Research Profiles: 林文瑋, Wen-Wei Lin | Kaohsiung Medical University

Resume
Publication
Project
Patent

Education

School — Major — Degree	Duration
國立中山大學 — 生物醫學研究所(畢) — 博士 Doctorate, Institute of Biomedical Sciences, National Sun Yat-sen University	2011/09 — 2017/03
國立臺灣大學 — 口腔生物科學研究所(畢) — 碩士 Master, Graduate Institute of Oral Biology, National Taiwan University	2009/09 — 2011/06
高雄醫學大學 — 生物醫學暨環境生物學系(畢) — 學士 Bachelor, Department of Biomedical Science and Environment Biology, Kaohsiung Medical University	2005/09 — 2009/06

Intramural Experience

Office/Department/Institute	Position	Duration
研究發展處學術研究組 Division of Academic Research	Head	2024/08/01 — 2025/07/31
學士後醫學系 School of Post-Baccalaureate Medicine	Associate Professor	2022/08/01 —
學士後醫學系 School of Post-Baccalaureate Medicine	Assistant Professor	2020/08/01 — 2022/07/31
實驗診斷學科 Department of Laboratory Medicine	Assistant Professor	2018/02/01 — 2020/07/31

Discipline

NO	Discipline	Expertise
1	生物醫農類 Biology, Medicine and Agriculture	生物學之生化及分子生物 Biochemistry and Molecular Biology

Research & Technology Platform Open to the Outside

Genetic engineering, protein production, Lentivirus preparation

Interested Area(s)for Interdisciplinary Research

基因檢測、抗體藥物開發、蛋白藥物開發

Genetic diagnosis, Antibody drugs development, protein drugs development

Area(s) of Expertise & Research

免疫學、蛋白質體學、分子細胞生物學、實驗診斷學蛋白質藥物開發、分子免疫學、抗體基因工程、腫瘤生物學、臨床檢測

Protein drugs development, Molecular immunology, Antibody engineering, Cancer biology, clinical diagnosis

