Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學大學 — 藥學系(畢) — 博士 Doctorate, , |
2005/08 — 2009/06 |
|
高雄醫學大學 — 藥學研究所(畢) — 碩士 Master, , |
2003/08 — 2005/07 |
|
高雄醫學大學 — 藥學系(畢) — 學士 Bachelor, , |
1999/08 — 2003/07 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 藥學院研發組 Research and Developmen | Head | 2026/08/01 — 2027/07/31 |
| 藥學系 School of Pharmacy | Professor | 2024/08/01 — |
| 藥學系 School of Pharmacy | Associate Professor | 2020/08/01 — 2024/07/31 |
| 藥學系 School of Pharmacy | Assistant Professor | 2017/02/01 — 2020/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy |
| 2 | 自然科學類 Natural Sciences | 化學 Chemistry |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
基因分析、分析化學毛細管電泳法開發、基因檢測方法開發、特殊引子及探針設計及應用、奈米粒子合成及應用
Capillary electrophoresis in pharmacokinetic and pharmacogenetic analysis. Synthesis and application of nanoparticles. Biosensors in pharmacokinetic and pharmacogenetic analysis.
Area(s) of Expertise & Research
儀器分析、藥物分析、基因分析、分析化學毛細管電泳法開發、基因檢測方法開發、特殊引子及探針設計及應用、奈米粒子合成及應用
Development of capillary electrophoresis methods Development of gene detection techniques Design and application of specific primer and probe Synthesis and application of nanoparticles
Publication
| NO | Publication |
|---|---|
| 1 | Label-free fluorescent quantification of L858R single-nucleotide variant in EGFR gene in single-tube magnetic purification system Label-free fluorescent quantification of L858R single-nucleotide variant in EGFR gene in single-tube magnetic purification system |
| 2 | The Specific Low-Interference dsDNA Copper Nanoclusters for Visual Fluorescent Detection and Quantification of the EGFR L858R Point Mutation in Whole Single-Tube Magnetic Purification System The Specific Low-Interference dsDNA Copper Nanoclusters for Visual Fluorescent Detection and Quantification of the EGFR L858R Point Mutation in Whole Single-Tube Magnetic Purification System |
| 3 | Magnetic-assisted catalytic hairpin assembly fluorescent aptasensor for highly sensitive detection of amyloid-beta oligomers as Alzheimer's disease biomarker Magnetic-assisted catalytic hairpin assembly fluorescent aptasensor for highly sensitive detection of amyloid-beta oligomers as Alzheimer's disease biomarker |
| 4 | Novel Primer Design for Significantly Reducing Fluorescent Interferences in the Synthesis of DNA-Templated Copper Nanoclusters for the Detection of the HLA‑B*5801 Gene Novel Primer Design for Significantly Reducing Fluorescent Interferences in the Synthesis of DNA-Templated Copper Nanoclusters for the Detection of the HLA‑B*5801 Gene |
| 5 | Carbon nanomaterials in nucleic acid diagnostics: Advances in sensing and amplification Carbon nanomaterials in nucleic acid diagnostics: Advances in sensing and amplification |
| 6 | Rapid biomonitoring of fluoropyrimidine-based chemotherapy drugs and their biometabolites in colorectal cancer patients’ blood samples using an in-syringe-based fast drug extraction technique followed by LC-MS/MS analysis Rapid biomonitoring of fluoropyrimidine-based chemotherapy drugs and their biometabolites in colorectal cancer patients’ blood samples using an in-syringe-based fast drug extraction technique followed by LC-MS/MS analysis |
