Education
| School — Major — Degree | Duration |
|---|---|
|
國立陽明大學 — 公共衛生研究所(畢) — 博士 Doctorate, , |
2004/09 — 2009/01 |
|
國立臺灣大學 — 生化科學研究所(畢) — 碩士 Master, , |
1999/09 — 2001/11 |
|
國立交通大學 — 應用化學系(畢) — 學士 Bachelor, , |
1995/09 — 1999/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 天然藥物研究所博士班 PhD Program in Natural Products | Director | 2024/08/01 — 2027/07/31 |
| 天然藥物研究所 Graduate Institute of Natural Products | Director | 2024/08/01 — 2027/07/31 |
| 天然藥物研究所碩士班 Master's Program in Natural Products | Director | 2024/08/01 — 2027/07/31 |
| 天然藥物研究所 Graduate Institute of Natural Products | Professor | 2023/02/01 — |
| 天然藥物研究所 Graduate Institute of Natural Products | Associate Professor | 2018/08/01 — 2023/01/31 |
| 天然藥物研究所 Graduate Institute of Natural Products | Assistant Professor | 2013/08/01 — 2018/07/31 |
| 天然藥物研究所 Graduate Institute of Natural Products | Assistant Professor | 2013/02/23 — 2013/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 生技製藥國家型科技計畫 National Science and Technology Program for Biotechnology and Pharmaceuticals |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 基因體醫學國家型科技計畫 National Research Program for Genomic Medicine (NRPGM) |
| 3 | 生物醫農類 Biology, Medicine and Agriculture | 醫學之生化及分子生物 Medical Biochemistry and Molecular Biology |
| 4 | 生物醫農類 Biology, Medicine and Agriculture | 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
植物新藥開發、mass spectrometric networking
botanic drug discovery, mass spectrometric networking
Area(s) of Expertise & Research
肝癌癌幹細胞與細胞內氧化狀態衡定調節機轉、藥物篩選平台開發與高通量藥物篩選、新興傳染病藥物開發細胞分子生物學、癌症生物學、生物化學、有機化學
Cell biology, Molecular biology, Cancer biology, Biochemistry, Organic chemistry
Publication
| NO | Publication |
|---|---|
| 1 | Assessment of skin safety and anti-pollution activity of Clitoria ternatea L. (butterfly pea) flower extract. Assessment of skin safety and anti-pollution activity of Clitoria ternatea L. (butterfly pea) flower extract. |
| 2 | Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease and Early-Stage Renal Dysfunction in a Rodent Model Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease and Early-Stage Renal Dysfunction in a Rodent Model |
| 3 | Threo-2,3-bis-(4-hydroxy-3-methoxyphenyl)-3-methoxypropanol (THMP) Inhibits Bladder Cancer Cell Proliferation via Oxidative Stress-dependent Apoptosis and DNA Damage Threo-2,3-bis-(4-hydroxy-3-methoxyphenyl)-3-methoxypropanol (THMP) Inhibits Bladder Cancer Cell Proliferation via Oxidative Stress-dependent Apoptosis and DNA Damage |
| 4 | Honokiol regulates Acute respiratory distress syndrome (ARDS)-associated pulmonary fibrosis via the miR-19a-3p/POSTN axis. Honokiol regulates Acute respiratory distress syndrome (ARDS)-associated pulmonary fibrosis via the miR-19a-3p/POSTN axis. |
| 5 | 懸浮微粒引發之皮膚損傷：用於表皮穩態與治療標的之 AhR–Nrf2 雙途徑機制 Particulate Matter-Induced Skin Injury: A Dual-Pathway AhR–Nrf2 Framework for Epidermal Homeostasis and Therapeutic Targeting |
| 6 | 自Uvaria micrantha發現具有抗發炎和成骨潛力的二次代謝物 Discovery of metabolites from Uvaria micrantha exhibiting anti-inflammatory and osteogenic potentials |
