MENU

 Education

School ¡X Major ¡X Degree Duration

»O¥_Âå¾Ç¤j¾Ç ¡X ÃľǨt(²¦) ¡X ³Õ¤h

Doctorate, School of Pharmacy, Taipei Medical University

2000/09 ¡X 2008/06

»O¥_Âå¾Ç°| ¡X ÃľǬã¨s©Ò(²¦) ¡X ºÓ¤h

Master,  ,  

1998/09 ¡X 2000/06

»O¥_Âå¾Ç°| ¡X ÃľǨt(²¦) ¡X ¾Ç¤h

Bachelor,  ,  

1993/09 ¡X 1998/06

 Intramural Experience

Office/Department/Institute Position Duration
ÃľǨt School of Pharmacy   Professor 2024/08/01 ¡X  
ÃľǨt School of Pharmacy   Associate Professor 2021/02/01 ¡X 2024/07/31
ÃľǨt School of Pharmacy   Assistant Professor 2018/02/01 ¡X 2021/01/31

 Extramural Experience

DEPNO Position- Office/Department/Institute Duration
¤¸°öÂå¨Æ¬ì§Þ¤j¾Ç¥Íª«¬ì§Þº[»sÃħ޳N¨t °Æ±Ð±Â 1040201 ¡X 1070131
¤¸°öÂå¨Æ¬ì§Þ¤j¾Ç¥Íª«¬ì§Þº[»sÃħ޳N¨t §U²z±Ð±Â 0990901 ¡X 1040131

 Discipline

 

 Research & Technology Platform Open to the Outside

Drug delivery system development and solid dosage formulation design -immediate release(orally disintegrating tablet or orally dissolving tablet , Effervescent tablet). - Delayed controlled release dosage form (matrix, erosin, hydrophilic-gel type, membrane control type, osmotic pump type, pulse type) and Oral time-controlled and site-controlled drug delivery systems.

 Interested Area(s)for Interdisciplinary Research

¤fµÄ½Ã¥Í¡BÃÄùÛ«O°·­¹«~¡B¤¤¯óÃÄ¡B¥ÍÂå§÷®Æ¡B¹B°ÊÂå¾Ç

Oral hygiene, cosmeceutical health food, Chinese herbal medicine, biomedical materials, sports medicine.

 Area(s) of Expertise & Research

ÃĪ«¾¯«¬³]­p»P¶Ç»¼¨t²Î¡BÃľ¯¾Ç¡B¤u·~ÃľǡB±±ÄÀ»s¾¯¾ÇÃĪ«¾¯«¬¶}µo³]­p¡BÃĪ«¶Ç»¼¨t²Î¡BÃľ¯¾Ç¡B¤u·~ÃľǡB½Õ±±ÄÀ¾¯«¬¶}µo

Development and Design of drug dosage form, Drug delivery system, Pharmaceutics, Industrial pharmacy, Development of modified release dosage forms (extended-release, prolonged-release, controlled-release, slow release and sustained-release)

 Publication

NO Publication
1

¶W­µªi»²§U®ø¸Ñªº¥Ò»Ä²æ²Ó­M¥~°ò½è©M¿}´ß¯À©`¦ÌÅÖºû½Æ¦X¤ô¾®½¦»P´I§t¦å¤pªOªº¦å¼ßµ²¦X¥Î©ó¿}§¿¯f¶Ë¤fªvÀø
ªL¤d¦p#, ªL§»Â³#, Wen-Chen You, Hsiu-O Ho, Ming-Thau Sheu, Ling-Chun Chen*, Wei-Jie Cheng* - - 1 - Journal of Functional Biomaterials - JOURNAL OF FUNCTIONAL BIOMATERIALS 2023 14¨÷(8´Á):423­¶
(IF: 4.8, »â°ì±Æ¦W: 20, »â°ì´Á¥Z¼Æ: 45, »â°ì±Æ¦W: 44.44%)

