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 Education

School — Major — Degree Duration

中國醫藥大學 — 藥物化學研究所(畢) — 博士

Doctorate, Graduate Institute of Pharmaceutical Chemistry, China Medical University

2005/09 — 2013/06

中國醫藥大學 — 藥物化學研究所(畢) — 碩士

Master, Graduate Institute of Pharmaceutical Chemistry, China Medical University

2003/09 — 2005/06

中國醫藥大學 — 藥學系(畢) — 學士

Bachelor, School of Pharmacy, China Medical University

1998/09 — 2002/06

 Intramural Experience

Office/Department/Institute Position Duration
藥學系 School of Pharmacy   Assistant Professor 2023/08/01 —  

 Extramural Experience

 

 Discipline

 

 Research & Technology Platform Open to the Outside

 

 Interested Area(s)for Interdisciplinary Research

生物資訊,生物微流體晶片技術,藥物活性評估等等跨領域合作

 

 Area(s) of Expertise & Research

藥物化學,天然化合物之藥理活性優化,藥物動力學,中草藥藥物交互作用,脂質奈米顆粒藥物遞送系統與相關應用

Medicinal chemistry, Biofuntional optimization of natural products, pharmacokinetics, Herb-drug relationship in pharmacokinetics & their biotransformation, Lipid nanoparticles (LNP) drug delivery system, Design & synthesize ionizable lipids for LNPs

 Publication

NO Publication
1

脂質體抗生素殺死腫瘤相關細菌會產生誘導抗腫瘤免疫反應的新抗原
Menglin Wang, Benoit Rousseau, Kunyu Qiu, Guannan Huang, Yu Zhang, Hang Su, Christine Le Bihan-Benjamin, Ines Khati, Oliver Artz, Michael B Foote, 鄭雍怡, Kuo-Hsiung Lee, Michael Z Miao, Yue Sun, Philippe-Jean Bousquet, Marc Hilmi, Elise Dumas, Anne-Sophie Hamy, Fabien Reyal, Lin Lin, Paul M Armistead, Wantong Song, Ava Vargason, Janelle C Arthur, Yun Liu, Jianfeng Guo, Xuefei Zhou, Juliane Nguyen, Yongqun He, Jenny P-Y Ting, Aaron C Anselmo, Leaf Huang - - 2 - NATURE BIOTECHNOLOGY - NATURE BIOTECHNOLOGY 2023 2023卷(Sep期):25頁
(IF: 46.9, 領域排名: 2, 領域期刊數: 156, 領域排名: 1.28%)

Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses.
Menglin Wang, Benoit Rousseau, Kunyu Qiu, Guannan Huang, Yu Zhang, Hang Su, Christine Le Bihan-Benjamin, Ines Khati, Oliver Artz, Michael B Foote, Yung-Yi Cheng, Kuo-Hsiung Lee, Michael Z Miao, Yue Sun, Philippe-Jean Bousquet, Marc Hilmi, Elise Dumas, Anne-Sophie Hamy, Fabien Reyal, Lin Lin, Paul M Armistead, Wantong Song, Ava Vargason, Janelle C Arthur, Yun Liu, Jianfeng Guo, Xuefei Zhou, Juliane Nguyen, Yongqun He, Jenny P-Y Ting, Aaron C Anselmo, Leaf Huang - - 2 - NATURE BIOTECHNOLOGY - NATURE BIOTECHNOLOGY 2023;2023(Sep):25
(IF: 46.9, Journal Ranking: 2, Number of Journals of this Field: 156, Ranking: 1.28%)

2

作為抗腫瘤劑的新型別白樺/別白樺素-核苷綴合物的合成與生物評估
Yanli Wang, Xiaowan Huang, Xiao Zhang, Jingchen Wang, Keyan Li, Guotao Liu, Kexin Lu, Xiang Zhang, Chengping Xie, Teresa Zheng, 鄭雍怡*, Qiang Wang* - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES (BASEL, SWITZERLAND) 2022 27卷(15期):4738頁
(IF: 0, 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Synthesis and Biological Evaluation of Novel Allobetulon/Allobetulin-Nucleoside Conjugates as AntitumorAgents.
Yanli Wang, Xiaowan Huang, Xiao Zhang, Jingchen Wang, Keyan Li, Guotao Liu, Kexin Lu, Xiang Zhang, Chengping Xie, Teresa Zheng, Yung-Yi Cheng*, Qiang Wang* - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES (BASEL, SWITZERLAND) 2022;27(15):4738
(IF: 0, Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

