Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學院 — 藥學研究所(畢) — 博士 Doctorate, , |
— 1992/06 |
|
高雄醫學院 — 藥學研究所(畢) — 碩士 Master, , |
— 1988/06 |
|
高雄醫學院 — 藥學系(畢) — 學士 Bachelor, , |
— 1983/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 藥學院 College of Pharmacy | Dean | 2024/02/01 — 2027/01/31 |
| 藥學系 School of Pharmacy | Professor | 2016/02/01 — |
| 香粧品學系 Department of Fragrance and Cosmetic Science | Professor | 2013/08/01 — 2016/01/31 |
| 藥學系 School of Pharmacy | Professor | 2001/08/01 — 2013/07/31 |
| 藥學系 School of Pharmacy | Associate Professor | 1992/08/01 — 2001/07/31 |
| 藥學系 School of Pharmacy | Lecturer | 1988/08/01 — 1992/07/31 |
| 藥學系 School of Pharmacy | Teaching Assistant | 1987/08/01 — 1988/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy |
| 2 | 自然科學類 Natural Sciences | 化學 Chemistry |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
Organic Synthesis, Organometallics, Medicinal Chemistry, Green Chemistry
Area(s) of Expertise & Research
有機合成；有機金屬化學；藥物化學；綠色化學
Organic Synthesis, Organometallics, Medicinal Chemistry, Green Chemistry
Publication
| NO | Publication |
|---|---|
| 1 | Xestoquinone是一種有效的拓撲異構酶 II 和 HSP90 雙重抑製劑，其通過 ROS 誘導來抑制HSP-90以治療白血病 The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, Is Mediated through ROS-Induced Inhibition of HSP-90 |
| 2 | 在水中利用鉑催化2,3-二置換吲哚類與烯丙酯類進行選擇性的氮-烯丙基化反應 Platinum-catalyzed selective N-allylation of 2,3-disubstituted indoles with allylic acetates in water |
| 3 | 藉由聚乙二醇-水系統利用鈀催化使吲哚類進行選擇性的氮-烯丙基化反應 Palladium-catalyzed selective N-allylation of indoles assisted by PEG–water system |
| 4 | 小果薔薇乙醇萃取物藉由In Vitro和In Vivo試驗，探討活化Phosphatase和Tensin Homolog達到抗血癌 ：抗白血病研究新知 The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect |
| 5 | 晴類的連續流氫化和還原重氫反應：一種簡單得到α,α-Dideutero Amines的方法 Continuous-Flow Hydrogenation and Reductive Deuteration of Nitriles: a Simple Access to α,α-Dideutero Amines |
| 6 | 利用鉑催化使2,3-二置換吲哚類與烯丙酯類進行烯丙基化反應 Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates |
| 7 | 利用豬模型觀察使用腹主動脈內汽球造成再灌注傷害的病生理變化 Porcine model for observing changes due to ischemia/reperfusion injury secondary to intra-abdominal endovascular balloon occlusion |
| 8 | 金絲桃藉由抑制NFkB及活化Nrf2途徑減緩鼠模型之cisplatin腎毒性 Hyperin inhibits nuclear factor kappa B and activates nuclear factor E2-related factor-2 signaling pathways in cisplatin-induced acute kidney injury in mice |
| 9 | 探索新型N-alkyl 4-anilinofuro[2,3-b]quinoline (CIL-102)衍生物對前列腺癌細胞之作用 Discovery of Novel N-alkyl 4-anilinofuro[2,3-b]quinoline Derivatives (CIL-102 Derivatives) Against Castration-Resistant Human Prostate Cancers |
| 10 | 探索含呃基萘衍生物作為Nrf2激活劑的新型結構 Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators |
| 11 | 新型含呃香豆素衍生物於體外和小鼠模式實驗作為有效的Nrf2/ARE激活劑 Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model |
