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 Education

School — Major — Degree Duration

國立成功大學 — 臨床藥學與藥物科技研究所(畢) — 博士

Doctorate, Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University

2008/09 — 2012/12

國立交通大學 — 生物科技研究所(畢) — 碩士

Master, Department of Biological Science and Technology, National Chiao Tung University

2003/07 — 2005/06

國立交通大學 — 生物科技系(畢) — 學士

Bachelor, Department of Biological Science and Technology, National Chiao Tung University

1999/09 — 2003/06

 Intramural Experience

Office/Department/Institute Position Duration
學士後醫學系 School of Post-Baccalaureate Medicine   Assistant Professor 2023/08/01 —  

 Extramural Experience

DEPNO Position- Office/Department/Institute Duration
  助理教授 1120201 — 1120731

 Discipline

 

 Research & Technology Platform Open to the Outside

 

 Interested Area(s)for Interdisciplinary Research

 

 

 Area(s) of Expertise & Research

研究專長:細胞生物學、生理學、分子醫學、轉譯醫學、再生醫學、標靶治療、癌症抗藥性, 研究領域: 1. 癌症(探討核內KIT蛋白調控之基因表現在胃腸道基質瘤中癌化之角色與治療標的; 探討現有標靶藥物對具Temozolomide抗藥性之多形性膠質母細胞瘤治療之可行性與作用機轉) 2. 精神疾患(探討雙極性疾患中生物標記蛋白對神經細胞的分子機轉)

 

 Publication

NO Publication
1

A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells.
Hui Hua Chang, Yao-Yuan Chang, Bing-Chen Tsai, Li-Jyun Chen, An-Chi Chang, Jian-Ying Chuang, Po-Wu Gean*, 薛元碩* - - 1 - CANCERS - CANCERS 2022 14卷(18期):4537頁
(IF: 5.2, 領域排名: 72, 領域期刊數: 241, 領域排名: 29.88%)

A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells.
Hui Hua Chang, Yao-Yuan Chang, Bing-Chen Tsai, Li-Jyun Chen, An-Chi Chang, Jian-Ying Chuang, Po-Wu Gean*, Yuan-Shuo Hsueh* - - 1 - CANCERS - CANCERS 2022;14(18):4537
(IF: 5.2, Journal Ranking: 72, Number of Journals of this Field: 241, Ranking: 29.88%)

2

A Longitudinal Study of the Association between the Polymorphism and Treatment Response in Patients with Bipolar Disorder.
Hui Hua Chang*, 薛元碩, Yung Wen Cheng, Huai-Hsuan Tseng - - 2 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022 23卷(17期):9635頁
(IF: 5.6, 領域排名: 66, 領域期刊數: 285, 領域排名: 23.16%)

A Longitudinal Study of the Association between the Polymorphism and Treatment Response in Patients with Bipolar Disorder.
Hui Hua Chang*, Yuan-Shuo Hsueh, Yung Wen Cheng, Huai-Hsuan Tseng - - 2 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022;23(17):9635
(IF: 5.6, Journal Ranking: 66, Number of Journals of this Field: 285, Ranking: 23.16%)

3

Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve.
Chao-Chin Hsu*, Isabel Hsu, Li-Hsuan Lee, 薛元碩, Chih-Ying Lin, Hui Hua Chang* - - 1 - BIOMEDICINES - BIOMEDICINES 2022 10卷(6期):1312頁
(IF: 4.7, 領域排名: 69, 領域期刊數: 277, 領域排名: 24.91%)

Intraovarian Injection of Recombinant Human Follicle-Stimulating Hormone for Luteal-Phase Ovarian Stimulation during Oocyte Retrieval Is Effective in Women with Impending Ovarian Failure and Diminished Ovarian Reserve.
Chao-Chin Hsu, Isabel Hsu, Li-Hsuan Lee, Yuan-Shuo Hsueh, Chih-Ying Lin, Hui Hua Chang - - 1 - BIOMEDICINES - BIOMEDICINES 2022;10(6):1312
(IF: 4.7, Journal Ranking: 69, Number of Journals of this Field: 277, Ranking: 24.91%)

4

Ovarian Follicular Growth through Intermittent Vaginal Gonadotropin Administration in Diminished Ovarian Reserve Women.
Chao-Chin Hsu*, Isabel Hsu, Li-Hsuan Lee, Rosie Hsu, 薛元碩, Chih-Ying Lin, Hui Hua Chang* - - 1 - PHARMACEUTICS - PHARMACEUTICS 2022 14卷(4期):869頁
(IF: 5.4, 領域排名: 51, 領域期刊數: 277, 領域排名: 18.41%)

