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 Education

School — Major — Degree Duration

國立臺灣大學 — 解剖學暨細胞生物學研究所(畢) — 博士

Doctorate, Graduate Institute of Anatomy and Cell Biology, National Taiwan University

2010/08 — 2015/02

國立臺灣大學 — 解剖學暨細胞生物學研究所(畢) — 碩士

Master, Graduate Institute of Anatomy and Cell Biology, National Taiwan University

2008/08 — 2010/07

國立臺灣大學 — 生命科學系(畢) — 學士

Bachelor, Department of Life Science, National Taiwan University

2004/09 — 2008/06

 Intramural Experience

Office/Department/Institute Position Duration
解剖學科 Department of Anatomy   Assistant Professor 2016/08/01 —  

 Extramural Experience

 

 Discipline

 

 Research & Technology Platform Open to the Outside

 

 Interested Area(s)for Interdisciplinary Research

代謝體相關研究,癌症抗藥性機制以及新藥開發之研究

 

 Area(s) of Expertise & Research

缺血再灌流傷害,與粒線體相關之細胞凋亡機制,microRNA,肺癌細胞之抗藥性機制,exosome在各種疾病中所扮演的角色肝臟缺血再灌流傷害的保護機制,與粒線體相關之細胞凋亡機制,外質體在前制約訓練的保護機制中所扮演的角色,微型核糖核酸在缺血再灌流傷害中所扮演的角色

The protective mechanisms of hepatic ischemia-reperfusion injury, mitochondria-related apoptosis, the role of exosomes in the protective mechanisms of preconditioning, the protective effects of microRNAs in ischemia-reperfusion injury

 Publication

NO Publication
1

腎小管粒線體 ATP 合成酶功能障礙在馬來酸誘導的急性腎損傷中的關鍵作用
林祐賢, 梁展榮, 楊敏瑜, Phang-Lang Chen, 王子銘, 陳彥樺, 施耀翔, 劉旺達, 邱建智, 姜至剛, 林常申, 林含貞 - - 1 - APOPTOSIS - APOPTOSIS 2024 29卷(5-6期):620-634頁
(IF: 6.1, 領域排名: 47, 領域期刊數: 313, 領域排名: 15.02%)

Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury
Hugo Y-H Lin, Chan-Jung Liang, Ming-Yu Yang, Phang-Lang Chen, Tzu-Ming Wang, Yen-Hua Chen, Yao-Hsiang Shih, Wangta Liu, Chien-Chih Chiu, Chih-Kang Chiang, Chang-Shen Lin, Han-Chen Lin - - 1 - APOPTOSIS - APOPTOSIS 2024;29(5-6):620-634
(IF: 6.1, Journal Ranking: 47, Number of Journals of this Field: 313, Ranking: 15.02%)

2

利用甘露糖苷包覆阿黴素標靶治療MDA-MB-231乳癌細胞
蘇語涵, 林含貞#, 李幸燕, 連芷萱, 施耀翔, 賴千蕙* - - 1 - ACS Applied Nano Materials - ACS APPLIED NANO MATERIALS 2023 6卷(6期):4957-4968頁
(IF: 6.14, 領域排名: 101, 領域期刊數: 345, 領域排名: 29.28%)

Mannoside-Functionalized Silica Nanocomposite-Encapsulated Doxorubicin for MDA-MB-231 Cancer Cell Targeting and Delivery
Yu-Han Su, Han-Chen Lin, Hsing-Yen Li, Chih-Hsuan Lien, Yao-Hsiang Shih, Chian-Hui Lai* - - 1 - ACS Applied Nano Materials - ACS APPLIED NANO MATERIALS 2023;6(6):4957-4968
(IF: 6.14, Journal Ranking: 101, Number of Journals of this Field: 345, Ranking: 29.28%)

3

運動正常化高血壓小鼠的海馬迴腎素血管緊縮素系統並回復空間記憶、神經新生與血腦屏障滲漏
張瀛雙, 林志隆, Chu-Wan Lee, 林含貞, Yi-Ting Wu, 施耀翔* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022 23卷(10期):5531頁
(IF: 6.208, 領域排名: 69, 領域期刊數: 296, 領域排名: 23.31%)