Publication

NO	Publication
1	Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication. 林文瑋, 黃奕中, 王焰增, 林昀萱, 賴凱洛, 陳建樹, 鄭添祿, 張誌祥, 呂玉玲, 陳巧雲, 莊智弘 - - 1 - VIRUS RESEARCH - VIRUS RESEARCH 2023 329卷(0期):199092頁 (IF: 5, 領域排名: 13, 領域期刊數: 36, 領域排名: 36.11%) Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication. Wen-Wei Lin, Yi-Jung Huang, Yen-Tseng Wang, Yun-Syuan Lin, Nonsikelelo Mazibuko, Chien-Shu Chen, Tian-Lu Cheng, Chih-Shiang Chang, Yu-Ling Leu, Chiao-Yun Chen, Chih-Hung Chuang - - 1 - VIRUS RESEARCH - VIRUS RESEARCH 2023;329(0):199092 (IF: 5, Journal Ranking: 13, Number of Journals of this Field: 36, Ranking: 36.11%)
2	A lesion selective albumin CTLA4Ig as a safe and effective treatment for collagen induced arthritis Jiang FY#, Zhang YZ#, Tai YH#, Chou CY, Hsieh YC, Chang YC, Huang HC, Li ZQ, 謝元欽, 陳怡如, 黃柏誠, 蘇昱誠, 林文瑋, Lin HC, Chao JI, 袁行修, 王雲銘, 鄭添祿, 鄒協成* - - 1 - Inflammation and Regeneration - INFLAMMATION AND REGENERATION 2023 1卷(43期):13頁 (IF: 8.1, 領域排名: 28, 領域期刊數: 161, 領域排名: 17.39%) A lesion selective albumin CTLA4Ig as a safe and effective treatment for collagen induced arthritis Jiang FY#, Zhang YZ#, Tai YH#, Chou CY, Hsieh YC, Chang YC, Huang HC, Li ZQ, Hsieh YC, Chen IJ, Huang BC, Su YC, Lin WW, Lin HC, Chao JI, Yuan SSF, Wang YM, Cheng TL, Tzou SC* - - 1 - Inflammation and Regeneration - INFLAMMATION AND REGENERATION 2023;1(43):13 (IF: 8.1, Journal Ranking: 28, Number of Journals of this Field: 161, Ranking: 17.39%)
3	A Low-Cost, Sensitive Reporter System Using Membrane-Tethered Horseradish Peroxidase for Efficient Gene Expression Analysis 張慕申, 李佳怡#, 劉恩碩, 趙玹, 吳歆瑜, 張語嫣, 留妍菱, 陳宇彤, 蘇昱誠, 王焰增, 鄭添祿, 顏嘉宏, 林政緯, 黃信凱, 林文瑋 - - 1 - Analytical Chemistry - ANALYTICAL CHEMISTRY 2023 95卷(38期):14341-14349頁 (IF: 7.4, 領域排名: 7, 領域期刊數: 86, 領域排名: 8.14%) A Low-Cost, Sensitive Reporter System Using Membrane-Tethered Horseradish Peroxidase for Efficient Gene Expression Analysis Chang MS, Lee CY#, Liu ES, Chao H, Wu HY, Chang YY, Liu YL, Chen YT, Su YC, Wang YT, Cheng TL, Yen CH, Lin CW, Huang HK, Lin WW - - 1 - Analytical Chemistry - ANALYTICAL CHEMISTRY 2023;95(38):14341-14349 (IF: 7.4, Journal Ranking: 7, Number of Journals of this Field: 86, Ranking: 8.14%)
4	Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis. 鄭凱文, 曾志華#, 陳怡如, 黃柏誠, 劉慧如, 何愷文, 林文瑋, 莊智弘, 黃旻儀, 呂玉玲, Steve R Roffler, 王焰增, 陳義龍, 鄭添祿 - - 1 - PHARMACOLOGICAL RESEARCH - PHARMACOLOGICAL RESEARCH 2022 177卷(1期):106115頁 (IF: 10.334, 領域排名: 15, 領域期刊數: 279, 領域排名: 5.38%) Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis. Kai-Wen Cheng, Chih-Hua Tseng#, I-Ju Chen, Bo-Cheng Huang, Hui-Ju Liu, Kai-Wen Ho, Wen-Wei Lin, Chih-Hung Chuang, Ming-Yii Huang, Yu-Lin Leu, Steve R Roffler, Jaw-Yuan Wang, Yeh-Long Chen, Tian-Lu Cheng - - 1 - PHARMACOLOGICAL RESEARCH - PHARMACOLOGICAL RESEARCH 2022;177(1):106115 (IF: 10.334, Journal Ranking: 15, Number of Journals of this Field: 279, Ranking: 5.38%)
5	Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group Minh-Tram T. Nguyen, 施宇謙#, 林夢璇#, 羅傅倫, 蕭巧郁, 鄭添祿, 林文瑋, 林恩琪, 鐘育志, 張晉源, 蘇昱誠 - - 1 - Communications Chemistry - COMMUNICATIONS CHEMISTRY 2022 5卷(1期):88頁 (IF: 7.211, 領域排名: 43, 領域期刊數: 179, 領域排名: 24.02%) Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group Minh-Tram T. Nguyen, Yu-Chien Shih#, Meng-Hsuan Lin#, Steve R. Roffler, Chiao-Yu Hsiao, Tian-Lu Cheng, Wen-Wei Lin, En-Chi Lin, Yuh-Jyh Jong, Chin-Yuan Chang, Yu-Cheng Su - - 1 - Communications Chemistry - COMMUNICATIONS CHEMISTRY 2022;5(1):88 (IF: 7.211, Journal Ranking: 43, Number of Journals of this Field: 179, Ranking: 24.02%)
6	Structural insights into Nirmatrelvir (PF-07321332)-3C-like SARS-CoV-2 protease complexation: a ligand Gaussian accelerated molecular dynamics study. 王焰增, 廖俊閔, 林文瑋, 李佳靜, 黃柏誠, 鄭添祿, 陳惇杰 - - 1 - PHYSICAL CHEMISTRY CHEMICAL PHYSICS : PCCP - PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2022 24卷(37期):22898-22904頁 (IF: 3.945, 領域排名: 9, 領域期刊數: 36, 領域排名: 25.00%) Structural insights into Nirmatrelvir (PF-07321332)-3C-like SARS-CoV-2 protease complexation: a ligand Gaussian accelerated molecular dynamics study. Yeng-Tseng Wang, Jun-Min Liao, Wen-Wei Lin, Chia-Ching Li, Bo-Cheng Huang, Tian-Lu Cheng, Tun-Chieh Chen - - 1 - PHYSICAL CHEMISTRY CHEMICAL PHYSICS : PCCP - PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2022;24(37):22898-22904 (IF: 3.945, Journal Ranking: 9, Number of Journals of this Field: 36, Ranking: 25.00%)
