Education
| School — Major — Degree | Duration |
|---|---|
|
國立成功大學 — 基礎醫學研究所(畢) — 博士 Doctorate, Institute of Basic Medical Sciences, National Cheng Kung University |
2004/09 — 2010/07 |
|
高雄醫學大學 — 藥學系(畢) — 學士 Bachelor, School of Pharmacy, Kaohsiung Medical University |
1999/09 — 2003/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 天然藥物研究所 Graduate Institute of Natural Products | Associate Professor | 2022/08/01 — |
| 天然藥物研究所 Graduate Institute of Natural Products | Assistant Professor | 2015/02/01 — 2022/07/31 |
Extramural Experience
| DEPNO | Position- Office/Department/Institute | Duration |
|---|---|---|
| 國立成功大學基礎醫學研究所 | 助理教授 | 1020801 — 1040131 |
| 國立成功大學醫學系藥理學科暨研究所 | 博士後助理研究員 | 0990901 — 1020731 |
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 生理 Physiology |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 藥理及毒理 Pharmacology and Toxicology |
| 3 | 生物醫農類 Biology, Medicine and Agriculture | 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology |
| 4 | 生物醫農類 Biology, Medicine and Agriculture | 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
細胞離子平衡調節和人類疾病機轉及治療探討; 細胞骨架和訊息傳遞之調控; 化學治療引發神經病變的預防及治療; 皮膚防護屏障及防護探討;
Ion transport systems, human diseases, and therapeutic approaches; Cytoskeletal dynamics and cell migration; Neurological disorder and neuroprotective approaches; Skin barriers and protective approaches;
Area(s) of Expertise & Research
研究專長: 天然物藥理學; 細胞分子生物學; 細胞生理學; 腫瘤生物學; 訊息傳遞; 尖端生物醫學影像技術; 研究領域: 細胞離子平衡調節和人類疾病機轉及治療探討; 細胞骨架和訊息傳遞之調控; 化學治療引發神經病變的預防及治療; 皮膚防護屏障及防護探討;
RESEARCH EXPERTISE: Natural product pharmacology; Molecular cell biology; Cellular physiology; Tumor biology; Signal transduction; Advanced bio-imaging techniques; RESEARCH INTERESTS: Ion transport systems, human diseases, and therapeutic approaches; Cytoskeleton dynamics and cell migration; Neuroprotective agents against chemotherapy-induced neurotoxic effects; Skin barriers and protective approaches;
Publication
| NO | Publication |
|---|---|
| 1 | New acorane-sesequiterpenes and anti-retinoblastoma constituents from the marine algicolous fungus Trichoderma harzianum NTU2180 guided by molecular networking strategy. New acorane-sesequiterpenes and anti-retinoblastoma constituents from the marine algicolous fungus Trichoderma harzianum NTU2180 guided by molecular networking strategy. |
| 2 | Development of β-carotene-loaded casein nanoparticles with enhanced stability, permeability, and antioxidant activity that mitigates dexamethasone-induced muscle atrophy Development of β-carotene-loaded casein nanoparticles with enhanced stability, permeability, and antioxidant activity that mitigates dexamethasone-induced muscle atrophy |
| 3 | Discovery of Zoanthamine Alkaloids from with Antioxidant and Neuroprotective Activities. Discovery of Zoanthamine Alkaloids from with Antioxidant and Neuroprotective Activities. |
| 4 | Dual activation of AhR and Nrf2 pathways by the natural stilbenoid tapinarof protects against particulate matter-induced skin barrier dysfunction. Dual activation of AhR and Nrf2 pathways by the natural stilbenoid tapinarof protects against particulate matter-induced skin barrier dysfunction. |
| 5 | Different synaptic mechanisms of intermittent and continuous theta-burst stimulations in a severe foot-shock induced and treatment-resistant depression in a rat model. Different synaptic mechanisms of intermittent and continuous theta-burst stimulations in a severe foot-shock induced and treatment-resistant depression in a rat model. |
