrenergic blocking agent derived from ferulic acid, an active ingredient of ligusticum wallichii FRANCH)
|
1996/08/01 ~ 1997/07/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 茶鹼類衍生物用於腦損傷誘導之神經性疾患 | 中華民國 | 2016/12/11 | I561524 |