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 Education

School — Major — Degree Duration

國立成功大學 — 臨床藥學與藥物科技研究所(畢) — 博士

Doctorate, Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University

2008/09 — 2012/12

國立交通大學 — 生物科技研究所(畢) — 碩士

Master, Department of Biological Science and Technology, National Chiao Tung University

2003/07 — 2005/06

國立交通大學 — 生物科技系(畢) — 學士

Bachelor, Department of Biological Science and Technology, National Chiao Tung University

1999/09 — 2003/06

 Intramural Experience

Office/Department/Institute Position Duration
學士後醫學系 School of Post-Baccalaureate Medicine   Assistant Professor 2023/08/01 —  

 Extramural Experience

DEPNO Position- Office/Department/Institute Duration
  助理教授 1120201 — 1120731

 Discipline

 

 Research & Technology Platform Open to the Outside

 

 Interested Area(s)for Interdisciplinary Research

 

 

 Area(s) of Expertise & Research

研究專長:細胞生物學、生理學、分子醫學、轉譯醫學、再生醫學、標靶治療、癌症抗藥性, 研究領域: 1. 癌症(探討核內KIT蛋白調控之基因表現在胃腸道基質瘤中癌化之角色與治療標的; 探討現有標靶藥物對具Temozolomide抗藥性之多形性膠質母細胞瘤治療之可行性與作用機轉) 2. 精神疾患(探討雙極性疾患中生物標記蛋白對神經細胞的分子機轉)

 

 Publication

NO Publication
1

Ethanol extract of Vanilla planifolia stems reduces PAK6 expression and induces cell death in glioblastoma cells.
Hui Hua Chang, Alice Y W Chang, 蔡秉宸, 陳昱如, 吳淞郡,陳俐君, Yi-Xuan Lin, 薛元碩* - - 1 - JOURNAL OF CELLULAR AND MOLECULAR MEDICINE - JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2024 28卷(17期):e70065頁
(IF: 4.3, 領域排名: 58, 領域期刊數: 189, 領域排名: 30.69%)

Ethanol extract of Vanilla planifolia stems reduces PAK6 expression and induces cell death in glioblastoma cells.
Hui Hua Chang, Alice Y W Chang, Bing-Chen Tsai, Yu-Ju Chen, Sung-Ghun Wu, Li-Jyun Chen, Yi-Xuan Lin, Yuan-Shuo Hsueh - - 1 - JOURNAL OF CELLULAR AND MOLECULAR MEDICINE - JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2024;28(17):e70065
(IF: 4.3, Journal Ranking: 58, Number of Journals of this Field: 189, Ranking: 30.69%)

2

A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells.
Hui Hua Chang, Yao-Yuan Chang, Bing-Chen Tsai, Li-Jyun Chen, An-Chi Chang, Jian-Ying Chuang, Po-Wu Gean*, 薛元碩* - - 1 - CANCERS - CANCERS 2022 14卷(18期):4537頁
(IF: 5.2, 領域排名: 72, 領域期刊數: 241, 領域排名: 29.88%)

A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells.
Hui Hua Chang, Yao-Yuan Chang, Bing-Chen Tsai, Li-Jyun Chen, An-Chi Chang, Jian-Ying Chuang, Po-Wu Gean*, Yuan-Shuo Hsueh* - - 1 - CANCERS - CANCERS 2022;14(18):4537
(IF: 5.2, Journal Ranking: 72, Number of Journals of this Field: 241, Ranking: 29.88%)

3

A Longitudinal Study of the Association between the Polymorphism and Treatment Response in Patients with Bipolar Disorder.
Hui Hua Chang*, 薛元碩, Yung Wen Cheng, Huai-Hsuan Tseng - - 2 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022 23卷(17期):9635頁
(IF: 5.6, 領域排名: 66, 領域期刊數: 285, 領域排名: 23.16%)

A Longitudinal Study of the Association between the Polymorphism and Treatment Response in Patients with Bipolar Disorder.
Hui Hua Chang*, Yuan-Shuo Hsueh, Yung Wen Cheng, Huai-Hsuan Tseng - - 2 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022;23(17):9635
(IF: 5.6, Journal Ranking: 66, Number of Journals of this Field: 285, Ranking: 23.16%)

4

Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve.
Chao-Chin Hsu*, Isabel Hsu, Li-Hsuan Lee, 薛元碩, Chih-Ying Lin, Hui Hua Chang* - - 1 - BIOMEDICINES - BIOMEDICINES 2022 10卷(6期):1312頁
(IF: 4.7, 領域排名: 69, 領域期刊數: 277, 領域排名: 24.91%)

Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve.
Chao-Chin Hsu, Isabel Hsu, Li-Hsuan Lee, Yuan-Shuo Hsueh, Chih-Ying Lin, Hui Hua Chang - - 1 - BIOMEDICINES - BIOMEDICINES 2022;10(6):1312
(IF: 4.7, Journal Ranking: 69, Number of Journals of this Field: 277, Ranking: 24.91%)

