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 Education

School — Major — Degree Duration

國立臺灣大學 — 生理學研究所(畢) — 博士

Doctorate,  ,  

2006/08 — 2014/01

高雄醫學大學 — 醫學研究所(畢) — 碩士

Master,  ,  

2000/08 — 2002/06

高雄醫學大學 — 復健醫學系(畢) — 學士

Bachelor,  ,  

1994/08 — 2000/06

高雄醫學大學 — 醫學社會學系(畢) — 學士

Bachelor,  ,  

1994/08 — 2000/06

 Intramural Experience

Office/Department/Institute Position Duration
學士後醫學系 School of Post-Baccalaureate Medicine   Associate Professor 2022/08/01 —  
學士後醫學系 School of Post-Baccalaureate Medicine   Assistant Professor 2020/08/01 — 2022/07/31
生理學科 Department of Physiology   Assistant Professor 2017/08/01 — 2020/07/31

 Extramural Experience

 

 Discipline

 

 Research & Technology Platform Open to the Outside

Cellular electrophysiology Patch-clamp

 Interested Area(s)for Interdisciplinary Research

藥理學 運動醫學 物理治療 神經科學

neurophysiology synapse

 Area(s) of Expertise & Research

生理學; 離子通道; 細胞電生理學; 神經細胞生物學;

Ion channel; Cellular electrophysiology; Neurophysiology

 Publication

NO Publication
1

電壓依賴性鈉通道貝塔第四型胜肽與七氟菊酯調控電壓依賴性鈉通道的門閥開關和回返性鈉電流產生
Hsing-Jung Lai, Ming-Jen Lee, 游昕瑋, Kuan-Wen Chen, 蔡克勵, 林碧珍, 黃烱瑋* - - 1 - Pesticide Biochemistry and Physiology - PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2024 200卷(2024期):105833頁
(IF: 4.7, 領域排名: 7, 領域期刊數: 100, 領域排名: 7.00%)

Biophysical mechanisms underlying tefluthrin-induced modulation of gating changes and resurgent current generation in the human Nav1.4 channel
Hsing-Jung Lai, Ming-Jen Lee, Hsin-Wei Yu, Kuan-Wen Chen, Ke-Li Tsai, Pi-Chen Lin, Chiung-Wei Huang* - - 1 - Pesticide Biochemistry and Physiology - PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2024;200(2024):105833
(IF: 4.7, Journal Ranking: 7, Number of Journals of this Field: 100, Ranking: 7.00%)

2

兩名先天性副肌強直患者突變 Nav1.4 通道的鈉電流復甦的動力學改變
Ming-Jen Lee#, 林碧珍#, 林明宏, 邱馨瑩, Kai Wang, 黃烱瑋* - - 2 - Biology-Basel - BIOLOGY-BASEL 2022 11卷(4期):613頁
(IF: 5.079, 領域排名: 16, 領域期刊數: 93, 領域排名: 17.20%)

Kinetic alterations in resurgent sodium currents of mutant Nav1.4 channel in two patients affected by paramyotonia con-genita
Ming-Jen Lee#, Pi-Chen Lin#, Ming-Hong Lin, Hsin-Ying Clair Chiou, Kai Wang, Chiung-Wei Huang* - - 2 - Biology-Basel - BIOLOGY-BASEL 2022;11(4):613
(IF: 5.079, Journal Ranking: 16, Number of Journals of this Field: 93, Ranking: 17.20%)

3

副肌強直患者中改變回返性鈉電流的變化有助於肌肉的過度興奮
黃烱瑋, La, H.J, 林碧珍, Ming-Jen Lee* - - 1 - Biomedicines - BIOMEDICINES 2021 9卷(1期):51頁
(IF: 4.757, 領域排名: 86, 領域期刊數: 279, 領域排名: 30.82%)

Changes in Resurgent Sodium Current Contribute to the Hyperexcitability of Muscles in Patients with Paramyotonia Congenita
Chiung-Wei Huang, Hsing-Jung Lai, Pi-Chen Lin, Ming-Jen Lee* - - 1 - Biomedicines - BIOMEDICINES 2021;9(1):51
(IF: 4.757, Journal Ranking: 86, Number of Journals of this Field: 279, Ranking: 30.82%)