7	Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules Hsiao CY, Meng JL#, Hong JZ, Ly XH, Lin MH, Chang CY, Minh-Tram T Nguyen, 鄭添祿, 林文瑋, Pierre-Alain Burnouf, Talal Salem Al-Qaisi, 劉恩碩, 蘇昱誠* - - 1 - Bioconjugate Chemistry - BIOCONJUGATE CHEMISTRY 2022 33卷(11期):2180-2188頁 (IF: 4.7, 領域排名: 13, 領域期刊數: 77, 領域排名: 16.88%) Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules Hsiao CY, Meng JL#, Hong JZ, Ly XH, Lin MH, Chang CY, Minh-Tram T Nguyen, Cheng TL, Lin WW, Pierre-Alain Burnouf, Talal Salem Al-Qaisi, Liu ES, Su YC* - - 1 - Bioconjugate Chemistry - BIOCONJUGATE CHEMISTRY 2022;33(11):2180-2188 (IF: 4.7, Journal Ranking: 13, Number of Journals of this Field: 77, Ranking: 16.88%)
8	Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe 莊智弘, 鄭添祿, 陳威鈞, 黃奕中, 王信二, 駱彥成, 謝元欽, 林文瑋, 謝雅茹, 柯建志, 黃抗節, 李景欽, 黃旼儀 - - 1 - Frontiers in Microbiology - FRONTIERS IN MICROBIOLOGY 2022 13卷(-期):896588頁 (IF: 6.064, 領域排名: 34, 領域期刊數: 136, 領域排名: 25.00%) Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe Chuang CH, Cheng TL, Chen WC, Huang YJ, Wang HE, Lo YC, Hsieh YC, Lin WW, Hsieh YJ, Ke CC, Huang KC, Lee JC, Huang MY - - 1 - Frontiers in Microbiology - FRONTIERS IN MICROBIOLOGY 2022;13(-):896588 (IF: 6.064, Journal Ranking: 34, Number of Journals of this Field: 136, Ranking: 25.00%)
9	Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group. Minh-Tram T Nguyen#, Yu-Chien Shih#, Meng-Hsuan Lin#, 羅傅倫, Chiao-Yu Hsiao, 鄭添祿, 林文瑋, En-Chi Lin, 鐘育志, 張晉源, 蘇昱誠 - - 1 - COMMUNICATIONS CHEMISTRY - COMMUNICATIONS CHEMISTRY 2022 5卷(1期):88頁 (IF: 5.9, 領域排名: 51, 領域期刊數: 178, 領域排名: 28.65%) Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group. Minh-Tram T Nguyen, Yu-Chien Shih, Meng-Hsuan Lin, Steve R Roffler, Chiao-Yu Hsiao, Tian-Lu Cheng, Wen-Wei Lin, En-Chi Lin, Yuh-Jyh Jong, Chin-Yuan Chang, Yu-Cheng Su - - 1 - COMMUNICATIONS CHEMISTRY - COMMUNICATIONS CHEMISTRY 2022;5(1):88 (IF: 5.9, Journal Ranking: 51, Number of Journals of this Field: 178, Ranking: 28.65%)
10	Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy. 林文瑋, 鄭以安, 李佳靜, 何愷文, 陳慧蓁, 陳怡如, 黃柏誠, 劉蕙如, 呂韻綺, 鄭秋敏, 黃旼儀, 賴鴻文, 鄭添祿 - - 1 - Scientific reports - SCIENTIFIC REPORTS 2021 11卷(1期):7598頁 (IF: 4.996, 領域排名: 19, 領域期刊數: 73, 領域排名: 26.03%) Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy. Wen-Wei Lin, Yi-An Cheng, Chia-Ching Li, Kai-Wen Ho, Huei-Jen Chen, I-J U Chen, Bo-Cheng Huang, Hui-Ju Liu, Yun-Chi Lu, Chiu-Min Cheng, Ming-Yii Huang, Hung-Wen Lai, Tian-Lu Cheng* - - 1 - Scientific reports - SCIENTIFIC REPORTS 2021;11(1):7598 (IF: 4.996, Journal Ranking: 19, Number of Journals of this Field: 73, Ranking: 26.03%)
11	Fibrinogen-Like Protein 1 Serves as an Anti-Inflammatory Agent for Collagen-Induced Arthritis Therapy in Mice 林文瑋, 何愷文, 蘇湘涵, 方恬芳, 鄒協成, 陳怡如, 呂韻綺, 張慕申, 蔡允榛, 劉恩碩, 蘇昱誠, 王焰增, 鄭添祿, 黃信凱 - - 1 - Frontiers in Immunology - FRONTIERS IN IMMUNOLOGY 2021 12卷(-期):767868頁 (IF: 8.786, 領域排名: 33, 領域期刊數: 161, 領域排名: 20.50%) Fibrinogen-Like Protein 1 Serves as an Anti-Inflammatory Agent for Collagen-Induced Arthritis Therapy in Mice Lin WW, Ho KW, Su HH, Fang TF, Tzou SC, Chen IJ, Lu YC, Chang MS, Tsai YC, Liu ES, Su YC, Wang YT, Cheng TL, Huang HK - - 1 - Frontiers in Immunology - FRONTIERS IN IMMUNOLOGY 2021;12(-):767868 (IF: 8.786, Journal Ranking: 33, Number of Journals of this Field: 161, Ranking: 20.50%)
12	Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy. 林文瑋, 呂韻綺, 黃柏誠, 莊智弘, 鄭以安, 陳怡如, 劉蕙如, 何愷文, 廖子毅, 劉恩碩, 吳亭儀, 張榮賢, 洪詩婷, 鄭添祿 - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2021 11卷(1期):14846頁 (IF: 4.996, 領域排名: 19, 領域期刊數: 73, 領域排名: 26.03%) Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy. Wen-Wei Lin, Yun-Chi Lu, Bo-Cheng Huang, Chih-Hung Chuang, Yi-An Cheng, I-Ju Chen, Hui-Ju Liu, Kai-Wen Ho, Tzu-Yi Liao, En-Shuo Liu, Ting-Yi Wu, Long-Sen Chang, Shih-Ting Hong, Tian-Lu Cheng - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2021;11(1):14846 (IF: 4.996, Journal Ranking: 19, Number of Journals of this Field: 73, Ranking: 26.03%)
13	Ab Locks for Improving the Selectivity and Safety of Antibody Drugs 林文瑋, 呂韻綺, 莊智弘, 鄭添祿* - - 1 - Journal of Biomedical Science - JOURNAL OF BIOMEDICAL SCIENCE 2020 27卷(1期):76頁 (IF: 8.41, 領域排名: 15, 領域期刊數: 140, 領域排名: 10.71%) Ab Locks for Improving the Selectivity and Safety of Antibody Drugs Wen-Wei Lin, Yun-Chi Lu, Chih-Hung Chuang, Tian-Lu Cheng* - - 1 - Journal of Biomedical Science - JOURNAL OF BIOMEDICAL SCIENCE 2020;27(1):76 (IF: 8.41, Journal Ranking: 15, Number of Journals of this Field: 140, Ranking: 10.71%)
14	Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes. 陳怡如, 鄭以安, 何愷文, 林文瑋, 鄭凱文, 呂韻綺, 謝元欽, 黃建喬, 莊智弘, 陳芳銘, 蘇昱誠, 羅傅倫, 鄭添祿 - - 1 - Acta biomaterialia - ACTA BIOMATERIALIA 2020 111卷(-期):386-397頁 (IF: 8.947, 領域排名: 10, 領域期刊數: 90, 領域排名: 11.11%) Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes. I-Ju Chen, Yi-An Cheng, Kai-Wen Ho, Wen-Wei Lin, Kai-Wen Cheng, Yun-Chi Lu, Yuan-Chin Hsieh, Chien-Chiao Huang, Chih-Hung Chuang, Fang-Ming Chen, Yu-Cheng Su, Steve R Roffler, Tian-Lu Cheng - - 1 - Acta biomaterialia - ACTA BIOMATERIALIA 2020;111(-):386-397 (IF: 8.947, Journal Ranking: 10, Number of Journals of this Field: 90, Ranking: 11.11%)
