Education
| School — Major — Degree | Duration |
|---|---|
|
國立臺灣大學 — 藥理學研究所(畢) — 博士 Doctorate, Pharmacology, National Taiwan University |
2002/09 — 2008/06 |
|
國立臺灣大學 — 藥理學研究所(畢) — 碩士 Master, Pharmacology, National Taiwan University |
2000/09 — 2002/07 |
|
高雄醫學大學 — 藥學系(畢) — 學士 Bachelor, Pharmacy, Kaohsiung Medical University |
1996/09 — 2000/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 學士後醫學系 School of Post-Baccalaureate Medicine | Professor | 2023/08/01 — |
| 學士後醫學系 School of Post-Baccalaureate Medicine | Assistant Professor | 2020/08/01 — 2020/01/31 |
| 學士後醫學系 School of Post-Baccalaureate Medicine | Associate Professor | 2020/02/01 — 2023/07/31 |
| 藥理學科 Department of Pharmacology | Assistant Professor | 2017/02/01 — 2020/07/31 |
Extramural Experience
| DEPNO | Position- Office/Department/Institute | Duration |
|---|---|---|
| 敏惠醫護管理專科學校 | 助理教授 | 1010909 — 1060131 |
Discipline
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
劑型改變：結構變化
Area(s) of Expertise & Research
科學中藥藥理探討 老藥新用 抗癌暨神經發炎藥物開發 抑制淋巴管新生藥物開發
Pharmacological action of traditional Chinese medicine, drug repurposing, development of anti-cancer and anti-neuroinflammation drugs, development of drugs for inhibiting lymphangiogenesis
Publication
| NO | Publication |
|---|---|
| 1 | 芳樟醇，一種植物芳香化合物，在帕金森氏症實驗模型中具保護多巴胺神經元及改善運動功能和骨骼肌強度的作用 Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson's Disease. |
| 2 | Hernandonine 介導的肝細胞癌自噬細胞死亡：p53 和 YAP 訊號路徑的相互作用 Hernandonine-mediated autophagic cell death in hepatocellular carcinoma: Interplay of p53 and YAP signaling pathways |
| 3 | Rhopaloic Acid A 透過 JNK/BNIP3/Nix 介導的粒線體自噬觸發口腔癌中線粒體損傷誘導的細胞凋亡 Rhopaloic acid A triggers mitochondria damage-induced apoptosis in oral cancer by JNK/BNIP3/Nix-mediated mitophagy |
| 4 | 抗菌胜肽Piscidin 4透過ERK/SIRT1/PGC-1α訊號路徑誘導膀胱癌凋亡 The Antimicrobial Peptide Tilapia Piscidin 4 Induced the Apoptosis of Bladder Cancer Through ERK/SIRT1/PGC-1α Signaling Pathway |
| 5 | Nobiletin 衍生物 5-acetoxy-6,7,8,3',4'-pentamethoxyflavone 透過抑制小膠質細胞中的 TLR4/MyD88/MAPK 訊號通路和 STAT3 來抑制神經炎症 Nobiletin derivative, 5-acetoxy-6,7,8,3',4'-pentamethoxyflavone, inhibits neuroinflammation through the inhibition of TLR4/MyD88/MAPK signaling pathways and STAT3 in microglia |
| 6 | 老藥新用抗精神病藥物三氟拉嗪透過 ROS/自噬途徑誘導 SLC7A11/GPX4 調控的口腔癌鐵死亡 Repurposing of the Antipsychotic Trifluoperazine Induces SLC7A11/GPX4- Mediated Ferroptosis of Oral Cancer via the ROS/Autophagy Pathway |
| 7 | 白花丹素藉由ROS調控的內質網壓力和粒線體功能障礙造成抗藥性口腔癌细胞凋亡 Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction |
| 8 | α7 菸鹼型乙酰膽鹼受體在腦部疾病中的生理功能和治療應用 Physiologic Functions and Therapeutic Applications of α7 Nicotinic Acetylcholine Receptor in Brain Disorders |
| 9 | Eugenosedin-A 改善肥胖相關高血糖經由調控 ATP 敏感性鉀通道及胰島素分泌在胰臟乙型細胞 Eugenosedin-A improves obesity-related hyperglycemia by regulating ATP-sensitive K channels and insulin secretion in pancreatic β cells. |