| 6 | Chemical investigations and cytotoxic effects of metabolites from Antrodia camphorata against human hepatocellular carcinoma cells. Chemical investigations and cytotoxic effects of metabolites from Antrodia camphorata against human hepatocellular carcinoma cells. |
| 7 | 2,6-Disubstituted Piperidine Alkaloids with Neuroprotective Activity from Hippobroma longiflora. 2,6-Disubstituted Piperidine Alkaloids with Neuroprotective Activity from Hippobroma longiflora. |
| 8 | An efficient cellular image-based platform for high-content screening of neuroprotective agents against chemotherapy-induced neuropathy. An efficient cellular image-based platform for high-content screening of neuroprotective agents against chemotherapy-induced neuropathy. |
| 9 | Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition. Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition. |
| 10 | The Important Role of Ion Transport System in Cervical Cancer The Important Role of Ion Transport System in Cervical Cancer |
| 11 | NIR-Triggered Generation of Reactive Oxygen Species and Photodynamic Therapy Based on Mesoporous Silica-Coated LiYF Upconverting Nanoparticles. NIR-Triggered Generation of Reactive Oxygen Species and Photodynamic Therapy Based on Mesoporous Silica-Coated LiYF Upconverting Nanoparticles. |
| 12 | Undescribed alkyne-geranylcyclohexenetriols from the endophyte Diaporthe caulivora 09F0132 and their anti-melanogenic activity. Undescribed alkyne-geranylcyclohexenetriols from the endophyte Diaporthe caulivora 09F0132 and their anti-melanogenic activity. |
| 13 | 山菅蘭成分中的酪胺酸酶抑制劑 Tyrosinase Inhibitors Derived from Chemical Constituents of Dianella ensifolia |
| 14 | Self-Emulsifying Phospholipid Preconcentrates for the Enhanced Photoprotection of Luteolin Self-Emulsifying Phospholipid Preconcentrates for the Enhanced Photoprotection of Luteolin |
| 15 | Additional alkaloids from Zoanthus vietnamensis with neuroprotective and anti-angiogenic effects. Additional alkaloids from Zoanthus vietnamensis with neuroprotective and anti-angiogenic effects. |
| 16 | Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell–Normal Keratinocyte Dual-Selective NRF2 Regulator Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell–Normal Keratinocyte Dual-Selective NRF2 Regulator |
| 17 | Oenothera laciniata Hill Extracts Exhibits Antioxidant Effects and Attenuates Melanogenesis in B16-F10 Cells via Downregulating CREB/MITF/Tyrosinase and Upregulating p-ERK and p-JNK. Oenothera laciniata Hill Extracts Exhibits Antioxidant Effects and Attenuates Melanogenesis in B16-F10 Cells via Downregulating CREB/MITF/Tyrosinase and Upregulating p-ERK and p-JNK. |
| 18 | Polypharmacy and pattern of medication use in community-dwelling older adults: A systematic review. Polypharmacy and pattern of medication use in community-dwelling older adults: A systematic review. |
| 19 | The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS. The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS. |
| 20 | Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment |
| 21 | Investigations into Chemical Components from with Photoprotective and Anti-Melanogenic Activities. Investigations into Chemical Components from with Photoprotective and Anti-Melanogenic Activities. |
| 22 | Different types of components obtained from Monascus purpureus with neuroprotective and anti-inflammatory potentials Different types of components obtained from Monascus purpureus with neuroprotective and anti-inflammatory potentials |
