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Publication |
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作為新型細胞週期蛋白依賴性蛋白激酶 8 (CDK8) 抑製劑的 indolin-2-one 衍生物的設計、合成和活性評估
徐瑞怡, 許凱程#, 孫竫, 周敬軒, Tony Eight Lin, 宋姿瑩, 曾惠如, 顏士中,楊家榮, 黃偉展*. - - 1 - BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE - BIOMEDICINE & PHARMACOTHERAPY 2023 159卷(1期):114258頁
(IF: 7.5, 領域排名: 27, 領域期刊數: 136, 領域排名: 19.85%) Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors.
Jui-Yi Hsu, Kai-Cheng Hsu, Ching Sun, Ching-Hsuan Chou, Tony Eight Lin, Tzu-Ying Sung, Hui-Ju Tseng, Shih-Chung Yen, Chia-Ron Yang, Wei-Jan Huang - - 1 - BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE - BIOMEDICINE & PHARMACOTHERAPY 2023;159(1):114258
(IF: 7.5, Journal Ranking: 27, Number of Journals of this Field: 136, Ranking: 19.85%) |
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Pdia4 抑製劑PS1在 db/db 小鼠 β 細胞發病機制和糖尿病中的藥理學和機制研究。
曾惠如, 陳雯曲#, 郭恬芬, Greta Yang, 馮儆珊, 陳慧明, 陳宗彥, 李宗翰, 楊文欽*, 蔡耿彰*, 黃偉展* - - 1 - CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - CELLULAR AND MOLECULAR LIFE SCIENCES 2023 80卷(4期):101頁
(IF: 8, 領域排名: 36, 領域期刊數: 285, 領域排名: 12.63%) Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice.
Hui-Ju Tseng, Wen-Chu Chen, Tien-Fen Kuo, Greta Yang, Ching-Shan Feng, Hui-Ming Chen, Tzung-Yan Chen, Tsung-Han Lee, Wen-Chin Yang, Keng-Chang Tsai, Wei-Jan Huang - - 1 - CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - CELLULAR AND MOLECULAR LIFE SCIENCES 2023;80(4):101
(IF: 8, Journal Ranking: 36, Number of Journals of this Field: 285, Ranking: 12.63%) |
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設計、合成和生物活性評估雙標靶單胺氧化酶 A 和熱休克蛋白 90 抑製劑具N-甲基炔丙胺綴合的 4-異丙基間苯二酚結構用於膠質母細胞瘤的
曾惠如, Suddhasatwa Banerjee#, 錢斌, 賴玫蓉, 吳 彤芸, 徐宗溢, Tony Eight Lin, 許凱程, 莊國祥, 劉景 平*, 陳景虹* - - 1 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2023 256卷(1期):115459頁
(IF: 6.7, 領域排名: 7, 領域期刊數: 60, 領域排名: 11.67%) Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma.
Hui-Ju Tseng, Suddhasatwa Banerjee, Bin Qian, Mei-Jung Lai, Tung-Yun Wu, Tsung-I Hsu, Tony Eight Lin, Kai-Cheng Hsu, Kuo-Hsiang Chuang, Jing-Ping Liou, Jean C Shih - - 1 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2023;256(1):115459
(IF: 6.7, Journal Ranking: 7, Number of Journals of this Field: 60, Ranking: 11.67%) |
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具有有效第 II 類組蛋白去乙醯酶抑制活性的 C-4 取代吩惡嗪異羥肟酸的合成和活性測試
朱鎔駿, 曾惠如#, 李松柏, 許凱程, 忻凌偉, 梁如皓, Tony Eight Lin, 高念楚, 陳亮傑, 呂宛珣, 王惠鈞, 黃偉展* - - 1 - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2023 38卷(1期):2212326頁
(IF: 5.6, 領域排名: 11, 領域期刊數: 60, 領域排名: 18.33%) Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities.
Jung-Chun Chu, Hui-Ju Tseng, Sung-Bau Lee, Kai-Cheng Hsu, Ling-Wei Hsin, Ru-Hao Liang, Tony Eight Lin, Nain-Chu Gao, Liang-Chieh Chen, Wan-Hsun Lu, Andrew H-J Wang, Wei-Jan Huang - - 1 - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2023;38(1):2212326
(IF: 5.6, Journal Ranking: 11, Number of Journals of this Field: 60, Ranking: 18.33%) |
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使用基於結構的虛擬篩選方法鑑定用於治療急性髓系白血病的 FLT3 和 MNK2 雙重抑製劑
顏士中,陳亮傑#,黃瀚立,皇甫維君,陳怡穎,Tony Eight Lin,連思婷,曾惠如,宋姿瑩,Jui-Hua Hsieh,黃偉展,潘秀玲,許凱程* - - 1 - BIOORGANIC CHEMISTRY - BIOORGANIC CHEMISTRY 2022 121卷(1期):105675頁
(IF: 5.1, 領域排名: 7, 領域期刊數: 52, 領域排名: 13.46%) Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach.