| 10 | 6-甲氧基黃酮通過抑制 TLR4/MyD88/p38 MAPK/NF-κB 依賴性通路和激活 HO-1/NQO-1 信號通路來抑制脂多醣刺激的小膠質細胞中的神經炎症 6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling |
| 11 | 異甘草素通過葡萄糖調節蛋白 78 下調抑制胃癌幹細胞、調節腫瘤微環境和抑制腫瘤生長 Isoliquiritigenin Inhibits Gastric Cancer Stemness, Modulates Tumor Microenvironment, and Suppresses Tumor Growth through Glucose-Regulated Protein 78 Downregulation |
| 12 | 木黴通過細胞凋亡誘導的線粒體功能障礙和 HDAC-2 介導的信號傳導抑制口腔癌的生長 Trichodermin inhibits the growth of oral cancer through apoptosis-induced mitochondrial dysfunction and HDAC-2-mediated signaling |
| 13 | 氯丙嗪是一種抗精神病藥，可通過調節人口腔癌中PI3K / AKT / mTOR介導的自噬途徑來誘導G2 / M期阻滯和細胞凋亡 Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer |
| 14 | 鼻腔灌洗液外泌體中粘蛋白 5AC 顯著上調，可能促進 COX-2、VEGF 和 MMP-9 的表達：對鼻息肉發病機制的影響 Mucin 5AC is significantly upregulated in exosomes from the nasal lavage fluid and may promote the expression of COX-2, VEGF and MMP-9: an implication in nasal polyp pathogenesis |
| 15 | Rhopaloic acid A 通過 ROS 介導的信號傳導在膀胱癌中誘導細胞凋亡、自噬和 MAPK 激活 Rhopaloic acid A induces apoptosis, autophagy and MAPK activation through ROS-mediated signaling in bladder cancer |
| 16 | Loganin 預防 CXCL12/CXCR4 調控神經性疼痛透過 NLRP3發炎體在神經損傷的大鼠 Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via the NLRP3 inflammasome axis in nerve-injured rats. |
| 17 | Heteronemin 通過 ARF-1 和 MMP-9/VE-Cadherin/Vimentin 抑制淋巴管生成 Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin |
| 18 | ZnO納米顆粒通過線粒體功能障礙和p70S6K信號通路誘導牙齦鱗狀細胞癌中caspase依賴性凋亡 ZnO Nanoparticles Induced Caspase-Dependent Apoptosis in Gingival Squamous Cell Carcinoma through Mitochondrial Dysfunction and p70S6K Signaling Pathway |
| 19 | Hispidulin抑制脂多醣激活的BV2小膠質細胞的神經炎症，並減弱Akt，NF-κB和STAT3途徑的激活。 Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway |
| 20 | Phomaketide A抑制人淋巴管內皮細胞的淋巴管生成 Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells |
| 21 | 活性氧物質調控丁香苷在乳腺癌細胞中的化學預防作用 Reactive oxygen species mediate the chemopreventive effects of syringin in breast cancer cells. |
| 22 | 闡明中藥的分子機制：以對抗急性氣道病毒感染的配方為例 Unraveling the Molecular Mechanism of Traditional Chinese Medicine: Formulas Against Acute Airway Viral Infections as Examples. |
| 23 | 靜磁場誘導神經幹/前驅細胞的早期分化並促進成熟 Static Magnetic Field Induced Neural Stem/Progenitor Cell Early Differentiation and Promotes Maturation |
| 24 | 黃嘌呤衍生KMUP-1反轉高糖毒性活化之Kv通道經由cAMP/PKA訊息路徑於大鼠胰島乙型細胞 Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells |
| 25 | 2,3,5,4'-四羥基二苯乙烯-2-O-β-D-葡萄糖苷對氧化偶氮甲烷誘導的結直腸癌大鼠異常隱球灶形成的化學預防作用 Chemopreventive Potential of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats. |
| 26 | KMUP-1保護streptozotocin引起腸系膜動脈功能障礙藉由活化ATP敏感性之鉀離子通道 KMUP-1 protects against streptozotocin-induced mesenteric artery dysfunction via activation of ATP-sensitive potassium channels |