| 7 | Plumbagin sensitizes leukemia cells to cisplatin by promoting oxidative stress, apoptosis, and DNA damage. Plumbagin sensitizes leukemia cells to cisplatin by promoting oxidative stress, apoptosis, and DNA damage. |
| 8 | Aurone analog LYK01 exerts oxidative stress-dependent antiproliferation, G2/M arrest, apoptosis, and DNA damage of oral cancer cells involving MAPK modulation. Aurone analog LYK01 exerts oxidative stress-dependent antiproliferation, G2/M arrest, apoptosis, and DNA damage of oral cancer cells involving MAPK modulation. |
| 9 | Biomarker potential of nuclear Nrf2 activation in the ABC subtype of diffuse large B‑cell lymphoma. Biomarker potential of nuclear Nrf2 activation in the ABC subtype of diffuse large B‑cell lymphoma. |
| 10 | 粒線體AKT1訊號在代謝症候群腎小管損傷中的作用 The Role of Mitochondrial AKT1 Signaling in Renal Tubular Injury of Metabolic Syndrome. |
| 11 | Flavonoid-Sesquiterpenoid Hybrids from the Leaves of Syzygium simile and Their Anti-Lipid Droplet Accumulation Activities Flavonoid-Sesquiterpenoid Hybrids from the Leaves of Syzygium simile and Their Anti-Lipid Droplet Accumulation Activities |
| 12 | Excavatolide C has oxidative-stress-dependent antiproliferative and apoptotic effects against breast cancer cells. Excavatolide C has oxidative-stress-dependent antiproliferative and apoptotic effects against breast cancer cells. |
| 13 | Taming Pancreatic Cancer: Ardisia virens Kurz-Derived 4-Hydroxy-2-Methoxy-6-Tridecylphenyl Acetate as a Potent Tubulin Polymerization Inhibitor for Targeted Pancreatic Ductal Adenocarcinoma Therapy Taming Pancreatic Cancer: Ardisia virens Kurz-Derived -4Hydroxy-2-Methoxy-6-Tridecylphenyl Acetate as a Potent Tubulin Polymerization Inhibitor for Targeted Pancreatic Ductal Adenocarcinoma Therapy |
| 14 | Sofalcone Suppresses Dengue Virus Replication by Activating Heme Oxygenase-1-Mediated Antiviral Interferon Responses. Sofalcone Suppresses Dengue Virus Replication by Activating Heme Oxygenase-1-Mediated Antiviral Interferon Responses. |
| 15 | Dual activation of AhR and Nrf2 pathways by the natural stilbenoid tapinarof protects against particulate matter-induced skin barrier dysfunction. Dual activation of AhR and Nrf2 pathways by the natural stilbenoid tapinarof protects against particulate matter-induced skin barrier dysfunction. |
| 16 | Corrigendum to "The Role of Mitochondrial AKT1 Signaling in Renal Tubular Injury of Metabolic Syndrome" [ Volume 10, Issue 3, March 2025, Pages 906-920]. Corrigendum to "The Role of Mitochondrial AKT1 Signaling in Renal Tubular Injury of Metabolic Syndrome" [ Volume 10, Issue 3, March 2025, Pages 906-920]. |
| 17 | Excavatolide E triggers oxidative stress-associated apoptosis and DNA damage to inhibit bladder cancer cell proliferation. Excavatolide E triggers oxidative stress-associated apoptosis and DNA damage to inhibit bladder cancer cell proliferation. |
| 18 | Taming pancreatic cancer: Ardisia virens Kurz-Derived 4-hydroxy-2-methoxy-6-tridecylphenyl acetate as a potent tubulin polymerization inhibitor for targeted pancreatic ductal adenocarcinoma therapy Taming pancreatic cancer: Ardisia virens Kurz-Derived 4-hydroxy-2-methoxy-6-tridecylphenyl acetate as a potent tubulin polymerization inhibitor for targeted pancreatic ductal adenocarcinoma therapy |