| 12 | Lantabetulic酸衍生物誘導人類前列腺癌細胞G1期阻滯和凋亡 Lantabetulic Acid Derivatives Induce G1 Arrest and Apoptosis in Human Prostate Cancer Cells |
| 13 | 合成苯胺喹林衍生物並藉由在polo-like kinase表現的效應來評估其抗腫瘤活性 Synthesis and antitumor activity evaluation of anilinoquinoline derivatives by the effect on the expression of polo-like kinase |
| 14 | 在台灣Methyltetrahydrofolate Reductase (MTHFR) Polymorphisms與分離的開放性動脈導管之間的關連研究 Correlation Between Methyltetrahydrofolate Reductase (MTHFR) Polymorphisms and Isolated Patent Ductus Arteriosus in Taiwan |
| 15 | 藉由誘導干擾素抗病毒反應的新型抗C型肝炎病毒製劑-苯胺香豆素類衍生物 Novel anilinocoumarin derivatives as agents against hepatitis C virus by the induction of IFN-mediated antiviral responses |
| 16 | Anti-hepatitis C virus RdRp activity and replication of novel anilinobenzothiazole derivatives Anti-hepatitis C virus RdRp activity and replication of novel anilinobenzothiazole derivatives |
| 17 | 從Ganoderma tsugae分離的 lanostanoids 對黃嘌呤氧化酶的抑制 Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae |
| 18 | 在水中利用簡單的鈀催化劑進行無活化劑一壺的碳-烯丙基化反應 Activator-free and one-pot C-allylation by simple palladium catalyst in water |
| 19 | Anilinoquinoline衍生物的合成及抗C肝活性評估 Synthesis and anti-HCV activity evaluation of anilinoquinoline derivatives |
| 20 | Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities |
| 21 | 福木成分的細胞毒性和抗氧化 Cytotoxic and antioxidant constituents from Garcinia subelliptica |
| 22 | 在水中利用PEG-4000促進鈀催化氮—烯丙基化反應：以奈胺類為例 PEG-4000 promoted palladium-catalyzed N-allylation in water: Aminonaphthalene as an example |
| 23 | Guttiferaceous植物中的Xanthine oxidase抑制成分triterpenoid and phloroglucinol透過ROS機制誘導NTUB1細胞的凋亡 Xanthine oxidase inhibitory triterpenoid and phloroglucinol from guttiferaceous plants inhibit growth and induced apoptosis in human NTUB1 cells through a ROS-dependent mechanism. |
| 24 | Antioxidant xanthone衍生物透過ROS加強cisplatin對NTUB1細胞的毒殺作用 Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS. |
| 25 | 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells |
| 26 | 從Nelumbo nucifera Gaertn. cv. Rosa-plena的葉子分離出的化學成分 Chemical constituents from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena |
| 27 | 從Momordica charantia的莖與果實分離得到的抗氧化成分 Antioxidant constituents from the stems and fruits of Momordica charantia |
| 28 | 利用簡單的鈀催化使弱親核性的奈胺類進行碳-氮鍵的形成 Simple palladium-catalyzed C-N bond formation for poor nucleophilicity of aminonaphthalenes |
| 29 | Anthraquinone derivatives在膀胱癌細胞誘發G2/M arrest 和apoptosis Anthraquinone derivatives induce G2/M cell cycle arrest and apoptosis in NTUB1 cells |
| 30 | 利用碘調解烯雙炔類進行分段環化反應得到碘化的Benzo[a]carbazoles Iodine-Mediated Cascade Cyclization of Enediynes to Iodinated Benzo[a]carbazoles |
