Education
| School — Major — Degree | Duration |
|---|---|
|
國立國防醫學院 — 醫學科學研究所(畢) — 博士 Doctorate, , |
2004/09 — 2012/06 |
|
國立清華大學 — 生命科學系(畢) — 碩士 Master, , |
1999/09 — 2001/06 |
|
國立中山大學 — 生物科學系(畢) — 學士 Bachelor, , |
1995/09 — 1999/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 研究發展處實驗動物中心 Center for Laboratory Animals | Director | 2025/08/01 — 2026/07/31 |
| 微生物暨免疫學科 Department of Microbiology & Immunology | Associate Professor | 2022/02/01 — |
| 微生物暨免疫學科 Department of Microbiology & Immunology | Assistant Professor | 2016/02/01 — 2022/01/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 微生物及免疫學 Microbiology and Immunology |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
自體免疫學、胃腸道免疫學、腫瘤免疫學
Area(s) of Expertise & Research
自體免疫學、胃腸道免疫學、腫瘤免疫學自體免疫學及腫瘤免疫學
Autoimmunology and tumor immunology
Publication
| NO | Publication |
|---|---|
| 1 | Clostridium butyricumMIYAIRI 588 Reduces Colorectal Adenomatous Polyp Recurrence: A Randomized Crossover Trial Clostridium butyricumMIYAIRI 588 Reduces Colorectal Adenomatous Polyp Recurrence: A Randomized Crossover Trial |
| 2 | Polycyclic aromatic hydrocarbon aggravates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease through disturbing hepatocyte sphingolipid metabolism. Polycyclic aromatic hydrocarbon aggravates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease through disturbing hepatocyte sphingolipid metabolism. |
| 3 | Macrophage MRC2 Deficiency Mitigates HFD-Induced MASLD by Downregulating CD147-Regulated TNF-α Production Macrophage MRC2 Facilitates MASLD via the CD147-TNF-α Axis Macrophage MRC2 Deficiency Mitigates HFD-Induced MASLD by Downregulating CD147-Regulated TNF-α Production Macrophage MRC2 Facilitates MASLD via the CD147-TNF-α Axis |
| 4 | Corrigendum: Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models. Corrigendum: Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models. |
| 5 | The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4. The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4. |
| 6 | S100A6 participates in initiation of autoimmune encephalitis and is under epigenetic control S100A6 participates in initiation of autoimmune encephalitis and is under epigenetic control |
| 7 | Copper Exposure Induces Epithelial-Mesenchymal Transition-Related Fibrotic Change via Autophagy and Increase Risk of Lung Fibrosis in Human Copper Exposure Induces Epithelial-Mesenchymal Transition-Related Fibrotic Change via Autophagy and Increase Risk of Lung Fibrosis in Human |
| 8 | HCV Core Protein-ISX Axis Promotes Chronic Liver Disease Progression via Metabolic Remodeling and Immune Suppression. HCV Core Protein-ISX Axis Promotes Chronic Liver Disease Progression via Metabolic Remodeling and Immune Suppression. |
| 9 | Aryl hydrocarbon receptor-kynurenine axis promotes oncogenic activity in BCP-ALL. Aryl hydrocarbon receptor-kynurenine axis promotes oncogenic activity in BCP-ALL. |
| 10 | Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models. Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models. |
