Education
| School — Major — Degree | Duration |
|---|---|
|
國立成功大學 — 基礎醫學研究所(畢) — 博士 Doctorate, Institute of Basic Medical Sciences, National Cheng Kung University |
2010/09 — 2016/06 |
|
國立成功大學 — 細胞生物與解剖學研究所(肄) — 碩士 Master, Department of Cell Biology and Anatomy, National Cheng Kung University |
2009/02 — 2010/08 |
|
國立中興大學 — 昆蟲學系(畢) — 學士 Bachelor, Department of Entomology, National Chung Hsing University |
2004/09 — 2008/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 解剖學科 Department of Anatomy | Assistant Professor | 2022/02/01 — |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 解剖、病理及法醫 Anatomy, Pathology and Forensic Medicine |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
腫瘤學與藥物治療：開發標靶抗癌新藥、評估現有藥物在癌症治療中的新應用。 代謝與免疫調控：探討代謝與免疫在癌症、神經退行性疾病及心血管疾病中的交互作用。 生物標誌物與轉譯醫學：開發癌症、心血管疾病與神經退行性疾病的生物標誌物，促進臨床應用。 細胞外囊泡與微環境調控：研究外泌體與腫瘤微環境在疾病進展中的角色，探索新療法。
Oncology & Drug Therapy: Developing targeted cancer therapies and evaluating novel applications of existing drugs. Metabolic & Immune Regulation: Investigating the interplay between metabolism, immune regulation, cancer, neurodegeneration, and cardiovascular diseases. Biomarkers & Translational Medicine: Identifying biomarkers for cancer, cardiovascular, and neurodegenerative diseases to facilitate clinical applications. Extracellular Vesicles & Microenvironment Modulation: Exploring the role of exosomes and the tumor microenvironment in disease progression and potential therapeutic strategies.
Area(s) of Expertise & Research
心血管疾病，癌症研究，神經科學
Cardiovascular diseases, Cancer research, Neuroscience
Publication
| NO | Publication |
|---|---|
| 1 | Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins and PD-L1 expression in human gastric cancer cells. Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins and PD-L1 expression in human gastric cancer cells. |
| 2 | Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function. Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function. |
| 3 | Vismodegib Potentiates Marine Antimicrobial Peptide Tilapia Piscidin 4-Induced Cytotoxicity in Human Non-Small Cell Lung Cancer Cells. Vismodegib Potentiates Marine Antimicrobial Peptide Tilapia Piscidin 4-Induced Cytotoxicity in Human Non-Small Cell Lung Cancer Cells. |
| 4 | Combination of Vismodegib and Paclitaxel Enhances Cytotoxicity via Bak-mediated Mitochondrial Damage in EGFR-Mutant Non-Small Cell Lung Cancer Cells. Combination of Vismodegib and Paclitaxel Enhances Cytotoxicity via Bak-mediated Mitochondrial Damage in EGFR-Mutant Non-Small Cell Lung Cancer Cells. |
| 5 | Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia. Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia. |
| 6 | Marine Antimicrobial Peptide Epinecidin-1 Inhibits Proliferation Induced by Lipoteichoic acid and Causes cell Death in non-small cell lung cancer Cells via Mitochondria Damage. Marine Antimicrobial Peptide Epinecidin-1 Inhibits Proliferation Induced by Lipoteichoic acid and Causes cell Death in non-small cell lung cancer Cells via Mitochondria Damage. |
| 7 | Antihypertensive agent losartan promotes tongue squamous cell carcinoma cell proliferation via EGFR/ERK1/2/cyclin D1 signaling axis. Antihypertensive agent losartan promotes tongue squamous cell carcinoma cell proliferation via EGFR/ERK1/2/cyclin D1 signaling axis. |
| 8 | High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice. High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice. |
| 9 | Dietary fatty acids differentially affect secretion of pro-inflammatory cytokines in human THP-1 monocytes. Dietary fatty acids differentially affect secretion of pro-inflammatory cytokines in human THP-1 monocytes. |
| 10 | Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. |
| 11 | High-Spatiotemporal-Resolution Ultrasound Flow Imaging to Determine Cerebrovascular Hemodynamics in Alzheimer's Disease Mice Model. High-Spatiotemporal-Resolution Ultrasound Flow Imaging to Determine Cerebrovascular Hemodynamics in Alzheimer's Disease Mice Model. |
| 12 | High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens. High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens. |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
115 — N 國科會(原科技部) — NSTC113-2320-B-037-027-MY3 — 1 個人型
核內TYRO3引發的胞外囊泡在大腸癌發展的功能與角色(3/3)( )
|
2026/08/01 ~ 2027/07/31 |
| 2 |
114 — N 國科會(原科技部) — NSTC113-2320-B-037-027-MY3 — 1 個人型
核內TYRO3引發的胞外囊泡在大腸癌發展的功能與角色(2/3)( )
|
2025/08/01 ~ 2027/07/31 |
| 3 |
113 — N 國科會(原科技部) — NSTC113-2320-B-037-027-MY3 — 1 個人型
核內TYRO3引發的胞外囊泡在大腸癌發展的功能與角色(1/3)( )
|
2024/08/01 ~ 2027/07/31 |
| 4 |
112 — Q 新聘教師計畫(校內) — KMU-Q113008 —
探討大腸癌中細胞核內TYRO3造成免疫檢查點抑制抗性的作用機制( )
|
2024/01/01 ~ 2024/12/31 |
| 5 |
111 — N 國科會(原科技部) — MOST109-2326-B-037-002-MY3 — 1 個人型
TYRO3人核在大腸直腸癌發展中的功能及角色(3/3)( )
|
2022/08/01 ~ 2023/07/31 |
| 6 |
111 — Q 新聘教師計畫(校內) — KMU-Q112004 —
探討BRD3是否與細胞核中TYRO3的胞內結構域作用而促進結直腸癌的發生( )
|
2023/01/01 ~ 2023/12/31 |
| 7 |
110 — N 國科會(原科技部) — MOST109-2326-B-037-002-MY3 — 1 個人型
TYRO3人核在大腸直腸癌發展中的功能及角色(2/3)( )
|
2022/02/01 ~ 2023/07/31 |