Exercise Normalized the Hippocampal Renin-Angiotensin System and Restored Spatial Memory Function, Neurogenesis, and Blood-Brain Barrier Permeability in the 2K1C-Hypertensive Mouse
Ying-Shuang Chang, Chih-Lung Lin, Chu-Wan Lee, Han-Chen Lin, Yi-Ting Wu, Yao-Hsiang Shih* - - 1 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022;23(10):5531
(IF: 6.208, Journal Ranking: 69, Number of Journals of this Field: 296, Ranking: 23.31%)

4

氯丙嗪是一種抗精神病藥,可通過調節人口腔癌中PI3K / AKT / mTOR介導的自噬途徑來誘導G2 / M期阻滯和細胞凋亡
An-Jie Jhou, Hao-Chiun Chang#, Chih-Chang Hung, 林含貞, 李怡琛, 劉旺達, Kuang-Fen Han, Yu-Wei Lai, 林美瑩, 李建興* - - 1 - Biochemical Pharmacology - BIOCHEMICAL PHARMACOLOGY 2021 184卷(0期):114403頁
(IF: 6.1, 領域排名: 46, 領域期刊數: 279, 領域排名: 16.49%)

Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer
An-Jie Jhou, Hao-Chiun Chang#, Chih-Chang Hung, Han-Chen Lin, Yi-Chen Lee, Wang-ta Liu, Kuang-Fen Han, Yu-Wei Lai, Mei-Ying Lin, Chien-Hsing Lee* - - 1 - Biochemical Pharmacology - BIOCHEMICAL PHARMACOLOGY 2021;184(0):114403
(IF: 6.1, Journal Ranking: 46, Number of Journals of this Field: 279, Ranking: 16.49%)

5

Exploring the Impact of Glyoxal Glycation on β-Amyloid Peptide (Aβ) Aggregation in Alzheimer's Disease.
Kai-Wei Hu, Hsiu-Fang Fan, 林含貞, Jian-Wei Huang, Yu-Chieh Chen, Cai-Ling Shen, 施耀翔, Ling-Hsien Tu* - - 1 - THE JOURNAL OF PHYSICAL CHEMISTRY. B - JOURNAL OF PHYSICAL CHEMISTRY B 2021 125卷(21期):5559-5571頁
(IF: 2.991, 領域排名: 93, 領域期刊數: 162, 領域排名: 57.41%)

Exploring the Impact of Glyoxal Glycation on β-Amyloid Peptide (Aβ) Aggregation in Alzheimer's Disease.
Kai-Wei Hu, Hsiu-Fang Fan, Han-Chen Lin, Jian-Wei Huang, Yu-Chieh Chen, Cai-Ling Shen, Yao-Hsiang Shih, Ling-Hsien Tu - - 1 - THE JOURNAL OF PHYSICAL CHEMISTRY. B - JOURNAL OF PHYSICAL CHEMISTRY B 2021;125(21):5559-5571
(IF: 2.991, Journal Ranking: 93, Number of Journals of this Field: 162, Ranking: 57.41%)

6

MDA-MB-231乳癌細胞對於不同大小的glycosilica 奈米粒子的攝取偏好
李幸燕, 林含貞#, Bo-Jie Huang, Alex Zhen Kai Lo, Syafiqah Saidin, Chian-Hui Lai* - - 1 - Langmuir - LANGMUIR 2020 36卷(38期):11374-11382頁
(IF: 3.882, 領域排名: 70, 領域期刊數: 179, 領域排名: 39.11%)

Size Preferences Uptake of Glycosilica Nanoparticles to MDA-MB-231 Cell
Hsing-Yen Li, Han-Chen Lin#, Bo-Jie Huang, Alex Zhen Kai Lo, Syafiqah Saidin , Chian-Hui Lai* - - 1 - Langmuir - LANGMUIR 2020;36(38):11374-11382
(IF: 3.882, Journal Ranking: 70, Number of Journals of this Field: 179, Ranking: 39.11%)

