Education
| School — Major — Degree | Duration |
|---|---|
|
臺北醫學大學 — 醫學科學研究所(畢) — 博士 Doctorate, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University |
2005/09 — 2012/06 |
|
臺北醫學大學 — 藥學系(畢) — 學士 Bachelor, School of Pharmacy, Taipei Medical University |
1999/09 — 2003/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 藥學系 School of Pharmacy | Assistant Professor | 2017/08/01 — |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 藥理及毒理 Pharmacology and Toxicology |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology |
| 3 | 生物醫農類 Biology, Medicine and Agriculture | 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
小分子及奈米新藥研發
small molecular and nanoparticle drug design
Area(s) of Expertise & Research
中醫藥、生藥療效評估、抗腫瘤、抗病毒、分子生物學中藥學，生藥開發及生藥藥理學，腫瘤學，病毒學，分子生物學
Pharmacy, Pharmacology, Oncology, Virology, Molecular biology
Publication
| NO | Publication |
|---|---|
| 1 | Arylquin 1 透過劑量依賴性細胞毒性、細胞凋亡誘導以及與放射治療的協同作用在膠質母細胞瘤模型中發揮抗腫瘤作用 Antitumor Efficacy of Arylquin 1 through Dose-Dependent Cytotoxicity, Apoptosis Induction, and Synergy with Radiotherapy in Glioblastoma Models |
| 2 | Involvement of cell surface glycosaminoglycans in chebulagic acid's and punicalagin's antiviral activities against Coxsackievirus A16 infection Involvement of cell surface glycosaminoglycans in chebulagic acid's and punicalagin's antiviral activities against Coxsackievirus A16 infection |
| 3 | 升麻甲醇萃取物誘導 G1 細胞週期停滯和凋亡並抑制膠質瘤細胞轉移 Methanolic Extract of Cimicifuga foetida Induces G Cell Cycle Arrest and Apoptosis and Inhibits Metastasis of Glioma Cells. |
| 4 | High expression of NLRP12 predicts poor prognosis in patients with intracranial glioma. High expression of NLRP12 predicts poor prognosis in patients with intracranial glioma. |
| 5 | Galectin-3 Mediates Tumor Progression in Astrocytoma by Regulating Glycogen Synthase Kinase-3β Activity. Galectin-3 Mediates Tumor Progression in Astrocytoma by Regulating Glycogen Synthase Kinase-3β Activity. |
| 6 | High Thioredoxin Domain-Containing Protein 11 Expression Is Associated with Tumour Progression in Glioma. High Thioredoxin Domain-Containing Protein 11 Expression Is Associated with Tumour Progression in Glioma. |
| 7 | 台灣第 2 型糖尿病患者患有可能肌少症或肌少症與身體組成、營養攝取、血清維生素 D 和身體活動的關聯性 Association of Possible Sarcopenia or Sarcopenia with Body Composition, Nutritional Intakes, Serum Vitamin D Levels, and Physical Activity among Patients with Type 2 Diabetes Mellitus in Taiwan |
| 8 | 超音波輔助消解的甲酸脫細胞外基質和糖殼素奈米纖維複合水凝膠與富含血小板的血漿結合用於糖尿病傷口治療 Composite Hydrogels of Ultrasound-Assisted-Digested Formic Acid-Decellularized Extracellular Matrix and Sacchachitin Nanofibers Incorporated with Platelet-Rich Plasma for Diabetic Wound Treatment |
| 9 | 使用共載於基於卵磷脂的自奈米乳化預濃縮物 (LBSNEP) 中的吉西他濱和紫杉醇口服節律治療胰臟癌。 Oral metronomic therapy of pancreatic cancer with gemcitabine and paclitaxel co-loaded in lecithin-based Self-Nanoemulsifying preconcentrate (LBSNEP). |
| 10 | Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma. Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma. |
| 11 | Therapeutic Effect of Mitochondrial Division Inhibitor-1 (Mdivi-1) on Hyperglycemia-Exacerbated Early and Delayed Brain Injuries after Experimental Subarachnoid Hemorrhage Therapeutic Effect of Mitochondrial Division Inhibitor-1 (Mdivi-1) on Hyperglycemia-Exacerbated Early and Delayed Brain Injuries after Experimental Subarachnoid Hemorrhage |
| 12 | Correlation between Cancer Stem Cells, Inflammation and Malignant Transformation in a DEN-Induced Model of Hepatic Carcinogenesis. Correlation between Cancer Stem Cells, Inflammation and Malignant Transformation in a DEN-Induced Model of Hepatic Carcinogenesis. |
| 13 | Prognostic Impact of Low-Level p53 Expression on Brain Astrocytomas Immunopositive for Epidermal Growth Factor Receptor. Prognostic Impact of Low-Level p53 Expression on Brain Astrocytomas Immunopositive for Epidermal Growth Factor Receptor. |
| 14 | miR-3059-3p Regulates Glioblastoma Multiforme Radiosensitivity Enhancement through the Homologous Recombination Pathway of DNA Repair. miR-3059-3p Regulates Glioblastoma Multiforme Radiosensitivity Enhancement through the Homologous Recombination Pathway of DNA Repair. |
| 15 | High expression of GSKIP is associated with poor prognosis in meningioma. High expression of GSKIP is associated with poor prognosis in meningioma. |
| 16 | Hepatoprotective effect of botanical drug formula on high-fat diet-induced non-alcoholic fatty liver disease by inhibiting lipogenesis and promoting anti-oxidation Hepatoprotective effect of botanical drug formula on high-fat diet-induced non-alcoholic fatty liver disease by inhibiting lipogenesis and promoting anti-oxidation |