3

輻射對他莫昔芬藥物動力學和生物轉化的影響
鄭雍怡, Teresa Zheng, Michael W Chang, Jeffrey W Dalley, Yu-Jen Chen, Tung-Hu Tsai, Chen-Hsi Hsieh - - 1 - FRONTIERS IN ONCOLOGY - FRONTIERS IN ONCOLOGY 2022 12卷(Feb期):833108頁
(IF: 4.7, 領域排名: 85, 領域期刊數: 241, 領域排名: 35.27%)

Impact of Irradiation on the Pharmacokinetics and Biotransformation of Tamoxifen.
Yung-Yi Cheng, Teresa Zheng, Michael W Chang, Jeffrey W Dalley, Yu-Jen Chen, Tung-Hu Tsai, Chen-Hsi Hsieh - - 1 - FRONTIERS IN ONCOLOGY - FRONTIERS IN ONCOLOGY 2022;12(Feb):833108
(IF: 4.7, Journal Ranking: 85, Number of Journals of this Field: 241, Ranking: 35.27%)

4

New phorbol ester derivatives as potent anti-HIV agents.
Qi-Run Li#, 鄭雍怡#, Lei Zhao, Xiao-Lei Huang, Xiao-Gang Jiang, Ya-Dong Cui, Susan L Morris-Natschke, Masuo Goto, Chin-Ho Chen, Kuo-Hsiung Lee, Dao-Feng Chen, Jian Zhang - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2021 50卷(Oct期):128319頁
(IF: 2.7, 領域排名: 18, 領域期刊數: 52, 領域排名: 34.62%)

New phorbol ester derivatives as potent anti-HIV agents.
Qi-Run Li#, Yung-Yi Cheng#, Lei Zhao, Xiao-Lei Huang, Xiao-Gang Jiang, Ya-Dong Cui, Susan L Morris-Natschke, Masuo Goto, Chin-Ho Chen, Kuo-Hsiung Lee, Dao-Feng Chen, Jian Zhang - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2021;50(Oct):128319
(IF: 2.7, Journal Ranking: 18, Number of Journals of this Field: 52, Ranking: 34.62%)

5

索拉非尼在大鼠之臨床前藥物動力學交互作用和組織病理學分析
Chin-Tsung Ting, 鄭雍怡, Tung-Hu Tsai - - 1 - ACS OMEGA - ACS OMEGA 2021 6卷(4期):3060-3067頁
(IF: 4.1, 領域排名: 69, 領域期刊數: 178, 領域排名: 38.76%)

Preclinical Pharmacokinetic Interaction and Histopathological Analyses of on Sorafenib in Rats.
Chin-Tsung Ting, Yung-Yi Cheng, Tung-Hu Tsai - - 1 - ACS OMEGA - ACS OMEGA 2021;6(4):3060-3067
(IF: 4.1, Journal Ranking: 69, Number of Journals of this Field: 178, Ranking: 38.76%)

6

強效抗腫瘤劑的薯蕷皂苷元衍生物:合成、細胞毒性和作用機轉
Hong Yin, Min-Jie Zhang, Ren-Feng An, Jing Zhou, Wei Liu, Susan L Morris-Natschke, 鄭雍怡, Kuo-Hsiung Lee, Xue-Feng Huang - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2021 84卷(3期):616-629頁
(IF: 5.1, 領域排名: 33, 領域期刊數: 238, 領域排名: 13.87%)

Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action.
Hong Yin, Min-Jie Zhang, Ren-Feng An, Jing Zhou, Wei Liu, Susan L Morris-Natschke, Yung-Yi Cheng, Kuo-Hsiung Lee, Xue-Feng Huang - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2021;84(3):616-629
(IF: 5.1, Journal Ranking: 33, Number of Journals of this Field: 238, Ranking: 13.87%)