| 31 | 2',5'-dimethoxychalcone 衍生物之合成與作用於微管之活性評估 Synthesis and biological evaluation of 2',5'-dimethoxychalcone derivatives as microtubule-targeted anticancer agents |
| 32 | 從Cinnamomum subavenium根部的化學成分 Chemical constituents from the roots of Cinnamomum subavenium |
| 33 | 從Michelia compresa var. lanyuensis莖部的化學成分 Chemical Constituents from the Stems of Michelia compressa VAR. lanyuensis |
| 34 | 棕櫚生育三烯醇的護肝功效評估 Hepatoprotection by palm tocotrienol-rich fraction |
| 35 | 從台灣穗花杉分離得到具有抑制黃嘌呤氧化酶的三帖;類，在正常人類尿道上皮細胞與 膀胱癌細胞中能藉由減少活性氧來保護cispplatin誘發之細胞死亡 Xanthine oxidase inhibitory terpenoids of Amentotaxus formosana protect cisplatin-induced cell death by reducing reactive oxygen species (ROS) in normal human urothelial and bladder cancer cells |
| 36 | 利用鈀（II）催化烯雙缺類進行環化反應形成benzo[a]carbazoles的合成即予反應機制探討 Synthetic development and mechanistic study on Pd(II)-catalyzed cyclization of enediynes to benzo[a]carbazoles |
| 37 | 黃酮類衍生物的合成、抗血小板與血管擴張活性 Synthesis, antiplatelet and vasorelaxing activities of xanthone derivatives |
| 38 | 1-(2-((Z)-6-(2-(Trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)-piperidin-2-one 可能成為具有潛力的細胞凋亡藥劑 1-(2-((Z)-6-(2-(Trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)-piperidin-2-one as a new potent apoptosis agent |
| 39 | Ursolic acid衍生物在NTUB1細胞中透過產生自由基引發細胞週期停滯及凋亡 Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species |
| 40 | Phloroglucinols抑制chemical mediators and xanthine oxidase並在膀胱上皮細胞中透過減少自由基抵抗cisplatin誘發的細胞凋亡 Phloroglucinols inhibit chemical mediators and xanthine oxidase, and protect cisplatin-induced cell death by reducing reactive oxygen species in normal human urothelial and bladder cancer cells. |
| 41 | 利用微波使 2-alkynylbenzonitriles與疊氮化鈉進行環加成反應：選擇性地合成tetrazolo[5,1-a]pyridines and 4,5-disubstituted-2H-1,2,3- triazoles Microwave-assisted cycloadditions of 2-alkynylbenzonitriles with sodium azide: selective synthesis of tetrazolo[5,1-a]pyridines and 4,5-disubstituted-2H-1,2,3- triazoles |
| 42 | 18b-glycyrrhetinic acid衍生物的合成、抗發炎、抗氧化活性 Synthesis, anti-inflammatory, and antioxidant activities of 18b-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors |
| 43 | 在水中直接利用鈀/羧酸催化環1,3-二酮類與烯丙醇類進行碳-烯丙基化反應 Direct palladium/carboxylic acid-catalyzed C-allylation of cyclic 1,3-diones with allylic alcohols in water |
| 44 | Cell death induced by flavonoid glycosides with and without copper Cell death induced by flavonoid glycosides with and without copper |
| 45 | Phloroglucinols with prooxidant activity from Garcinia subelliptica Phloroglucinols with prooxidant activity from Garcinia subelliptica |
| 46 | Synthesis and cytotoxic, anti-inflammatory, and anti-oxidant activities of 2',5'-dialkoxylchalcones as cancer chemopreventive agents Synthesis and cytotoxic, anti-inflammatory, and anti-oxidant activities of 2',5'-dialkoxylchalcones as cancer chemopreventive agents |
