Education
| School — Major — Degree | Duration |
|---|---|
|
國立中山大學 — 生物醫學研究所(畢) — 博士 Doctorate, Institute of Biomedical Sciences, National Sun Yat-sen University |
2008/09 — 2014/06 |
|
高雄醫學大學 — 香粧品學系(畢) — 學士 Bachelor, Department of Fragrance and Cosmetic Science, Kaohsiung Medical University |
2004/09 — 2008/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 香粧品學系 Department of Fragrance and Cosmetic Science | Associate Professor | 2022/02/01 — |
| 香粧品學系 Department of Fragrance and Cosmetic Science | Assistant Professor | 2017/02/01 — 2022/01/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 生物學之生化及分子生物 Biochemistry and Molecular Biology |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
Area(s) of Expertise & Research
1. 生物學之生化及分子生物 2. 外泌體
1. Biochemistry and Molecular Biology 2. Exosome
Publication
| NO | Publication |
|---|---|
| 1 | Development on potential skin anti-aging agents of Cosmos caudatus Kunth via inhibition of collagenase, MMP-1 and MMP-3 activities. Development on potential skin anti-aging agents of Cosmos caudatus Kunth via inhibition of collagenase, MMP-1 and MMP-3 activities. |
| 2 | Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway. Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway. |
| 3 | SUMO-Activating Enzyme Subunit 1 Is Associated with Poor Prognosis, Tumor Progression, and Radio-Resistance in Colorectal Cancer. SUMO-Activating Enzyme Subunit 1 Is Associated with Poor Prognosis, Tumor Progression, and Radio-Resistance in Colorectal Cancer. |
| 4 | Carboxyl Group-Modified Myoglobin Induces TNF-α-Mediated Apoptosis in Leukemia Cells. Carboxyl Group-Modified Myoglobin Induces TNF-α-Mediated Apoptosis in Leukemia Cells. |
| 5 | Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells. Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells. |
| 6 | Resveratrol inhibits matrix metalloproteinase-1 and -3 expression by suppressing of p300/NFκB acetylation in TNF-α-treated human dermal fibroblasts Resveratrol inhibits matrix metalloproteinase-1 and -3 expression by suppressing of p300/NFκB acetylation in TNF-α-treated human dermal fibroblasts |
| 7 | Preparation of High-Performance Metal-Free UV/Near Infrared-Shielding Films for Human Skin Protection Preparation of High-Performance Metal-Free UV/Near Infrared-Shielding Films for Human Skin Protection |
| 8 | Fabrication of oxide-based near infrared-shielding coatings for a smart window to prevent infrared-induced photoaging in human skin Fabrication of oxide-based near infrared-shielding coatings for a smart window to prevent infrared-induced photoaging in human skin |
| 9 | Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis. Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis. |
| 10 | Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient. Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient. |
| 11 | Compound C induces autophagy and apoptosis in parental and hydroquinone-selected malignant leukemia cells through the ROS/p38 MAPK/AMPK/TET2/FOXP3 axis. Compound C induces autophagy and apoptosis in parental and hydroquinone-selected malignant leukemia cells through the ROS/p38 MAPK/AMPK/TET2/FOXP3 axis. |
| 12 | Blocking of negative charged carboxyl groups converts Naja atra,neurotoxin to cardiotoxin-like protein Blocking of negative charged carboxyl groups converts Naja atra,neurotoxin to cardiotoxin-like protein |