5

Ovarian Follicular Growth through Intermittent Vaginal Gonadotropin Administration in Diminished Ovarian Reserve Women.
Chao-Chin Hsu*, Isabel Hsu, Li-Hsuan Lee, Rosie Hsu, 薛元碩, Chih-Ying Lin, Hui Hua Chang* - - 1 - PHARMACEUTICS - PHARMACEUTICS 2022 14卷(4期):869頁
(IF: 5.4, 領域排名: 51, 領域期刊數: 277, 領域排名: 18.41%)

Ovarian Follicular Growth through Intermittent Vaginal Gonadotropin Administration in Diminished Ovarian Reserve Women.
Chao-Chin Hsu*, Isabel Hsu, Li-Hsuan Lee, Rosie Hsu, Yuan-Shuo Hsueh, Chih-Ying Lin, Hui Hua Chang* - - 1 - PHARMACEUTICS - PHARMACEUTICS 2022;14(4):869
(IF: 5.4, Journal Ranking: 51, Number of Journals of this Field: 277, Ranking: 18.41%)

6

A heat shock protein 90 inhibitor reduces oncoprotein expression and induces cell death in heterogeneous glioblastoma cells with EGFR, PDGFRA, CDK4, and NF1 aberrations.
Kuan-Ta Ho, Pei-Fan Chen, Jian-Ying Chuang, Po-Wu Gean*, 薛元碩* - - 1 - LIFE SCIENCES - LIFE SCIENCES 2022 288卷(120176期):1頁
(IF: 6.1, 領域排名: 35, 領域期刊數: 277, 領域排名: 12.64%)

A heat shock protein 90 inhibitor reduces oncoprotein expression and induces cell death in heterogeneous glioblastoma cells with EGFR, PDGFRA, CDK4, and NF1 aberrations.
Kuan-Ta Ho, Pei-Fan Chen, Jian-Ying Chuang, Po-Wu Gean*, Yuan-Shuo Hsueh* - - 1 - LIFE SCIENCES - LIFE SCIENCES 2022;288(120176):1
(IF: 6.1, Journal Ranking: 35, Number of Journals of this Field: 277, Ranking: 12.64%)

7

Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats.
Chao-Chin Hsu, Leonard Hsu, 薛元碩, Chih-Ying Lin, Hui Hua Chang*, Chao-Tien Hsu - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021 22卷(19期):10769頁
(IF: 5.6, 領域排名: 66, 領域期刊數: 285, 領域排名: 23.16%)

Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats.
Chao-Chin Hsu, Leonard Hsu, Yuan-Shuo Hsueh, Chih-Ying Lin, Hui Hua Chang*, Chao-Tien Hsu - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021;22(19):10769
(IF: 5.6, Journal Ranking: 66, Number of Journals of this Field: 285, Ranking: 23.16%)

8

Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration.
薛元碩#, Yan-Jye Shyong#, Hsiu-Ching Yu, Shu-Jhen Jheng, Shang-Wen Lin, Hua-Lin Wu, Jui-Chen Tsai - - 1 - PHARMACEUTICS - PHARMACEUTICS 2021 13卷(9期):1386頁
(IF: 5.4, 領域排名: 51, 領域期刊數: 277, 領域排名: 18.41%)

Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration.
Yuan-Shuo Hsueh#, Yan-Jye Shyong#, Hsiu-Ching Yu, Shu-Jhen Jheng, Shang-Wen Lin, Hua-Lin Wu, Jui-Chen Tsai - - 1 - PHARMACEUTICS - PHARMACEUTICS 2021;13(9):1386
(IF: 5.4, Journal Ranking: 51, Number of Journals of this Field: 277, Ranking: 18.41%)

9

Changes in striatal dopamine transporters in bipolar disorder and valproate treatment.
薛元碩, Chih-Ying Lin, Nan-Tsing Chiu, Yen Kuang Yang, Po See Chen*, Hui Hua Chang* - - 1 - EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS - EUROPEAN PSYCHIATRY 2021 64卷(1期):e9頁
(IF: 7.8, 領域排名: 18, 領域期刊數: 155, 領域排名: 11.61%)

Changes in striatal dopamine transporters in bipolar disorder and valproate treatment.
Yuan-Shuo Hsueh, Chih-Ying Lin, Nan-Tsing Chiu, Yen Kuang Yang, Po See Chen*, Hui Hua Chang* - - 1 - EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS - EUROPEAN PSYCHIATRY 2021;64(1):e9
(IF: 7.8, Journal Ranking: 18, Number of Journals of this Field: 155, Ranking: 11.61%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
113 — N 國科會(原科技部) — NSTC113-2320-B-037-025 — 1 個人型
探討瓜氨酸化轉譯後修飾之蛋白質在神經膠質母細胞瘤生成和惡化的角色( )
2024/08/01 ~ 2025/07/31
2
112 — Q 新聘教師計畫(校內) — KMU-Q113010 —  
探討PAK6在異質性神經膠質母細胞瘤中的致癌角色與可行性治療( )
2024/01/01 ~ 2024/12/31
3
112 — X 高奇合作計畫 — 113CM-KMU-10 —  
探討尿液miRNA在台灣尿路上皮癌病人預後與治療的角色( )
2024/08/01 ~ 2025/07/31

 Patent