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 Education

School — Major — Degree Duration

臺北醫學大學 — 醫學科學研究所(畢) — 博士

Doctorate, Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University

2005/09 — 2012/06

臺北醫學大學 — 藥學系(畢) — 學士

Bachelor, School of Pharmacy, Taipei Medical University

1999/09 — 2003/06

 Intramural Experience

Office/Department/Institute Position Duration
藥學系 School of Pharmacy   Assistant Professor 2017/08/01 —  

 Extramural Experience

 

 Discipline

NO Discipline Expertise
1 生物醫農類 Biology, Medicine and Agriculture 藥理及毒理 Pharmacology and Toxicology
2 生物醫農類 Biology, Medicine and Agriculture 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology
3 生物醫農類 Biology, Medicine and Agriculture 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy

 Research & Technology Platform Open to the Outside

in vitro and in vivo BBB model

 Interested Area(s)for Interdisciplinary Research

小分子及奈米新藥研發

small molecular and nanoparticle drug design

 Area(s) of Expertise & Research

中醫藥、生藥療效評估、抗腫瘤、抗病毒、分子生物學中藥學,生藥開發及生藥藥理學,腫瘤學,病毒學,分子生物學

Pharmacy, Pharmacology, Oncology, Virology, Molecular biology

 Publication

NO Publication
1

High expression of NLRP12 predicts poor prognosis in patients with intracranial glioma.
鄭宇文, 陳泱伊, 林千如, 陳怡庭, 劉安祥, 蔡鴻培*, 關皚麗* - - 1 - JOURNAL OF THE CHINESE MEDICAL ASSOCIATION : JCMA - JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 2023 86卷(1期):88-97頁
(IF: 3, 領域排名: 75, 領域期刊數: 167, 領域排名: 44.91%)

High expression of NLRP12 predicts poor prognosis in patients with intracranial glioma.
Yu-Wen Cheng, Yang-Yi Chen, Chien-Ju Lin, Yi-Ting Chen, Ann-Shung Lieu, Hung-Pei Tsai, Aij-Lie Kwan - - 1 - JOURNAL OF THE CHINESE MEDICAL ASSOCIATION : JCMA - JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 2023;86(1):88-97
(IF: 3, Journal Ranking: 75, Number of Journals of this Field: 167, Ranking: 44.91%)

2

Galectin-3 Mediates Tumor Progression in Astrocytoma by Regulating Glycogen Synthase Kinase-3β Activity.
蔡鴻培, 林千如, 劉安祥, 陳怡庭, 曾子庭, 關皚麗, 羅永欽* - - 1 - CURRENT ISSUES IN MOLECULAR BIOLOGY - CURRENT ISSUES IN MOLECULAR BIOLOGY 2023 45卷(4期):3591-3602頁
(IF: 3.1, 領域排名: 173, 領域期刊數: 285, 領域排名: 60.70%)

Galectin-3 Mediates Tumor Progression in Astrocytoma by Regulating Glycogen Synthase Kinase-3β Activity.
Hung-Pei Tsai, Chien-Ju Lin, Ann-Shung Lieu, Yi-Ting Chen, Tzu-Ting Tseng, Aij-Lie Kwan, Joon-Khim Loh* - - 1 - CURRENT ISSUES IN MOLECULAR BIOLOGY - CURRENT ISSUES IN MOLECULAR BIOLOGY 2023;45(4):3591-3602
(IF: 3.1, Journal Ranking: 173, Number of Journals of this Field: 285, Ranking: 60.70%)

3

High Thioredoxin Domain-Containing Protein 11 Expression Is Associated with Tumour Progression in Glioma.
陳映佐, 鍾嘉勵, 鄭宇文, 林千如, 曾子廷, Shu-Shong Hsu, 蔡鴻培*, 關皚麗* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023 24卷(17期):13367頁
(IF: 5.6, 領域排名: 66, 領域期刊數: 285, 領域排名: 23.16%)

High Thioredoxin Domain-Containing Protein 11 Expression Is Associated with Tumour Progression in Glioma.
Ying-Tso Chen, Chia-Li Chung, Yu-Wen Cheng, Chien-Ju Lin, Tzu-Ting Tseng, Shu-Shong Hsu, Hung-Pei Tsai, Aij-Lie Kwan - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023;24(17):13367
(IF: 5.6, Journal Ranking: 66, Number of Journals of this Field: 285, Ranking: 23.16%)