15	以分子模擬進行 Tsg101 UEV 蛋白與環狀胜肽抑制劑之研究林文瑋, 王郁仁, 柯正雯, 鄭添祿, 王焰增* - - 1 - Polymers - POLYMERS 2020 12卷(10期):2235頁 (IF: 4.329, 領域排名: 18, 領域期刊數: 88, 領域排名: 20.45%) Cyclic Peptide Inhibitors of the Tsg101 UEV Protein Interactions Refined through Global Docking and Gaussian Accelerated Molecular Dynamics Simulations Wen-Wei Lin, Yu-Jen Wang, Cheng-Wen Ko, Tain-Lu Cheng, Yeng-Tseng Wang* - - 1 - Polymers - POLYMERS 2020;12(10):2235 (IF: 4.329, Journal Ranking: 18, Number of Journals of this Field: 88, Ranking: 20.45%)
16	Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer 鄭以安#, 陳怡如#, 蘇昱誠, 鄭凱文, 呂韻綺, 林文瑋, 謝元欽, 高千涵, 陳芳銘, 羅傅倫, 鄭添祿 - - 1 - Biomaterials Science - BIOMATERIALS SCIENCE 2019 7卷(8期):3404-3417頁 (IF: 6.183, 領域排名: 6, 領域期刊數: 38, 領域排名: 15.79%) Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer Cheng YA#, Chen IJ#, Su YC, Cheng KW, Lu YC, Lin WW, Hsieh YC, Kao CH, Chen FM, Roffler SR, Cheng TL - - 1 - Biomaterials Science - BIOMATERIALS SCIENCE 2019;7(8):3404-3417 (IF: 6.183, Journal Ranking: 6, Number of Journals of this Field: 38, Ranking: 15.79%)
17	Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein 黃建喬#, 鄭凱文#, 謝元欽, 林文瑋, 鄭秋敏, 袁行修, 陳怡如, 鄭以安, 黃柏誠, 呂韻綺, 董宜青, 鄭添祿 - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2019 9卷(1期):9931頁 (IF: 3.998, 領域排名: 17, 領域期刊數: 71, 領域排名: 23.94%) Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein Huang CC, Cheng KW, Hsieh YC, Lin WW, Cheng CM, Yuan SS, Chen IJ, Cheng YA, Huang BC, Lu YC, Tung YC, Cheng TL - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2019;9(1):9931 (IF: 3.998, Journal Ranking: 17, Number of Journals of this Field: 71, Ranking: 23.94%)
18	聚乙二醇的IgM和IgG抗體均可以改變甲氧基聚乙二醇-表觀蛋白β在小鼠中的生物活性張恬靜, 陳炳梅, 林文瑋, 余珮華, 邱怡文, 陳垣崇, 鄔哲源, 鄭添祿, 黃道揚, 羅傅倫 - - 1 - Pharmaceutics - PHARMACEUTICS 2019 12卷(1期):15頁 (IF: 4.421, 領域排名: 44, 領域期刊數: 270, 領域排名: 16.30%) Both IgM and IgG Antibodies Against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice Chang TC, Chen BM, Lin WW, Yu PH, Chiu YW, Chen YT, Wu JY, Cheng TL, Hwang DY, Roffler AS - - 1 - Pharmaceutics - PHARMACEUTICS 2019;12(1):15 (IF: 4.421, Journal Ranking: 44, Number of Journals of this Field: 270, Ranking: 16.30%)
19	Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy 呂韻綺#, 莊智弘#, 莊國祥, 陳怡如, 黃柏誠, 李文翰, 王信二, 李哲嘉, 鄭以安, 鄭凱文, 王照元, 謝元欽, 林文瑋, 鄭添祿 - - 1 - PLoS Biology - PLOS BIOLOGY 2019 17卷(6期):e3000286頁 (IF: 7.076, 領域排名: 6, 領域期刊數: 93, 領域排名: 6.45%) Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy Lu YC#, Chuang CH#, Chuang KH, Chen IJ, Huang BC, Lee WH, Wang HE, Li JJ, Cheng YA, Cheng KW, Wang JY, Hsieh YC, Lin WW, Cheng TL - - 1 - PLoS Biology - PLOS BIOLOGY 2019;17(6):e3000286 (IF: 7.076, Journal Ranking: 6, Number of Journals of this Field: 93, Ranking: 6.45%)
20	建構可被蛋白酶活化的選擇性抗體陳怡如,莊智弘#, 謝元欽,呂韻綺,林文瑋,黃建喬,鄭達駿,鄭以安,鄭凱文,王焰增,陳芳銘,鄭添祿,鄒協成 - - 1 - Scientific Reports - Scientific Reports 2017 14卷(7期):11587頁 (IF: 4.122, 領域排名: 12, 領域期刊數: 64, 領域排名: 18.75%) Selective antibody activation through protease-activated proantibodies that mask binding sites with inhibitory domains I-Ju Chen, Chih-Hung Chuang#, Yuan-Chin Hsieh, Yun-Chi Lu, Wen-Wei Lin, Chien-Chiao Huang, Ta-Chun Cheng, Yi-An Cheng, Kai-Wen Cheng, Yeng-Tseng Wang, Fang-Ming Chen, Tian-Lu Cheng and Shey-Cherng Tzou. - - 1 - Scientific Reports - Scientific Reports 2017;14(7):11587 (IF: 4.122, Journal Ranking: 12, Number of Journals of this Field: 64, Ranking: 18.75%)
21	Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules 林文瑋,謝元欽,鄭以安,莊國祥,黃建喬,莊智弘,陳怡如,鄭凱文,呂韻綺,鄭達駿,王焰曾,羅傅倫,鄭添祿 - - 1 - ANALYTICAL CHEMISTRY - Anal Chem 2016 20卷(88期):12371-12379頁 (IF: 6.3, 領域排名: 4, 領域期刊數: 76, 領域排名: 5.26%) Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules Lin, Wen-Wei; Hsieh, Yuan-Chin; Cheng, Yi-An; Chuang, Kuo-Hsiang; Huang, Chien-Chiao; Chuang, Chih-Hung; Chen, I-Ju ; Cheng, Kai-Wen; Lu, Yun-Chi ; Cheng, Ta-Chun; Wang, Yeng-Tseng; Roffler, Steve; Cheng, Tian-Lu. - - 1 - ANALYTICAL CHEMISTRY - Anal Chem 2016;20(88):12371-12379 (IF: 6.3, Journal Ranking: 4, Number of Journals of this Field: 76, Ranking: 5.26%)
22	上皮細胞粘附分子透過激活重編程因子和結腸癌中上皮間質轉化基因表達調節腫瘤起始和腫瘤發生林政緯, 廖美英, 林文瑋, 王逸平, 呂東盈, 吳漢忠 - - 1 - The Journal of Biological Chemistry - J Biol Chem 2012 287卷(47期):39449-59頁 (IF: 4.773, 領域排名: 66, 領域期刊數: 290, 領域排名: 22.76%) Epithelial Cell Adhesion Molecule Regulates Tumor Initiation and Tumorigenesis via Activating Reprogramming Factors and Epithelial-Mesenchymal Transition Gene Expression in Colon Cancer Lin CW, Liao MY, Lin WW, Wang YP, Lu TY, Wu HC - - 1 - The Journal of Biological Chemistry - J Biol Chem 2012;287(47):39449-59 (IF: 4.773, Journal Ranking: 66, Number of Journals of this Field: 290, Ranking: 22.76%)