7

青萼素A和冬凌草甲素生物素化衍生物的合成及其抗癌活性
Xiao-Lei Huang, Jing-Lei Chen, Xian-Lun Li, Lei Zhao, Ya-Dong Cui, Jiang-Yun Liu, Susan L Morris-Natschke, Goto Masuo, 鄭雍怡, Kuo-Hsiung Lee, Dao-Feng Chen, Jian Zhang - - 1 - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2021 23卷(7期):703-711頁
(IF: 1.7, 領域排名: 143, 領域期刊數: 238, 領域排名: 60.08%)

Synthesis and anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin.
Xiao-Lei Huang, Jing-Lei Chen, Xian-Lun Li, Lei Zhao, Ya-Dong Cui, Jiang-Yun Liu, Susan L Morris-Natschke, Goto Masuo, Yung-Yi Cheng, Kuo-Hsiung Lee, Dao-Feng Chen, Jian Zhang - - 1 - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2021;23(7):703-711
(IF: 1.7, Journal Ranking: 143, Number of Journals of this Field: 238, Ranking: 60.08%)

8

強效抗 HIV 活性的新型樺木酸-核苷互接化合物
Qiang Wang, Yujiang Li, Liyun Zheng, Xiaowan Huang, Yanli Wang, Chin-Ho Chen, 鄭雍怡, Susan L Morris-Natschke, Kuo-Hsiung Lee - - 0 - ACS MEDICINAL CHEMISTRY LETTERS - ACS MEDICINAL CHEMISTRY LETTERS 2020 11卷(11期):2290-2293頁
(IF: 4.2, 領域排名: 21, 領域期刊數: 60, 領域排名: 35.00%)

Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.
Qiang Wang, Yujiang Li, Liyun Zheng, Xiaowan Huang, Yanli Wang, Chin-Ho Chen, Yung-Yi Cheng, Susan L Morris-Natschke, Kuo-Hsiung Lee - - 0 - ACS MEDICINAL CHEMISTRY LETTERS - ACS MEDICINAL CHEMISTRY LETTERS 2020;11(11):2290-2293
(IF: 4.2, Journal Ranking: 21, Number of Journals of this Field: 60, Ranking: 35.00%)

9

從天然產物中開發抗流感藥物
Zhi-Jun Zhang, Susan L Morris-Natschke, 鄭雍怡, Kuo-Hsiung Lee, Rong-Tao Li - - 1 - MEDICINAL RESEARCH REVIEWS - MEDICINAL RESEARCH REVIEWS 2020 40卷(6期):2290-2338頁
(IF: 13.3, 領域排名: 1, 領域期刊數: 60, 領域排名: 1.67%)

Development of anti-influenza agents from natural products.
Zhi-Jun Zhang, Susan L Morris-Natschke, Yung-Yi Cheng, Kuo-Hsiung Lee, Rong-Tao Li - - 1 - MEDICINAL RESEARCH REVIEWS - MEDICINAL RESEARCH REVIEWS 2020;40(6):2290-2338
(IF: 13.3, Journal Ranking: 1, Number of Journals of this Field: 60, Ranking: 1.67%)

10

天然抗愛滋病毒三萜類化合物及其類似物的最新進展
Hai-Feng Wu, Susan L Morris-Natschke, Xu-Dong Xu, Mei-Hua Yang, 鄭雍怡, Shi-Shan Yu, Kuo-Hsiung Lee - - 1 - MEDICINAL RESEARCH REVIEWS - MEDICINAL RESEARCH REVIEWS 2020 40卷(6期):2339-2385頁
(IF: 13.3, 領域排名: 1, 領域期刊數: 60, 領域排名: 1.67%)

Recent advances in natural anti-HIV triterpenoids and analogs.
Hai-Feng Wu, Susan L Morris-Natschke, Xu-Dong Xu, Mei-Hua Yang, Yung-Yi Cheng, Shi-Shan Yu, Kuo-Hsiung Lee - - 1 - MEDICINAL RESEARCH REVIEWS - MEDICINAL RESEARCH REVIEWS 2020;40(6):2339-2385
(IF: 13.3, Journal Ranking: 1, Number of Journals of this Field: 60, Ranking: 1.67%)