4

台灣第 2 型糖尿病患者患有可能肌少症或肌少症與身體組成、營養攝取、血清維生素 D 和身體活動的關聯性
徐妤婷,林建宇,林千如,李洮俊,張文心* - - 1 - Nutrients - NUTRIENTS 2023 15卷(18期):3892頁
(IF: 5.9, 領域排名: 17, 領域期刊數: 88, 領域排名: 19.32%)

Association of Possible Sarcopenia or Sarcopenia with Body Composition, Nutritional Intakes, Serum Vitamin D Levels, and Physical Activity among Patients with Type 2 Diabetes Mellitus in Taiwan
Yu-Ting Hsu, Jian-Yu Lin, Chien-Ju Lin, Yau-Jiunn Lee, Wen-Hsin Chang* - - 1 - Nutrients - NUTRIENTS 2023;15(18):3892
(IF: 5.9, Journal Ranking: 17, Number of Journals of this Field: 88, Ranking: 19.32%)

5

超音波輔助消解的甲酸脫細胞外基質和糖殼素奈米纖維複合水凝膠與富含血小板的血漿結合用於糖尿病傷口治療
林千如#, 林宏糧#, Wen-Chen You, Hsiu-O Ho, Ming-Thau Sheu, Ling-Chun Chen*, Wei-Jie Cheng* - - 1 - Journal of Functional Biomaterials - JOURNAL OF FUNCTIONAL BIOMATERIALS 2023 14卷(8期):423頁
(IF: 4.8, 領域排名: 20, 領域期刊數: 45, 領域排名: 44.44%)

Composite Hydrogels of Ultrasound-Assisted-Digested Formic Acid-Decellularized Extracellular Matrix and Sacchachitin Nanofibers Incorporated with Platelet-Rich Plasma for Diabetic Wound Treatment
Chien-Ju Lin#, Hong-Liang Lin#, Wen-Chen You, Hsiu-O Ho, Ming-Thau Sheu, Ling-Chun Chen*, Wei-Jie Cheng* - - 1 - Journal of Functional Biomaterials - JOURNAL OF FUNCTIONAL BIOMATERIALS 2023;14(8):423
(IF: 4.8, Journal Ranking: 20, Number of Journals of this Field: 45, Ranking: 44.44%)

6

使用共載於基於卵磷脂的自奈米乳化預濃縮物 (SNEP) 中的吉西他濱和紫杉醇口服節律治療胰臟癌。
林千如, Wen-Ting Cheng, Ling-Chun Chen, Tzu-Ling Chen, Ming-Thau Sheu, 林宏糧* - - 1 - INTERNATIONAL JOURNAL OF PHARMACEUTICS - INTERNATIONAL JOURNAL OF PHARMACEUTICS 2023 645卷(X期):123370頁
(IF: 5.8, 領域排名: 40, 領域期刊數: 277, 領域排名: 14.44%)

Oral metronomic therapy of pancreatic cancer with gemcitabine and paclitaxel co-loaded in lecithin-based Self-Nanoemulsifying preconcentrate (SNEP).
Chien-Ju Lin, Wen-Ting Cheng, Ling-Chun Chen, Tzu-Ling Chen, Ming-Thau Sheu, Hong-Liang Lin* - - 1 - INTERNATIONAL JOURNAL OF PHARMACEUTICS - INTERNATIONAL JOURNAL OF PHARMACEUTICS 2023;645(X):123370
(IF: 5.8, Journal Ranking: 40, Number of Journals of this Field: 277, Ranking: 14.44%)

7

Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.
林奕呈, 張智輝, 張詠斌, 郭仕勳, 鄭宇文, 劉安祥, 曾子廷, 林千如, 蔡鴻培*, 關皚麗* - - 1 - CELLS - CELLS 2023 12卷(19期):2420頁
(IF: 6, 領域排名: 60, 領域期刊數: 191, 領域排名: 31.41%)

Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.
I-Cheng Lin, Chih-Hui Chang, Yoon Bin Chong, Shih-Hsun Kuo, Yu-Wen Cheng, Ann-Shung Lieu, Tzu-Ting Tseng, Chien-Ju Lin, Hung-Pei Tsai, Aij-Lie Kwan - - 1 - CELLS - CELLS 2023;12(19):2420
(IF: 6, Journal Ranking: 60, Number of Journals of this Field: 191, Ranking: 31.41%)

8

Therapeutic Effect of Mitochondrial Division Inhibitor-1 (Mdivi-1) on Hyperglycemia-Exacerbated Early and Delayed Brain Injuries after Experimental Subarachnoid Hemorrhage
鍾嘉勵, 黃裕樺, 林千如, 張詠斌, 吳淑釧, 蔡志仁, 蔡鴻培*, 關皚麗* - - 2 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022 23卷(13期):6924頁
(IF: 6.208, 領域排名: 69, 領域期刊數: 296, 領域排名: 23.31%)