Project

NO	YEAR — Source — No — Type Project Name	Duration
1	113 — N 國科會(原科技部) — NSTC113-2314-B-037-042 — 1 個人型開發具蛋白?活化特性之前驅抗程序細胞死亡蛋白一型抗體以提升來那度胺與地塞米松合併治療多發性骨髓瘤之療效與安全性( )	2024/08/01 ~ 2025/07/31
2	112 — DK 前瞻重點(原校院) — KMU-DK(A)113013 — 探討纖維原樣蛋白加速類風濕性關節炎小鼠模式肺部發炎之機制與治療策略( )	2024/01/01 ~ 2024/12/31
3	112 — N 國科會(原科技部) — NSTC112-2628-B-037-001 — 1 個人型開發蛋白酶可激活之前驅抗原嵌合受體T細胞(Pro-CAR-T)以提升免疫細胞療法對疾病區域之選擇性、抗癌療效並降低副作用(3/3)( )	2023/08/01 ~ 2024/07/31
4	112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-081-B — 8 大專學生研究計畫 113年度大專學生研究計畫-黃稜燁(生物3)( )	2024/07/01 ~ 2025/02/28
5	112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-082-B — 8 大專學生研究計畫 113年度大專學生研究計畫-楊雅婷(生物3)( )	2024/07/01 ~ 2025/02/28
6	111 — DK 前瞻重點(原校院) — KMU-DK(B)112002-1 — 2 整合型開發前驅抗 ROR1 嵌合受體 T 細胞以治療三陰性乳癌並降低副作用( )	2023/01/01 ~ 2023/12/31
7	111 — N 國科會(原科技部) — MOST111-2628-B-037-010 — 1 個人型開發蛋白酶可激活之前驅抗原嵌合受體T細胞(Pro-CAR-T)以提升免疫細胞療法對疾病區域之選擇性、抗癌療效並降低副作用(2/3)( )	2022/08/01 ~ 2023/07/31
8	110 — DK 前瞻重點(原校院) — KMU-DK(B)111004-1 — 探討妙利散益生菌與 β-catenin 抑制劑可轉換免疫活性低腫瘤(cold tumor)為免疫活性高腫瘤(hot tumor)之機制( )	2022/01/01 ~ 2022/12/31
9	110 — N 國科會(原科技部) — MOST110-2628-B-037-010 — 1 個人型開發蛋白酶可激活之前驅抗原嵌合受體T細胞(Pro-CAR-T)以提升免疫細胞療法對疾病區域之選擇性、抗癌療效並降低副作用(1/3)( )	2021/08/01 ~ 2022/07/31
10	110 — NK 高醫-中山合作計畫 — — 2 整合型以阿茲海默症小鼠動物模式探討對酸鹼度可控的雙功能抗體於活體內之藥物動力學、生物分布與治療療效( )	2021/01/01 ~ 2021/12/31
11	110 — Z 大專學生研究計畫及博士後 — MOST111-2813-C-037-031-B — 8 大專學生研究計畫 111年度大專學生研究計畫-鄭瓔(生物3)( )	2022/07/01 ~ 2023/02/28
12	109 — DK 前瞻重點(原校院) — KMU-DK(B)110006-3 — 建立商品化anti-PEG抗體檢測ELISA kit來檢測病人血清中anti-PEG抗體含量用以最佳化PEG修飾藥物(Lipo-Dox)之使用( )	2021/01/01 ~ 2021/12/31
13	109 — KC 高醫陽明交大 — NCTUKMU109-DR-02 — 1 個人型以HepG2細胞模式探討抗發炎藥物治療脂肪肝差異表現基因( )	2020/08/01 ~ 2021/07/31
14	109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-037-B — 8 大專學生研究計畫 110年度大專學生研究計畫-李佳怡(生技3)( )	2021/07/01 ~ 2022/02/28
15	109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-038-B — 8 大專學生研究計畫 110年度大專學生研究計畫-蔡允榛(生技3)( )	2021/07/01 ~ 2022/02/28
16	108 — DK 前瞻重點(原校院) — KMU-DK(整)109004~3 — PolyGlycero修飾藥物的免疫性測試及檢測試劑開發( )	2020/01/01 ~ 2020/12/31
17	108 — N 國科會(原科技部) — MOST107-2320-B-037-028-MY2 — 1 個人型開發可被蛋白酶水解之釋控雙功能抗體以穿透血腦障壁並提升阿茲海默症治療效果(2/2)( )	2019/08/01 ~ 2020/07/31
18	108 — NK 高醫-中山合作計畫 — NSYSUKMU108-I008-3 — 2 整合型利用晶體結構解析高親和力anti-PD-1 抗體-抗原複合物之正確結合位以優化電腦預測系統之精確性( )	2019/01/01 ~ 2019/12/31
19	108 — Q 新聘教師計畫(校內) — KMU-Q109002 — 開發Pro-Canakinumab (Pro-anti-IL-1β Ab)前驅抗體藥物選擇性中和病灶區之IL-1β抗原以提升慢性阻塞性肺病療效並降低副作用( )	2020/01/01 ~ 2020/12/31
20	108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-043-B — 8 大專學生研究計畫 109年度大專學生研究計畫-方恬芳(生技3)( )	2020/07/01 ~ 2021/02/28
21	107 — N 國科會(原科技部) — MOST107-2320-B-037-028-MY2 — 1 個人型開發可被蛋白酶水解之釋控雙功能抗體以穿透血腦障壁並提升阿茲海默症治療效果(1/2)( )	2018/08/01 ~ 2020/07/31
22	107 — Q 新聘教師計畫(校內) — KMU-Q108001 — 利用腫瘤浸潤B細胞開發新穎大腸直腸癌症診斷及治療標的之專一性抗體藥物( )	2019/01/01 ~ 2019/12/31
23	107 — Y 高醫-彰基合作計畫 — 108-CCH-KMU-010 — 1 個人型雙功能抗體(αHER2�~α-mPEG)一步製程賦予糖苷轉換微脂體(GSL)腫瘤專一性，以提升乳癌及卵巢癌之標靶療效( )	2019/01/01 ~ 2019/12/31

Patent

NO	Patent Name	Country	Certified Date	Patent No
1	二級抗體所辨識之抗原決定位及其用途	中華民國	2017/08/01	I593967
2	二級抗體所辨識之抗原決定位及其用途	美國	2016/10/04	9,458,243
3	二級抗體所辨識之抗原決定位及其用途	美國	2019/01/15	10,180,433
4	控制蚊媒傳染疾病傳播之微生物製劑	中華民國	2021/05/21	I728264