| 19 | Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells. Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells. |
| 20 | The SAR analysis of dietary polyphenols and their antagonistic effects on bortezomib at physiological concentrations. The SAR analysis of dietary polyphenols and their antagonistic effects on bortezomib at physiological concentrations. |
| 21 | Indigofera suffruticosa aerial parts extract induce G2/M arrest and ATR/CHK1 pathway in Jurkat cells. Indigofera suffruticosa aerial parts extract induce G2/M arrest and ATR/CHK1 pathway in Jurkat cells. |
| 22 | Spatheliachromen mitigates methylglyoxal-induced myotube atrophy by activating Nrf2, inhibiting ubiquitin-mediated protein degradation, and restoring mitochondrial function. Spatheliachromen mitigates methylglyoxal-induced myotube atrophy by activating Nrf2, inhibiting ubiquitin-mediated protein degradation, and restoring mitochondrial function. |
| 23 | Diet Supplementation with Prinsepiae Nux Extract in Broiler Chickens: Its Effect on Growth Performance and Expression of Antioxidant, Pro-Inflammatory, and Heat Shock Protein Genes. Diet Supplementation with Prinsepiae Nux Extract in Broiler Chickens: Its Effect on Growth Performance and Expression of Antioxidant, Pro-Inflammatory, and Heat Shock Protein Genes. |
| 24 | Unveiling the potential of medicinal herbs as the source for screening toward the inhibition of Nrf2. Unveiling the potential of medicinal herbs as the source for screening toward the inhibition of Nrf2. |
| 25 | Globospiramine from Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations. Globospiramine from Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations. |
| 26 | Improving the Thrombocytopenia Adverse Reaction of Belinostat Using Human Serum Albumin Nanoparticles. Improving the Thrombocytopenia Adverse Reaction of Belinostat Using Human Serum Albumin Nanoparticles. |
| 27 | New 3,4-seco-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge Spongia sp. New 3,4--3,19-Dinor- and Spongian-New 3,4-seco-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge Spongia sp.Diterpenoid Lactones from the Marine Sponge sp. |
| 28 | 慢性腎臟病 1 至 4 期患者獨立於糖尿病的代謝症候群腎臟結局風險：ICKD 數據庫 The Risk of Renal Outcome of Metabolic Syndrome independent of Diabetes in Patients with CKD stage 1 to 4: The ICKD database |
| 29 | Attenuation of Lipopolysaccharide-Induced Inflammatory Responses through Inhibition of the NF-κB Pathway and the Increased NRF2 Level by a Flavonol-Enriched -Butanol Fraction from . Attenuation of Lipopolysaccharide-Induced Inflammatory Responses through Inhibition of the NF-κB Pathway and the Increased NRF2 Level by a Flavonol-Enriched -Butanol Fraction from . |
| 30 | Chemical Constituents and Bioactive Principles from the Mexican Truffle and Fermented Products of the Derived Fungus MZ496986. Chemical Constituents and Bioactive Principles from the Mexican Truffle and Fermented Products of the Derived Fungus MZ496986. |
| 31 | Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression. Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression. |