Therapeutic Effect of Mitochondrial Division Inhibitor-1 (Mdivi-1) on Hyperglycemia-Exacerbated Early and Delayed Brain Injuries after Experimental Subarachnoid Hemorrhage
Chia-Li Chung, Yu-Hua Huang, Chien-Ju Lin, Yoon-Bin Chong, Shu-Chuan Wu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwan - - 2 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022;23(13):6924
(IF: 6.208, Journal Ranking: 69, Number of Journals of this Field: 296, Ranking: 23.31%)

9

Correlation between Cancer Stem Cells, Inflammation and Malignant Transformation in a DEN-Induced Model of Hepatic Carcinogenesis.
吳俊杰,林千如, 郭功楷, 陳婉姿, 柯成國, 蔡志仁, 蔡鴻培*, 楊曉芳* - - 1 - CURRENT ISSUES IN MOLECULAR BIOLOGY - CURRENT ISSUES IN MOLECULAR BIOLOGY 2022 44卷(7期):2879-2886頁
(IF: 2.976, 領域排名: 216, 領域期刊數: 296, 領域排名: 72.97%)

Correlation between Cancer Stem Cells, Inflammation and Malignant Transformation in a DEN-Induced Model of Hepatic Carcinogenesis.
Chun-Chieh Wu, Chien-Ju Lin, Kong-Kai Kuo, Wan-Tzu Chen, Chen-Guo Ker, Chee-Yin Chai, Hung-Pei Tsai, Sheau-Fang Yang - - 1 - CURRENT ISSUES IN MOLECULAR BIOLOGY - CURRENT ISSUES IN MOLECULAR BIOLOGY 2022;44(7):2879-2886
(IF: 2.976, Journal Ranking: 216, Number of Journals of this Field: 296, Ranking: 72.97%)

10

Prognostic Impact of Low-Level p53 Expression on Brain Astrocytomas Immunopositive for Epidermal Growth Factor Receptor.
蔡鴻培, 林千如, 吳界欣, 陳怡庭, 呂穎怡, 關皚麗, 劉安祥* - - 1 - CURRENT ISSUES IN MOLECULAR BIOLOGY - CURRENT ISSUES IN MOLECULAR BIOLOGY 2022 44卷(9期):4142-4151頁
(IF: 2.976, 領域排名: 216, 領域期刊數: 296, 領域排名: 72.97%)

Prognostic Impact of Low-Level p53 Expression on Brain Astrocytomas Immunopositive for Epidermal Growth Factor Receptor.
Hung-Pei Tsai, Chien-Ju Lin, Chieh-Hsin Wu, Yi-Ting Chen, Ying-Yi Lu, Aij-Lie Kwan, Ann-Shung Lieu - - 1 - CURRENT ISSUES IN MOLECULAR BIOLOGY - CURRENT ISSUES IN MOLECULAR BIOLOGY 2022;44(9):4142-4151
(IF: 2.976, Journal Ranking: 216, Number of Journals of this Field: 296, Ranking: 72.97%)

11

miR-3059-3p Regulates Glioblastoma Multiforme Radiosensitivity Enhancement through the Homologous Recombination Pathway of DNA Repair.
鄭宇文, 林千如, 郭仕勳, 劉安祥, 蔡志仁, 蔡鴻培*, 關皚麗* - - 1 - JOURNAL OF ONCOLOGY - JOURNAL OF ONCOLOGY 2022 2022卷(0期):7250278頁
(IF: 4.501, 領域排名: 113, 領域期刊數: 245, 領域排名: 46.12%)

miR-3059-3p Regulates Glioblastoma Multiforme Radiosensitivity Enhancement through the Homologous Recombination Pathway of DNA Repair.
Yu-Wen Cheng, Chien-Ju Lin, Shih-Hsun Kuo, Ann-Shung Lieu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwan - - 1 - JOURNAL OF ONCOLOGY - JOURNAL OF ONCOLOGY 2022;2022(0):7250278
(IF: 4.501, Journal Ranking: 113, Number of Journals of this Field: 245, Ranking: 46.12%)

12

High expression of GSKIP is associated with poor prognosis in meningioma.
鄭宇文, 陳泱伊, 林千如, 劉安祥, 蔡鴻培*, 關皚麗* - - 1 - MEDICINE - MEDICINE 2022 101卷(50期):e32209頁
(IF: 1.817, 領域排名: 122, 領域期刊數: 172, 領域排名: 70.93%)