| 47 | Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum Phloroglucinols with antioxidant activity and xanthonolignoids from the heartwood of Hypericum geminiflorum |
| 48 | 在水中利用鉑催化奈胺類與烯丙酯類進行烯丙基化反應 Platinum-catalyzed allylation of aminonaphthalenes with allylic acetates in water |
| 49 | 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines 是一個新型的antitubulin試劑 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents |
| 50 | 2-(6-aryl-3(Z)-hexen-1,5-diynyl) 苯胺類作為一類新的強有力抗微管蛋白劑。 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents. |
| 51 | 利用鉑催化奈胺類與乙酸烯丙酯類進行烯丙基化反應 Platinum-catalyzed allylation of aminonaphthalenes with allylic acetates |
| 52 | 在水中直接利用烯丙醇類進行鈀/羧酸催化苯胺類烯丙基化反應 Direct palladium/carboxylic acid-catalyzed allylation of anilines with allylic alcohols in water |
| 53 | 直接利用烯丙醇類進行鈀催化酸性及少親核性苯胺類進行烯丙基化反應 Palladium-catalyzed allylation of acidic and less nucleophilic anilines using allylic alcohols directly |
| 54 | 利用2-丁烯-1,4-二醇使2-胺酚類進行鈀催化位向特異性前後兩次烯丙基化反應 Palladium-catalyzed regiospecific tandem allylation of 2-aminophenols using 2-butene-1,4-diol |
| 55 | 利用鈀催化使1,2-苯二胺與順-1,4-二乙醯氧基-2-丁烯進行前後兩次烯丙基化反應 Palladium-catalyzed tandem allylation of 1,2-phenylenediamines with cis-1,4-diacetoxy-2-butene |
| 56 | 直接利用奈胺類化合物使烯丙醇類化合物進行鈀催化胺化反應 Direct palladium(0)-catalyzed amination of allylic alcohols with aminonaphthalenes |
| 57 | 直接利用2-丁烯-1,4-二醇使鄰-苯二胺類化合物進行鈀催化前後兩次烯丙基化反應 Palladium-catalyzed tandem allylation of o-phenylenediamines using 2-butene-1,4-diol directly |
| 58 | 直接利用烯丙醇類化合物使苯胺類化合物進行鉑催化烯丙基化反應 Direct platinum-catalyzed allylation of anilines using allylic alcohols |
| 59 | 直接利用烯丙醇類化合物使苯胺類化合物進行鈀催化烯丙基化反應的位向和立體選擇性 Regio- and stereoselectivity in palladium(0)-catalyzed allylation of anilines using allylic alcohols directly |
| 60 | 利用鈀催化氮—（2—環己烯）溴化乙醯胺類衍生物的環化反應合成口比口各啶類衍生物 The synthesis of pyrrolidine derivatives by the palladium-catalyzed cyclization of N-(2-cyclohexenyl)bromoacetamide derivatives |
| 61 | 利用苯胺類化合物進行鈀催化烯丙醇類化合物的胺化反應 Palladium-catalyzed amination of allylic alcohols using anilines |
| 62 | 在四異丙氧基鈦的存在下，直接利用烯丙醇類化合物進行鈀催化苯胺類化合物的氮—烯丙基化反應 Palladium-catalyzed N-allylation of anilines by direct use of allyl alcohols in the presence of titanium(IV) isopropoxide |
| 63 | 鈀催化合成5—和5,7—置換口引口朵類衍生物 Palladium-catalyzed synthesis of 5- and 5,7-substituted indole derivatives |
| 64 | 直接利用烯丙醇類化合物進行一種有效的鈀催化路徑形成氮—烯丙基胺類化合物 An efficient, palladium-catalyzed route to N-allylanilines by direct use of allyl alcohols |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
105 — N 國科會(原科技部) — MOST105-2113-M-037-017 — 1 個人型
在綠色化學上利用釕催化烯丙基烷化反應( )
|
2016/08/01 ~ 2018/07/31 |