11

Nanocarrier-mediated immunogenic chemotherapy for triple negative breast cancer.
Yun Liu, Nasha Qiu, Limei Shen, Qi Liu, Jing Zhang, 鄭雍怡, Kuo-Hsiung Lee, Leaf Huang - - 1 - JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY - JOURNAL OF CONTROLLED RELEASE 2020 323卷(2020期):431-441頁
(IF: 10.8, 領域排名: 12, 領域期刊數: 277, 領域排名: 4.33%)

Nanocarrier-mediated immunogenic chemotherapy for triple negative breast cancer.
Yun Liu, Nasha Qiu, Limei Shen, Qi Liu, Jing Zhang, Yung-Yi Cheng, Kuo-Hsiung Lee, Leaf Huang - - 1 - JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY - JOURNAL OF CONTROLLED RELEASE 2020;323(2020):431-441
(IF: 10.8, Journal Ranking: 12, Number of Journals of this Field: 277, Ranking: 4.33%)

12

Cucurbitane-Type Triterpenoids from the Vines of and Their Anti-inflammatory Activities.
Hung-Tse Huang, Li-Jie Zhang, Hui-Chi Huang, Syh-Yuan Hwang, Chia-Lun Wu, Yu-Chi Lin, Chia-Ching Liaw, 鄭雍怡, Susan L Morris-Natschke, Chung-Yi Huang, Kuo-Hsiung Lee, Yao-Haur Kuo - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2020 83卷(5期):1400-1408頁
(IF: 5.1, 領域排名: 33, 領域期刊數: 238, 領域排名: 13.87%)

Cucurbitane-Type Triterpenoids from the Vines of and Their Anti-inflammatory Activities.
Hung-Tse Huang, Li-Jie Zhang, Hui-Chi Huang, Syh-Yuan Hwang, Chia-Lun Wu, Yu-Chi Lin, Chia-Ching Liaw, Yung-Yi Cheng, Susan L Morris-Natschke, Chung-Yi Huang, Kuo-Hsiung Lee, Yao-Haur Kuo - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2020;83(5):1400-1408
(IF: 5.1, Journal Ranking: 33, Number of Journals of this Field: 238, Ranking: 13.87%)

13

Anti-HIV tigliane diterpenoids from Reutealis trisperma.
Yan Lu, Ya-Si Huang, Chin-Ho Chen, Toshiyuki Akiyama, Susan L Morris-Natschke, 鄭雍怡, Ih-Sheng Chen, Sheng-Zehn Yang, Dao-Feng Chen, Kuo-Hsiung Lee - - 1 - PHYTOCHEMISTRY - PHYTOCHEMISTRY 2020 174卷(2020期):112360頁
(IF: 3.8, 領域排名: 58, 領域期刊數: 238, 領域排名: 24.37%)

Anti-HIV tigliane diterpenoids from Reutealis trisperma.
Yan Lu, Ya-Si Huang, Chin-Ho Chen, Toshiyuki Akiyama, Susan L Morris-Natschke, Yung-Yi Cheng, Ih-Sheng Chen, Sheng-Zehn Yang, Dao-Feng Chen, Kuo-Hsiung Lee - - 1 - PHYTOCHEMISTRY - PHYTOCHEMISTRY 2020;174(2020):112360
(IF: 3.8, Journal Ranking: 58, Number of Journals of this Field: 238, Ranking: 24.37%)

14

Kalshiolin A, new lignan from Kalimeris shimadai
Guo-Kai Wang, Wen-Fang Jin, Nan Zhang, Gang Wang, 鄭雍怡, Susan L Morris-Natschke, Masuo Goto, Zhong-Yu Zhou, Jin-Song Liu, Kuo-Hsiung Lee - - 1 - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2020 22卷(5期):489-495頁
(IF: 1.7, 領域排名: 143, 領域期刊數: 238, 領域排名: 60.08%)