High expression of GSKIP is associated with poor prognosis in meningioma.
Yu-Wen Cheng, Yang-Yi Chen, Chien-Ju Lin, Ann-Shung Lieu, Hung-Pei Tsai, Aij-Lie Kwan - - 1 - MEDICINE - MEDICINE 2022;101(50):e32209
(IF: 1.817, Journal Ranking: 122, Number of Journals of this Field: 172, Ranking: 70.93%)

13

Hepatoprotective effect of botanical drug formula on high-fat diet-induced non-alcoholic fatty liver disease by inhibiting lipogenesis and promoting anti-oxidation
De-Shan Ning, Yu-Ju Chen, 林千如, Ching-Chiung Wang, Hong-Wei Zhao, Kun-Teng Wang, Ming-Chung Lee, Lemmuel L Tayo, Wan-Chun Chiu, Chiu-Li Yeh, Chia-Jung Lee* - - 1 - Frontiers in Pharmacology - FRONTIERS IN PHARMACOLOGY 2022 13卷(X期):1026912頁
(IF: 5.6, 領域排名: 45, 領域期刊數: 277, 領域排名: 16.25%)

Hepatoprotective effect of botanical drug formula on high-fat diet-induced non-alcoholic fatty liver disease by inhibiting lipogenesis and promoting anti-oxidation
De-Shan Ning, Yu-Ju Chen, Chien-Ju Lin, Ching-Chiung Wang, Hong-Wei Zhao, Kun-Teng Wang, Ming-Chung Lee, Lemmuel L Tayo, Wan-Chun Chiu, Chiu-Li Yeh, Chia-Jung Lee* - - 1 - Frontiers in Pharmacology - FRONTIERS IN PHARMACOLOGY 2022;13(X):1026912
(IF: 5.6, Journal Ranking: 45, Number of Journals of this Field: 277, Ranking: 16.25%)

14

High expression of Sp1 is associated with recurrence of meningioma
Ping-ChuanLiu,劉安祥,林千如,蔡鴻培,蔡志仁,關皚麗* - - 1 - World Neurosurgery - WORLD NEUROSURGERY 2021 149卷(x期):e1056-e1060頁
(IF: 2.104, 領域排名: 161, 領域期刊數: 208, 領域排名: 77.40%)

High expression of Sp1 is associated with recurrence of meningioma
Ping-Chuan Liu, Ann-Shung Lieu, Chien-Ju Lin, Hung-Pei Tsai, Chee-Yin Chai, Aij-Lie Kwan* - - 1 - World Neurosurgery - WORLD NEUROSURGERY 2021;149(x):e1056-e1060
(IF: 2.104, Journal Ranking: 161, Number of Journals of this Field: 208, Ranking: 77.40%)

15

Identification of the phytobioactive Polygonum cuspidatum as an antiviral source for restricting dengue virus entry
Yu-TingKuo,Ching-HsuanLiu,Jin-WeiLi,林千如,AlagieJassey,Huey-NanWu,GueyChuenPerng,顏銘宏,Liang-TzungLin* - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2020 10卷(1期):16378頁
(IF: 3.998, 領域排名: 17, 領域期刊數: 71, 領域排名: 23.94%)

Identification of the phytobioactive Polygonum cuspidatum as an antiviral source for restricting dengue virus entry
Yu-Ting Kuo, Ching-Hsuan Liu, Jin-Wei Li, Chien-Ju Lin, Alagie Jassey, Huey-Nan Wu, Guey Chuen Perng, Ming-Hong Yen, Liang-Tzung Lin* - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2020;10(1):16378
(IF: 3.998, Journal Ranking: 17, Number of Journals of this Field: 71, Ranking: 23.94%)

16

Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein
Ting-Chun Hung, Alagie Jassey, Ching-Hsuan Liu, 林千如, Chun-Ching Lin, Shu Hui Wong, Jonathan Y. Wang, 顏銘宏*, Liang-Tzung Lin* - - 1 - Phytomedicine - PHYTOMEDICINE 2019 53卷(-期):62-69頁
(IF: 4.268, 領域排名: 2, 領域期刊數: 28, 領域排名: 7.14%)

Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein
Ting-Chun Hung, Alagie Jassey, Ching-Hsuan Liu, Chien-Ju Lin, Chun-Ching Lin, Shu Hui Wong, Jonathan Y. Wang, Ming-Hong Yen*, Liang-Tzung Lin* - - 1 - Phytomedicine - PHYTOMEDICINE 2019;53(-):62-69
(IF: 4.268, Journal Ranking: 2, Number of Journals of this Field: 28, Ranking: 7.14%)