NO	Publication
1	Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication. 林文瑋, 黃奕中, 王焰增, 林昀萱, 賴凱洛, 陳建樹, 鄭添祿, 張誌祥, 呂玉玲, 陳巧雲, 莊智弘 - - 1 - VIRUS RESEARCH - VIRUS RESEARCH 2023 329卷(0期):199092頁 (IF: 5, 領域排名: 13, 領域期刊數: 36, 領域排名: 36.11%) Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication. Wen-Wei Lin, Yi-Jung Huang, Yen-Tseng Wang, Yun-Syuan Lin, Nonsikelelo Mazibuko, Chien-Shu Chen, Tian-Lu Cheng, Chih-Shiang Chang, Yu-Ling Leu, Chiao-Yun Chen, Chih-Hung Chuang - - 1 - VIRUS RESEARCH - VIRUS RESEARCH 2023;329(0):199092 (IF: 5, Journal Ranking: 13, Number of Journals of this Field: 36, Ranking: 36.11%)
2	A lesion selective albumin CTLA4Ig as a safe and effective treatment for collagen induced arthritis Jiang FY#, Zhang YZ#, Tai YH#, Chou CY, Hsieh YC, Chang YC, Huang HC, Li ZQ, 謝元欽, 陳怡如, 黃柏誠, 蘇昱誠, 林文瑋, Lin HC, Chao JI, 袁行修, 王雲銘, 鄭添祿, 鄒協成* - - 1 - Inflammation and Regeneration - INFLAMMATION AND REGENERATION 2023 1卷(43期):13頁 (IF: 8.1, 領域排名: 28, 領域期刊數: 161, 領域排名: 17.39%) A lesion selective albumin CTLA4Ig as a safe and effective treatment for collagen induced arthritis Jiang FY#, Zhang YZ#, Tai YH#, Chou CY, Hsieh YC, Chang YC, Huang HC, Li ZQ, Hsieh YC, Chen IJ, Huang BC, Su YC, Lin WW, Lin HC, Chao JI, Yuan SSF, Wang YM, Cheng TL, Tzou SC* - - 1 - Inflammation and Regeneration - INFLAMMATION AND REGENERATION 2023;1(43):13 (IF: 8.1, Journal Ranking: 28, Number of Journals of this Field: 161, Ranking: 17.39%)
3	A Low-Cost, Sensitive Reporter System Using Membrane-Tethered Horseradish Peroxidase for Efficient Gene Expression Analysis 張慕申, 李佳怡#, 劉恩碩, 趙玹, 吳歆瑜, 張語嫣, 留妍菱, 陳宇彤, 蘇昱誠, 王焰增, 鄭添祿, 顏嘉宏, 林政緯, 黃信凱, 林文瑋 - - 1 - Analytical Chemistry - ANALYTICAL CHEMISTRY 2023 95卷(38期):14341-14349頁 (IF: 7.4, 領域排名: 7, 領域期刊數: 86, 領域排名: 8.14%) A Low-Cost, Sensitive Reporter System Using Membrane-Tethered Horseradish Peroxidase for Efficient Gene Expression Analysis Chang MS, Lee CY#, Liu ES, Chao H, Wu HY, Chang YY, Liu YL, Chen YT, Su YC, Wang YT, Cheng TL, Yen CH, Lin CW, Huang HK, Lin WW - - 1 - Analytical Chemistry - ANALYTICAL CHEMISTRY 2023;95(38):14341-14349 (IF: 7.4, Journal Ranking: 7, Number of Journals of this Field: 86, Ranking: 8.14%)
4	Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis. 鄭凱文, 曾志華#, 陳怡如, 黃柏誠, 劉慧如, 何愷文, 林文瑋, 莊智弘, 黃旻儀, 呂玉玲, Steve R Roffler, 王焰增, 陳義龍, 鄭添祿 - - 1 - PHARMACOLOGICAL RESEARCH - PHARMACOLOGICAL RESEARCH 2022 177卷(1期):106115頁 (IF: 10.334, 領域排名: 15, 領域期刊數: 279, 領域排名: 5.38%) Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis. Kai-Wen Cheng, Chih-Hua Tseng#, I-Ju Chen, Bo-Cheng Huang, Hui-Ju Liu, Kai-Wen Ho, Wen-Wei Lin, Chih-Hung Chuang, Ming-Yii Huang, Yu-Lin Leu, Steve R Roffler, Jaw-Yuan Wang, Yeh-Long Chen, Tian-Lu Cheng - - 1 - PHARMACOLOGICAL RESEARCH - PHARMACOLOGICAL RESEARCH 2022;177(1):106115 (IF: 10.334, Journal Ranking: 15, Number of Journals of this Field: 279, Ranking: 5.38%)
5	Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group Minh-Tram T. Nguyen, 施宇謙#, 林夢璇#, 羅傅倫, 蕭巧郁, 鄭添祿, 林文瑋, 林恩琪, 鐘育志, 張晉源, 蘇昱誠 - - 1 - Communications Chemistry - COMMUNICATIONS CHEMISTRY 2022 5卷(1期):88頁 (IF: 7.211, 領域排名: 43, 領域期刊數: 179, 領域排名: 24.02%) Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group Minh-Tram T. Nguyen, Yu-Chien Shih#, Meng-Hsuan Lin#, Steve R. Roffler, Chiao-Yu Hsiao, Tian-Lu Cheng, Wen-Wei Lin, En-Chi Lin, Yuh-Jyh Jong, Chin-Yuan Chang, Yu-Cheng Su - - 1 - Communications Chemistry - COMMUNICATIONS CHEMISTRY 2022;5(1):88 (IF: 7.211, Journal Ranking: 43, Number of Journals of this Field: 179, Ranking: 24.02%)
6	Structural insights into Nirmatrelvir (PF-07321332)-3C-like SARS-CoV-2 protease complexation: a ligand Gaussian accelerated molecular dynamics study. 王焰增, 廖俊閔, 林文瑋, 李佳靜, 黃柏誠, 鄭添祿, 陳惇杰 - - 1 - PHYSICAL CHEMISTRY CHEMICAL PHYSICS : PCCP - PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2022 24卷(37期):22898-22904頁 (IF: 3.945, 領域排名: 9, 領域期刊數: 36, 領域排名: 25.00%) Structural insights into Nirmatrelvir (PF-07321332)-3C-like SARS-CoV-2 protease complexation: a ligand Gaussian accelerated molecular dynamics study. Yeng-Tseng Wang, Jun-Min Liao, Wen-Wei Lin, Chia-Ching Li, Bo-Cheng Huang, Tian-Lu Cheng, Tun-Chieh Chen - - 1 - PHYSICAL CHEMISTRY CHEMICAL PHYSICS : PCCP - PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2022;24(37):22898-22904 (IF: 3.945, Journal Ranking: 9, Number of Journals of this Field: 36, Ranking: 25.00%)