| 13 | Albendazole藉由非有絲分裂之影響條控人類血癌細胞透過SIRT3/ROS/p38 MAPK/TTP上調TNF-a而導致細胞凋亡 Non-mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-α upregulation |
| 14 | 三氧化二砷透過抑制TET2-FOXP3-Lyn-Akt 路徑調控MCL1表現誘導人類白血並細胞凋亡 The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells. |
| 15 | Membrane-damaging activities of mannosylated ovalbumin are involved in,its antibacterial action Membrane-damaging activities of mannosylated ovalbumin are involved in,its antibacterial action |
| 16 | Hydroquinone誘導FOXP3‑ADAM17‑Lyn‑Akt‑p21訊息路徑促進人類血癌細胞U937惡性化 Hydroquinone‑induced FOXP3‑ADAM17‑Lyn‑Akt‑p21 signaling axis promotes malignant progression of human leukemia U937 cells |
| 17 | Detection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon Detection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon |
| 18 | 糖基修飾白蛋白具有破膜活性 Ovalbumin with Glycated Carboxyl Groups Shows Membrane-Damaging Activity |
| 19 | Quinacrine透過FOXP3/miR-183/β-TrCP/SP1誘導BAX表現增加造成人類急性白血病細胞U937細胞凋亡 Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/β-TrCP/SP1 axis-mediated BAX upregulation |
| 20 | Amsacrine藉由抑制AKT與ERK所調控之MCL1穩定性而誘導人類白血病細胞U937細胞凋亡 Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1 |
| 21 | 沒食子酸修飾之金奈米粒子在乳癌細胞MDA-MB-231中透過降低p300穩定性與NFkB/c-Jun活性抑制EGF所誘導MMP-9表現 Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells |
| 22 | 沒食子酸抑制人類乳癌細胞MCF-7中EGFR/Src/Akt/Erk誘導之MMP-9表現 Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells |
| 23 | 拮抗台灣雨傘節α-Bungarotoxin之DNA適體可辨認台灣眼鏡蛇心臟毒素 DNA Aptamers against Taiwan Banded Krait α-Bungarotoxin Recognize Taiwan Cobra Cardiotoxins. |
| 24 | 2‐(4‐Aminophenyl)‐7‐methoxybenzothiazole活化p38 MAPK上調TNFa/TNFR2表現而誘導人類血癌細胞U937細胞凋亡 The association between p38 MAPK‐mediated TNF‐a/TNFR2 up‐regulation and 2‐(4‐Aminophenyl)‐7‐methoxybenzothiazole‐induced apoptosis in human leukemia U937 cells |
| 25 | Quinacrine 誘導人體白血病 K562 細胞通過 P38 MAPK 引起 BCL 2 向下調控 ERK/ c-Jun 和抑制 BCL2L1 表現。 Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression |
| 26 | 人類血癌細胞U937中TNF-a誘導NFkB與AP-1導致之DNA looping調控MMP-9表現 NFkB-and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcription in TNF-a-treated human leukemia U937 cells |
| 27 | mannosylated bovine serum albumin具有抗菌與破膜活性 Antibacterial and membrane-damaging activities of mannosylated bovine serum albumin |
| 28 | 台灣眼鏡蛇磷脂酶 A2 抑制 ERK 介導 ADAM17 發展， 因而減少在人類白血病 U937 細胞中 TNF-α production 的分泌。 Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells. |
| 29 | 人類血癌細胞朱K562中simvastatin誘導NFkB/p65下調與JNK1/c-Jun/ATF-2活化，導致MMP-9表現下降但不影響MMP-2表現 Simvastatin induces NFkB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells |
| 30 | 人類血癌細胞中Amsacrine抑制基質金屬蛋白酶MMP-2/MMP-9表現 Amsacrine suppresses matrix metalloproteinase‐2 (MMP‐2)/MMP‐9 expression in human leukemia cells |
| 31 | '醣基修飾BSA具有膜擾動活性 Bovine serum albumin with glycated carboxyl groups shows membrane-perturbing activities |
| 32 | 眼鏡蛇心臟毒素的 fusogenicity ，如鹼性蛋白質在鞘磷脂囊泡中含有氧化磷脂和膽固醇。 Fusogenicity of Naja naja atra cardiotoxin-like basic protein on sphingomyelin vesicles containing oxidized phosphatidylcholine and cholesterol. |
| 33 | p38MAPK 和 ERK 相互之間的干擾是透過人類白血病U937細胞中 MAPK誘導蛋白質磷酸化 2A catalytic subunit α 和 MAPK phosphatase-1 的表現。 Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells. |