Composite Hydrogels of Ultrasound-Assisted-Digested Formic Acid-Decellularized Extracellular Matrix and Sacchachitin Nanofibers Incorporated with Platelet-Rich Plasma for Diabetic Wound Treatment
Chien-Ju Lin#, Hong-Liang Lin#, Wen-Chen You, Hsiu-O Ho, Ming-Thau Sheu, Ling-Chun Chen*, Wei-Jie Cheng* - - 1 - Journal of Functional Biomaterials - JOURNAL OF FUNCTIONAL BIOMATERIALS 2023;14(8):423
(IF: 4.8, Journal Ranking: 20, Number of Journals of this Field: 45, Ranking: 44.44%)

2

¨Ï¥Î¦@¸ü©ó°ò©ó§ZÁC¯×ªº¦Û©`¦Ì¨Å¤Æ¹w¿@ÁYª« (LBSNEP) ¤¤ªº¦N¦è¥LÀØ©Mµµ§ü¾J¤fªA¸`«ßªvÀø¯ØŦÀù¡C
ªL¤d¦p, Wen-Ting Cheng, Ling-Chun Chen, Tzu-Ling Chen, Ming-Thau Sheu, ªL§»Â³* - - 1 - INTERNATIONAL JOURNAL OF PHARMACEUTICS - INTERNATIONAL JOURNAL OF PHARMACEUTICS 2023 645¨÷(-´Á):123370­¶
(IF: 5.8, »â°ì±Æ¦W: 40, »â°ì´Á¥Z¼Æ: 277, »â°ì±Æ¦W: 14.44%)

Oral metronomic therapy of pancreatic cancer with gemcitabine and paclitaxel co-loaded in lecithin-based Self-Nanoemulsifying preconcentrate (LBSNEP).
Chien-Ju Lin, Wen-Ting Cheng, Ling-Chun Chen, Tzu-Ling Chen, Ming-Thau Sheu, Hong-Liang Lin* - - 1 - INTERNATIONAL JOURNAL OF PHARMACEUTICS - INTERNATIONAL JOURNAL OF PHARMACEUTICS 2023;645(-):123370
(IF: 5.8, Journal Ranking: 40, Number of Journals of this Field: 277, Ranking: 14.44%)

3

Development of a Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) of Ciprofloxacin Hydrochloride
±ç¨|·¢, Wen-Ting Cheng, Ling-Chun Chen, Ming-Thau Sheu, ªL§»Â³* - - 1 - Pharmaceutics - PHARMACEUTICS 2023 15¨÷(5´Á):1428­¶
(IF: 5.4, »â°ì±Æ¦W: 51, »â°ì´Á¥Z¼Æ: 277, »â°ì±Æ¦W: 18.41%)

Development of a Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) of Ciprofloxacin Hydrochloride
Yu-Kai Liang, Wen-Ting Cheng, Ling-Chun Chen, Ming-Thau Sheu, Hong-Liang Lin* - - 1 - Pharmaceutics - PHARMACEUTICS 2023;15(5):1428
(IF: 5.4, Journal Ranking: 51, Number of Journals of this Field: 277, Ranking: 18.41%)

4

³z¹L²K¥[ßm¤þ¥ÒÅÖºû¯À©M³z©ú½è»Ä¨Ïªy¬¥¨F©i·»½¦¨ã¦³­ì¦ì¾®½¦©Ê©MÂH½¤ÂHªþ©Ê¡AÀ³¥Î©µªø¨¤½¤º¢¯d©MÃĪ«¿é°e
Ling-Chun Chen, Shyr-Yi Lin, Wei-Jie Cheng, Ming-Thau Sheu, Áéºöªå, Chen-Hsuan Hsu, ªL§»Â³* - - 1 - Drug Delivery - DRUG DELIVERY 2023 30¨÷(1´Á):2158964­¶
(IF: 6, »â°ì±Æ¦W: 37, »â°ì´Á¥Z¼Æ: 277, »â°ì±Æ¦W: 13.36%)

Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery
Ling-Chun Chen, Shyr-Yi Lin, Wei-Jie Cheng, Ming-Thau Sheu, Chi-Yun Chung, Chen-Hsuan Hsu, ªL§»Â³* - - 1 - Drug Delivery - DRUG DELIVERY 2023;30(1):2158964
(IF: 6, Journal Ranking: 37, Number of Journals of this Field: 277, Ranking: 13.36%)

