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 Education

School ¡X Major ¡X Degree Duration

°ê¨¾Âå¾Ç°| ¡X ¥Í©R¬ì¾Ç¬ã¨s©Ò(²¦) ¡X ³Õ¤h

Doctorate, Graduate Institute of Life Sciences, National Defense Medical Center

2006/09 ¡X 2012/01

ªø©°¤j¾Ç ¡X Âå¾Ç¥Íª«§Þ³N¬ã¨s©Ò(²¦) ¡X ºÓ¤h

Master, Department of Medical Biotechnology and Laboratory Science, Chang Gung University

2003/09 ¡X 2005/06

¤¤¤sÂå¾Ç¤j¾Ç ¡X ¥Í©R¬ì¾Ç¨t(²¦) ¡X ¾Ç¤h

Bachelor, Department of Biomedical Sciences, Chung Shan Medical University

1999/09 ¡X 2003/06

 Intramural Experience

Office/Department/Institute Position Duration
ÃIJz¾Ç¬ì Department of Pharmacology   Assistant Professor 2025/08/01 ¡X  

 Extramural Experience

DEPNO Position- Office/Department/Institute Duration
¸q¤jÂå°|Âå¾Ç¬ã¨s³¡ §U²z¬ã¨s­û 1100726 ¡X 1140731
ÀR©y¤j¾Ç¤ÆùÛ«~¬ì¾Ç¨t §U²z±Ð±Â 1070801 ¡X 1100725

 Discipline

 

 Research & Technology Platform Open to the Outside

 

 Interested Area(s)for Interdisciplinary Research

µoª¢ÃIJz¾Ç, Àù¯gÃIJz¾Ç, ¸~½F§K¬Ì·LÀô¹Ò

 

 Area(s) of Expertise & Research

µoª¢ÃIJz¾Ç, Àù¯gÃIJz¾Ç, ¸~½F§K¬Ì·LÀô¹Ò

Inflammation pharmacology; cancer pharmacology; tumor immune microenvironments

 Publication

NO Publication
1

Development of potent and selective tetrahydro-£]-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer.
Aya Fathy, Amro Allam, Ahmed K ElHady, Dalia S El-Gamil, Kai-Chun Lin, Yen-Hua Chang, Yu-Hsuan Lee, Sebastian Hilscher, Mike Schutkowski, Hany S Ibrahim, Shun-Hua Chen, ³¯«T§», Ashraf H Abadi, Wolfgang Sippl, ³¯¬f¥ô*, Yi-Sheng Cheng, Mohammad Abdel-Halim - - 1 - RSC MEDICINAL CHEMISTRY - RSC MEDICINAL CHEMISTRY 2025 16¨÷(0´Á):2754­¶
(IF: 3.6, »â°ì±Æ¦W: 32, »â°ì´Á¥Z¼Æ: 72, »â°ì±Æ¦W: 44.44%)

Development of potent and selective tetrahydro-£]-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer.
Aya Fathy, Amro Allam, Ahmed K ElHady, Dalia S El-Gamil, Kai-Chun Lin, Yen-Hua Chang, Yu-Hsuan Lee, Sebastian Hilscher, Mike Schutkowski, Hany S Ibrahim, Shun-Hua Chen, Chun-Hong Chen, Ashraf H Abadi, Wolfgang Sippl, Po-Jen Chen*, Yi-Sheng Cheng, Mohammad Abdel-Halim - - 1 - RSC MEDICINAL CHEMISTRY - RSC MEDICINAL CHEMISTRY 2025;16(0):2754
(IF: 3.6, Journal Ranking: 32, Number of Journals of this Field: 72, Ranking: 44.44%)

2

Unlocking the potential of novel tetrahydro-£]-carboline-based HDAC6 inhibitors for colorectal cancer therapy: Design, synthesis and biological evaluation.
Noreen Hemida, Dalia S El-Gamil, Ahmed K ElHady, Kai-Chun Lin, Yen-Hua Chang, Sebastian Hilscher, Mike Schutkowski, Hany S Ibrahim, Mostafa M Hamed, Shun-Hua Chen, Chun-Hong Chen, Ashraf H Abadi, Wolfgang Sippl, ³¯¬f¥ô*, Yi-Sheng Cheng, Mohammad Abdel-Halim - - 1 - BIOORGANIC CHEMISTRY - BIOORGANIC CHEMISTRY 2025 160¨÷(0´Á):108454­¶
(IF: 4.7, »â°ì±Æ¦W: 5, »â°ì´Á¥Z¼Æ: 57, »â°ì±Æ¦W: 8.77%)