| 7 | 功能性金奈米粒子應用於核酸分析和傳遞 Functional gold nanoparticles for analysis and delivery of nucleic acids |
| 8 | Unlocking early detection of Alzheimer's Disease: The emerging role of nanomaterial-based optical sensors Unlocking early detection of Alzheimer's Disease: The emerging role of nanomaterial-based optical sensors |
| 9 | Identification and simultaneous quantification of potential genotoxic impurities in first-line HIV drug dolutegravir sodium using fast ultrasonication-assisted extraction method coupled with GC–MS and in-silico toxicity assessment Identification and simultaneous quantification of potential genotoxic impurities in first-line HIV drug dolutegravir sodium using fast ultrasonication-assisted extraction method coupled with GC–MS and in-silico toxicity assessment |
| 10 | Unlocking early detection of Alzheimer's disease: The emerging role of nanomaterial-based optical sensors. Unlocking early detection of Alzheimer's disease: The emerging role of nanomaterial-based optical sensors. |
| 11 | Fast genotyping of K-RAS codons 12 and 13 based on streptavidin magnetic microbeads equipped with biotin-coupled single base-pair mismatch PCR (SM-PCR) Fast genotyping of K-RAS codons 12 and 13 based on streptavidin magnetic microbeads equipped with biotin-coupled single base-pair mismatch PCR (SM-PCR) |
| 12 | One Single Tube Reaction of Aptasensor-Based Magnetic Sensing System for Selective Fluorescent Detection of VEGF in Plasma One Single Tube Reaction of Aptasensor-Based Magnetic Sensing System for Selective Fluorescent Detection of VEGF in Plasma |
| 13 | Dual‑probe ligation without PCR for fluorescent sandwich assay of EGFR nucleotide variants in magnetic gene capture platform Dual‑probe ligation without PCR for fluorescent sandwich assay of EGFR nucleotide variants in magnetic gene capture platform |
| 14 | Identifiable universal fluorescent multiplex PCR equipped with capillary electrophoresis for genotyping of exons 1 to 5 in human red and green pigment genes Identifiable universal fluorescent multiplex PCR equipped with capillary electrophoresis for genotyping of exons 1 to 5 in human red and green pigment genes |
| 15 | 三步毛細管電泳線上濃縮技術應用於測定人體血漿中之dabigatran和其代謝物 A three-step stacking capillary electrophoresis of field-amplified sample injection, sweeping, and micellar collapse for determination of dabigatran and its active metabolite in human plasma |
| 16 | 三步疊加毛細管電泳法搭配化學計量實驗設計應用於分析捲菸產品中五種特有之亞硝胺 A chemometric experimental design with three-step stacking capillary electrophoresis for analysis of five tobacco-specific nitrosamines in cigarette products |
| 17 | 開發構象開關誘導雜合的螢光適體感測器應用於檢測β-澱粉樣蛋白寡聚體 Fluorescent aptasensor based on conformational switch-induced hybridization for facile detection of β‑amyloid oligomers |
| 18 | Copper nanoclusters on specific-primer PCR fragments with magnetic capture for the label-free fluorescent sensing of the T315I single nucleotide variant in the BCR–ABL1 gene Copper nanoclusters on specific-primer PCR fragments with magnetic capture for the label-free fluorescent sensing of the T315I single nucleotide variant in the BCR–ABL1 gene |