5

¥ì¥ß´À±d»P¹p©¬Åð¯À©`¦Ì¨Å¤fªA¨Ö¥Î¨ó¦P¼W±j¯ØŦÀùÀø®Ä
Yu-Hsuan Liu, Ling-Chun Chen, Wen-Ting Cheng, Pu-Sheng Wei, Chien-Ming Hsieh, Ming-Thau Sheu, Shyr-Yi Lin, Hsiu-O Ho*, ªL§»Â³* - - 1 - Pharmaceutics - PHARMACEUTICS 2023 15¨÷(2´Á):473­¶
(IF: 5.4, »â°ì±Æ¦W: 51, »â°ì´Á¥Z¼Æ: 277, »â°ì±Æ¦W: 18.41%)

Synergistic Combination of Irinotecan and Rapamycin Orally Delivered by Nanoemulsion for Enhancing Therapeutic Efficacy of Pancreatic Cancer
Yu-Hsuan Liu, Ling-Chun Chen, Wen-Ting Cheng, Pu-Sheng Wei, Chien-Ming Hsieh, Ming-Thau Sheu, Shyr-Yi Lin, Hsiu-O Ho*, Hong-Liang Lin* - - 1 - Pharmaceutics - PHARMACEUTICS 2023;15(2):473
(IF: 5.4, Journal Ranking: 51, Number of Journals of this Field: 277, Ranking: 18.41%)

6

COVID-19 ¬Ì­]±µºØ»P±aª¬¯p¯lªºÃöÁp¡G¨t²Îµû»ù©M²Î¦X¤ÀªR
¦¶¹Å°¶, Zhu Liduzi Jiesisibieke, Yu-Pei Yang, §dÄ_¯], ªL§»Â³*, Tao-Hsin Tung* - - 1 - EXPERT REVIEW OF VACCINES - EXPERT REVIEW OF VACCINES 2022 21¨÷(5´Á):601-608­¶
(IF: 6.2, »â°ì±Æ¦W: 45, »â°ì´Á¥Z¼Æ: 161, »â°ì±Æ¦W: 27.95%)

Association of COVID-19 vaccination with herpes zoster: a systematic review and meta-analysis
Chia-Wei Chu, Zhu Liduzi Jiesisibieke, Yu-Pei Yang, Pao-Chu Wu, Hong-Liang Lin*, Tao-Hsin Tung* - - 1 - EXPERT REVIEW OF VACCINES - EXPERT REVIEW OF VACCINES 2022;21(5):601-608
(IF: 6.2, Journal Ranking: 45, Number of Journals of this Field: 161, Ranking: 27.95%)

7

利¥Î卵ÁC¯×°ò½è²V¦X»E¦Xª«·L­M(lbMPMs)來´£¤É«p¦µ×ô©M¤ì蘭¾Jªº·»¸Ñ度©M¥ÍÅé¥i¥Î率
ªL§»Â³, Wen-Ting Cheng, Ling-Chun Chen, Hsiu-O Ho, Shyr-Yi Lin*, Chien-Ming Hsieh* - - 1 - Int. J. Nanomed. - INTERNATIONAL JOURNAL OF NANOMEDICINE 2021 16¨÷(-´Á):651-665­¶
(IF: 7.033, »â°ì±Æ¦W: 31, »â°ì´Á¥Z¼Æ: 279, »â°ì±Æ¦W: 11.11%)

Honokiol/Magnolol-loaded Self-assembling Lecithin-based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability
Hong-Liang Lin(ªL§»Â³), Wen-Ting Cheng, Ling-Chun Chen, Hsiu-O Ho, Shyr-Yi Lin*, Chien-Ming Hsieh* - - 1 - Int. J. Nanomed. - INTERNATIONAL JOURNAL OF NANOMEDICINE 2021;16(-):651-665
(IF: 7.033, Journal Ranking: 31, Number of Journals of this Field: 279, Ranking: 11.11%)