7

Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells.
林含貞, Keng-Fang Hsu#, Chiao-Ling Lai, Tzu-Chien Wu, 陳慧芬*, Chian-Hui Lai* - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES 2020 25卷(8期):1853頁
(IF: 4.411, 領域排名: 63, 領域期刊數: 179, 領域排名: 35.20%)

Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells.
Han-Chen Lin, Keng-Fang Hsu#, Chiao-Ling Lai, Tzu-Chien Wu, Hui-Fen Chen*, Chian-Hui Lai* - - 1 - MOLECULES (BASEL, SWITZERLAND) - MOLECULES 2020;25(8):1853
(IF: 4.411, Journal Ranking: 63, Number of Journals of this Field: 179, Ranking: 35.20%)

8

Mannosyl electrochemical impedance cytosensor for label-free MDA-MB-231 cancer cell detection
湯宜璇, 林含貞, 賴巧苓, 陳泊余*, 賴千蕙* - - 1 - Biosensors and Bioelectronics - BIOSENSORS & BIOELECTRONICS 2018 116卷(0期):100-107頁
(IF: 8.173, 領域排名: 2, 領域期刊數: 83, 領域排名: 2.41%)

Mannosyl electrochemical impedance cytosensor for label-free MDA-MB-231 cancer cell detection
Yi-Hsuan Tang, Han-Chen Lin, Chiao-Ling Lai, Po-Yu Chen*, Chian-Hui Lai* - - 1 - Biosensors and Bioelectronics - BIOSENSORS & BIOELECTRONICS 2018;116(0):100-107
(IF: 8.173, Journal Ranking: 2, Number of Journals of this Field: 83, Ranking: 2.41%)

9

探討由白色念珠菌以及非白色念珠菌所引起之念珠菌菌血症之因子與結果
Wei-JuLee,Jen-FuHsu,Mei-YinLai,Ming-ChouChiang,林含貞,Hsuan-RongHuang,I.-HsyuanWu,Shih-MingChu,Ren-HueiFu,Ming-HorngTsai* - - 1 - American Journal of Infection Control - AMERICAN JOURNAL OF INFECTION CONTROL 2018 46卷(12期):1387-1393頁
(IF: 4.303, 領域排名: 80, 領域期刊數: 210, 領域排名: 38.10%)

Factors and outcomes associated with candidemia caused by non-albicans Candida spp versus Candida albicans in children
Wei-Ju Lee, Jen-Fu Hsu, Mei-Yin Lai, Ming-Chou Chiang, Han-Chen Lin, Hsuan-Rong Huang, I.-Hsyuan Wu, Shih-Ming Chu, Ren-Huei Fu, Ming-Horng Tsai* - - 1 - American Journal of Infection Control - AMERICAN JOURNAL OF INFECTION CONTROL 2018;46(12):1387-1393
(IF: 4.303, Journal Ranking: 80, Number of Journals of this Field: 210, Ranking: 38.10%)

10

二十碳五烯酸會降低腫瘤細胞中吲哚胺2,3-雙加氧酶1的表現
王志強,楊志仁,吳俐嫻,林含貞,溫志宏,李哲欣* - - 1 - International Journal of medical sciences. - INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 2018 15卷(12期):1296-1303頁
(IF: 2.284, 領域排名: 46, 領域期刊數: 155, 領域排名: 29.68%)

Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cells
Chih-Chiang Wang, Chih-Jen Yang, Li-Hsien Wu, Han-Chen Lin, Zhi-Hong Wen, Che-Hsin Lee* - - 1 - International Journal of medical sciences. - INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 2018;15(12):1296-1303
(IF: 2.284, Journal Ranking: 46, Number of Journals of this Field: 155, Ranking: 29.68%)