Kalshiolin A, new lignan from Kalimeris shimadai
Guo-Kai Wang, Wen-Fang Jin, Nan Zhang, Gang Wang, Yung-Yi Cheng, Susan L Morris-Natschke, Masuo Goto, Zhong-Yu Zhou, Jin-Song Liu, Kuo-Hsiung Lee - - 1 - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH - JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 2020;22(5):489-495
(IF: 1.7, Journal Ranking: 143, Number of Journals of this Field: 238, Ranking: 60.08%)

15

Carbazole Alkaloids from : Isolation, Characterization, and Anti-HIV Evaluation.
Jing-Hua Yang, Xin-Yi Wang, Yi-Ping Zhou, Rong Lu, Chin-Ho Chen, Meng-Han Zhang, 鄭雍怡, Susan L Morris-Natschke, Kuo-Hsiung Lee, Yun-Song Wang - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES 2019 25卷(1期):99頁
(IF: 4.6, 領域排名: 97, 領域期刊數: 285, 領域排名: 34.04%)

Carbazole Alkaloids from : Isolation, Characterization, and Anti-HIV Evaluation.
Jing-Hua Yang, Xin-Yi Wang, Yi-Ping Zhou, Rong Lu, Chin-Ho Chen, Meng-Han Zhang, Yung-Yi Cheng, Susan L Morris-Natschke, Kuo-Hsiung Lee, Yun-Song Wang - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES 2019;25(1):99
(IF: 4.6, Journal Ranking: 97, Number of Journals of this Field: 285, Ranking: 34.04%)

16

Kalshinoids A–F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae
Guo-Kai Wang, Nan Zhang, Jian-Neng Yao, Yang Yu, Gang Wang, Chin-Chuan Hung, 鄭雍怡, Susan L Morris-Natschke, Zhong-Yu Zhou, Jin-Song Liu, Kuo-Hsiung Lee - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2019 82卷(12期):3372-3378頁
(IF: 5.1, 領域排名: 33, 領域期刊數: 238, 領域排名: 13.87%)

Kalshinoids A–F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae
Guo-Kai Wang, Nan Zhang, Jian-Neng Yao, Yang Yu, Gang Wang, Chin-Chuan Hung, Yung-Yi Cheng, Susan L Morris-Natschke, Zhong-Yu Zhou, Jin-Song Liu, Kuo-Hsiung Lee - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2019;82(12):3372-3378
(IF: 5.1, Journal Ranking: 33, Number of Journals of this Field: 238, Ranking: 13.87%)

17

Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
Zhong Chen, Kuo-Yen Huang, Yong Ling, Masuo Goto, Hua-Qing Duan, Xiao-Hang Tong, Yan-Li Liu, 鄭雍怡, Susan L Morris-Natschke, Pan-Chyr Yang, Shi-Lin Yang, Kuo-Hsiung Lee - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2019 82卷(11期):3065-3073頁
(IF: 5.1, 領域排名: 33, 領域期刊數: 238, 領域排名: 13.87%)

Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
Zhong Chen, Kuo-Yen Huang, Yong Ling, Masuo Goto, Hua-Qing Duan, Xiao-Hang Tong, Yan-Li Liu, Yung-Yi Cheng, Susan L Morris-Natschke, Pan-Chyr Yang, Shi-Lin Yang, Kuo-Hsiung Lee - - 1 - JOURNAL OF NATURAL PRODUCTS - JOURNAL OF NATURAL PRODUCTS 2019;82(11):3065-3073
(IF: 5.1, Journal Ranking: 33, Number of Journals of this Field: 238, Ranking: 13.87%)

18

Development of a Validated UPLC-MS/MS Method for Analyzing Major Ginseng Saponins from Various Ginseng Species.
Ling Yang, Chi-Lin Li, 鄭雍怡, Tung-Hu Tsai - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES 2019 24卷(22期):4065頁
(IF: 4.6, 領域排名: 97, 領域期刊數: 285, 領域排名: 34.04%)

Development of a Validated UPLC-MS/MS Method for Analyzing Major Ginseng Saponins from Various Ginseng Species.
Ling Yang, Chi-Lin Li, Yung-Yi Cheng, Tung-Hu Tsai - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES 2019;24(22):4065
(IF: 4.6, Journal Ranking: 97, Number of Journals of this Field: 285, Ranking: 34.04%)

 Project

 

 Patent