8

¥H¤@Áç²£»s TEMPO ®ñ¤Æªº sacchachitin ©`¦ÌÅÖºû (TOSCNFs)±´°Q¼W±j°©¦A¥Í¥Î¤ä¬[
Meng-Huang Wu, Weu Wang, Fang-Ching Chao, Chien-Ming Hsieh, Ling-Chun Chen, ªL§»Â³, Hsiu-O Ho, Tsung-Jen Huang*, Ming-Thau Sheu*. - - 1 - Carbonhy Polym. - CARBOHYDRATE POLYMERS 2021 254¨÷(-´Á):117270­¶
(IF: 10.723, »â°ì±Æ¦W: 3, »â°ì´Á¥Z¼Æ: 90, »â°ì±Æ¦W: 3.33%)

One-pot fabrication of sacchachitin for production of TEMPO-oxidized sacchachitin nanofibers (TOSCNFs) utilized as scaffolds to enhance bone regeneration
Meng-Huang Wu, Weu Wang, Fang-Ching Chao, Chien-Ming Hsieh, Ling-Chun Chen, ªL§»Â³, Hsiu-O Ho, Tsung-Jen Huang*, Ming-Thau Sheu*. - - 1 - Carbonhy Polym. - CARBOHYDRATE POLYMERS 2021;254(-):117270
(IF: 10.723, Journal Ranking: 3, Number of Journals of this Field: 90, Ranking: 3.33%)

9

Rhizochitosan ªº»s³Æ©Mªí¼x¤Î¨ä»P¦å¤pªO¿@ÁYª«µ²¦X¹ï«P¶i¶Ë¤f¡¦X
Ling-Chun Chen, Shyr-Yi Lin, Ming-Thau Sheu, Ching-Hua Su, ªL§»Â³*, Chien-Ming Hsieh* - - 1 - Carbohydr Polym . - CARBOHYDRATE POLYMERS 2021 268¨÷(-´Á):118239­¶
(IF: 10.723, »â°ì±Æ¦W: 3, »â°ì´Á¥Z¼Æ: 90, »â°ì±Æ¦W: 3.33%)

Fabrication and characterization of Rhizochitosan and its incorporation with platelet concentrates to promote wound healing
Ling-Chun Chen, Shyr-Yi Lin, Ming-Thau Sheu, Ching-Hua Su, Hong-Liang Lin*, Chien-Ming Hsieh* - - 1 - Carbohydr Polym . - CARBOHYDRATE POLYMERS 2021;268(-):118239
(IF: 10.723, Journal Ranking: 3, Number of Journals of this Field: 90, Ranking: 3.33%)

10

CPT11»PP-¿}³J¥Õ/CYP 3A4Âù¥\¯à§í»s¾¯³q¹L¦Û¯Ç¦Ì¨Å¤Æ¯Ç¦Ì¨Åµ²¦X­Gº¢¯d§Þ³N´£°ª¹ï¯Ø¸¢Àùªº¤fªA¥ÍÅé¥i¥Î²v©MÀø®Ä
Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, ªL§»Â³*, Chien-Ming Hsieh* - - 1 - DRUG DELIVERY - DRUG DELIVERY 2021 28¨÷(1´Á):2205-2217­¶
(IF: 6.819, »â°ì±Æ¦W: 34, »â°ì´Á¥Z¼Æ: 279, »â°ì±Æ¦W: 12.19%)

CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas
Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin*, Chien-Ming Hsieh* - - 1 - DRUG DELIVERY - DRUG DELIVERY 2021;28(1):2205-2217
(IF: 6.819, Journal Ranking: 34, Number of Journals of this Field: 279, Ranking: 12.19%)