Shih-Chung Yen, Liang-Chieh Chen, Han-Li Huang, Wei-Chun HuangFu, Yi-Ying Chen, Tony Eight Lin, Ssu-Ting Lien, Hui-Ju Tseng, Tzu-Ying Sung, Jui-Hua Hsieh, Wei-Jan Huang, Shiow-Lin Pan, Kai-Cheng Hsu - - 1 - BIOORGANIC CHEMISTRY - BIOORGANIC CHEMISTRY 2022;121(1):105675
(IF: 5.1, Journal Ranking: 7, Number of Journals of this Field: 52, Ranking: 13.46%) |
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O-甲基化黃酮醇作為白血病激酶的多激酶抑製劑具有治療急性髓系白血病的潛在作用
顏士中,吳逸玟#,黃振僑,趙敏吾,杜皇儒,陳亮傑,Tony Eight Lin,宋姿瑩,曾惠如,朱鎔駿,黃偉展,楊家榮,皇甫維君,潘秀玲*,許凱程* - - 1 - PHYTOMEDICINE : INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY - PHYTOMEDICINE 2022 100卷(1期):154061頁
(IF: 7.9, 領域排名: 3, 領域期刊數: 60, 領域排名: 5.00%) O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia.
Shih-Chung Yen, Yi-Wen Wu, Cheng-Chiao Huang, Min-Wu Chao, Huang-Ju Tu, Liang-Chieh Chen, Tony Eight Lin, Tzu-Ying Sung, Hui-Ju Tseng, Jung-Chun Chu, Wei-Jan Huang, Chia-Ron Yang, Wei-Chun HuangFu, Shiow-Lin Pan, Kai-Cheng Hsu - - 1 - PHYTOMEDICINE : INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY - PHYTOMEDICINE 2022;100(1):154061
(IF: 7.9, Journal Ranking: 3, Number of Journals of this Field: 60, Ranking: 5.00%) |
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合成和活性測試含有吩噻嗪衍生物的異羥肟酸作為有效的第 II 類組蛋白去乙醯酶抑製劑
許凱程, 朱鎔駿, 曾惠如, 劉昌邑, 王皓青, Tony Eight Lin, 李宏聖, 忻凌偉, Andrew H. -J. Wang, 林建煌, 黃偉展* - - 1 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021 219卷(1期):113419頁
(IF: 6.7, 領域排名: 7, 領域期刊數: 60, 領域排名: 11.67%) Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors.
Kai-Cheng Hsu, Jung-Chun Chu, Hui-Ju Tseng, Chia-I Liu, Hao-Ching Wang, Tony Eight Lin, Hong-Sheng Lee, Ling-Wei Hsin, Andrew H-J Wang, Chien-Huang Lin, Wei-Jan Huang - - 1 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021;219(1):113419
(IF: 6.7, Journal Ranking: 7, Number of Journals of this Field: 60, Ranking: 11.67%) |
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受 Yakuchinone B 啟發的胰島澱粉樣多肽聚集抑製劑的合成
徐瑞怡,Ashish Rao Sathyan,許凱程,陳亮傑,顏政昌,曾惠如,吳坤璋,劉慧康*,黃偉展* - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2021 84卷(4期):1096-1103頁
(IF: 5.1, 領域排名: 33, 領域期刊數: 238, 領域排名: 13.87%) Synthesis of Yakuchinone B-Inspired Inhibitors against Islet Amyloid Polypeptide Aggregation.
Jui-Yi Hsu, Ashish Rao Sathyan, Kai-Cheng Hsu, Liang-Chieh Chen, Cheng-Chung Yen, Hui-Ju Tseng, Kun-Chang Wu, Hui-Kang Liu, Wei-Jan Huang - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2021;84(4):1096-1103
(IF: 5.1, Journal Ranking: 33, Number of Journals of this Field: 238, Ranking: 13.87%) |
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研究選定的類黃酮衍生物作為有效的 FLT3 抑製劑，用於治療急性髓性白血病
顏士中,陳亮傑#,黃瀚立,吳心婷,吳逸玟,Tony Eight Lin,宋姿瑩,連思婷,曾惠如,潘秀玲,黃偉展*,許凱程* - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2021 84卷(1期):1-10頁
(IF: 5.1, 領域排名: 33, 領域期刊數: 238, 領域排名: 13.87%) Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia.
