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 Education

School — Major — Degree Duration

國立成功大學 — 基礎醫學研究所(畢) — 博士

Doctorate, Department of Basic Medical Sciences, National Cheng Kung University

2009/09 — 2015/07

國立成功大學 — 細胞生物暨解剖學研究所(肄) — 碩士

Master, Department of Cell Biology and Anatomy, National Cheng Kung University

2008/09 — 2009/07

國立嘉義大學 — 生物資源學系(畢) — 學士

Bachelor, Department of Biological Resources, National ChiaYi University

2004/09 — 2008/07

 Intramural Experience

Office/Department/Institute Position Duration
解剖學科 Department of Anatomy   Associate Professor 2022/08/01 —  
解剖學科 Department of Anatomy   Assistant Professor 2019/02/01 — 2022/07/31

 Extramural Experience

 

 Discipline

NO Discipline Expertise
1 生物醫農類 Biology, Medicine and Agriculture 解剖、病理及法醫 Anatomy, Pathology and Forensic Medicine
2 科學教育類 Science Education 醫學教育 Medical Education

 Research & Technology Platform Open to the Outside

 

 Interested Area(s)for Interdisciplinary Research

轉譯醫學,實驗動物模式建立,神經退化疾病

 

 Area(s) of Expertise & Research

神經科學,神經退化疾病,阿茲海默症人體解剖學,組織學,神經解剖學,細胞生物學,蛋白質體學,神經退化疾病,阿茲海默症,神經病理

Human Anatomy, Histology, Neuroanatomy, Cell biology, Proteomics, Neurodegenerative Disease, Alzheimer's Disease, Neuropathology

 Publication

NO Publication
1

腎小管粒線體 ATP 合成酶功能障礙在馬來酸誘導的急性腎損傷中的關鍵作用
林祐賢, 梁展榮, 楊敏瑜, Phang-Lang Chen, 王子銘, 陳彥樺, 施耀翔, 劉旺達, 邱建智, 姜至剛, 林常申, 林含貞 - - 1 - APOPTOSIS - APOPTOSIS 2024 29卷(5-6期):620-634頁
(IF: 6.1, 領域排名: 47, 領域期刊數: 313, 領域排名: 15.02%)

Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury
Hugo Y-H Lin, Chan-Jung Liang, Ming-Yu Yang, Phang-Lang Chen, Tzu-Ming Wang, Yen-Hua Chen, Yao-Hsiang Shih, Wangta Liu, Chien-Chih Chiu, Chih-Kang Chiang, Chang-Shen Lin, Han-Chen Lin - - 1 - APOPTOSIS - APOPTOSIS 2024;29(5-6):620-634
(IF: 6.1, Journal Ranking: 47, Number of Journals of this Field: 313, Ranking: 15.02%)

2

利用甘露糖苷包覆阿黴素標靶治療MDA-MB-231乳癌細胞
蘇語涵, 林含貞#, 李幸燕, 連芷萱, 施耀翔, 賴千蕙* - - 1 - ACS Applied Nano Materials - ACS APPLIED NANO MATERIALS 2023 6卷(6期):4957-4968頁
(IF: 6.14, 領域排名: 101, 領域期刊數: 345, 領域排名: 29.28%)

Mannoside-Functionalized Silica Nanocomposite-Encapsulated Doxorubicin for MDA-MB-231 Cancer Cell Targeting and Delivery
Yu-Han Su, Han-Chen Lin, Hsing-Yen Li, Chih-Hsuan Lien, Yao-Hsiang Shih, Chian-Hui Lai* - - 1 - ACS Applied Nano Materials - ACS APPLIED NANO MATERIALS 2023;6(6):4957-4968
(IF: 6.14, Journal Ranking: 101, Number of Journals of this Field: 345, Ranking: 29.28%)

3

High-Frequency Fluctuation Intensity as a Predictor of Post-Stenotic Dilatation in Swine.
Bo-Wen Lin, Pao-Yen Lin, 施耀翔, Cheng-Lin Wu, Yeng-Ting Wu, Meei Jyh Jiang* - - 1 - IEEE TRANSACTIONS ON BIO-MEDICAL ENGINEERING - IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 2023 70卷(3期):991-999頁
(IF: 4.6, 領域排名: 34, 領域期刊數: 96, 領域排名: 35.42%)