| 2 |
104 — N 國科會(原科技部) — MOST104-2113-M-037-002 — 1 個人型
在綠色化學上利用奈米金屬催化含氮化合物進行烯丙基化反應的研究( )
|
2015/08/01 ~ 2016/07/31 |
| 3 |
103 — N 國科會(原科技部) — NSC101-2113-M-037-008-MY3 — 1 個人型
在綠色化學上利用金屬催化選擇性地形成碳-碳、碳-氮及碳-氧鍵的研究(3/3)( )
|
2014/08/01 ~ 2015/07/31 |
| 4 |
102 — H 衛福部 — 102TFDA-MD-038 —
化粧品臨床試驗中心規劃暨安全管理研究( )
|
2013/09/06 ~ 2013/12/31 |
| 5 |
102 — N 國科會(原科技部) — NSC101-2113-M-037-008-MY3 — 1 個人型
在綠色化學上利用金屬催化選擇性地形成碳-碳、碳-氮及碳-氧鍵的研究(2/3)( )
|
2013/08/01 ~ 2015/07/31 |
| 6 |
101 — N 國科會(原科技部) — NSC101-2113-M-037-008-MY3 — 1 個人型
在綠色化學上利用金屬催化選擇性地形成碳-碳、碳-氮及碳-氧鍵的研究(1/3)( )
|
2012/08/01 ~ 2015/07/31 |
| 7 |
100 — N 國科會(原科技部) — NSC98-2119-M-037-001-MY3 — 1 個人型
在綠色化學上利用金屬催化進行烯丙基化及芳香化反應的研究(3/3)( )
|
2011/08/01 ~ 2012/07/31 |
| 8 |
099 — N 國科會(原科技部) — NSC98-2119-M-037-001-MY3 — 1 個人型
在綠色化學上利用金屬催化進行烯丙基化及芳香化反應的研究(2/3)( )
|
2010/08/01 ~ 2012/07/31 |
| 9 |
098 — N 國科會(原科技部) — NSC98-2119-M-037-001-MY3 — 1 個人型
在綠色化學上利用金屬催化進行烯丙基化及芳香化反應的研究(1/3)( )
|
2009/08/01 ~ 2012/07/31 |
| 10 |
098 — Z 大專學生研究計畫及博士後 — NSC99-2815-C-037-025-M — 8 大專學生研究計畫
99年度大專學生參與專題研究計畫-王詩涵( )
|
2010/07/01 ~ 2011/02/28 |
| 11 |
097 — N 國科會(原科技部) — NSC95-2113-M-037-011-MY3 — 1 個人型
在環保化學上利用鈀及鉑催化烯丙基化及芳香化反應(3/3)( )
|
2008/08/01 ~ 2009/07/31 |
| 12 |
097 — Z 大專學生研究計畫及博士後 — 98-2815-C-037-025-B — 8 大專學生研究計畫
98年度大專學生參與專題研究計畫--陳佑如( )
|
2009/07/01 ~ 2010/02/28 |
| 13 |
096 — N 國科會(原科技部) — NSC95-2113-M-037-011-MY3 — 1 個人型
在環保化學上利用鈀及鉑催化烯丙基化及芳香化反應(2/3)( )
|
2007/08/01 ~ 2009/07/31 |
| 14 |
096 — N 國科會(原科技部) — NSC96-2745-M-037-003-URD — 2 整合型
生物活性分子篩選中心-(子計畫三):唑類生物鹼衍生物的製備及抗癌評估(3/3)( )
|
2007/08/01 ~ 2008/07/31 |
| 15 |
095 — N 國科會(原科技部) — NSC95-2113-M-037-011-MY3 — 1 個人型
在環保化學上利用鈀及鉑催化烯丙基化及芳香化反應(1/3)( )
|
2006/08/01 ~ 2009/07/31 |
| 16 |
095 — N 國科會(原科技部) — NSC95-2745-M-037-001-URD — 2 整合型
生物活性分子篩選中心-(子計畫三):唑類生物鹼衍生物的製備及抗癌評估(2/3)( )
|
2006/08/01 ~ 2007/07/31 |
| 17 |
094 — N 國科會(原科技部) — NSC94-2113-M-037-005- — 1 個人型
利用金屬催化進行烯丙基化和胺化反應的研究( )
|
2005/08/01 ~ 2006/07/31 |
| 18 |
094 — N 國科會(原科技部) — NSC94-2745-M-037-003-URD — 2 整合型
生物活性分子篩選中心-(子計畫三):唑類生物鹼衍生物的製備及抗癌評估(1/3)( )
|
2005/08/01 ~ 2006/07/31 |
| 19 |
094 — Z 大專學生研究計畫及博士後 — NSC95-2815-C-037-003-M — 8 大專學生研究計畫
大專暑期計畫--王麗雅( )
|
2006/07/01 ~ 2007/02/28 |
| 20 |
093 — N 國科會(原科技部) — NSC93-2113-M-037-008- — 1 個人型
在水中直接利用烯丙醇類進行鈀和鉑催化氮—和碳—烯丙基化反應的研究( )
|
2004/08/01 ~ 2005/07/31 |
| 21 |
093 — Z 大專學生研究計畫及博士後 — NSC94-2815-C-037-002-M — 8 大專學生研究計畫
( )
|
2005/07/01 ~ 2006/02/28 |
| 22 |
092 — N 國科會(原科技部) — NSC92-2113-M-037-025- — 1 個人型
直接利用烯丙醇類化合物進行鈀和鉑催化烯丙基置換反應的研究(3/3)( )
|
2003/08/01 ~ 2004/07/31 |
| 23 |
091 — N 國科會(原科技部) — NSC91-2113-M-037-005 — 1 個人型
直接利用烯丙醇類化合物進行鈀和鉑催化烯丙基置換反應的研究(2/3)( )
|
2002/08/01 ~ 2006/07/31 |
| 24 |
090 — N 國科會(原科技部) — NSC90-2113-M-037-017 — 1 個人型