| 11 | Reciprocal Regulation of Cancer-Associated Fibroblasts and Tumor Microenvironment in Gastrointestinal Cancer: Implications for Cancer Dormancy. Reciprocal Regulation of Cancer-Associated Fibroblasts and Tumor Microenvironment in Gastrointestinal Cancer: Implications for Cancer Dormancy. |
| 12 | 針對癌症相關成纖維細胞對抗消化系統腫瘤進展的天然化合物：治療見解 Natural compounds targeting cancer-associated fibroblasts against digestive system tumor progression: Therapeutic insights |
| 13 | 兩名先天性副肌強直患者突變 Nav1.4 通道的鈉電流復甦的動力學改變 Kinetic alterations in resurgent sodium currents of mutant Nav1.4 channel in two patients affected by paramyotonia con-genita |
| 14 | Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit |
| 15 | Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells. Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells. |
| 16 | The efficacy of culture-guided versus empirical therapy with high-dose proton pump inhibitor as third-line treatment of Helicobacter pylori infection: A real-world clinical experience. The efficacy of culture-guided versus empirical therapy with high-dose proton pump inhibitor as third-line treatment of Helicobacter pylori infection: A real-world clinical experience. |
| 17 | Suppressive Effects of 4-(Phenylsulfanyl) Butan-2-One on CCL-1 Production via Histone Acetylation in Monocytes. Suppressive Effects of 4-(Phenylsulfanyl) Butan-2-One on CCL-1 Production via Histone Acetylation in Monocytes. |
| 18 | Immunological map in COVID-19. Immunological map in COVID-19. |
| 19 | WLS/wntless 在通過 WNT 信號獨立機制控制樹突細胞穩態方面至關重要 WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism |
| 20 | Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions |
| 21 | SPAK Deficiency Attenuates Chemotherapy-Induced Intestinal Mucositis SPAK Deficiency Attenuates Chemotherapy-Induced Intestinal Mucositis |
| 22 | 易週糖注射劑調節中樞神經系統中組織浸潤Th1/Th17細胞的發育和致腦炎Th1細胞的致病性 Dulaglutide modulates the development of tissue-infiltrating Th1/Th17 cells and the pathogenicity of encephalitogenic Th1 cells in the Central Nervous System |
| 23 | Immunopathological effects of Agaricus blazei Murill polysaccharides against Schistosoma mansoni infection by Th1 and NK1 cells differentiation Immunopathological effects of Agaricus blazei Murill polysaccharides against Schistosoma mansoni infection by Th1 and NK1 cells differentiation |
| 24 | S100A6 促進 B 淋巴細胞通過自身免疫性腦炎的血腦屏障滲透 S100A6 Promotes B Lymphocyte Penetration Through the Blood-Brain Barrier in Autoimmune Encephalitis |
| 25 | 幽門螺旋桿菌藉間質細胞之COLEC12, PGE2-EP2/4,於胃相關疾病所扮演之先天免疫反應 Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases |
| 26 | 嗎啡透過上調Connexin 43表達來誘導成纖維細胞活化: 創傷癒合中纖維化的意義 Morphine Induces Fibroblast Activation through Up-regulation of Connexin 43 Expression: Implication of Fibrosis in Wound Healing |
| 27 | Pentachloropseudilin通過加速靶細胞中細胞表面II型TGF-β受體的轉換來抑制轉化生長因子-β（TGF-β）活性 Pentachloropseudilin Inhibits Transforming Growth Factor-β (TGF-β) Activity by Accelerating Cell-Surface Type II TGF-β Receptor Turnover in Target Cells |
| 28 | Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis |
| 29 | Glucosamine modulates T cell differentiation through downregulating N-linked glycosylation of CD25 Glucosamine modulates T cell differentiation through downregulating N-linked glycosylation of CD25 |
| 30 | Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses |
| 31 | DDX3X Biomarker Correlates with Poor Survival in Human Gliomas DDX3X Biomarker Correlates with Poor Survival in Human Gliomas |
| 32 | Targeting tumor necrosis factor receptor 1 assembly reverses Th17-mediated colitis through boosting a Th2 response Targeting tumor necrosis factor receptor 1 assembly reverses Th17-mediated colitis through boosting a Th2 response |
| 33 | T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in non-obese diabetic mice by increasing Th1 and Th17 cells T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in non-obese diabetic mice by increasing Th1 and Th17 cells |
| 34 | Overexpression of Galectin-9 in Islets Prolongs Grafts Survival via Downregulation of Th1 Responses Overexpression of Galectin-9 in Islets Prolongs Grafts Survival via Downregulation of Th1 Responses |
| 35 | Different Modulation of Ptpn22 in Effector and Regulatory T Cells Leads to Attenuation of Autoimmune Diabetes in Transgenic Nonobese Diabetic Mice Different Modulation of Ptpn22 in Effector and Regulatory T Cells Leads to Attenuation of Autoimmune Diabetes in Transgenic Nonobese Diabetic Mice |
| 36 | B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells |
| 37 | Molecular and functional studies of tilapia (Oreochromis mossambicus) NMDA receptor NR1 subunits Molecular and functional studies of tilapia (Oreochromis mossambicus) NMDA receptor NR1 subunits |
| 38 | Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
113 — N 國科會(原科技部) — NSTC113-2314-B-037-044 — 1 個人型
研究胃癌的甘露糖受體在調控腫瘤微環境免疫塑形的關鍵影響( )
|
2024/08/01 ~ 2025/07/31 |
| 2 |
113 — Z 大專學生研究計畫及博士後 — NSTC114-2813-C-037-007-B — 8 大專學生研究計畫
114年度大專學生研究計畫-蘇子瑄(醫學3)( )
|
2025/07/01 ~ 2026/02/28 |
| 3 |
112 — N 國科會(原科技部) — NSTC112-2314-B-037-093 — 1 個人型
研究甘露糖受體調節侵襲性胃癌細胞分泌趨化激素及作用於腫瘤微環境免疫塑形的關鍵角色( )
|
2023/08/01 ~ 2024/07/31 |
| 4 |
112 — N 國科會(原科技部) — NSTC112-2320-B-037-005 — 2 整合型
研究腸道特異性同源箱(intestine-specific homeobox ;ISX)-誘導的脂質代謝失衡在慢性肝病的影響-研究腸道特異性同源箱-甘露糖受體軸線在高脂肪飲食誘導非酒精性脂肪肝疾病進展中對於肝細胞脂肪酸代謝和巨噬細胞功能的調節影響(3/3)( )
|
2023/08/01 ~ 2024/07/31 |
| 5 |
111 — N 國科會(原科技部) — MOST109-2314-B-037-034-MY3 — 1 個人型
研究MRC2在胃癌生成過程中的分子機轉:從臨床至基礎的剖析(3/3)( )
|
2022/08/01 ~ 2023/07/31 |
| 6 |
111 — N 國科會(原科技部) — MOST111-2320-B-037-032 — 2 整合型
研究腸道特異性同源箱(intestine-specific homeoboxISX)-誘導的脂質代謝失衡在慢性肝病的影響-研究腸道特異性同源箱-甘露糖受體軸線在高脂肪飲食誘導非酒精性脂肪肝疾病進展中對於肝細胞脂肪酸代謝和巨噬細胞功能的調節影響(2/3)( )
|
2022/08/01 ~ 2023/07/31 |
| 7 |
110 — N 國科會(原科技部) — MOST109-2314-B-037-034-MY3 — 1 個人型
研究MRC2在胃癌生成過程中的分子機轉:從臨床至基礎的剖析(2/3)( )
|
2021/08/01 ~ 2023/07/31 |
| 8 |
110 — N 國科會(原科技部) — MOST110-2320-B-037-009 — 2 整合型
研究腸道特異性同源箱(intestine-specific homeobox ISX)-誘導的脂質代謝失衡在慢性肝病的影響-研究腸道特異性同源箱-甘露糖受體軸線在高脂肪飲食誘導非酒精性脂肪肝疾病進展中對於肝細胞脂肪酸代謝和巨噬細胞功能的調節影響(1/3)( )
|
2021/08/01 ~ 2022/07/31 |
| 9 |
110 — NK 高醫-中山合作計畫 — — 1 個人型
