Education
| School — Major — Degree | Duration |
|---|---|
|
國立臺灣大學 — 生理學研究所(畢) — 博士 Doctorate, , |
2006/08 — 2014/01 |
|
高雄醫學大學 — 醫學研究所(畢) — 碩士 Master, , |
2000/08 — 2002/06 |
|
高雄醫學大學 — 復健醫學系(畢) — 學士 Bachelor, , |
1994/08 — 2000/06 |
|
高雄醫學大學 — 醫學社會學系(畢) — 學士 Bachelor, , |
1994/08 — 2000/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 學士後醫學系 School of Post-Baccalaureate Medicine | Associate Professor | 2022/08/01 — |
| 學士後醫學系 School of Post-Baccalaureate Medicine | Assistant Professor | 2020/08/01 — 2022/07/31 |
| 生理學科 Department of Physiology | Assistant Professor | 2017/08/01 — 2020/07/31 |
Extramural Experience
Discipline
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
生理學 神經科學 藥理學 神經生理
neurophysiology synapse plasticity ion channel parmacology
Area(s) of Expertise & Research
生理學; 離子通道; 細胞電生理學; 神經細胞生物學;
Ion channel; Cellular electrophysiology; Neurophysiology
Publication
| NO | Publication |
|---|---|
| 1 | 電壓依賴性鈉通道貝塔第四型胜肽與七氟菊酯調控電壓依賴性鈉通道的門閥開關和回返性鈉電流產生 Biophysical mechanisms underlying tefluthrin-induced modulation of gating changes and resurgent current generation in the human Nav1.4 channel |
| 2 | 多元不飽和脂肪酸作為 COVID-19 引起的嗅覺喪失的潛在治療方法 Polyunsaturated Fatty Acids as Potential Treatments for COVID-19-Induced Anosmia |
| 3 | 兩名先天性副肌強直患者突變 Nav1.4 通道的鈉電流復甦的動力學改變 Kinetic alterations in resurgent sodium currents of mutant Nav1.4 channel in two patients affected by paramyotonia con-genita |
| 4 | 副肌強直患者中改變回返性鈉電流的變化有助於肌肉的過度興奮 Changes in Resurgent Sodium Current Contribute to the Hyperexcitability of Muscles in Patients with Paramyotonia Congenita |
| 5 | 大麻選擇性結合電壓依賴性那通道Nav1.4並透過結合在慢性的不活化門閥 Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Nav1.4 in Its Slow-Inactivated State and Inhibits Sodium Current |
| 6 | SCN4A突變後改變回返性鈉電流造成鈉通道肌強直症後群 Changes of Resurgent Na+ Currents in the Nav1.4 Channel Resulting from an SCN4A Mutation Contributing to Sodium Channel Myotonia. |
| 7 | 巨噬細胞遷移抑制因子作為新合成化合物 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline 的潛在靶標。 Macrophage Migration InMacrophage Migration Inhibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline.hibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline. |
| 8 | 活性氧物質調控丁香苷在乳腺癌細胞中的化學預防作用 Reactive oxygen species mediate the chemopreventive effects of syringin in breast cancer cells. |
| 9 | 肢端紅痛症透過SCN9A突變後因回返性鈉電流遇熱產生異質性提高症狀 Anomalous enhancement of resurgent Na+ currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia. |
| 10 | 確定黨參和黃芪水提物在肝細胞中的功能和生物標誌物。 Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells. |
| 11 | Sandensolide誘導口腔癌細胞和斑馬魚異種移植模型中的氧化壓力調控的細胞凋亡 Sandensolide Induces Oxidative Stress-Mediated Apoptosis in Oral Cancer Cells and in Zebrafish Xenograft Model |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
114 — N 國科會(原科技部) — NSTC112-2320-B-037-010-MY3 — 1 個人型
電壓依賴性鈉通道貝塔第四型胜肽與七氟菊酯調控電壓依賴性鈉通道(Nav1.4)門閥開關之生物物理基礎(3/3)( )
|
2025/08/01 ~ 2026/07/31 |
| 2 |
113 — N 國科會(原科技部) — NSTC112-2320-B-037-010-MY3 — 1 個人型
電壓依賴性鈉通道貝塔第四型胜肽與七氟菊酯調控電壓依賴性鈉通道(Nav1.4)門閥開關之生物物理基礎(2/3)( )
|
2024/08/01 ~ 2026/07/31 |
| 3 |
112 — N 國科會(原科技部) — NSTC112-2320-B-037-010-MY3 — 1 個人型
電壓依賴性鈉通道貝塔第四型胜肽與七氟菊酯調控電壓依賴性鈉通道(Nav1.4)門閥開關之生物物理基礎(1/3)( )
|
2023/08/01 ~ 2026/07/31 |
| 4 |
111 — M 高醫(種子計畫) — KMU-M112004 —
三種鉀離子通道C端結構區域的門閥開關變化引發布魯卡達症候群之分子機轉( )
|
2023/01/01 ~ 2023/12/31 |
| 5 |
110 — N 國科會(原科技部) — MOST110-2320-B-037-004 — 1 個人型
電壓依賴性Nav1.5鈉通道與不同類型鉀通道的門閥開關變化引發布魯卡達症候群之分子機轉( )
|
2021/08/01 ~ 2022/07/31 |
| 6 |
109 — N 國科會(原科技部) — MOST109-2320-B-037-009 — 1 個人型
先天性副肌強直症之Nav1.4通道開關構型變化:探索溫度效應與藥物調節( )
|
2020/08/01 ~ 2021/07/31 |
| 7 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-032 — 1 個人型
肌強直症及相關疾患之Nav1.4通道開關構型變化:症狀成因與藥物治療之探索( )
|
2019/08/01 ~ 2020/07/31 |
| 8 |
107 — Q 新聘教師計畫(校內) — KMU-Q108004 —
探討不同突變行鉀離子通到之門閥開關造成布蓋達症候群的分子機轉( )
|
2019/01/01 ~ 2019/12/31 |
| 9 |
106 — N 國科會(原科技部) — MOST107-2320-B-037-004 — 1 個人型
電壓依賴性Nav1.4鈉通道的門閥開關變化與相關肌肉強直症之分子與藥理調節機轉( )
|
2018/06/01 ~ 2019/10/31 |
| 10 |
106 — Q 新聘教師計畫(校內) — KMU-Q107007 —
突變型電壓依賴性Nav1.4鈉通道之門閥開關變化引發先天性肌肉強直症的分子病理機轉( )
|
2018/01/01 ~ 2018/12/31 |