High-Frequency Fluctuation Intensity as a Predictor of Post-Stenotic Dilatation in Swine.
Bo-Wen Lin, Pao-Yen Lin, Yao-Hsiang Shih, Cheng-Lin Wu, Yeng-Ting Wu, Meei Jyh Jiang - - 1 - IEEE TRANSACTIONS ON BIO-MEDICAL ENGINEERING - IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 2023;70(3):991-999
(IF: 4.6, Journal Ranking: 34, Number of Journals of this Field: 96, Ranking: 35.42%)

4

6-甲氧基黃酮通過抑制 TLR4/MyD88/p38 MAPK/NF-κB 依賴性通路和激活 HO-1/NQO-1 信號通路來抑制脂多醣刺激的小膠質細胞中的神經炎症
Wu-Fu Chen, 施耀翔, Hsuan-Chih Liu, Cheng-I Cheng, Chi-I Chang, Chung-Yi Chen, In-Pin Lin, 林美瑩, 李建興* - - 1 - Phytomedicine - PHYTOMEDICINE 2022 99卷(-期):154025頁
(IF: 6.656, 領域排名: 1, 領域期刊數: 30, 領域排名: 3.33%)

6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling
Wu-Fu Chen, Yao-Hsiang Shih, Hsuan-Chih Liu, Cheng-I Cheng, Chi-I Chang, Chung-Yi Chen, In-Pin Lin, Mei-Ying Lin, Chien-Hsing Lee* - - 1 - Phytomedicine - PHYTOMEDICINE 2022;99(-):154025
(IF: 6.656, Journal Ranking: 1, Number of Journals of this Field: 30, Ranking: 3.33%)

5

運動正常化高血壓小鼠的海馬迴腎素血管緊縮素系統並回復空間記憶、神經新生與血腦屏障滲漏
張瀛雙, 林志隆, Chu-Wan Lee, 林含貞, Yi-Ting Wu, 施耀翔* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022 23卷(10期):5531頁
(IF: 6.208, 領域排名: 69, 領域期刊數: 296, 領域排名: 23.31%)

Exercise Normalized the Hippocampal Renin-Angiotensin System and Restored Spatial Memory Function, Neurogenesis, and Blood-Brain Barrier Permeability in the 2K1C-Hypertensive Mouse
Ying-Shuang Chang, Chih-Lung Lin, Chu-Wan Lee, Han-Chen Lin, Yi-Ting Wu, Yao-Hsiang Shih* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022;23(10):5531
(IF: 6.208, Journal Ranking: 69, Number of Journals of this Field: 296, Ranking: 23.31%)

6

Zfra抑制TRAPPC6AΔ相關路徑引起的神經退化
Yu-Hao Lin, 施耀翔#, Ye Vone Yap, Yen-Wei Chen, Hsiang-Lin Kuo, Tsung-Yun Liu, Li-Jin Hsu, Yu-Min Kuo, Nan-Shan Chang* - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022 23卷(23期):14510頁
(IF: 6.208, 領域排名: 69, 領域期刊數: 296, 領域排名: 23.31%)

Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration
Yu-Hao Lin, Yao-Hsiang Shih#,Ye Vone Yap,Yen-Wei Chen,Hsiang-Lin Kuo, Tsung-Yun Liu, Li-Jin Hsu, Yu-Min Kuo, Nan-Shan Chang* - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022;23(23):14510
(IF: 6.208, Journal Ranking: 69, Number of Journals of this Field: 296, Ranking: 23.31%)

7

Exploring the Impact of Glyoxal Glycation on β-Amyloid Peptide (Aβ) Aggregation in Alzheimer's Disease.
Kai-Wei Hu, Hsiu-Fang Fan, 林含貞, Jian-Wei Huang, Yu-Chieh Chen, Cai-Ling Shen, 施耀翔, Ling-Hsien Tu* - - 1 - THE JOURNAL OF PHYSICAL CHEMISTRY. B - JOURNAL OF PHYSICAL CHEMISTRY B 2021 125卷(21期):5559-5571頁
(IF: 2.991, 領域排名: 93, 領域期刊數: 162, 領域排名: 57.41%)