| 32 | Physapruin A Exerts Endoplasmic Reticulum Stress to Trigger Breast Cancer Cell Apoptosis via Oxidative Stress. Physapruin A Exerts Endoplasmic Reticulum Stress to Trigger Breast Cancer Cell Apoptosis via Oxidative Stress. |
| 33 | A Low-Cost, Sensitive Reporter System Using Membrane-Tethered Horseradish Peroxidase for Efficient Gene Expression Analysis A Low-Cost, Sensitive Reporter System Using Membrane-Tethered Horseradish Peroxidase for Efficient Gene Expression Analysis |
| 34 | High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach. High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach. |
| 35 | Chemical constituents with anti-lipid droplet accumulation and anti-inflammatory activity from Elaeagnus glabra Chemical constituents with anti-lipid droplet accumulation and anti-inflammatory activity from Elaeagnus glabra |
| 36 | Cryptocaryone Promotes ROS-Dependent Antiproliferation and Apoptosis in Ovarian Cancer Cells. Cryptocaryone Promotes ROS-Dependent Antiproliferation and Apoptosis in Ovarian Cancer Cells. |
| 37 | Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. |
| 38 | Comparison of a novel lateral-flow device to galactomannan assay at different time periods for detections of invasive aspergillosis. Comparison of a novel lateral-flow device to galactomannan assay at different time periods for detections of invasive aspergillosis. |
| 39 | Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells. Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells. |
| 40 | Antibladder Cancer Effects of Excavatolide C by Inducing Oxidative Stress, Apoptosis, and DNA Damage In Vitro. Antibladder Cancer Effects of Excavatolide C by Inducing Oxidative Stress, Apoptosis, and DNA Damage In Vitro. |
| 41 | Physapruin A enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation. Physapruin A enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation. |
| 42 | Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy. Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy. |
| 43 | Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation. Methanol Extract of Commelina Plant Inhibits Oral Cancer Cell Proliferation. |
| 44 | The Role of Nonapoptotic Programmed Cell Death - Ferroptosis, Necroptosis, and Pyroptosis - in Pancreatic Ductal Adenocarcinoma Treatment. The Role of Nonapoptotic Programmed Cell Death - Ferroptosis, Necroptosis, and Pyroptosis - in Pancreatic Ductal Adenocarcinoma Treatment. |
| 45 | Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced, Damage in Keratinocyte Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced, Damage in Keratinocyte |
| 46 | Spongenolactones A-C, Bioactive 5,5,6,6,5-Pentacyclic Spongian, Diterpenes from the Red Sea Sponge Spongia sp. Spongenolactones A-C, Bioactive 5,5,6,6,5-Pentacyclic Spongian, Diterpenes from the Red Sea Sponge Spongia sp. |
| 47 | Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one, with Lipid Lowering Effects in Hepatocytes Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one, with Lipid Lowering Effects in Hepatocytes |
| 48 | The Chemically Highly Diversified Metabolites from the Red Sea Marine, Sponge Spongia sp. The Chemically Highly Diversified Metabolites from the Red Sea Marine, Sponge Spongia sp. |