7	Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules Hsiao CY, Meng JL#, Hong JZ, Ly XH, Lin MH, Chang CY, Minh-Tram T Nguyen, 鄭添祿, 林文瑋, Pierre-Alain Burnouf, Talal Salem Al-Qaisi, 劉恩碩, 蘇昱誠* - - 1 - Bioconjugate Chemistry - BIOCONJUGATE CHEMISTRY 2022 33卷(11期):2180-2188頁 (IF: 4.7, 領域排名: 13, 領域期刊數: 77, 領域排名: 16.88%) Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules Hsiao CY, Meng JL#, Hong JZ, Ly XH, Lin MH, Chang CY, Minh-Tram T Nguyen, Cheng TL, Lin WW, Pierre-Alain Burnouf, Talal Salem Al-Qaisi, Liu ES, Su YC* - - 1 - Bioconjugate Chemistry - BIOCONJUGATE CHEMISTRY 2022;33(11):2180-2188 (IF: 4.7, Journal Ranking: 13, Number of Journals of this Field: 77, Ranking: 16.88%)
8	Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe 莊智弘, 鄭添祿, 陳威鈞, 黃奕中, 王信二, 駱彥成, 謝元欽, 林文瑋, 謝雅茹, 柯建志, 黃抗節, 李景欽, 黃旼儀 - - 1 - Frontiers in Microbiology - FRONTIERS IN MICROBIOLOGY 2022 13卷(-期):896588頁 (IF: 6.064, 領域排名: 34, 領域期刊數: 136, 領域排名: 25.00%) Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe Chuang CH, Cheng TL, Chen WC, Huang YJ, Wang HE, Lo YC, Hsieh YC, Lin WW, Hsieh YJ, Ke CC, Huang KC, Lee JC, Huang MY - - 1 - Frontiers in Microbiology - FRONTIERS IN MICROBIOLOGY 2022;13(-):896588 (IF: 6.064, Journal Ranking: 34, Number of Journals of this Field: 136, Ranking: 25.00%)
9	Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group. Minh-Tram T Nguyen#, Yu-Chien Shih#, Meng-Hsuan Lin#, 羅傅倫, Chiao-Yu Hsiao, 鄭添祿, 林文瑋, En-Chi Lin, 鐘育志, 張晉源, 蘇昱誠 - - 1 - COMMUNICATIONS CHEMISTRY - COMMUNICATIONS CHEMISTRY 2022 5卷(1期):88頁 (IF: 5.9, 領域排名: 51, 領域期刊數: 178, 領域排名: 28.65%) Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group. Minh-Tram T Nguyen, Yu-Chien Shih, Meng-Hsuan Lin, Steve R Roffler, Chiao-Yu Hsiao, Tian-Lu Cheng, Wen-Wei Lin, En-Chi Lin, Yuh-Jyh Jong, Chin-Yuan Chang, Yu-Cheng Su - - 1 - COMMUNICATIONS CHEMISTRY - COMMUNICATIONS CHEMISTRY 2022;5(1):88 (IF: 5.9, Journal Ranking: 51, Number of Journals of this Field: 178, Ranking: 28.65%)
10	Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy. 林文瑋, 鄭以安, 李佳靜, 何愷文, 陳慧蓁, 陳怡如, 黃柏誠, 劉蕙如, 呂韻綺, 鄭秋敏, 黃旼儀, 賴鴻文, 鄭添祿 - - 1 - Scientific reports - SCIENTIFIC REPORTS 2021 11卷(1期):7598頁 (IF: 4.996, 領域排名: 19, 領域期刊數: 73, 領域排名: 26.03%) Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy. Wen-Wei Lin, Yi-An Cheng, Chia-Ching Li, Kai-Wen Ho, Huei-Jen Chen, I-J U Chen, Bo-Cheng Huang, Hui-Ju Liu, Yun-Chi Lu, Chiu-Min Cheng, Ming-Yii Huang, Hung-Wen Lai, Tian-Lu Cheng* - - 1 - Scientific reports - SCIENTIFIC REPORTS 2021;11(1):7598 (IF: 4.996, Journal Ranking: 19, Number of Journals of this Field: 73, Ranking: 26.03%)
11	Fibrinogen-Like Protein 1 Serves as an Anti-Inflammatory Agent for Collagen-Induced Arthritis Therapy in Mice 林文瑋, 何愷文, 蘇湘涵, 方恬芳, 鄒協成, 陳怡如, 呂韻綺, 張慕申, 蔡允榛, 劉恩碩, 蘇昱誠, 王焰增, 鄭添祿, 黃信凱 - - 1 - Frontiers in Immunology - FRONTIERS IN IMMUNOLOGY 2021 12卷(-期):767868頁 (IF: 8.786, 領域排名: 33, 領域期刊數: 161, 領域排名: 20.50%) Fibrinogen-Like Protein 1 Serves as an Anti-Inflammatory Agent for Collagen-Induced Arthritis Therapy in Mice Lin WW, Ho KW, Su HH, Fang TF, Tzou SC, Chen IJ, Lu YC, Chang MS, Tsai YC, Liu ES, Su YC, Wang YT, Cheng TL, Huang HK - - 1 - Frontiers in Immunology - FRONTIERS IN IMMUNOLOGY 2021;12(-):767868 (IF: 8.786, Journal Ranking: 33, Number of Journals of this Field: 161, Ranking: 20.50%)
12	Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy. 林文瑋, 呂韻綺, 黃柏誠, 莊智弘, 鄭以安, 陳怡如, 劉蕙如, 何愷文, 廖子毅, 劉恩碩, 吳亭儀, 張榮賢, 洪詩婷, 鄭添祿 - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2021 11卷(1期):14846頁 (IF: 4.996, 領域排名: 19, 領域期刊數: 73, 領域排名: 26.03%) Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy. Wen-Wei Lin, Yun-Chi Lu, Bo-Cheng Huang, Chih-Hung Chuang, Yi-An Cheng, I-Ju Chen, Hui-Ju Liu, Kai-Wen Ho, Tzu-Yi Liao, En-Shuo Liu, Ting-Yi Wu, Long-Sen Chang, Shih-Ting Hong, Tian-Lu Cheng - - 1 - SCIENTIFIC REPORTS - SCIENTIFIC REPORTS 2021;11(1):14846 (IF: 4.996, Journal Ranking: 19, Number of Journals of this Field: 73, Ranking: 26.03%)
13	Ab Locks for Improving the Selectivity and Safety of Antibody Drugs 林文瑋, 呂韻綺, 莊智弘, 鄭添祿* - - 1 - Journal of Biomedical Science - JOURNAL OF BIOMEDICAL SCIENCE 2020 27卷(1期):76頁 (IF: 8.41, 領域排名: 15, 領域期刊數: 140, 領域排名: 10.71%) Ab Locks for Improving the Selectivity and Safety of Antibody Drugs Wen-Wei Lin, Yun-Chi Lu, Chih-Hung Chuang, Tian-Lu Cheng* - - 1 - Journal of Biomedical Science - JOURNAL OF BIOMEDICAL SCIENCE 2020;27(1):76 (IF: 8.41, Journal Ranking: 15, Number of Journals of this Field: 140, Ranking: 10.71%)