Unlocking the potential of novel tetrahydro-£]-carboline-based HDAC6 inhibitors for colorectal cancer therapy: Design, synthesis and biological evaluation.
Noreen Hemida, Dalia S El-Gamil, Ahmed K ElHady, Kai-Chun Lin, Yen-Hua Chang, Sebastian Hilscher, Mike Schutkowski, Hany S Ibrahim, Mostafa M Hamed, Shun-Hua Chen, Chun-Hong Chen, Ashraf H Abadi, Wolfgang Sippl, Po-Jen Chen*, Yi-Sheng Cheng, Mohammad Abdel-Halim - - 1 - BIOORGANIC CHEMISTRY - BIOORGANIC CHEMISTRY 2025;160(0):108454
(IF: 4.7, Journal Ranking: 5, Number of Journals of this Field: 57, Ranking: 8.77%)

3

Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses.
Yu-Cheng Chen, Yao-Rong Lee, Yu-Chia Chang, Yi-Hsuan Wang, Shu-Yen Fang, Ching-Hsiung Lin, ³¯¬f¥ô*, Tsong-Long Hwang - - 1 - JOURNAL OF ETHNOPHARMACOLOGY - JOURNAL OF ETHNOPHARMACOLOGY 2025 346¨÷(0´Á):119653­¶
(IF: 5.4, »â°ì±Æ¦W: 5, »â°ì´Á¥Z¼Æ: 45, »â°ì±Æ¦W: 11.11%)

Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses.
Yu-Cheng Chen, Yao-Rong Lee, Yu-Chia Chang, Yi-Hsuan Wang, Shu-Yen Fang, Ching-Hsiung Lin, Po-Jen Chen*, Tsong-Long Hwang - - 1 - JOURNAL OF ETHNOPHARMACOLOGY - JOURNAL OF ETHNOPHARMACOLOGY 2025;346(0):119653
(IF: 5.4, Journal Ranking: 5, Number of Journals of this Field: 45, Ranking: 11.11%)

4

Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38£\ MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses.
Yi-Han Chang, Yi-Chen Lee, Shun-Hua Chen, Shu-Yen Fang, Tzu-Peng Cheng, Ching-Ho Chi, Keng-Chang Tsai, ³¯¬f¥ô*, Hsin-Yi Hung - - 2 - BIOCHEMICAL PHARMACOLOGY - BIOCHEMICAL PHARMACOLOGY 2025 235¨÷(0´Á):116806­¶
(IF: 5.6, »â°ì±Æ¦W: 33, »â°ì´Á¥Z¼Æ: 352, »â°ì±Æ¦W: 9.38%)

Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38£\ MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses.
Yi-Han Chang, Yi-Chen Lee, Shun-Hua Chen, Shu-Yen Fang, Tzu-Peng Cheng, Ching-Ho Chi, Keng-Chang Tsai, Po-Jen Chen*, Hsin-Yi Hung - - 2 - BIOCHEMICAL PHARMACOLOGY - BIOCHEMICAL PHARMACOLOGY 2025;235(0):116806
(IF: 5.6, Journal Ranking: 33, Number of Journals of this Field: 352, Ranking: 9.38%)

 Project

NO
YEAR ¡X Source ¡X No ¡X Type
Project Name
Duration
1
115 ¡X N °ê¬ì·|(­ì¬ì§Þ³¡) ¡X NSTC113-2320-B-037-032-MY3 ¡X 1 ­Ó¤H«¬
±´°Q¥xÆW¥Õ¤Î¤ÑµMª«¹ï¤j¸zª½¸zÀù»P¶Ý¤¤©Ê¥Õ¦å²y¥æ¤¬§@¥Î¤§¼vÅT¤Î¨äÀø®Äµû¦ô(3/3)( )
2026/08/01 ~ 2027/07/31
2
114 ¡X N °ê¬ì·|(­ì¬ì§Þ³¡) ¡X NSTC113-2320-B-037-032-MY3 ¡X 1 ­Ó¤H«¬
±´°Q¥xÆW¥Õ¤Î¤ÑµMª«¹ï¤j¸zª½¸zÀù»P¶Ý¤¤©Ê¥Õ¦å²y¥æ¤¬§@¥Î¤§¼vÅT¤Î¨äÀø®Äµû¦ô(2/3)( )
2025/08/01 ~ 2027/07/31

 Patent