| 49 | The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2,, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2,, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma |
| 50 | Composition decipherment of Ficus pumila var. awkeotsang and its, potential on COVID-19 symptom amelioration and in silico prediction of, SARS-CoV-2 interference Composition decipherment of Ficus pumila var. awkeotsang and its, potential on COVID-19 symptom amelioration and in silico prediction of, SARS-CoV-2 interference |
| 51 | Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts |
| 52 | Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation. Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation. |
| 53 | Physalis peruviana-Derived Physapruin A (PHA) Inhibits Breast Cancer Cell Proliferation and Induces Oxidative-Stress-Mediated Apoptosis and DNA Damage. Physalis peruviana-Derived Physapruin A (PHA) Inhibits Breast Cancer Cell Proliferation and Induces Oxidative-Stress-Mediated Apoptosis and DNA Damage. |
| 54 | Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell–Normal Keratinocyte Dual-Selective NRF2 Regulator Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell–Normal Keratinocyte Dual-Selective NRF2 Regulator |
| 55 | Management of Myeloma Bone Lesions. Management of Myeloma Bone Lesions. |
| 56 | Withaferin A Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress. Withaferin A Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress. |
| 57 | Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis. Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis. |
| 58 | Metformin在糖尿病視網膜病變、老化、癌症之新觀點：非凋亡細胞死亡、免疫抑制及超乎單磷酸腺苷活化蛋白質激酶之作用 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway |
| 59 | Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment |
| 60 | Oleanolic Acid Nanofibers Attenuated Particulate Matter-Induced Oxidative Stress in Keratinocytes. Oleanolic Acid Nanofibers Attenuated Particulate Matter-Induced Oxidative Stress in Keratinocytes. |
| 61 | Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs. Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs. |
| 62 | Exosome-derived differentiation antagonizing non-protein coding RNA with risk of hepatitis C virus-related hepatocellular carcinoma recurrence. Exosome-derived differentiation antagonizing non-protein coding RNA with risk of hepatitis C virus-related hepatocellular carcinoma recurrence. |
| 63 | Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation. Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation. |
| 64 | Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2. Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2. |
| 65 | Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii Secondary Metabolites and Bioactivities of Aspergillus ochraceopetaliformis Isolated from Anthurium brownii |
| 66 | Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators. Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators. |