17

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16.
Wang JY, 林千如, Liu CH, Lin LT* - - 1 - Journal of Visualized Experiments - JOVE-JOURNAL OF VISUALIZED EXPERIMENTS 2019 149卷(x期):e59920頁
(IF: 1.163, 領域排名: 45, 領域期刊數: 71, 領域排名: 63.38%)

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16.
Wang JY, Lin CJ, Liu CH, Lin LT* - - 1 - Journal of Visualized Experiments - JOVE-JOURNAL OF VISUALIZED EXPERIMENTS 2019;149(x):e59920
(IF: 1.163, Journal Ranking: 45, Number of Journals of this Field: 71, Ranking: 63.38%)

18

Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding
林千如, Ching-Hsuan Liu, Jonathan Y. Wang, Chun-Ching Lin, Yi-Fang Li, Christopher D. Richardson, 林良宗* - - 1 - Emerging Microbes & Infections - EMERGING MICROBES & INFECTIONS 2018 7卷(x期):162頁
(IF: 6.032, 領域排名: 15, 領域期刊數: 127, 領域排名: 11.81%)

Small molecules targeting coxsackievirus A16 capsid inactivate viral particles and prevent viral binding
Chien-Ju Lin, Ching-Hsuan Liu, Jonathan Y. Wang, Chun-Ching Lin, Yi-Fang Li, Christopher D. Richardson and Liang-Tzung Lin - - 1 - Emerging Microbes & Infections - EMERGING MICROBES & INFECTIONS 2018;7(x):162
(IF: 6.032, Journal Ranking: 15, Number of Journals of this Field: 127, Ranking: 11.81%)

19

Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection.
Ting-Chun Hung, Alagie Jassey, 林千如, Ching-Hsuan Liu, Chun-Ching Lin, 顏銘宏 *, Liang-Tzung Lin* - - 1 - Viruses - VIRUSES-BASEL 2018 10卷(12期):669頁
(IF: 3.761, 領域排名: 11, 領域期刊數: 35, 領域排名: 31.43%)

Methanolic Extract of Rhizoma Coptidis Inhibits the Early Viral Entry Steps of Hepatitis C Virus Infection.
Ting-Chun Hung, Alagie Jassey, Chien-Ju Lin, Ching-Hsuan Liu, Chun-Ching Lin, Ming-Hong Yen*, Liang-Tzung Lin* - - 1 - Viruses - VIRUSES-BASEL 2018;10(12):669
(IF: 3.761, Journal Ranking: 11, Number of Journals of this Field: 35, Ranking: 31.43%)

20

Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration.
Poh-Shiow Yeh, Weu Wang , 張雅銨, 林千如, Jhi-Joung Wang, 陳瑞明* - - 1 - Cancer Letters - Cancer Lett. 2016 370卷(1期):66-77頁
(IF: 5.992, 領域排名: 23, 領域期刊數: 213, 領域排名: 10.80%)

Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration.
Poh-Shiow Yeh, Weu Wang , Ya-An Chang, Chien-Ju Lin, Jhi-Joung Wang, Ruei-Ming Chen* - - 1 - Cancer Letters - Cancer Lett. 2016;370(1):66-77
(IF: 5.992, Journal Ranking: 23, Number of Journals of this Field: 213, Ranking: 10.80%)

21

Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis.
林千如, 張雅銨, Yi-Ling Lin, Shing Hwa Liu, Cheng-Kuei Chang, 陳瑞明* - - 1 - Phytomedicine - Phytomedicine 2016 23卷(5期):517-527頁
(IF: 3.526, 領域排名: 2, 領域期刊數: 26, 領域排名: 7.69%)

Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis.
Chien-Ju Lin, Ya-An Chang, Yi-Ling Lin, Shing Hwa Liu, Cheng-Kuei Chang, Ruei-Ming Chen* - - 1 - Phytomedicine - Phytomedicine 2016;23(5):517-527
(IF: 3.526, Journal Ranking: 2, Number of Journals of this Field: 26, Ranking: 7.69%)

22

Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis.
林千如,林怡伶, Frank Luh, 閻雲*, 陳瑞明* - - 1 - Oncotarget - Oncotarget 2016 7卷(27期):42408-42421頁
(IF: 5.008, 領域排名: 36, 領域期刊數: 213, 領域排名: 16.90%)

Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis.
Chien-Ju Lin, Yi-Ling Lin, Frank Luh, Yun Yen*, Ruei-Ming Chen* - - 1 - Oncotarget - Oncotarget 2016;7(27):42408-42421
(IF: 5.008, Journal Ranking: 36, Number of Journals of this Field: 213, Ranking: 16.90%)

23

Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway.
林千如, 陳大樑, Yuan-Yun Tseng, Gong-Jhe Wu, Ming-Hui Hsieh, Yung-Wei Lin, 陳瑞明* - - 1 - Toxicology and Applied Pharmacology - Toxicol Appl Phar 2016 304卷(X期):59-69頁
(IF: 3.791, 領域排名: 15, 領域期刊數: 92, 領域排名: 16.30%)

Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway.
Chien-Ju Lin, Ta-Liang Chen, Yuan-Yun Tseng, Gong-Jhe Wu, Ming-Hui Hsieh, Yung-Wei Lin, Ruei-Ming Chen* - - 1 - Toxicology and Applied Pharmacology - Toxicol Appl Phar 2016;304(X):59-69
(IF: 3.791, Journal Ranking: 15, Number of Journals of this Field: 92, Ranking: 16.30%)

24

Data analysesofhonokiol-inducedautophagy of humangliomacells in vitro and in vivo
Wu GJ, 林千如, Lin YW, Chen RM* - - 1 - Data in Brief - 2016 9卷(x期):667-672頁
(IF: 0, 領域排名: 0, 領域期刊數: 0, 領域排名: -%)

Data analysesofhonokiol-inducedautophagy of humangliomacells in vitro and in vivo
Wu GJ, Lin CJ, Lin YW, Chen RM - - 1 - Data in Brief - 2016;9(x):667-672
(IF: 0, Journal Ranking: 0, Number of Journals of this Field: 0, Ranking: -%)

25

Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression.
林宗瑤, 李進成, 陳顧中, 林千如, 施純明* - - 1 - Chemico-Biological Interactions - Chem-Biol Interact. 2015 232卷(x期):49-57頁
(IF: 3.077, 領域排名: 18, 領域期刊數: 75, 領域排名: 24.00%)

Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression.
Tsung-Yao Lin, Chin-Cheng Lee, Ku-Chung Chen, Chien-Ju Lin, Chwen-Ming Shih* - - 1 - Chemico-Biological Interactions - Chem-Biol Interact. 2015;232(x):49-57
(IF: 3.077, Journal Ranking: 18, Number of Journals of this Field: 75, Ranking: 24.00%)

26

Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death.
林千如, 陳瑞雄, 楊良友, 施純明* - - 1 - Cell Death and Disease - Cell Death Dis 2014 5卷(x期):e1147頁
(IF: 5.177, 領域排名: 49, 領域期刊數: 185, 領域排名: 26.49%)

Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death.
Chien-Ju Lin, Thay-Hsiung Chen, Liang-Yo Yang, Chwen-Ming Shih* - - 1 - Cell Death and Disease - Cell Death Dis 2014;5(x):e1147
(IF: 5.177, Journal Ranking: 49, Number of Journals of this Field: 185, Ranking: 26.49%)

27

GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism.
Tsu-Tuan Wu, Yu-Ting Tai, Yih-Giun Cherng, Tyng-Guey Chen, 林千如, 陳大樑, 張懷嘉, 陳瑞明* - - 1 - PLoS ONE - PLoS ONE 2013 8卷(8期):e72404頁
(IF: 3.73, 領域排名: 7, 領域期刊數: 56, 領域排名: 12.50%)

GATA-2 transduces LPS-induced il-1β gene expression in macrophages via a toll-like receptor 4/MD88/MAPK-dependent mechanism.
Tsu-Tuan Wu, Yu-Ting Tai, Yih-Giun Cherng, Tyng-Guey Chen, Chien-Ju Lin, Ta-Liang Chen, Huai-Chia Chang, Ruei-Ming Chen* - - 1 - PLoS ONE - PLoS ONE 2013;8(8):e72404
(IF: 3.73, Journal Ranking: 7, Number of Journals of this Field: 56, Ranking: 12.50%)

28

Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes.
劉安正, 王聖豪, Sz-Ying Hou, 林千如, Wen-Ta Chiu, Sheng-Huang Hsiao, Thay-Hsiung Chen*, 施純明* - - 1 - Evidence-Based Complementary and Alternative Medicine - Evid-Based Compl Alt 2013 2013卷(X期):354840頁
(IF: 1.722, 領域排名: 8, 領域期刊數: 21, 領域排名: 38.10%)

Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes.
Ann-Jeng Liu, Sheng-Hao Wang, Sz-Ying Hou, Chien-Ju Lin, Wen-Ta Chiu, Sheng-Huang Hsiao, Thay-Hsiung Chen*, Chwen-Ming Shih* - - 1 - Evidence-Based Complementary and Alternative Medicine - Evid-Based Compl Alt 2013;2013(X):354840
(IF: 1.722, Journal Ranking: 8, Number of Journals of this Field: 21, Ranking: 38.10%)

29

Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy.
林千如, 李進成, 施勇綸, 林宗瑤, 王聖豪, Yuh-Feng Lin, 施純明* - - 1 - Free Radical Biology & Medicine - Free Radical Biol Med 2012 52卷(2期):377-391頁
(IF: 5.423, 領域排名: 18, 領域期刊數: 121, 領域排名: 14.88%)

Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy.
Chien-Ju Lin, Chin-Cheng Lee, Yung-Luen Shih, Tsung-Yao Lin, Sheng-Hao Wang, Yuh-Feng Lin, Chwen-Ming Shih* - - 1 - Free Radical Biology & Medicine - Free Radical Biol Med 2012;52(2):377-391
(IF: 5.423, Journal Ranking: 18, Number of Journals of this Field: 121, Ranking: 14.88%)

30

Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells.
林千如, 李進成, 施勇綸, Chien-Huang Lin, 王聖豪, Thay-Hsiung Chen, 施純明* - - 1 - PLoS ONE - PLoS ONE 2012 7卷(6期):e38706頁
(IF: 3.73, 領域排名: 7, 領域期刊數: 56, 領域排名: 12.50%)

Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells.
Chien-Ju Lin, Chin-Cheng Lee, Yung-Luen Shih, Chien-Huang Lin, Sheng-Hao Wang, Thay-Hsiung Chen, Chwen-Ming Shih* - - 1 - PLoS ONE - PLoS ONE 2012;7(6):e38706
(IF: 3.73, Journal Ranking: 7, Number of Journals of this Field: 56, Ranking: 12.50%)

31

The role of endoplasmic reticulum in cadmium-induced mesangial cell apoptosis.
王聖豪, 施勇綸, 李進成, 陳偉立, 林千如, Yung-Sheng Lin, Kuan-Hsun Wu*, 施純明* - - 1 - Chemico-Biological Interactions - Chem-Biol Interact. 2009 181卷(X期):45-51頁
(IF: 3.077, 領域排名: 18, 領域期刊數: 75, 領域排名: 24.00%)

The role of endoplasmic reticulum in cadmium-induced mesangial cell apoptosis.
Sheng-Hao Wang, Yung-Luen Shih, Chin-Cheng Lee, Wei-Li Chen, Chien-Ju Lin, Yung-Sheng Lin, Kuan-Hsun Wu*, Chwen-Ming Shih* - - 1 - Chemico-Biological Interactions - Chem-Biol Interact. 2009;181(X):45-51
(IF: 3.077, Journal Ranking: 18, Number of Journals of this Field: 75, Ranking: 24.00%)

32

Antioxidant N-Acetylcysteine Blocks Nerve Growth Factor–Induced H2O2/ERK Signaling in PC12 Cells.
楊良友, 柯文昌, 林俊茂, Jia-Wei Lin, Jen-Chine Wu, 林千如, Huey-Hwa Cheng, 施純明* - - 1 - Annals of the New York Academy of Sciences - Ann. N.Y. Acad. Sci. 2005 1042卷(X期):325-337頁
(IF: 1.789, 領域排名: 7, 領域期刊數: 45, 領域排名: 15.56%)

Antioxidant N-Acetylcysteine Blocks Nerve Growth Factor–Induced H2O2/ERK Signaling in PC12 Cells.
Liang-Yo Yang, Wun-Chang Ko, Chun-Mao Lin, Jia-Wei Lin, Jen-Chine Wu, Chien-Ju Lin, Huey-Hwa Cheng, Chwen-Ming Shih* - - 1 - Annals of the New York Academy of Sciences - Ann. N.Y. Acad. Sci. 2005;1042(X):325-337
(IF: 1.789, Journal Ranking: 7, Number of Journals of this Field: 45, Ranking: 15.56%)

33

Detection of apoptosis and necrosis in normal human lung cells using 1H NMR spectroscopy.
施純明, 柯文昌, 楊良友, 林千如, 吳瑞昇, 羅翠勻, Shwu-Huey Wang, Chien-Tsu Chen - - 1 - Annals of the New York Academy of Sciences - Ann. N.Y. Acad. Sci. 2005 1042卷(X期):488-496頁
(IF: 1.789, 領域排名: 7, 領域期刊數: 45, 領域排名: 15.56%)