11

微型核醣核酸183透過抑制凋亡因子Apaf-1調控後制約訓練的保護效應
林含貞, 劉心雲, 顏爾言, 李財坤, 賴逸儒* - - 1 - Antioxidants&Redox Signaling - ANTIOXID REDOX SIGN 2017 26卷(11期):583-597頁
(IF: 7.093, 領域排名: 11, 領域期刊數: 133, 領域排名: 8.27%)

microRNA-183 Mediates Protective Postconditioning of the Liver by Repressing Apaf-1.
Lin Han-Chen, Liu Shin-Yun, Yen Er-Yen, Li Tsai-Kun, and Lai I-Rue - - 1 - Antioxidants&Redox Signaling - ANTIOXID REDOX SIGN 2017;26(11):583-597
(IF: 7.093, Journal Ranking: 11, Number of Journals of this Field: 133, Ranking: 8.27%)

12

連接蛋白43抑制吲哚胺2,3-雙加氧酶1
林含貞,楊志仁,管玉貂,王唯匡,張文瑋,李哲欣* - - 1 - international journal of medical sciences - 2017 14卷(12期):1181-1188頁
(IF: 2.399, 領域排名: 36, 領域期刊數: 155, 領域排名: 23.23%)

The inhibition of indoleamine 2, 3-dioxygenase 1 by connexin 43
Han-Chen Lin, Chih-Jen Yang, Yu-Diao Kuan, Wei-Kuang Wang, Wen-Wei Chang, and Che-Hsin Lee - - 1 - international journal of medical sciences - 2017;14(12):1181-1188
(IF: 2.399, Journal Ranking: 36, Number of Journals of this Field: 155, Ranking: 23.23%)

13

黃耆萃取物透過調控ERK訊息傳遞路徑抑制黑色素生成
Yu-TzuTsao,Chun-YuKuo,Yu-DiaoKuan,林含貞,Li-HsienWu,Che-HsinLee* - - 1 - International Journal of medical sciences - INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 2017 14卷(11期):1049-1053頁
(IF: 2.399, 領域排名: 36, 領域期刊數: 155, 領域排名: 23.23%)

The Extracts of Astragalus membranaceus Inhibit Melanogenesis through the ERK Signaling Pathway
Yu-Tzu Tsao, Chun-Yu Kuo, Yu-Diao Kuan, Han-Chen Lin, Li-Hsien Wu, Che-Hsin Lee* - - 1 - International Journal of medical sciences - INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 2017;14(11):1049-1053
(IF: 2.399, Journal Ranking: 36, Number of Journals of this Field: 155, Ranking: 23.23%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
110 — N 國科會(原科技部) — MOST110-2320-B-037-017 — 1 個人型
以細胞及動物模式探討空氣污染細懸浮微粒引起之內皮損傷的機轉( )
2021/08/01 ~ 2022/07/31
2
108 — N 國科會(原科技部) — MOST107-2320-B-037-005-MY3 — 1 個人型
後制約訓練以及游離粒線體對肝臟缺血再灌流傷害的保護效應與機制(3/3)( )
2020/05/01 ~ 2021/04/30
3
107 — NK 高醫-中山合作計畫 — NSYSUKMU107-P004 — 1 個人型
檜木醇藉由抑制吲哚胺2,3雙加氧酶表現抑制腫瘤免疫耐受性( )
2018/01/01 ~ 2018/12/31
4
107 — N 國科會(原科技部) — MOST107-2320-B-037-005-MY3 — 1 個人型
後制約訓練以及游離粒線體對肝臟缺血再灌流傷害的保護效應與機制(2/3)( )
2019/05/01 ~ 2021/04/30
5
106 — NK 高醫-中山合作計畫 — NSYSKMU106P006 — 1 個人型
探討連接蛋白 43在腫瘤免疫耐受性的角色( )
2017/01/01 ~ 2017/12/31
6
106 — N 國科會(原科技部) — MOST107-2320-B-037-005-MY3 — 1 個人型
後制約訓練以及游離粒線體對肝臟缺血再灌流傷害的保護效應與機制(1/3)( )
2018/05/01 ~ 2021/04/30
7
105 — Q 新聘教師計畫(校內) — KMU-Q106008 —  
奈米化薑黃素調控發炎肺臟上皮細胞表現黏附因子及其相關機構( )
2017/01/01 ~ 2017/12/31

 Patent