| 23 | Super-Resolution Microscopy Reveals That Stromal Interaction Molecule 1 Trafficking Depends on Microtubule Dynamics. Super-Resolution Microscopy Reveals That Stromal Interaction Molecule 1 Trafficking Depends on Microtubule Dynamics. |
| 24 | The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07. The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07. |
| 25 | The Role of Necroptosis in ROS-Mediated Cancer Therapies and Its Promising Applications The Role of Necroptosis in ROS-Mediated Cancer Therapies and Its Promising Applications |
| 26 | The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca2+ entry and cellular function The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca2+ entry and cellular function |
| 27 | 合成肝醣衍生物選擇性抑制PAR4媒介之血小板活化 Selective Inhibition of PAR4 (Protease-Activated Receptor 4)-Mediated Platelet Activation by a Synthetic Nonanticoagulant Heparin Analog |
| 28 | Store-Operated Ca2+ Entry in Tumor Progression: From Molecular Mechanisms to Clinical Implications Store-Operated Ca2+ Entry in Tumor Progression: From Molecular Mechanisms to Clinical Implications |
| 29 | Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation. |
| 30 | Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy. Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy. |
| 31 | STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion. STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion. |
| 32 | The STIM1-Orai1 pathway of store-operated Ca(2+) entry controls the checkpoint in cell cycle G1/S transition. The STIM1-Orai1 pathway of store-operated Ca(2+) entry controls the checkpoint in cell cycle G1/S transition. |
| 33 | The store-operated Ca(2+) entry-mediated signaling is important for cancer spread. The store-operated Ca(2+) entry-mediated signaling is important for cancer spread. |
| 34 | Integrating image-based high-content screening with mouse models identifies 5-hydroxydecanoate as a neuroprotective drug for paclitaxel-induced neuropathy Integrating image-based high-content screening with mouse models identifies 5-hydroxydecanoate as a neuroprotective drug for paclitaxel-induced neuropathy |
| 35 | Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors |
| 36 | Remodeling of calcium signaling in tumor progression Remodeling of calcium signaling in tumor progression |
| 37 | The ER Ca²⁺ sensor STIM1 regulates actomyosin contractility of migratory cells The ER Ca²⁺ sensor STIM1 regulates actomyosin contractility of migratory cells |
| 38 | Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. |
| 39 | The emerging role of KCl cotransport in tumor biology The emerging role of KCl cotransport in tumor biology |
| 40 | Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion |
| 41 | KCl cotransporter-3 down-regulates E-cadherin/beta-catenin complex to promote epithelial-mesenchymal transition KCl cotransporter-3 down-regulates E-cadherin/beta-catenin complex to promote epithelial-mesenchymal transition |
| 42 | Increased expression level of squamous cell carcinoma antigen 2 and 1 ratio is associated with poor prognosis in early-stage uterine cervical cancer Increased expression level of squamous cell carcinoma antigen 2 and 1 ratio is associated with poor prognosis in early-stage uterine cervical cancer |
| 43 | IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness |
| 44 | Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
114 — N 國科會(原科技部) — NSTC114-2320-B-037-014 — 1 個人型