闡明甘露糖受體在胃癌生長的潛在分子機( )
|
2021/01/01 ~ 2021/12/31 |
| 10 |
110 — Z 大專學生研究計畫及博士後 — MOST111-2813-C-037-075-B — 8 大專學生研究計畫
111年度大專學生研究計畫-鍾潔昕(呼吸3)( )
|
2022/07/01 ~ 2023/02/28 |
| 11 |
109 — N 國科會(原科技部) — MOST109-2314-B-037-034-MY3 — 1 個人型
研究MRC2在胃癌生成過程中的分子機轉:從臨床至基礎的剖析(1/3)( )
|
2020/08/01 ~ 2023/07/31 |
| 12 |
109 — NK 高醫-中山合作計畫 — NSYSUKMU109-I004-2 — 2 整合型
Explore how ANE influence macrophages to promote the initiation and progression of oral cancer( )
|
2020/01/01 ~ 2020/12/31 |
| 13 |
109 — Z 大專學生研究計畫及博士後 — HS1100622001-1 — 8 大專學生研究計畫
110年度財團法人健康科學文教基金會醫學系學生暑期研究計畫--邱冠蓉(醫學3)( )
|
2021/07/01 ~ 2021/09/30 |
| 14 |
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-017-B — 8 大專學生研究計畫
110年度大專學生研究計畫-孫湲淨(生技3)( )
|
2021/07/01 ~ 2022/02/28 |
| 15 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-003-MY2 — 1 個人型
剖析轉錄因子Blimp-1及其後轉譯修飾功能對自體免疫性腦脊髓炎疾病模式中調控適應性免疫功能的分子機轉(2/2)( )
|
2020/05/01 ~ 2020/10/31 |
| 16 |
108 — NK 高醫-中山合作計畫 — NSYSUKMU108-I005-1 — 2 整合型
pentabromopseudilin類天然物在抑制TGF-β作用之機轉探討( )
|
2019/01/01 ~ 2019/12/31 |
| 17 |
108 — Z 大專學生研究計畫及博士後 — HS1090622003-1 — 8 大專學生研究計畫
109年度財團法人健康科學文教基金會醫學系學生暑期研究計畫--黃昱睿(醫學4)( )
|
2020/07/01 ~ 2020/09/30 |
| 18 |
107 — NK 高醫-中山合作計畫 — NSYSUKMU107-I001-1 — 2 整合型
pentachloropseudilin類天然物在抑制TGF-B作用之機轉探討( )
|
2018/01/01 ~ 2018/12/31 |
| 19 |
107 — N 國科會(原科技部) — MOST108-2320-B-037-003-MY2 — 1 個人型
剖析轉錄因子Blimp-1及其後轉譯修飾功能對自體免疫性腦脊髓炎疾病模式中調控適應性免疫功能的分子機轉(1/2)( )
|
2019/05/01 ~ 2020/10/31 |
| 20 |
106 — NK 高醫-中山合作計畫 — — 2 整合型
以腸炎實驗動物模式探討溴化酪胺酸類(bromotryrosine)海洋天然物之作用及免疫調節機轉( )
|
2017/01/01 ~ 2017/12/31 |
| 21 |
106 — N 國科會(原科技部) — MOST104-2321-B-037-003-MY3 — 1 個人型
研究c-Maf及其後轉譯修飾功能對自體免疫性腦脊髓炎之免疫調控角色與發展新穎的基因治療策略:以創新的基因轉殖及基因減弱小鼠模式剖析之(3/3)( )
|
2017/08/01 ~ 2019/07/31 |
| 22 |
106 — Q 新聘教師計畫(校內) — KMU-Q107008 —
剖析轉錄因子Blimp-1及其後轉譯修飾功能對自體免疫性腦脊髓炎疾病模式中調控適應性免疫功能的分子機轉( )
|
2018/01/01 ~ 2018/12/31 |
| 23 |
106 — Z 大專學生研究計畫及博士後 — HS1070622008-1 — 8 大專學生研究計畫
107年度財團法人健康科學文教基金會醫學系學生暑期研究計畫--林庭意(醫學3)( )
|
2018/07/01 ~ 2018/09/30 |
| 24 |
105 — N 國科會(原科技部) — MOST104-2321-B-037-003-MY3 — 1 個人型
研究c-Maf及其後轉譯修飾功能對自體免疫性腦脊髓炎之免疫調控角色與發展新穎的基因治療策略:以創新的基因轉殖及基因減弱小鼠模式剖析之(2/3)( )
|
2016/08/01 ~ 2019/07/31 |
| 25 |
105 — Q 新聘教師計畫(校內) — KMU-Q106002 —
研究 Blimp-1 及其後轉譯修飾功能對GM-CSF基因調控之機轉並建構基因轉殖小鼠之自體免疫性腦脊髓炎的疾病模式( )
|
2017/01/01 ~ 2017/12/31 |
| 26 |
105 — TP 頂尖計畫(高醫) — KMU-TP105PR18 —
研究T細胞的Blimp-1基因對於高脂肪飲食所引起胰島素阻抗和第二型糖尿病程的影響( )
|
2017/03/01 ~ 2017/10/31 |
| 27 |
105 — Z 大專學生研究計畫及博士後 — MOST106-2813-C-037-015-B — 8 大專學生研究計畫
106年度大專學生研究計畫-陳怡穎(公衛2)( )
|
2017/07/01 ~ 2018/02/28 |
| 28 |
104 — N 國科會(原科技部) — MOST104-2321-B-037-003-MY3 — 1 個人型
研究c-Maf及其後轉譯修飾功能對自體免疫性腦脊髓炎之免疫調控角色與發展新穎的基因治療策略:以創新的基因轉殖及基因減弱小鼠模式剖析之(1/3)( )
|
2016/02/01 ~ 2019/07/31 |
| 29 |
104 — TP 頂尖計畫(高醫) — KMU-TP104PR17 —
To investigate the impacts of c-Maf SUMOylation in the IL-23- and IL-27- modulated T cell encephalitogenicity during the pathogenic processes of EAE( )
|
2016/04/01 ~ 2016/09/30 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 用於治療砷誘發之肺功能損傷之類黃酮藥物 | 中華民國 | 2023/10/11 | I818466 |
| 2 | 用於治療、預防或減輕肺功能損傷之類黃酮藥物 | 中華民國 | 2025/02/11 | I872951 |