| 19 | 穩定的發光聚（烯丙胺鹽酸鹽）-模板銅納米糰簇應用於選擇性感測地中海型貧血血漿中的Deferasirox Stable Luminescent Poly(Allylaminehydrochloride)-Templated Copper Nanoclusters for Selectively Turn-Off Sensing of Deferasirox in beta-Thalassemia Plasma |
| 20 | 利用SDS與親水性聚合物於MEKC分離模式下分離高和低分子量之透明質酸 The matrix of SDS integrated with linear hydrophilic polymer for resolution of high- and low-molecular weight hyaluronic acids in MEKC |
| 21 | 利用銅離子誘導多巴胺共軛碳點的猝滅和發光恢復應用於檢測血漿中的Deferasirox Cu2+-induced quenching and recovery of the luminescence of dopamine-conjugated carbon dots for sensing deferasirox in plasma |
| 22 | 利用單鏈分子反轉探針-滾環擴增搭配螢光銅納米團簇應用於檢測SMN基因的單核苷酸變異體以診斷脊髓肌肉萎縮症 Molecular inversion probe-rolling circle amplification with single-strand poly-T luminescent copper nanoclusters for fluorescent detection of single-nucleotide variant of SMN gene in diagnosis of spinal muscular atrophy |
| 23 | Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria |
| 24 | 應用奈米材料和光學傳感器於非法藥物之分析 Nanomaterial-based adsorbents and optical sensors for illicit drug analysis |
| 25 | Antibacterial Activity of BSA-Capped Gold Nanoclusters against Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Intermediate Staphylococcus aureus (VISA) Antibacterial Activity of BSA-Capped Gold Nanoclusters against Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Intermediate Staphylococcus aureus (VISA) |
| 26 | 利用毛細管電泳法分析運動神經原存活基因於 診斷脊髓肌肉萎縮症 Capillary Gel Electrophoresis for Analysis of Survival Motor Neuron Gene in Diagnosis of Spinal Muscular Atrophy |
| 27 | 利用基因捕捉與限制酶酵素釋放應用於直接螢光分析基因變異於診斷脊髓肌肉萎縮症 Specific Gene Capture Combined with Restriction-Fragment Release for Directly Fluorescent Genotyping of Single-Nucleotide Polymorphisms in Diagnosing Spinal Muscular Atrophy |
| 28 | Dialkyl anionic surfactant in field-amplified sample injection andsweeping-micellar electrokinetic chromatography for determinationof eight leanness-promoting -agonists in animal feeds Dialkyl anionic surfactant in field-amplified sample injection andsweeping-micellar electrokinetic chromatography for determinationof eight leanness-promoting -agonists in animal feeds |
| 29 | Molecular inversion probes equipped with discontinuous rolling cycle amplification for targeting nucleotide variants: Determining SMN1 and SMN2 genes in diagnosis of spinal muscular atrophy Molecular inversion probes equipped with discontinuous rolling cycle amplification for targeting nucleotide variants: Determining SMN1 and SMN2 genes in diagnosis of spinal muscular atrophy |
| 30 | DNA結合之金奈米粒子的生物醫學應用 Biomedical Applications of DNA-Conjugated Gold Nanoparticles |
| 31 | 非標示螢光奈米叢對杜馨氏肌肉萎縮症之基因診斷 Label-free fluorescent copper nanoclusters for genotyping of deletion and duplication of Duchenne muscular dystrophy |
| 32 | Direct assay of uroporphyrin and coproporphyrin in human urine by reverse-mode field amplified sample injection-sweeping and micellar electrokinetic chromatography Direct assay of uroporphyrin and coproporphyrin in human urine by reverse-mode field amplified sample injection-sweeping and micellar electrokinetic chromatography |