11

·s«¬¥i¿±µÈ©Mº}¯B¦¡­Gº¢¯dÃĪ«»¼°e¨t²Î¡]sfGRDDS¡^ªº»s³Æ©M¯S©Êªí¼xÀ³¥Î©ó´£ª@¥§¬¥´À¥§ªº¤fªA¥ÍÅé¥i¥Î²v
ªL§»Â³, Ling-Chun Chen, Wen-Ting Cheng, Wei-Jie Cheng, Hsiu-O Ho*, Ming-Thau Sheu - - 1 - Pharmaceutics - PHARMACEUTICS 2020 12¨÷(2´Á):137­¶
(IF: 6.321, »â°ì±Æ¦W: 29, »â°ì´Á¥Z¼Æ: 275, »â°ì±Æ¦W: 10.55%)

Preparation and Characterization of a Novel Swellable and Floating Gastroretentive Drug Delivery System (sfGRDDS) for Enhanced Oral Bioavailability of Nilotinib
Hong-Liang Lin, Ling-Chun Chen, Wen-Ting Cheng, Wei-Jie Cheng, Hsiu-O Ho* , Ming-Thau Sheu* - - 1 - Pharmaceutics - PHARMACEUTICS 2020;12(2):137
(IF: 6.321, Journal Ranking: 29, Number of Journals of this Field: 275, Ranking: 10.55%)

12

TEMPO®ñ¤Æ´X¤B¦hÁÞÅé©`¦ÌÅÖºû¡]TOSCNFs¡^µ²¦X¦å¤pªO¦å¼ß¡]PRP¡^ªvÀø°®²´¯g
ªL§»Â³, Ting-Huan Wu, Hsiu-O Ho, Fang-Ching Chao, Meng-Huang Wu, Der-Zen Liu, Ling-Chun Chen*, Ming-Thau Sheu* - - 1 - International Journal of Nanomedicine - INTERNATIONAL JOURNAL OF NANOMEDICINE 2020 15¨÷(-´Á):1721-1730­¶
(IF: 6.4, »â°ì±Æ¦W: 28, »â°ì´Á¥Z¼Æ: 275, »â°ì±Æ¦W: 10.18%)

TEMPO-Oxidized Sacchachitin Nanofibers (TOSCNFs) Combined with Platelet-Rich Plasma (PRP) for Management of Dry Eye Syndrome
Hong-Liang Lin, Ting-Huan Wu, Hsiu-O Ho, Fang-Ching Chao, Meng-Huang Wu, Der-Zen Liu, Ling-Chun Chen*, Ming-Thau Sheu* - - 1 - International Journal of Nanomedicine - INTERNATIONAL JOURNAL OF NANOMEDICINE 2020;15(-):1721-1730
(IF: 6.4, Journal Ranking: 28, Number of Journals of this Field: 275, Ranking: 10.18%)

13

Preparation and Characterization of Chemically TEMPO-oxidized and Mechanically Disintegrated Sacchachitin Nanofibers (SCNF) for Enhanced Diabetic Wound Healing
Fang-Ching Chao, Meng-Huang Wu, Ling-Chun Chen, ªL§»Â³, Der-Zen Liu, Hsiu-O Ho, Ming-Thau Sheu - - 1 - Carbohydrate Polymers - CARBOHYDRATE POLYMERS 2019 12¨÷(2´Á):7079¡X7094­¶
(IF: 6.044, »â°ì±Æ¦W: 2, »â°ì´Á¥Z¼Æ: 71, »â°ì±Æ¦W: 2.82%)

Preparation and Characterization of Chemically TEMPO-oxidized and Mechanically Disintegrated Sacchachitin Nanofibers (SCNF) for Enhanced Diabetic Wound Healing
Fang-Ching Chao, Meng-Huang Wu, Ling-Chun Chen, Hong-Liang Lin, Der-Zen Liu, Hsiu-O Ho, Ming-Thau Sheu - - 1 - Carbohydrate Polymers - CARBOHYDRATE POLYMERS 2019;12(2):7079¡X7094
(IF: 6.044, Journal Ranking: 2, Number of Journals of this Field: 71, Ranking: 2.82%)