Detection of apoptosis and necrosis in normal human lung cells using 1H NMR spectroscopy.
Chwen-Ming Shih, Wun-Chang Ko, Liang-Yo Yang, Chien-Ju Lin, Jui-Sheng Wu, Tsui-Yun Lo, Shwu-Huey Wang, Chien-Tsu Chen - - 1 - Annals of the New York Academy of Sciences - Ann. N.Y. Acad. Sci. 2005;1042(X):488-496
(IF: 1.789, Journal Ranking: 7, Number of Journals of this Field: 45, Ranking: 15.56%)

34

Cadmium toxicity toward caspase-independent apoptosis through the mitochondria–calcium pathway in mtDNA-depleted cells.
施勇綸, 林千如, Sheng-Wei Hsu, 王聖豪, 陳偉立, 李美足, 魏耀揮, 施純明* - - 1 - Annals of the New York Academy of Sciences - Ann. N.Y. Acad. Sci. 2005 1042卷(X期):497-505頁
(IF: 1.789, 領域排名: 7, 領域期刊數: 45, 領域排名: 15.56%)

Cadmium toxicity toward caspase-independent apoptosis through the mitochondria–calcium pathway in mtDNA-depleted cells.
Yung-Luen Shih, Chien-Ju Lin, Sheng-Wei Hsu, Sheng-Hao Wang, Wei-Li Chen, Mei-Tsu Lee, Yau-Huei Wei, Chwen-Ming Shih* - - 1 - Annals of the New York Academy of Sciences - Ann. N.Y. Acad. Sci. 2005;1042(X):497-505
(IF: 1.789, Journal Ranking: 7, Number of Journals of this Field: 45, Ranking: 15.56%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
112 — N 國科會(原科技部) — NSTC112-2320-B-037-023 — 1 個人型
討海洋源真菌Trichoderma brevicompactum NTU439之二次代謝產物木霉素Trichodermin用以治療惡性膠質細胞瘤之療效與機轉,及其對腫瘤微環境的影響( )
2023/08/01 ~ 2024/07/31
2
111 — M 高醫(種子計畫) — KMU-M112028 —  
開發蘇木甲醇萃取物結合具通透血腦障壁之標靶性奈米微脂體藥物應用於抗惡性膠質瘤之療效評估與機轉探討( )
2023/01/01 ~ 2023/12/31
3
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-055-B — 8 大專學生研究計畫
112年度大專學生研究計畫-謝惟如(藥學4)( )
2023/07/01 ~ 2024/02/29
4
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-056-B — 8 大專學生研究計畫
112年度大專學生研究計畫-黃晨瑄(藥學2)( )
2023/07/01 ~ 2024/02/29
5
110 — M 高醫(種子計畫) — KMU-M111008 —  
研究瑪瑙珠未成熟果實甲醇萃取 物與其抗癌活性成分之奈米製劑 抗惡性膠質瘤幹細胞之療效,及探 討SLC1A3基因於抗癌作用之角色( )
2022/01/01 ~ 2022/12/31
6
110 — Z 大專學生研究計畫及博士後 — MOST111-2813-C-037-065-B — 8 大專學生研究計畫
111年度大專學生研究計畫-林子維(藥學3)( )
2022/07/01 ~ 2023/02/28
7
109 — N 國科會(原科技部) — MOST109-2320-B-037-020 — 1 個人型
研究台灣肖楠葉萃取物與其抗癌活性成分抗惡性膠質瘤之進程、癌幹細胞生成、輔助放射/化學療法與奈米化製劑之功效及其機轉探討( )
2020/08/01 ~ 2021/07/31
8
108 — M 高醫(種子計畫) — KMU-M109019 —  
探討類黃酮成分flavokawains抗惡性膠質瘤及其應用於提升放射敏感性及免疫療法之功效與機轉( )
2020/01/01 ~ 2020/12/31
9
107 — Q 新聘教師計畫(校內) — KMU-Q108022 —  
活性天然物抗癌病毒71型之療效與機制探討( )
2019/01/01 ~ 2019/12/31
10
106 — N 國科會(原科技部) — MOST107-2320-B-037-002 — 1 個人型
抗腸病毒天然物之開發研究( )
2018/02/01 ~ 2018/10/31
11
106 — Q 新聘教師計畫(校內) — KMU-Q107014 —  
訶子萃取物抗克沙奇病毒之療效評估( )
2018/01/01 ~ 2018/12/31

 Patent