Ovarian Follicular Growth through Intermittent Vaginal Gonadotropin Administration in Diminished Ovarian Reserve Women.
Chao-Chin Hsu*, Isabel Hsu, Li-Hsuan Lee, Rosie Hsu, Yuan-Shuo Hsueh, Chih-Ying Lin, Hui Hua Chang* - - 1 - PHARMACEUTICS - PHARMACEUTICS 2022;14(4):869
(IF: 5.4, Journal Ranking: 51, Number of Journals of this Field: 277, Ranking: 18.41%)

5

A heat shock protein 90 inhibitor reduces oncoprotein expression and induces cell death in heterogeneous glioblastoma cells with EGFR, PDGFRA, CDK4, and NF1 aberrations.
Kuan-Ta Ho, Pei-Fan Chen, Jian-Ying Chuang, Po-Wu Gean*, 薛元碩* - - 1 - LIFE SCIENCES - LIFE SCIENCES 2022 288卷(120176期):1頁
(IF: 6.1, 領域排名: 35, 領域期刊數: 277, 領域排名: 12.64%)

A heat shock protein 90 inhibitor reduces oncoprotein expression and induces cell death in heterogeneous glioblastoma cells with EGFR, PDGFRA, CDK4, and NF1 aberrations.
Kuan-Ta Ho, Pei-Fan Chen, Jian-Ying Chuang, Po-Wu Gean*, Yuan-Shuo Hsueh* - - 1 - LIFE SCIENCES - LIFE SCIENCES 2022;288(120176):1
(IF: 6.1, Journal Ranking: 35, Number of Journals of this Field: 277, Ranking: 12.64%)

6

Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats.
Chao-Chin Hsu, Leonard Hsu, 薛元碩, Chih-Ying Lin, Hui Hua Chang*, Chao-Tien Hsu - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021 22卷(19期):10769頁
(IF: 5.6, 領域排名: 66, 領域期刊數: 285, 領域排名: 23.16%)

Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats.
Chao-Chin Hsu, Leonard Hsu, Yuan-Shuo Hsueh, Chih-Ying Lin, Hui Hua Chang*, Chao-Tien Hsu - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021;22(19):10769
(IF: 5.6, Journal Ranking: 66, Number of Journals of this Field: 285, Ranking: 23.16%)

7

Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration.
薛元碩#, Yan-Jye Shyong#, Hsiu-Ching Yu, Shu-Jhen Jheng, Shang-Wen Lin, Hua-Lin Wu, Jui-Chen Tsai - - 1 - PHARMACEUTICS - PHARMACEUTICS 2021 13卷(9期):1386頁
(IF: 5.4, 領域排名: 51, 領域期刊數: 277, 領域排名: 18.41%)

Nanostructured Lipid Carrier Gel Formulation of Recombinant Human Thrombomodulin Improve Diabetic Wound Healing by Topical Administration.
Yuan-Shuo Hsueh#, Yan-Jye Shyong#, Hsiu-Ching Yu, Shu-Jhen Jheng, Shang-Wen Lin, Hua-Lin Wu, Jui-Chen Tsai - - 1 - PHARMACEUTICS - PHARMACEUTICS 2021;13(9):1386
(IF: 5.4, Journal Ranking: 51, Number of Journals of this Field: 277, Ranking: 18.41%)

8

Changes in striatal dopamine transporters in bipolar disorder and valproate treatment.
薛元碩, Chih-Ying Lin, Nan-Tsing Chiu, Yen Kuang Yang, Po See Chen*, Hui Hua Chang* - - 1 - EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS - EUROPEAN PSYCHIATRY 2021 64卷(1期):e9頁
(IF: 7.8, 領域排名: 18, 領域期刊數: 155, 領域排名: 11.61%)

Changes in striatal dopamine transporters in bipolar disorder and valproate treatment.
Yuan-Shuo Hsueh, Chih-Ying Lin, Nan-Tsing Chiu, Yen Kuang Yang, Po See Chen*, Hui Hua Chang* - - 1 - EUROPEAN PSYCHIATRY : THE JOURNAL OF THE ASSOCIATION OF EUROPEAN PSYCHIATRISTS - EUROPEAN PSYCHIATRY 2021;64(1):e9
(IF: 7.8, Journal Ranking: 18, Number of Journals of this Field: 155, Ranking: 11.61%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
112 — Q 新聘教師計畫(校內) — KMU-Q113010 —  
探討PAK6在異質性神經膠質母細胞瘤中的致癌角色與可行性治療( )
2024/01/01 ~ 2024/12/31

 Patent