| 67 | 1,2,3,4,6 penta-O-galloyl-β-D-glucose ameliorates high-fat diet-induced nonalcoholic fatty liver disease and maintains the expression of genes involved in lipid homeostasis in mice. 1,2,3,4,6 penta-O-galloyl-β-D-glucose ameliorates high-fat diet-induced nonalcoholic fatty liver disease and maintains the expression of genes involved in lipid homeostasis in mice. |
| 68 | Qualitative and Quantitative Analysis of Ukrainian Species: A Fresh Look on Their Antioxidant Content and Biological Activities. Qualitative and Quantitative Analysis of Ukrainian Species: A Fresh Look on Their Antioxidant Content and Biological Activities. |
| 69 | HIV-1 Tat Interacts with a Kaposi's Sarcoma-Associated Herpesvirus Reactivation-Upregulated Antiangiogenic Long Noncoding RNA, LINC00313, and Antagonizes Its Function. HIV-1 Tat Interacts with a Kaposi's Sarcoma-Associated Herpesvirus Reactivation-Upregulated Antiangiogenic Long Noncoding RNA, LINC00313, and Antagonizes Its Function. |
| 70 | Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta- D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta- D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma |
| 71 | Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. |
| 72 | Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene |
| 73 | Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis and DNA damage against oral cancer cells through oxidative stress Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis and DNA damage against oral cancer cells through oxidative stress |
| 74 | Ethyl acetate extract of Nepenthes ventricosa x maxima exerts preferential killing to oral cancer cells Ethyl acetate extract of Nepenthes ventricosa x maxima exerts preferential killing to oral cancer cells |
| 75 | Loss of Glycine N-Methyltransferase Associates with Angiopoietin- 8 Expression in High Fat-Diet-Fed MiceLike Protein Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice |
| 76 | Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus |
| 77 | Gynura divaricata attenuates tumor growth and tumor relapse after cisplatin therapy in HCC xenograft model through suppression of cancer stem cell growth and Wnt/β-catenin signalling Gynura divaricata attenuates tumor growth and tumor relapse after cisplatin therapy in HCC xenograft model through suppression of cancer stem cell growth and Wnt/β-catenin signalling |
| 78 | 1,2,3,4,6-Penta-O-Galloyl-Beta-D-Glucopyranoside 可合併抑制MYC表現來抑制骨髓瘤之增生 1,2,3,4,6-Penta-O-Galloyl-Beta-D-Glucopyranoside Inhibits Proliferation of Multiple Myeloma Cells Accompanied with Suppression of MYC Expression |
| 79 | Scindapsus cf. hederaceus乙酸乙酯萃取物抑制人類非小細胞肺癌活性 Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress |
| 80 | High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake |
| 81 | Tat與TIP30交互作用促進Snail蛋白入核及肺癌細胞轉移 Human immunodeficiency virus Tat‐TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines |
| 82 | NRF2對於骨髓中之骨髓瘤抗藥性之角色 NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma. |
| 83 | MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma. MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma. |
| 84 | Characterization of the GNMT-HectH9-PREX2 Tripartite Relationship in the Pathogenesis of Hepatocellular Carcinoma. Characterization of the GNMT-HectH9-PREX2 Tripartite Relationship in the Pathogenesis of Hepatocellular Carcinoma. |