| 33 | Universal fluorescent tri-probe ligation equipped with capillary electrophoresis for targeting SMN1 and SMN2 genes in diagnosis of spinal muscular atrophy Universal fluorescent tri-probe ligation equipped with capillary electrophoresis for targeting SMN1 and SMN2 genes in diagnosis of spinal muscular atrophy |
| 34 | A “turn on/off” scorpion biosensor targeting point mutation of SMN gene for diagnosis of spinal muscular atrophy A “turn on/off” scorpion biosensor targeting point mutation of SMN gene for diagnosis of spinal muscular atrophy |
| 35 | 反向聚合酶鏈鎖反應毛細管電泳法對血友病 intron 22 inversion Type 1 及 2之分析研究 Separation of intron 22 inversion Type 1 and 2 of hemophilia A by modified inverse-shifting polymerase chain reaction and capillary gel electrophoresis |
| 36 | 毛細管電泳法診斷血友病第八凝血因子內顯子22反轉之基因分析 Genotyping of intron 22 inversion of factor VIII gene for diagnosis of hemophilia A by inverse-shifting polymerase chain reaction and capillary electrophoresis |
| 37 | 毛細管電泳法對杜馨氏肌肉萎縮症之外顯子1~20之基因分析 Genotyping of exons 1 to 20 in Duchenne muscular dystrophy by universal multiplex PCR and short-end capillary electrophoresis |
| 38 | 利用大體積檢品堆積毛細管電泳法分析carbamazepine及其五種代謝物 Analysis of carbamazepine and its five metabolites in serum by large volume sample stacking-sweeping capillary electrophoresis |
| 39 | 大體積堆積掃集毛細管電泳技術及實驗分析策略對十種濫用藥物之分析研究 Analysis of ten abused drugs in urine by large volume sample stacking-sweeping capillary electrophoresis with an experimental design strategy |
| 40 | 陽離子大量注射及掃集式MEKC毛細管電泳法對肉品中瘦肉精ractopamine之定量分析研究 Chemometric optimization of cation-selective exhaustive injection sweeping MEKC for quantification of ractopamine in porcine meat |
| 41 | 利用微乳化電動層析法分析飲料中phthalates之含量 Microemulsion electrokinetic chromatography for analysis of phthalates in soft drinks |
| 42 | 毛細管電泳法對人體血漿中(±)-threo-methylphenidate之對掌分析研究 Enantioseparation of (±)-threo-methylphenidate in human plasma by cyclodextrin-modified sample stacking capillary electrophoresis |
| 43 | 以化學統計設計進行大體積檢品堆積毛細管電泳法對化粧品中常用防腐劑之分析研究 Large volume sample stacking with electroosmotic flow and sweeping in capillary electrophoresis for determination of common preservatives in cosmetic products by chemometric experimental design |
| 44 | 肺癌藥物基因體學中利用毛細管電泳法針對表皮生長因子接受器之基因分析研究 Capillary electrophoretic genotyping of epidermal growth factor receptor for pharmacogenomic assay of |
| 45 | 創新型重覆性大體積檢品注入及掃描式微胞電動層析法對尿液中男性荷爾蒙運動禁藥之分析研究 A novel stacking method of repetitive large volume sample injection and sweeping MEKC for determination of androgenic steroids in urine |
| 46 | 利用同時檢測SMN基因劑量與SMN雜交基因判別SMN基因的相向性轉換存在於一華人族群 Identification of bidirectional gene conversion between SMN1 and SMN2 by simultaneous analysis of SMN dosage and hybrid genes in a Chinese population |
| 47 | 選擇性大量陽離子取樣及掃描式微胞電動層析法分析海洛因藥癮者使用使用美沙同後之血中濃度測定 Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for the analysis of methadone and its metabolites in serum of heroin addicts |
| 48 | 利用通用螢光引子聚合酵素鏈鎖反應及毛細管電泳法分析脊髓肌肉萎縮症之多區基因分析 Multi-exon genotyping of SMN gene in spinal muscular atrophy by universal fluorescent PCR and capillary electrophoresis |