以多環芳香烴受體AhR及抗氧化防禦Nrf2路徑之雙重活化策略對抗懸浮微粒誘導之皮膚屏障損傷：從分子機轉到天然保護劑開發( )
|
2025/08/01 ~ 2026/07/31 |
| 2 |
114 — NK 高醫-中山合作計畫 — — 1 個人型
嗜鹽微生物天然物之光保護與皮膚屏障修護活性研究(Study on the photoprotective and skin barrier repair activities of natural products from halophilic microorganisms)
|
2025/01/01 ~ 2025/12/31 |
| 3 |
113 — KK 高科大高醫產學合作補助 — — 3 產學合作
以芝麻副產物開發緩解化療病人神經病變之新穎口服營養補給品( )
|
2025/01/01 ~ 2025/12/31 |
| 4 |
113 — N 國科會(原科技部) — MOST111-2320-B-037-014-MY3 — 1 個人型
以細胞影像平台結合動物模式開發癌細胞專一性鈣離子訊息網絡標靶之新穎天然抗癌藥物(3/3)( )
|
2024/08/01 ~ 2025/07/31 |
| 5 |
113 — NK 高醫-中山合作計畫 — NK113P02 — 1 個人型
菟葵生物鹼之神經保護活性評估(Evaluation of Neuroprotective Activity of Zoanthid Alkaloids)
|
2024/01/01 ~ 2024/12/31 |
| 6 |
113 — Z 大專學生研究計畫及博士後 — NSTC114-2813-C-037-020-B — 8 大專學生研究計畫
114年度大專學生研究計畫-杜兆涵(醫技3)( )
|
2025/07/01 ~ 2026/02/28 |
| 7 |
112 — N 國科會(原科技部) — MOST111-2320-B-037-014-MY3 — 1 個人型
以細胞影像平台結合動物模式開發癌細胞專一性鈣離子訊息網絡標靶之新穎天然抗癌藥物(2/3)( )
|
2023/08/01 ~ 2025/07/31 |
| 8 |
112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-051-B — 8 大專學生研究計畫
113年度大專學生研究計畫-游新雅(藥學3)( )
|
2024/07/01 ~ 2025/02/28 |
| 9 |
111 — N 國科會(原科技部) — MOST111-2320-B-037-014-MY3 — 1 個人型
以細胞影像平台結合動物模式開發癌細胞專一性鈣離子訊息網絡標靶之新穎天然抗癌藥物(1/3)( )
|
2022/08/01 ~ 2025/07/31 |
| 10 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-057-B — 8 大專學生研究計畫
112年度大專學生研究計畫-李宏毅(藥學3)( )
|
2023/07/01 ~ 2024/02/29 |
| 11 |
110 — KK 高科大高醫產學合作補助 — —
以台灣常見海藻作為海洋天然美粧品原料開發與改善皮膚修護功效( )
|
2021/11/05 ~ 2022/11/04 |
| 12 |
110 — N 國科會(原科技部) — MOST108-2320-B-037-012-MY3 — 1 個人型
以高通量影像系統結合動物模式平台開發緩解化學治療引發神經病變之新穎天然藥物(3/3)( )
|
2021/08/01 ~ 2022/07/31 |
| 13 |
110 — Z 大專學生研究計畫及博士後 — MOST111-2813-C-037-061-B — 8 大專學生研究計畫
111年度大專學生研究計畫-曾彩妮(香粧3)( )
|
2022/07/01 ~ 2023/02/28 |
| 14 |
109 — N 國科會(原科技部) — MOST108-2320-B-037-012-MY3 — 1 個人型
以高通量影像系統結合動物模式平台開發緩解化學治療引發神經病變之新穎天然藥物(2/3)( )
|
2020/08/01 ~ 2022/07/31 |
| 15 |
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-147-B — 8 大專學生研究計畫
110年度大專學生研究計畫-張心慈(香粧3)( )
|
2021/07/01 ~ 2022/02/28 |
| 16 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-012-MY3 — 1 個人型
以高通量影像系統結合動物模式平台開發緩解化學治療引發神經病變之新穎天然藥物(1/3)( )
|
2019/08/01 ~ 2022/07/31 |
| 17 |
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-011-B — 8 大專學生研究計畫
109年度大專學生研究計畫-張揚晨(生技3)( )
|
2020/07/01 ~ 2021/02/28 |
| 18 |
107 — M 高醫(種子計畫) — KMU-M108010 —
探討內質網鈣離子感應蛋白於癌細胞功能的重要性( )
|
2019/01/01 ~ 2019/12/31 |
| 19 |
107 — Z 大專學生研究計畫及博士後 — MOST108-2813-C-037-070-B — 8 大專學生研究計畫
108年度大專學生研究計畫-翁意珺(牙醫4)( )
|
2019/07/01 ~ 2020/02/29 |
| 20 |
106 — M 高醫(種子計畫) — KMU-M107011 —
探討細胞移動過程中細胞骨架及內質網鈣離子感應蛋白的相互調控( )
|
2018/01/01 ~ 2018/12/31 |
| 21 |
105 — N 國科會(原科技部) — MOST103-2321-B-037-002-MY3 — 1 個人型
The impact of ER calcium sensors on cell migration and tumor in vasiveness(3/3)( )
|
2016/08/01 ~ 2017/07/31 |
| 22 |
105 — Q 新聘教師計畫(校內) — KMU-Q106009 —
利用高內涵細胞影像技術以開發具神經保護之天然藥物( )
|
2017/01/01 ~ 2017/12/31 |
| 23 |
104 — N 國科會(原科技部) — MOST103-2321-B-037-002-MY3 — 1 個人型
The impact of ER calcium sensors on cell migration and tumor in vasiveness(2/3)( )
|
2015/08/01 ~ 2017/07/31 |
| 24 |
104 — Q 新聘教師計畫(校內) — KMU-Q105008 —
解析癌細胞鈣離子訊息網絡之調控機制及細胞遷移功能探討( )
|
2016/01/01 ~ 2016/12/31 |
| 25 |
103 — N 國科會(原科技部) — MOST103-2321-B-037-002-MY3 —
The impact of ER calcium sensors on cell migration and tumor in vasiveness(1/3)( )
|
2015/02/01 ~ 2017/07/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 大豆間座殼菌(Diaporthe caulivora)萃取物用於抗紫外線傷害及減少色素沉澱的用途 | 中華民國 | 2022/02/11 | I755170 |
| 2 | 大豆?座?菌提取物用于抗紫外??害及?少色素沉?的用途 | 中國 | 2023/04/25 | 5906956 |
| 3 | 大豆?座?菌提取物用于抗紫外??害及?少色素沉?的用途 | 中國 | 2025/04/01 | 7843062 |