| 85 | Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development. Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development. |
| 86 | 2014年嚴重登革熱爆發於台灣 Severe Dengue Fever Outbreak in Taiwan |
| 87 | 藉由高通量篩選發現天然物PGG能透過誘發GNMT表現而抑制肝癌 Identification of 1,2,3,4,6-Penta-O-galloyl-b-Dglucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma. |
| 88 | 愛滋病毒藉由細胞與細胞間傳播時粒線體會在作用細胞產生極化現象 Mitochondria Polarization in the Contact Regions of Virus-Infected Effector Cells During Cell-to-Cell Transmission of HIV-1 |
| 89 | Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis |
| 90 | 尼曼匹克C2型蛋白(NPC2)透過ERK1/2訊息傳導途徑調節肝癌的進程 Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications |
| 91 | 第三號誘餌受體(DcR3)含量與感染愛滋病病毒病人慢病程進展相關 The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients |
| 92 | SARS冠狀病毒利用抗病毒抗體來促進感染主要藉由抗表面突起蛋白抗體 Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins |
| 93 | HIV-1 CRF07_BC的病人與B 亞型病人相比較表現出較低的病毒量-疾病的機制與發展之研究 Patients Infected with CRF07_BC Have Significantly Lower Viral Loads than Patients with HIV-1 Subtype B: Mechanism and Impact on Disease Progression |
| 94 | Identification of FKBP11 as a biomarker for hepatocellular carcinoma. Identification of FKBP11 as a biomarker for hepatocellular carcinoma. |
| 95 | Androgen response element of the glycine N-methyltransferase gene is located in the coding region of its first exon. Androgen response element of the glycine N-methyltransferase gene is located in the coding region of its first exon. |
| 96 | Characterization of Niemann-Pick Type C2 protein expression in multiple cancers using a novel NPC2 monoclonal antibody. Characterization of Niemann-Pick Type C2 protein expression in multiple cancers using a novel NPC2 monoclonal antibody. |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
117 — N 國科會(原科技部) — NSTC115-2320-B-037-018-MY3 — 1 個人型
探討台灣山茶葉部活性分層 CFLE10 透過脂解與氧化之代謝耦合改善 MASLD 之機制及其與 resmetirom 之臨床前協同療效評估(3/3)( )
|
2028/08/01 ~ 2029/07/31 |
| 2 |
116 — N 國科會(原科技部) — NSTC115-2320-B-037-018-MY3 — 1 個人型
探討台灣山茶葉部活性分層 CFLE10 透過脂解與氧化之代謝耦合改善 MASLD 之機制及其與 resmetirom 之臨床前協同療效評估(2/3)( )
|
2027/08/01 ~ 2029/07/31 |
| 3 |
115 — N 國科會(原科技部) — NSTC115-2320-B-037-018-MY3 — 1 個人型
探討台灣山茶葉部活性分層 CFLE10 透過脂解與氧化之代謝耦合改善 MASLD 之機制及其與 resmetirom 之臨床前協同療效評估(1/3)( )
|
2026/08/01 ~ 2029/07/31 |
| 4 |
115 — NK 高醫-中山合作計畫 — — 1 個人型
標靶導向性抗病毒感染之天然物與小分子藥物開發(Development of Target-Oriented Natural Products and Small Molecule Drugs for Antiviral Infections)
|
2026/01/01 ~ 2026/12/31 |
| 5 |
115 — TB 學院特色研究計畫 — KMU-TB115008 —
KMU校務精進-115學院-代謝相關疾病之天然物新藥開發與精準預防：整合篩選平台、AI標的預測、劑型開發與伴隨式診斷( )
|
2026/08/01 ~ 2027/07/31 |
| 6 |
114 — NK 高醫-中山合作計畫 — — 1 個人型
探討葡萄糖濃度對於多發性骨髓瘤細胞內代謝途徑與蛋白酶體抑制劑感受性的影響及其治療應用(The effect of glucose concentration on metabolism and susceptibility to proteasome in-hibitors of multiple myeloma and its therapeutic application)
|
2025/01/01 ~ 2025/12/31 |
| 7 |
114 — TB 學院特色研究計畫 — KMU-TB114005 —
【藥學院】代謝相關疾病之天然物新藥開發與精準預防(Natural Product Drug Discovery, Development, and Precision Prevention for Metabolic Disorders)
|
2025/01/01 ~ 2025/12/31 |
| 8 |
114 — TB 學院特色研究計畫 — KMU-TB114005-2 —