| 27 | 六氫薑黃素對大鼠角膜新生血管的抗血管生成作用 Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization |
| 28 | Sandensolide誘導口腔癌細胞和斑馬魚異種移植模型中的氧化壓力調控的細胞凋亡 Sandensolide Induces Oxidative Stress-Mediated Apoptosis in Oral Cancer Cells and in Zebrafish Xenograft Model |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
114 — N 國科會(原科技部) — NSTC112-2320-B-037-021-MY3 — 1 個人型
海綿天然物Rhopaloic acid A及其同類物抑制淋巴管新生以應用於抑制癌轉移：聚焦於粒線體功能、鐵依賴性死亡與銅依賴性死亡(3/3)( )
|
2025/08/01 ~ 2026/07/31 |
| 2 |
113 — N 國科會(原科技部) — NSTC112-2320-B-037-021-MY3 — 1 個人型
海綿天然物Rhopaloic acid A及其同類物抑制淋巴管新生以應用於抑制癌轉移：聚焦於粒線體功能、鐵依賴性死亡與銅依賴性死亡(2/3)( )
|
2024/08/01 ~ 2026/07/31 |
| 3 |
112 — KP 高醫屏科大 — NPUST-KMU-112-P004 — 1 個人型
探索海綿活性化合物Rhopaloic Acid A透過MAPK訊息傳遞與粒線體功能以抑制淋巴新生之作用與機轉( )
|
2023/01/01 ~ 2023/12/31 |
| 4 |
112 — N 國科會(原科技部) — NSTC112-2320-B-037-021-MY3 — 1 個人型
海綿天然物Rhopaloic acid A及其同類物抑制淋巴管新生以應用於抑制癌轉移：聚焦於粒線體功能、鐵依賴性死亡與銅依賴性死亡(1/3)( )
|
2023/08/01 ~ 2026/07/31 |
| 5 |
112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-047-B — 8 大專學生研究計畫
113年度大專學生研究計畫-唐欣瑜(藥學3)( )
|
2024/07/01 ~ 2025/02/28 |
| 6 |
111 — DK 前瞻重點(原校院) — KMU-DK(A)112005 — 1 個人型
探討慈恩胡頹子之抗神經發炎成分及其對神經退化性疾病的療效評估:聚焦於鐵依賴性死亡和粒線體功能( )
|
2023/01/01 ~ 2023/12/31 |
| 7 |
111 — N 國科會(原科技部) — MOST111-2628-B-037-009 — 1 個人型
探討台灣海綿二倍半帖類化合物的抗淋巴管新生機制及其對發炎致癌與癌轉移之療效評估(3/3)( )
|
2022/08/01 ~ 2023/07/31 |
| 8 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-058-B — 8 大專學生研究計畫
112年度大專學生研究計畫-陳苡臻(生物3)( )
|
2023/07/01 ~ 2024/02/29 |
| 9 |
110 — N 國科會(原科技部) — MOST110-2628-B-037-013 — 1 個人型
探討台灣海綿二倍半帖類化合物的抗淋巴管新生機制及其對發炎致癌與癌轉移之療效評估(2/3)( )
|
2021/08/01 ~ 2022/07/31 |
| 10 |
110 — Z 大專學生研究計畫及博士後 — MOST111-2813-C-037-064-B — 8 大專學生研究計畫
111年度大專學生研究計畫-陳苡臻(生物2)( )
|
2022/07/01 ~ 2023/02/28 |
| 11 |
109 — KP 高醫屏科大 — NPUST-KMU-109-P006 — 1 個人型
澤蘭黃酮抑制神經發炎機制及其對緩解神經性疼痛之療效評估( )
|
2020/01/01 ~ 2020/12/31 |
| 12 |
109 — N 國科會(原科技部) — MOST109-2628-B-037-009 — 1 個人型
探討台灣海綿二倍半帖類化合物的抗淋巴管新生機制及其對發炎致癌與癌轉移之療效評估(1/3)( )
|
2020/08/01 ~ 2021/07/31 |
| 13 |
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-145-B — 8 大專學生研究計畫
110年度大專學生研究計畫-張洺愷(藥學2)( )
|
2021/07/01 ~ 2022/02/28 |
| 14 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-018 — 1 個人型
六氫薑黃素及其同類物抑制口腔癌引起淋巴管新生及轉移之作用研究( )
|
2019/08/01 ~ 2020/07/31 |
| 15 |
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-007-B — 8 大專學生研究計畫
109年度大專學生研究計畫-陳筠雯(醫學3)( )
|
2020/07/01 ~ 2021/02/28 |
| 16 |
107 — Q 新聘教師計畫(校內) — KMU-Q108014 —
探討紅球薑萃取物抑制舌癌細胞之侵襲轉移之機制相關研究( )
|
2019/01/01 ~ 2019/12/31 |
| 17 |
107 — Z 大專學生研究計畫及博士後 — MOST108-2813-C-037-056-B — 8 大專學生研究計畫
108年度大專學生研究計畫-莊筑媛(醫技3)( )
|
2019/07/01 ~ 2020/02/29 |
| 18 |
106 — N 國科會(原科技部) — MOST106-2320-B-037-031 — 1 個人型
評估新穎ROCK抑制劑抑制乳癌細胞之侵襲轉移、上皮-間質轉換和結合化( )
|
2017/10/01 ~ 2018/09/30 |
| 19 |
106 — Q 新聘教師計畫(校內) — KMU-Q107009 —
評估新穎ROCK抑制劑抑制舌癌細胞之侵襲、轉移和上皮間質轉化之機制相關研究( )
|
2018/01/01 ~ 2018/12/31 |