直接利用烯丙醇類化合物進行鈀和鉑催化烯丙基置換反應的研究(1/3)(Palladium- and Platinum-Catalyzed Allylic Substitution Using Allylic Alcohols Directly)
|
2001/08/01 ~ 2002/07/31 |
| 25 |
089 — N 國科會(原科技部) — NSC 89-2113-M-037-027- — 1 個人型
直接利用烯丙醇類化合物進行鈀催化烯丙基胺化反應的立體及位向選擇性的研究(2/2)(Stereo-and Regioselectivity in Palladium-Catalyzed Allylic Amination by Direct Use of Allyl Alcohols)
|
2000/08/01 ~ 2001/07/31 |
| 26 |
088 — N 國科會(原科技部) — NSC 89-2113-M-037-005- — 1 個人型
直接利用烯丙醇類化合物進行鈀催化烯丙基胺化反應的立體及位向選擇性的研究(1/2)(Stereo-and Regioselectivity in Palladium-Catalyzed Allylic Amination by Direct Use of Allyl Alcohols)
|
1999/08/01 ~ 2000/07/31 |
| 27 |
087 — N 國科會(原科技部) — NSC88-2113-M037-015- — 1 個人型
直接利用烯丙醇類化物進行耙催化烯丙基化反應之研究(Palladium-catalyzed allylation by direct use of allyl alcohols)
|
1998/08/01 ~ 1999/07/31 |
| 28 |
086 — N 國科會(原科技部) — NSC87-2113-M037-004 —
從苯胺酸和酚類合成含氮和含氧雜環化合物的研究(Synthesis of nitrogen- and Oxygen-containing heterocycles from anilines and phenols)
|
1997/08/01 ~ 1998/07/31 |
| 29 |
085 — N 國科會(原科技部) — NSC86-2113-M037-004 —
經由烷基鈀錯體的參與合成雜環化合物的研究(Synthesis of heterocyclesw involving alkylpalladium complexes)
|
1996/08/01 ~ 1997/07/31 |
| 30 |
084 — N 國科會(原科技部) — NSC85-2113-M037-011 —
氮-丙烯基-α-硫乙醯銨的閉環反應(Cyclization of N-allyl-α-thioacetamides)
|
1995/08/01 ~ 1996/07/31 |
| 31 |
083 — N 國科會(原科技部) — NSC84-2331-B037-090 —
δ-Coniceine 衍生物的合成研究(Synthetic Studies on the δ-Coniceine Derivatives)
|
1994/08/01 ~ 1995/07/31 |
| 32 |
082 — N 國科會(原科技部) — NSC83-0208-M037-014 —
經由鈀催化閉環反應合成Pyrolizidines類化合物的研究(Synthesis of Pyrrolizidines via Palladium Catalyzed Cyclization)
|
1994/02/01 ~ 1995/07/31 |
| 33 |
081 — K 中央健保局 — 81-P28-01 —
利用醋酸鈀催化烯胺類化合物進行分子內閉環反應合成γ-carbolin-es 的研究(Intramolecular Cyclization of Enamines Involving Arylpalladium Comple- xes.Synthesis of γ-Carbolines)
|
1992/09/01 ~ 1995/08/31 |
| 34 |
081 — N 國科會(原科技部) — NSC82-0208-M037-014 —
烯胺類經由芳鈀錯體的參與進行分子內閉環合成E-carbolines的研究(Intramolecular Cyclization of Enamines Involoving Arylpalladium Complexes. Synthesis of γ-carbolines)
|
1993/02/01 ~ 1994/01/31 |
| 35 |
081 — N 國科會(原科技部) — NSC82-0412-B037-098-T —
利用碘化亞銅促進烯胺類環化的研究(Copper(I) Iodide-Promoted Cyclization of Enamines)
|
1993/01/01 ~ 1993/12/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 18β－甘草次酸衍生物及其合成方法 | 中華民國 | 2012/08/21 | I370821 |
| 2 | 18β- 甘草次酸衍生物及其合成方法 | 美國 | 2012/12/11 | 8,329,940 |
| 3 | 熊果酸衍生物及其醫藥組合物 | 中華民國 | 2013/02/21 | I386415 |
| 4 | 熊果酸衍生物及其醫藥組合物 | 美國 | 2014/05/20 | 8,729,055 |
| 5 | 作用於微小管抗癌藥物２’，５’－ｄｉｍｅｔｈｏｘｙｃｈａｌｃｏｎｅ衍生物之合成與活性評估 | 中華民國 | 2013/12/21 | I419687 |
| 6 | 18β-甘草次酸衍生物及其用途 | 中華民國 | 2014/02/01 | I424839 |
| 7 | 一種殺死癌細胞之18β-甘草次酸衍生物、其製備方法及包含18β-甘草次酸衍生物之醫藥組合物 | 美國 | 2014/04/01 | 8,686,178 |
| 8 | 18β- 甘草次酸衍生物及其合成方法 | 美國 | 2015/03/03 | 8,969,617 |
| 9 | 2-苯胺基-6-甲基苯并?唑衍生物及其製備方法與用途 | 中華民國 | 2016/08/01 | I543973 |