| 34 | 表現Bcr/Abl的血癌細胞中，hydroquinone誘導miR-122下調使ADAM17表現增加，進而增加TNF-a分泌 Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-a production in human leukemia cells with expressed Bcr/Abl |
| 35 | Guanidination的notexin促進磷脂酶A2獨立活性融合囊泡與脂質提供負曲率 Guanidination of notexin promotes its phospholipase A2 activity-independent fusogenicity on vesicles with lipid-supplied negative curvature |
| 36 | 沒食子酸下調MMP-2與MMP-9表現在表現Bcr/Abl之血癌細胞中 Gallic acid downregulates matrix metalloproteinase‐2 (MMP‐2) and MMP‐9 in human leukemia cells with expressed Bcr/Abl |
| 37 | Arecoline透過上調細胞膜上TNFR2表現誘導人類血癌細胞K562細胞凋亡 Arecoline‐induced death of human leukemia K562 cells is associated with surface up‐modulation of TNFR2 |
| 38 | 黑頸射毒眼鏡蛇 CMS- 9在兩性離子和anionic phospholipid vesicles的磷脂酶A2活性依賴和非融合活性依賴的表現 Phospholipase A2 activity-dependent and -independent fusogenic activity of Naja nigricollis CMS-9 on zwitterionic and anionic phospholipid vesicles |
| 39 | Naja nigricollis CMS‐9促進adaphostin處理的人類血癌細胞U937粒線體依賴細胞凋亡 Naja nigricollis CMS‐9 enhances the mitochondria‐mediated death pathway in adaphostin‐treated human leukaemia U937 cells |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
113 — NK 高醫-中山合作計畫 — NK113P19 — 1 個人型
蜂王漿類外泌體囊泡對痤瘡誘導菌的抗菌及抗發炎之研究(Study on the anti-microbial and anti-inflammation effect of royal jelly exosome-like vesicles against acne-inducing bacteria)
|
2024/01/01 ~ 2024/12/31 |
| 2 |
112 — M 高醫(種子計畫) — KMU-M113008 —
間質幹細胞來源之外泌體誘導芳香烴受體作為異位性皮膚炎皮膚屏障修復策略的研究( )
|
2024/01/01 ~ 2024/12/31 |
| 3 |
112 — NK 高醫-中山合作計畫 — — 1 個人型
角質細胞外泌體對皮膚屏障功能之影響(The effect of keratinocyte-derived exosomes in skin barrier function)
|
2023/01/01 ~ 2023/12/31 |
| 4 |
111 — N 國科會(原科技部) — MOST111-2320-B-037-027 — 1 個人型
間質幹細胞之胞外體於金黃色葡萄球菌引起皮膚屏障損傷之治療潛力與機制探討( )
|
2022/08/01 ~ 2023/07/31 |
| 5 |
111 — NK 高醫-中山合作計畫 — — 1 個人型
探討人類真皮細胞纖維母細胞中TNF-a對EZH2調控之機轉(A study on mechanism of TNF-a-regulated EZH2 expression in human dermal fibroblasts)
|
2022/01/01 ~ 2022/12/31 |
| 6 |
110 — N 國科會(原科技部) — MOST110-2320-B-037-026 — 1 個人型
抗菌胜肽於金黃色葡萄球菌引起皮膚屏障損傷之治療潛力與機制探討( )
|
2021/08/01 ~ 2022/07/31 |
| 7 |
110 — NK 高醫-中山合作計畫 — — 1 個人型
以沒食子酸還原奈米粒子抑制基質金屬蛋白酶在人類真皮細胞之表現( )
|
2021/01/01 ~ 2021/12/31 |
| 8 |
109 — N 國科會(原科技部) — MOST109-2320-B-037-008 — 1 個人型
探討EZH2在糖尿病慢性傷口的癒合中所扮演之角色( )
|
2020/08/01 ~ 2021/07/31 |
| 9 |
109 — NK 高醫-中山合作計畫 — NSYSUKMU109-P008 — 1 個人型
以沒食子酸還原金奈米粒子抑制高糖誘發基質金屬蛋白酶在人類真皮細胞之表現( )
|
2020/01/01 ~ 2020/12/31 |
| 10 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-033 — 1 個人型
皮膚中Sirt-1對金屬蛋白酶組織抑制劑的調控及其對傷口癒合之影響( )
|
2019/08/01 ~ 2020/07/31 |
| 11 |
108 — NK 高醫-中山合作計畫 — NSYSUKMU108-P035 — 1 個人型
TNF-α 誘導白血病細胞FOXP3 上調表現的分子機制( )
|
2019/01/01 ~ 2019/12/31 |
| 12 |
108 — TC 研究中心計畫 — KMU-TC108A03-7 — 6 研究中心
載銀多級孔生醫陶瓷於降低骨修復手術細菌感染風險之應用( )
|
2019/08/01 ~ 2020/07/31 |
| 13 |
107 — NK 高醫-中山合作計畫 — NSYSUKMU107-P008 — 1 個人型
三氧化二砷誘導人類白血病細胞凋亡之分子機制( )
|
2018/01/01 ~ 2018/12/31 |
| 14 |
107 — N 國科會(原科技部) — MOST107-2320-B-037-029 — 1 個人型
皮膚細胞中sirt-1對多梳家族蛋白目標基因甲基化之研究( )
|
2018/10/01 ~ 2019/09/30 |
| 15 |
107 — Q 新聘教師計畫(校內) — KMU-Q108010 —
紅外光誘導皮膚細胞老化之調控機制( )
|
2019/01/01 ~ 2019/12/31 |
| 16 |
106 — Q 新聘教師計畫(校內) — KMU-Q107001 —
合成氧化鋅鎵(ZnO:Ga)粉體對阻隔近紅外光誘導皮膚細胞老化之效能評估( )
|
2018/01/01 ~ 2018/12/31 |
| 17 |
106 — Z 大專學生研究計畫及博士後 — MOST107-2813-C-037-057-B — 8 大專學生研究計畫
107年度大專學生研究計畫-李昀怡(香粧2)( )
|
2018/07/01 ~ 2019/02/28 |