4

大麻選擇性結合電壓依賴性那通道Nav1.4並透過結合在慢性的不活化門閥
黃烱瑋, 林碧珍, Jian-Lin Chen, Ming-Jen Lee* - - 1 - Biomedicines - BIOMEDICINES 2021 9卷(9期):1411頁
(IF: 4.757, 領域排名: 86, 領域期刊數: 279, 領域排名: 30.82%)

Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Nav1.4 in Its Slow-Inactivated State and Inhibits Sodium Current
Chiung-Wei Huang, Pi-Chen Lin, Jian-Lin Chen and Ming-Jen Lee - - 1 - Biomedicines - BIOMEDICINES 2021;9(9):1411
(IF: 4.757, Journal Ranking: 86, Number of Journals of this Field: 279, Ranking: 30.82%)

5

SCN4A突變後改變回返性鈉電流造成鈉通道肌強直症後群
黃烱瑋, Lai HJ, 林碧珍, Lee MJ.* - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020 21卷(7期):E2593頁
(IF: 5.923, 領域排名: 67, 領域期刊數: 298, 領域排名: 22.48%)

Changes of Resurgent Na+ Currents in the Nav1.4 Channel Resulting from an SCN4A Mutation Contributing to Sodium Channel Myotonia.
Huang CW, Lai HJ, Lin PC, Lee MJ.* - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020;21(7):E2593
(IF: 5.923, Journal Ranking: 67, Number of Journals of this Field: 298, Ranking: 22.48%)

6

巨噬細胞遷移抑制因子作為新合成化合物 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline 的潛在靶標。
Ko PH, Shen YC, Murugan K, 黃烱瑋, Sivakumar G, Pal P, Liao CC, Luo KS, Chuang EY, Tsai MH, Lai LC*. - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2019 14卷(9期):2147頁
(IF: 4.011, 領域排名: 15, 領域期刊數: 69, 領域排名: 21.74%)

Macrophage Migration InMacrophage Migration Inhibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline.hibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline.
Ko PH, Shen YC, Murugan K, 黃烱瑋, Sivakumar G, Pal P, Liao CC, Luo KS, Chuang EY, Tsai MH, Lai LC*. - - 1 - Scientific Reports - SCIENTIFIC REPORTS 2019;14(9):2147
(IF: 4.011, Journal Ranking: 15, Number of Journals of this Field: 69, Ranking: 21.74%)

7

活性氧物質調控丁香苷在乳腺癌細胞中的化學預防作用
李建興*, 黃烱瑋, 張博智, 蕭君平, 林吟品, 林美瑩, Chih-Cheng Lai*, 陳中一* - - 1 - Phytomedicine - PHYTOMEDICINE 2019 61卷(-期):152844頁
(IF: 4.268, 領域排名: 23, 領域期刊數: 234, 領域排名: 9.83%)

Reactive oxygen species mediate the chemopreventive effects of syringin in breast cancer cells.
CH Lee, 黃烱瑋, PC Chang, JP Shiau, IP Lin, MY Lin, CC Lai, CY Chen - - 1 - Phytomedicine - PHYTOMEDICINE 2019;61(-):152844
(IF: 4.268, Journal Ranking: 23, Number of Journals of this Field: 234, Ranking: 9.83%)

8

肢端紅痛症透過SCN9A突變後因回返性鈉電流遇熱產生異質性提高症狀
黃烱瑋, Lai HJ, Huang PY, Lee MJ*, Kuo CC* - - 1 - Scientific reports - SCIENTIFIC REPORTS 2019 ?卷(9期):12251頁
(IF: 4.011, 領域排名: 15, 領域期刊數: 69, 領域排名: 21.74%)

Anomalous enhancement of resurgent Na+ currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia.
黃烱瑋, Lai HJ, Huang PY, Lee MJ, Kuo CC - - 1 - Scientific reports - SCIENTIFIC REPORTS 2019;?(9):12251
(IF: 4.011, Journal Ranking: 15, Number of Journals of this Field: 69, Ranking: 21.74%)

9

確定黨參和黃芪水提物在肝細胞中的功能和生物標誌物。
Ko PH, 黃烱瑋, Chang HH, Chuang EY, Tsai MH, Lai LC1* - - 1 - Chinese Medicine - CHINESE MEDICINE 2019 20卷(14期):10頁
(IF: 2.265, 領域排名: 9, 領域期刊數: 27, 領域排名: 33.33%)

Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells.
Ko PH, 黃烱瑋, Chang HH, Chuang EY, Tsai MH, Lai LC - - 1 - Chinese Medicine - CHINESE MEDICINE 2019;20(14):10
(IF: 2.265, Journal Ranking: 9, Number of Journals of this Field: 27, Ranking: 33.33%)

10

Sandensolide誘導口腔癌細胞和斑馬魚異種移植模型中的氧化壓力調控的細胞凋亡
Chung-I Yu, Chung-Yi Chen, 劉旺達, 張博智 , 黃炯瑋 , Kuang-Fen Han , In-Pin Lin ,林美瑩 ,李建興* - - 1 - Marine drugs - MARINE DRUGS 2018 16卷(10期):387頁
(IF: 4.379, 領域排名: 5, 領域期刊數: 59, 領域排名: 8.47%)

Sandensolide Induces Oxidative Stress-Mediated Apoptosis in Oral Cancer Cells and in Zebrafish Xenograft Model
Chung-I Yu, Chung-Yi Chen, Wangta Liu, Po-Chih Chang, Chiung-Wei Huang, Kuang-Fen Han, In-Pin Lin, Mei-Ying Lin, Chien-Hsing Lee * - - 1 - Marine drugs - MARINE DRUGS 2018;16(10):387
(IF: 4.379, Journal Ranking: 5, Number of Journals of this Field: 59, Ranking: 8.47%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
114 — N 國科會(原科技部) — NSTC112-2320-B-037-010-MY3 — 1 個人型
電壓依賴性鈉通道貝塔第四型胜肽與七氟菊酯調控電壓依賴性鈉通道(Nav1.4)門閥開關之生物物理基礎(3/3)( )
2025/08/01 ~ 2026/07/31
2
113 — N 國科會(原科技部) — NSTC112-2320-B-037-010-MY3 — 1 個人型
電壓依賴性鈉通道貝塔第四型胜肽與七氟菊酯調控電壓依賴性鈉通道(Nav1.4)門閥開關之生物物理基礎(2/3)( )
2024/08/01 ~ 2026/07/31
3
112 — N 國科會(原科技部) — NSTC112-2320-B-037-010-MY3 — 1 個人型
電壓依賴性鈉通道貝塔第四型胜肽與七氟菊酯調控電壓依賴性鈉通道(Nav1.4)門閥開關之生物物理基礎(1/3)( )
2023/08/01 ~ 2026/07/31
4
111 — M 高醫(種子計畫) — KMU-M112004 —  
三種鉀離子通道C端結構區域的門閥開關變化引發布魯卡達症候群之分子機轉( )
2023/01/01 ~ 2023/12/31
5
110 — N 國科會(原科技部) — MOST110-2320-B-037-004 — 1 個人型
電壓依賴性Nav1.5鈉通道與不同類型鉀通道的門閥開關變化引發布魯卡達症候群之分子機轉( )
2021/08/01 ~ 2022/07/31
6
109 — N 國科會(原科技部) — MOST109-2320-B-037-009 — 1 個人型
先天性副肌強直症之Nav1.4通道開關構型變化:探索溫度效應與藥物調節( )
2020/08/01 ~ 2021/07/31
7
108 — N 國科會(原科技部) — MOST108-2320-B-037-032 — 1 個人型
肌強直症及相關疾患之Nav1.4通道開關構型變化:症狀成因與藥物治療之探索( )
2019/08/01 ~ 2020/07/31
8
107 — Q 新聘教師計畫(校內) — KMU-Q108004 —  
探討不同突變行鉀離子通到之門閥開關造成布蓋達症候群的分子機轉( )
2019/01/01 ~ 2019/12/31
9
106 — N 國科會(原科技部) — MOST107-2320-B-037-004 — 1 個人型
電壓依賴性Nav1.4鈉通道的門閥開關變化與相關肌肉強直症之分子與藥理調節機轉( )
2018/06/01 ~ 2019/10/31
10
106 — Q 新聘教師計畫(校內) — KMU-Q107007 —  
突變型電壓依賴性Nav1.4鈉通道之門閥開關變化引發先天性肌肉強直症的分子病理機轉( )
2018/01/01 ~ 2018/12/31

 Patent