Shih-Chung Yen, Liang-Chieh Chen, Han-Li Huang, Sin-Ting Ngo, Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2021;84(1):1-10
(IF: 5.1, Journal Ranking: 33, Number of Journals of this Field: 238, Ranking: 13.87%) |
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合成和活性分析具吖啶結構的組蛋白去乙醯酶抑製劑作為多靶點藥物對抗阿爾茨海默病
曾惠如,林美香,蕭永基,楊瀅臻,朱鎔駿,陳俊詠,陳怡穎,Tony Eight Lin,蘇致柔,潘秀玲,陳亮傑,王震宇,許凱程*,黃偉展* - - 1 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020 192卷(1期):112193頁
(IF: 6.7, 領域排名: 7, 領域期刊數: 60, 領域排名: 11.67%) Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease.
Hui-Ju Tseng, Mei-Hsiang Lin, Young-Ji Shiao, Ying-Chen Yang, Jung-Chun Chu, Chun-Yung Chen, Yi-Ying Chen, Tony Eight Lin, Chih-Jou Su, Shiow-Lin Pan, Liang-Chieh Chen, Chen-Yu Wang, Kai-Cheng Hsu, Wei-Jan Huang - - 1 - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020;192(1):112193
(IF: 6.7, Journal Ranking: 7, Number of Journals of this Field: 60, Ranking: 11.67%) |
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選定的黃酮類化合物作為針對急性髓系白血病的 MNK 抑製劑的活性測試
陳亮傑,黃瀚立,皇甫維君,顏士中,吳心婷,吳逸玟,Tony Eight Lin,宋姿瑩,連思婷,曾惠如,潘秀玲,黃偉展,許凱程* - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2020 83卷(10期):2967-2975頁
(IF: 5.1, 領域排名: 33, 領域期刊數: 238, 領域排名: 13.87%) Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia.
Liang-Chieh Chen, Han-Li Huang, Wei-Chun HuangFu, Shih-Chung Yen, Sin-Ting Ngo, Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2020;83(10):2967-2975
(IF: 5.1, Journal Ranking: 33, Number of Journals of this Field: 238, Ranking: 13.87%) |
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設計二芳基庚烷衍生物作為第 IIa 類組蛋白去乙乙醯酶和 β-澱粉樣蛋白聚集雙重抑製劑
陳亮傑,曾惠如,劉昌邑,黃耘翌,顏政昌,翁靖如,呂岳霖,侯文琪,Tony Eight Lin,潘一虹,黃國魁,黃偉展*,許凱程* - - 1 - FRONTIERS IN PHARMACOLOGY - FRONTIERS IN PHARMACOLOGY 2018 9卷(1期):708頁
(IF: 5.6, 領域排名: 45, 領域期刊數: 277, 領域排名: 16.25%) Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and β-amyloid Aggregation.
Liang-Chieh Chen, Hui-Ju Tseng, Chang-Yi Liu, Yun-Yi Huang, Cheng-Chung Yen, Jing-Ru Weng, Yeh-Lin Lu, Wen-Chi Hou, Tony E Lin, I-Horng Pan, Kuo-Kuei Huang, Wei-Jan Huang, Kai-Cheng Hsu - - 1 - FRONTIERS IN PHARMACOLOGY - FRONTIERS IN PHARMACOLOGY 2018;9(1):708
(IF: 5.6, Journal Ranking: 45, Number of Journals of this Field: 277, Ranking: 16.25%) |
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使用計算機虛擬篩選方法發現新型第 IIa 類選擇性組蛋白去乙醯酶抑製劑
許凱程, 劉昌邑, Tony Eight Lin, 謝瑞華, 宋姿瑩, 曾惠如, 楊進木,黃偉展* - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2017 7卷(1期):3228頁
(IF: 4.6, 領域排名: 22, 領域期刊數: 73, 領域排名: 30.14%) Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach.
Kai-Cheng Hsu, Chang-Yi Liu, Tony Eight Lin, Jui-Hua Hsieh, Tzu-Ying Sung, Hui-Ju Tseng, Jinn-Moon Yang, Wei-Jan Huang - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2017;7(1):3228
(IF: 4.6, Journal Ranking: 22, Number of Journals of this Field: 73, Ranking: 30.14%) |
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Hispidulin 及其 d-標記衍生物的全合成和代謝穩定性
陳亮傑,許凱程,邱麗珠,曾惠如,黃偉展* - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES 2017 22卷(11期):1897頁
(IF: 4.6, 領域排名: 97, 領域期刊數: 285, 領域排名: 34.04%) Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative.
Liang-Chieh Chen, Kai-Cheng Hsu, Lih-Chu Chiou, Hui-Ju Tseng, Wei-Jan Huang - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES 2017;22(11):1897
(IF: 4.6, Journal Ranking: 97, Number of Journals of this Field: 285, Ranking: 34.04%) |
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