Exploring the Impact of Glyoxal Glycation on β-Amyloid Peptide (Aβ) Aggregation in Alzheimer's Disease.
Kai-Wei Hu, Hsiu-Fang Fan, Han-Chen Lin, Jian-Wei Huang, Yu-Chieh Chen, Cai-Ling Shen, Yao-Hsiang Shih, Ling-Hsien Tu - - 1 - THE JOURNAL OF PHYSICAL CHEMISTRY. B - JOURNAL OF PHYSICAL CHEMISTRY B 2021;125(21):5559-5571
(IF: 2.991, Journal Ranking: 93, Number of Journals of this Field: 162, Ranking: 57.41%)

8

TDP-43在阿茲海默氏症模式中與乙型類澱粉蛋白共同作用、抑制纖維化並惡化病理
施耀翔, Ling-HsienTu#, Ting-Yu Chang, Kiruthika Ganesan, Wei-Wei Chang, Pao-Sheng Chang, Yu-Sheng Fang, Yeh-Tung Lin, Lee-Way Jin, Yun-Ru Chen* - - 1 - Nature communications - NATURE COMMUNICATIONS 2020 11卷(1期):5950頁
(IF: 14.919, 領域排名: 4, 領域期刊數: 73, 領域排名: 5.48%)

TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease
Yao-Hsiang Shih, Ling-Hsien Tu, Ting-Yu Chang, Kiruthika Ganesan, Wei-Wei Chang, Pao-Sheng Chang, Yu-Sheng Fang, Yeh-Tung Lin, Lee-Way Jin, Yun-Ru Chen* - - 1 - Nature communications - NATURE COMMUNICATIONS 2020;11(1):5950
(IF: 14.919, Journal Ranking: 4, Number of Journals of this Field: 73, Ranking: 5.48%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
113 — N 國科會(原科技部) — MOST111-2320-B-037-011-MY3 — 1 個人型
探討運動藉是否藉由Nrf1與粒線體生合成改善高血壓引起的空間記憶損傷(3/3)( )
2024/08/01 ~ 2025/07/31
2
112 — N 國科會(原科技部) — MOST111-2320-B-037-011-MY3 — 1 個人型
探討運動藉是否藉由Nrf1與粒線體生合成改善高血壓引起的空間記憶損傷(2/3)( )
2023/08/01 ~ 2025/07/31
3
112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-023-B — 8 大專學生研究計畫
113年度大專學生研究計畫-邱中昱(醫學2)( )
2024/07/01 ~ 2025/02/28
4
112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-024-B — 8 大專學生研究計畫
113年度大專學生研究計畫-陳祈帆(醫學2)( )
2024/07/01 ~ 2025/02/28
5
111 — N 國科會(原科技部) — MOST111-2320-B-037-011-MY3 — 1 個人型
探討運動藉是否藉由Nrf1與粒線體生合成改善高血壓引起的空間記憶損傷(1/3)( )
2022/08/01 ~ 2025/07/31
6
110 — M 高醫(種子計畫) — KMU-M111022 —  
探討運動改善高血壓引起的海馬依存性空間記憶受損機制:血管緊缩素與神經新生所扮演的角色( )
2022/01/01 ~ 2022/12/31
7
109 — N 國科會(原科技部) — MOST108-2320-B-037-040-MY2 — 1 個人型
探討中樞腎素-血管收縮素在高血壓影響腦功能及阿茲海默症的角色(2/2)( )
2020/11/01 ~ 2021/07/31
8
109 — Q 新聘教師計畫(校內) — KMU-Q110009A —  
探討中樞腎素-血管收縮素在高血壓影響腦功能及阿茲海默症的角色( )
2021/01/01 ~ 2021/12/31
9
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-015-B — 8 大專學生研究計畫
110年度大專學生研究計畫-邵仲儀(運醫2)( )
2021/07/01 ~ 2022/02/28
10
108 — N 國科會(原科技部) — MOST108-2320-B-037-040-MY2 — 1 個人型
探討中樞腎素-血管收縮素在高血壓影響腦功能及阿茲海默症的角色(1/2)( )
2019/11/01 ~ 2021/07/31
11
108 — Q 新聘教師計畫(校內) — KMU-Q109007 —  
探討中樞腎素-血管收縮素在高血壓影響腦功能及阿茲海默症的角色( )
2020/01/01 ~ 2020/12/31

 Patent