| 17 | High expression of Sp1 is associated with recurrence of meningioma High expression of Sp1 is associated with recurrence of meningioma |
| 18 | Identification of the phytobioactive Polygonum cuspidatum as an antiviral source for restricting dengue virus entry Identification of the phytobioactive Polygonum cuspidatum as an antiviral source for restricting dengue virus entry |
| 19 | Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein |
| 20 | Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16. Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16. |
| 21 | Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding |
| 22 | Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection. Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection. |
| 23 | Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration. Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration. |
| 24 | Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis. Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis. |
| 25 | Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis. Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis. |
| 26 | Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway. Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway. |
| 27 | Data analysesofhonokiol-inducedautophagy of humangliomacells in vitro and in vivo Data analysesofhonokiol-inducedautophagy of humangliomacells in vitro and in vivo |
| 28 | Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression. Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression. |
| 29 | Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death. Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death. |
| 30 | GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism. GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism. |
| 31 | Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes. Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes. |
| 32 | Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy. Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy. |
| 33 | Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells. Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells. |
| 34 | The role of endoplasmic reticulum in cadmium-induced mesangial cell apoptosis. The role of endoplasmic reticulum in cadmium-induced mesangial cell apoptosis. |
| 35 | Antioxidant N-Acetylcysteine Blocks Nerve Growth Factor–Induced H2O2/ERK Signaling in PC12 Cells. Antioxidant N-Acetylcysteine Blocks Nerve Growth Factor–Induced H2O2/ERK Signaling in PC12 Cells. |
| 36 | Detection of apoptosis and necrosis in normal human lung cells using 1H NMR spectroscopy. Detection of apoptosis and necrosis in normal human lung cells using 1H NMR spectroscopy. |
| 37 | Cadmium toxicity toward caspase-independent apoptosis through the mitochondria–calcium pathway in mtDNA-depleted cells. Cadmium toxicity toward caspase-independent apoptosis through the mitochondria–calcium pathway in mtDNA-depleted cells. |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
113 — M 高醫(種子計畫) — KMU-M114005 —
台灣特有牛樟芝成分4-acetylantroquinonol B (4-AAQB)對高糖環境下膠質母細胞瘤的治療機制與療效評估：聚焦於KDM2B途徑調控下的腫瘤進程與對化學療法及放射治療的協同反應( )
|
2025/01/01 ~ 2025/12/31 |
| 2 |
112 — N 國科會(原科技部) — NSTC112-2320-B-037-023 — 1 個人型
討海洋源真菌Trichoderma brevicompactum NTU439之二次代謝產物木霉素Trichodermin用以治療惡性膠質細胞瘤之療效與機轉，及其對腫瘤微環境的影響( )
|
2023/08/01 ~ 2024/07/31 |
| 3 |
111 — M 高醫(種子計畫) — KMU-M112028 —
開發蘇木甲醇萃取物結合具通透血腦障壁之標靶性奈米微脂體藥物應用於抗惡性膠質瘤之療效評估與機轉探討( )
|
2023/01/01 ~ 2023/12/31 |
| 4 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-055-B — 8 大專學生研究計畫
112年度大專學生研究計畫-謝惟如(藥學4)( )
|
2023/07/01 ~ 2024/02/29 |
| 5 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-056-B — 8 大專學生研究計畫
112年度大專學生研究計畫-黃晨瑄(藥學2)( )
|
2023/07/01 ~ 2024/02/29 |
| 6 |
110 — M 高醫(種子計畫) — KMU-M111008 —
研究瑪瑙珠未成熟果實甲醇萃取 物與其抗癌活性成分之奈米製劑 抗惡性膠質瘤幹細胞之療效，及探 討SLC1A3基因於抗癌作用之角色( )
|
2022/01/01 ~ 2022/12/31 |
| 7 |
110 — Z 大專學生研究計畫及博士後 — MOST111-2813-C-037-065-B — 8 大專學生研究計畫
111年度大專學生研究計畫-林子維(藥學3)( )
|
2022/07/01 ~ 2023/02/28 |
| 8 |
109 — N 國科會(原科技部) — MOST109-2320-B-037-020 — 1 個人型
研究台灣肖楠葉萃取物與其抗癌活性成分抗惡性膠質瘤之進程、癌幹細胞生成、輔助放射/化學療法與奈米化製劑之功效及其機轉探討( )
|
2020/08/01 ~ 2021/07/31 |
| 9 |
108 — M 高醫(種子計畫) — KMU-M109019 —
探討類黃酮成分flavokawains抗惡性膠質瘤及其應用於提升放射敏感性及免疫療法之功效與機轉( )
|
2020/01/01 ~ 2020/12/31 |
| 10 |
107 — Q 新聘教師計畫(校內) — KMU-Q108022 —
活性天然物抗癌病毒71型之療效與機制探討( )
|
2019/01/01 ~ 2019/12/31 |
| 11 |
106 — N 國科會(原科技部) — MOST107-2320-B-037-002 — 1 個人型
抗腸病毒天然物之開發研究( )
|
2018/02/01 ~ 2018/10/31 |
| 12 |
106 — Q 新聘教師計畫(校內) — KMU-Q107014 —
訶子萃取物抗克沙奇病毒之療效評估( )
|
2018/01/01 ~ 2018/12/31 |