14

µw¯×°ò»E¤A²m¨ÈÓi»P½è²É½Æ¦X§@¬°¤H¦å²M¥Õ³J¥Õ©`¦Ì²É¤l®Ö¤ß¥H«D¦@»ùµ²¦XCRISPR / Cas9½è²É©ÎsiRNA¡A¥Î©ó§K¬ÌªvÀø¯}Ãa©Î¨IÀqPD-L1ªí²{
Wei-Jie Cheng,Ling-Chun Chen,Hsiu-O Ho,ªL§»Â³*,Ming-Thau Sheu** - - 1 - International Journal of Nanomedicine - INTERNATIONAL JOURNAL OF NANOMEDICINE 2018 2¨÷(13´Á):7079¡X7094­¶
(IF: 4.37, »â°ì±Æ¦W: 31, »â°ì´Á¥Z¼Æ: 261, »â°ì±Æ¦W: 11.88%)

Stearyl polyethylenimine complexed with plasmids as the core of human serum albumin nanoparticles noncovalently bound to CRISPR/Cas9 plasmids or siRNA for disrupting or silencing PD-L1 expression for immunotherapy
Wei-Jie Cheng, Ling-Chun Chen, Hsiu-O Ho, Hong-Liang Lin*, Ming-Thau Sheu* - - 1 - International Journal of Nanomedicine - INTERNATIONAL JOURNAL OF NANOMEDICINE 2018;2(13):7079¡X7094
(IF: 4.37, Journal Ranking: 31, Number of Journals of this Field: 261, Ranking: 11.88%)

 Project

NO
YEAR ¡X Source ¡X No ¡X Type
Project Name
Duration
1
113 ¡X N °ê¬ì·|(­ì¬ì§Þ³¡) ¡X NSTC113-2221-E-037-003 ¡X 1 ­Ó¤H«¬
¶}µo¦P®É¨ã¦³Âù®ÄÄÀ©ñ(³t®Ä»Pªø®ÄÄÀ©ñ)¤§ªü¥ß?Ðüª`®g¾¯³B¤è³]­p©MÃĪ«°Ê¤O¾Ç¬ã¨s( )
2024/08/01 ~ 2025/07/31
2
112 ¡X N °ê¬ì·|(­ì¬ì§Þ³¡) ¡X NSTC112-2221-E-037-002 ¡X 1 ­Ó¤H«¬
«D¦¬ÁY«¬·Å±Ó·P©Ê»E¨Å»Ä¥Ì¾J»Ä­ì¦ì¤ô½¦ÅéÀ³¥Î©ó¥Ö¤U±±ÄÀÂù¯S²§©Êanti- PSMA/anti-CD3±µ¦X§ÜÅé( )
2023/08/01 ~ 2024/07/31
3
111 ¡X N °ê¬ì·|(­ì¬ì§Þ³¡) ¡X MOST111-2221-E-037-004 ¡X 1 ­Ó¤H«¬
¤fªA¦Û¨Å¤Æ·L¦Ì¨Å¾¯¥]¸üCPT-11¤Îrapamycin«P¶i¯ØŦÀùªvÀøªº¨ó¦P§@¥Î( )
2022/08/01 ~ 2023/09/30
4
109 ¡X N °ê¬ì·|(­ì¬ì§Þ³¡) ¡X MOST109-2320-B-037-018 ¡X 1 ­Ó¤H«¬
·s¦¡¦Û©`¦Ì¨Å¤Æ­Gº¢¯dÃĪ«»¼°e¨t²Î¨ó¦PP-ÁÞ³J¥Õ©M²Ó­M¦â¯À(3A4)Âù¥\¯à§í¨î¾¯´£¤ÉIrinotecan¤fªA¥ÍÅé¥i¥Î²v»PªvÀø®Ä¯à¬ã¨s( )
2020/08/01 ~ 2021/07/31
5
108 ¡X Z ¤j±M¾Ç¥Í¬ã¨s­pµe¤Î³Õ¤h«á ¡X MOST109-2813-C-037-001-E ¡X 8 ¤j±M¾Ç¥Í¬ã¨s­pµe
109¦~«×¤j±M¾Ç¥Í¬ã¨s­pµe-¶À³Í羣(ÃľÇ3)( )
2020/07/01 ~ 2021/02/28

 Patent