| 49 | 利用毛細管電泳法分析脊髓肌肉萎縮症之SMN!/SMN2基因轉換分析 Universal fluorescent multiplex PCR and capillary electrophoresis for evaluation of gene conversion between SMN1/SMN2 in spinal muscular atrophy |
| 50 | 以通用多重聚合𡓨及毛細管電泳法定量脊髓肌肉萎縮症之SMN1/SMN2基因 Universal Multiplex PCR and Capillary Electrophoresis for Quantification of SMN1/SMN2 Genes in Spinal Muscular Atrophy |
| 51 | 利用毛細管電泳定量SMN1和SMN2用於診斷脊髓肌肉萎縮症 Quantification of SMN1 and SMN2 genes by capillary electrophoresis for diagnosis of spinal muscular atrophy |
| 52 | 以微胞電動毛細管電泳法同時測定化妝品中 l-ascorbic acid, ascorbic acid-2-phosphate magnesium salt, and ascorbic acid-6-palmitate三種成分 Simultaneous determination of l-ascorbic acid, ascorbic acid-2-phosphate magnesium salt, and ascorbic acid-6-palmitate in commercial cosmetics by micellar electrokinetic capillary electrophoresis |
| 53 | 利用大體積檢品堆積及電極反轉之毛細管電泳法分析mercaptopurine及其代謝物 Determination of mercaptopurine and its four metabolites by large volume sample stacking with polarity switching in capillary electrophoresis |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
115 — N 國科會(原科技部) — NSTC115-2113-M-037-016 — 1 個人型
高純度水溶性碳奈米粒子輔助微液滴毛細管微流體等溫基因放大技術平台之開發、應用及機轉探討(1/2)( )
|
2026/08/01 ~ 2027/07/31 |
| 2 |
115 — Z 大專學生研究計畫及博士後 — NSTC115-2811-M-037-012 — 9 博士後研究員
博士級研究人員--賴可朋( )
|
2026/08/01 ~ 2027/07/31 |
| 3 |
114 — N 國科會(原科技部) — NSTC114-2113-M-037-016 — 1 個人型
研究奈米複合材料輔助高通量毛細管線上等溫基因放大平台以應用於檢測HER2相關基因並探討其機制( )
|
2025/08/01 ~ 2026/07/31 |
| 4 |
113 — N 國科會(原科技部) — NSTC113-2113-M-037-011 — 1 個人型
開發毛細管微流體系統搭配奈米表面複合材料應用於快速檢測Irinotecan之藥物血中濃度及其相關基因(2/2)( )
|
2024/08/01 ~ 2025/07/31 |
| 5 |
113 — Z 大專學生研究計畫及博士後 — NSTC113-2811-M-037-007 — 9 博士後研究員
博士級研究人員--梁馨樺( )
|
2024/08/01 ~ 2025/07/31 |
| 6 |
112 — N 國科會(原科技部) — NSTC112-2113-M-037-020 — 1 個人型
開發毛細管微流體系統搭配奈米表面複合材料應用於快速檢測Irinotecan之藥物血中濃度及其相關基因(1/2)( )
|
2023/08/01 ~ 2024/07/31 |
| 7 |
111 — N 國科會(原科技部) — MOST111-2113-M-037-010 — 1 個人型
開發等溫基因放大平台搭配奈米材料與微型裝置應用於快速檢測HLA等相關基因( )
|
2022/08/01 ~ 2023/07/31 |
| 8 |
110 — N 國科會(原科技部) — MOST110-2113-M-037-013 — 1 個人型
開發試紙感測平台並搭配奈米材料應用於快速檢測相關基因之甲基化( )
|
2021/08/01 ~ 2022/07/31 |
| 9 |
109 — N 國科會(原科技部) — MOST108-2113-M-037-018-MY2 — 1 個人型
開發適體磁珠平台並搭配奈米材料應用於快速檢測血管內皮生長因子及其相關基因(2/2)( )
|
2020/08/01 ~ 2021/07/31 |
| 10 |
108 — N 國科會(原科技部) — MOST108-2113-M-037-018-MY2 — 1 個人型
開發適體磁珠平台並搭配奈米材料應用於快速檢測血管內皮生長因子及其相關基因(1/2)( )
|
2019/08/01 ~ 2021/07/31 |
| 11 |
107 — N 國科會(原科技部) — MOST106-2113-M-037-020-MY2 — 1 個人型
建立奈米粒子基因感測平台並應用於分析EGFR基因(2/2)( )
|
2018/08/01 ~ 2019/07/31 |
| 12 |
106 — N 國科會(原科技部) — MOST106-2113-M-037-020-MY2 — 1 個人型
建立奈米粒子基因感測平台並應用於分析EGFR基因(1/2)( )
|
2017/08/01 ~ 2019/07/31 |
| 13 |
106 — Q 新聘教師計畫(校內) — KMU-Q107013 —
發展奈米磁珠平台以應用於生物感測表皮生長因子受器基因( )
|
2018/01/01 ~ 2018/12/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 測定ＳＭＮ基因是否發生基因轉移或突變的方法 | 中華民國 | 2011/10/11 | I350312 |
| 2 | 測定SMN基因是否發生基因轉移或突變的方法 | 美國 | 2011/01/25 | 7,875,432 |
| 3 | 測定SMN基因是否發生基因轉移或突變的方法 | 美國 | 2011/11/29 | 8,067,568 |
| 4 | 測定SMN基因發生基因轉移或突變的方法 | 以色列 | 2015/03/01 | 210023 |
| 5 | 一種單核酸變異的基因檢測方法 | 中華民國 | 2026/06/21 | I929373 |