14	Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes. 陳怡如, 鄭以安, 何愷文, 林文瑋, 鄭凱文, 呂韻綺, 謝元欽, 黃建喬, 莊智弘, 陳芳銘, 蘇昱誠, 羅傅倫, 鄭添祿 - - 1 - Acta biomaterialia - ACTA BIOMATERIALIA 2020 111卷(-期):386-397頁 (IF: 8.947, 領域排名: 10, 領域期刊數: 90, 領域排名: 11.11%) Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes. I-Ju Chen, Yi-An Cheng, Kai-Wen Ho, Wen-Wei Lin, Kai-Wen Cheng, Yun-Chi Lu, Yuan-Chin Hsieh, Chien-Chiao Huang, Chih-Hung Chuang, Fang-Ming Chen, Yu-Cheng Su, Steve R Roffler, Tian-Lu Cheng - - 1 - Acta biomaterialia - ACTA BIOMATERIALIA 2020;111(-):386-397 (IF: 8.947, Journal Ranking: 10, Number of Journals of this Field: 90, Ranking: 11.11%)
15	以分子模擬進行 Tsg101 UEV 蛋白與環狀胜肽抑制劑之研究林文瑋, 王郁仁, 柯正雯, 鄭添祿, 王焰增* - - 1 - Polymers - POLYMERS 2020 12卷(10期):2235頁 (IF: 4.329, 領域排名: 18, 領域期刊數: 88, 領域排名: 20.45%) Cyclic Peptide Inhibitors of the Tsg101 UEV Protein Interactions Refined through Global Docking and Gaussian Accelerated Molecular Dynamics Simulations Wen-Wei Lin, Yu-Jen Wang, Cheng-Wen Ko, Tain-Lu Cheng, Yeng-Tseng Wang* - - 1 - Polymers - POLYMERS 2020;12(10):2235 (IF: 4.329, Journal Ranking: 18, Number of Journals of this Field: 88, Ranking: 20.45%)
16	Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer 鄭以安#, 陳怡如#, 蘇昱誠, 鄭凱文, 呂韻綺, 林文瑋, 謝元欽, 高千涵, 陳芳銘, 羅傅倫, 鄭添祿 - - 1 - Biomaterials Science - BIOMATERIALS SCIENCE 2019 7卷(8期):3404-3417頁 (IF: 6.183, 領域排名: 6, 領域期刊數: 38, 領域排名: 15.79%) Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer Cheng YA#, Chen IJ#, Su YC, Cheng KW, Lu YC, Lin WW, Hsieh YC, Kao CH, Chen FM, Roffler SR, Cheng TL - - 1 - Biomaterials Science - BIOMATERIALS SCIENCE 2019;7(8):3404-3417 (IF: 6.183, Journal Ranking: 6, Number of Journals of this Field: 38, Ranking: 15.79%)
17	Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein 黃建喬#, 鄭凱文#, 謝元欽, 林文瑋, 鄭秋敏, 袁行修, 陳怡如, 鄭以安, 黃柏誠, 呂韻綺, 董宜青, 鄭添祿 - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2019 9卷(1期):9931頁 (IF: 3.998, 領域排名: 17, 領域期刊數: 71, 領域排名: 23.94%) Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein Huang CC, Cheng KW, Hsieh YC, Lin WW, Cheng CM, Yuan SS, Chen IJ, Cheng YA, Huang BC, Lu YC, Tung YC, Cheng TL - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2019;9(1):9931 (IF: 3.998, Journal Ranking: 17, Number of Journals of this Field: 71, Ranking: 23.94%)
18	聚乙二醇的IgM和IgG抗體均可以改變甲氧基聚乙二醇-表觀蛋白β在小鼠中的生物活性張恬靜, 陳炳梅, 林文瑋, 余珮華, 邱怡文, 陳垣崇, 鄔哲源, 鄭添祿, 黃道揚, 羅傅倫 - - 1 - Pharmaceutics - PHARMACEUTICS 2019 12卷(1期):15頁 (IF: 4.421, 領域排名: 44, 領域期刊數: 270, 領域排名: 16.30%) Both IgM and IgG Antibodies Against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice Chang TC, Chen BM, Lin WW, Yu PH, Chiu YW, Chen YT, Wu JY, Cheng TL, Hwang DY, Roffler AS - - 1 - Pharmaceutics - PHARMACEUTICS 2019;12(1):15 (IF: 4.421, Journal Ranking: 44, Number of Journals of this Field: 270, Ranking: 16.30%)
19	Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy 呂韻綺#, 莊智弘#, 莊國祥, 陳怡如, 黃柏誠, 李文翰, 王信二, 李哲嘉, 鄭以安, 鄭凱文, 王照元, 謝元欽, 林文瑋, 鄭添祿 - - 1 - PLoS Biology - PLOS BIOLOGY 2019 17卷(6期):e3000286頁 (IF: 7.076, 領域排名: 6, 領域期刊數: 93, 領域排名: 6.45%) Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy Lu YC#, Chuang CH#, Chuang KH, Chen IJ, Huang BC, Lee WH, Wang HE, Li JJ, Cheng YA, Cheng KW, Wang JY, Hsieh YC, Lin WW, Cheng TL - - 1 - PLoS Biology - PLOS BIOLOGY 2019;17(6):e3000286 (IF: 7.076, Journal Ranking: 6, Number of Journals of this Field: 93, Ranking: 6.45%)
20	建構可被蛋白酶活化的選擇性抗體陳怡如,莊智弘#, 謝元欽,呂韻綺,林文瑋,黃建喬,鄭達駿,鄭以安,鄭凱文,王焰增,陳芳銘,鄭添祿,鄒協成 - - 1 - Scientific Reports - Scientific Reports 2017 14卷(7期):11587頁 (IF: 4.122, 領域排名: 12, 領域期刊數: 64, 領域排名: 18.75%) Selective antibody activation through protease-activated proantibodies that mask binding sites with inhibitory domains I-Ju Chen, Chih-Hung Chuang#, Yuan-Chin Hsieh, Yun-Chi Lu, Wen-Wei Lin, Chien-Chiao Huang, Ta-Chun Cheng, Yi-An Cheng, Kai-Wen Cheng, Yeng-Tseng Wang, Fang-Ming Chen, Tian-Lu Cheng and Shey-Cherng Tzou. - - 1 - Scientific Reports - Scientific Reports 2017;14(7):11587 (IF: 4.122, Journal Ranking: 12, Number of Journals of this Field: 64, Ranking: 18.75%)
21	Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules 林文瑋,謝元欽,鄭以安,莊國祥,黃建喬,莊智弘,陳怡如,鄭凱文,呂韻綺,鄭達駿,王焰曾,羅傅倫,鄭添祿 - - 1 - ANALYTICAL CHEMISTRY - Anal Chem 2016 20卷(88期):12371-12379頁 (IF: 6.3, 領域排名: 4, 領域期刊數: 76, 領域排名: 5.26%) Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules Lin, Wen-Wei; Hsieh, Yuan-Chin; Cheng, Yi-An; Chuang, Kuo-Hsiang; Huang, Chien-Chiao; Chuang, Chih-Hung; Chen, I-Ju ; Cheng, Kai-Wen; Lu, Yun-Chi ; Cheng, Ta-Chun; Wang, Yeng-Tseng; Roffler, Steve; Cheng, Tian-Lu. - - 1 - ANALYTICAL CHEMISTRY - Anal Chem 2016;20(88):12371-12379 (IF: 6.3, Journal Ranking: 4, Number of Journals of this Field: 76, Ranking: 5.26%)
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