【藥學院】代謝相關疾病之天然物新藥開發與精準預防 (2)(Natural Product Drug Discovery, Development, and Precision Prevention for Metabolic Disorders (2))
|
2026/01/01 ~ 2026/07/31 |
| 9 |
114 — TC 研究中心計畫 — KMU-TC114A03-1 — 6 研究中心
智慧型植物萃取物庫建構與多向鏈結平台建置計畫( )
|
2025/04/09 ~ 2025/12/31 |
| 10 |
113 — N 國科會(原科技部) — NSTC113-2320-B-037-018 — 1 個人型
建立體外脂肪性肝炎模型：整合多種報導子細胞進行MAFLD的藥物開發和機制研究( )
|
2024/08/01 ~ 2025/07/31 |
| 11 |
113 — NK 高醫-中山合作計畫 — NK113P26 — 1 個人型
探討LON protease 1在代謝性脂肪肝病進展到肝細胞癌過程中的角色(Investigating the Role of LON Protease 1 in the Progression of Metabolic Fatty Liver Disease to Hepatocellular Carcinoma)
|
2024/01/01 ~ 2024/12/31 |
| 12 |
113 — TC 研究中心計畫 — KMU-TC113A03-1 — 6 研究中心
【整合團隊計畫】總計畫、植物資源研發與應用平台( )
|
2024/01/01 ~ 2024/12/31 |
| 13 |
113 — Z 大專學生研究計畫及博士後 — NSTC114-2813-C-037-008-B — 8 大專學生研究計畫
114年度大專學生研究計畫-黃立瑄(香粧3)( )
|
2025/07/01 ~ 2026/02/28 |
| 14 |
112 — N 國科會(原科技部) — NSTC112-2314-B-037-088 — 1 個人型
整合素α6β4-ILK-β-catenin訊息途徑在代謝相關脂肪肝病關聯之肝細胞癌的發展過程中的角色及其治療應用( )
|
2023/08/01 ~ 2024/07/31 |
| 15 |
111 — N 國科會(原科技部) — MOST109-2314-B-037-047-MY3 — 1 個人型
Focal adhesion訊息路徑在非酒精性脂肪肝病進展到肝細胞癌過程中對於肝癌幹細胞特徵的影響(3/3)( )
|
2022/08/01 ~ 2023/08/31 |
| 16 |
111 — NK 高醫-中山合作計畫 — — 2 整合型
以抗發炎路徑為標靶篩選抗登革病毒及登革熱出血之天然藥物開發( )
|
2022/01/01 ~ 2022/12/31 |
| 17 |
110 — KP 高醫屏科大 — NPUST-KMU-110-P007 — 1 個人型
建立高通量細胞篩選系統於天然藥物中篩選出黏膜疫苗之佐劑( )
|
2021/01/01 ~ 2021/12/31 |
| 18 |
110 — N 國科會(原科技部) — MOST109-2314-B-037-047-MY3 — 1 個人型
Focal adhesion訊息路徑在非酒精性脂肪肝病進展到肝細胞癌過程中對於肝癌幹細胞特徵的影響(2/3)( )
|
2021/08/01 ~ 2023/08/31 |
| 19 |
110 — N 國科會(原科技部) — MOST111-2740-B-037-001 — 1 個人型
天然物藥庫暨高通量篩選核心平台( )
|
2022/05/01 ~ 2023/04/30 |
| 20 |
109 — G 農業部(原農委會) — 110農科-10.1.2-畜-1.2 —
紫色狼尾草等機能性草種之特性對經濟動物保健效果之評估-篩選適合開發為飼料添加物之中藥草( )
|
2021/01/01 ~ 2021/12/31 |
| 21 |
109 — KI 高醫國衛院 — KMU-KI110004 —
罕見疾病之標靶基因檢測及可食用材料藥物之開發( )
|
2020/08/01 ~ 2021/07/31 |
| 22 |
109 — N 國科會(原科技部) — MOST109-2314-B-037-047-MY3 — 1 個人型
Focal adhesion訊息路徑在非酒精性脂肪肝病進展到肝細胞癌過程中對於肝癌幹細胞特徵的影響(1/3)( )
|
2020/08/01 ~ 2023/08/31 |
| 23 |
109 — N 國科會(原科技部) — MOST110-2740-B-037-001 — 1 個人型
天然物藥庫暨高通量篩選核心平台( )
|
2021/05/01 ~ 2022/04/30 |
| 24 |
109 — Z 大專學生研究計畫及博士後 — MOST110-2813-C-037-148-B — 8 大專學生研究計畫
110年度大專學生研究計畫-柯慧芳(醫技3)( )
|
2021/07/01 ~ 2022/02/28 |
| 25 |
108 — G 農業部(原農委會) — 109農科-17.1.2-畜-L2 —
紫色狼尾草機能性特性對經濟動物保健效果之評估-主題(1)篩選適合開發為飼料添加物之中草藥( )
|
2020/01/01 ~ 2020/12/31 |
| 26 |
108 — N 國科會(原科技部) — MOST108-2320-B-037-014 — 1 個人型
蘭嶼赤楠萃取物改善非酒精性脂肪肝之功效研究與分子機轉探討( )
|
2019/08/01 ~ 2020/07/31 |
| 27 |
108 — N 國科會(原科技部) — MOST109-2740-B-037-001 —
天然物藥庫暨高通量篩選核心平台( )
|
2020/05/01 ~ 2021/04/30 |
| 28 |
107 — G 農業部(原農委會) — 108農科-21.1.2-畜-L2 —
108年度「畜牧試驗研究-01畜產科學研究」紫色狼尾草機能性特性對經濟動物保健效果之評估-主題(1)篩選適合開發為飼料添加物之中藥草( )
|
2019/01/01 ~ 2019/12/31 |
| 29 |
107 — N 國科會(原科技部) — MOST108-2319-B-037-001 —
天然物藥庫暨高通量篩選核心平台( )
|
2019/05/01 ~ 2020/04/30 |
| 30 |
107 — Z 大專學生研究計畫及博士後 — MOST108-2813-C-037-059-B — 8 大專學生研究計畫
108年度大專學生研究計畫-薛珮妤(香粧3)( )
|
2019/07/01 ~ 2020/02/29 |
| 31 |
106 — G 農業部(原農委會) — 107農科-22.1.2畜-L1 —
紫色狼尾草機能性特性及對經濟動物保健效果之評估-主題(1)篩選適合開發為飼料添加物之中草藥( )
|
2018/01/01 ~ 2018/12/31 |
| 32 |
106 — N 國科會(原科技部) — MOST104-2320-B-037-031-MY3 — 1 個人型
氧化還原狀態在肉瘤狀肝細胞癌形成過程之角色及在抗肝癌藥物開發之應用(3/3)( )
|
2017/08/01 ~ 2018/07/31 |
| 33 |
106 — N 國科會(原科技部) — MOST107-2321-B-037-001 — 1 個人型
建立適用於高通量藥物篩選之天然物純化劃分層藥庫(2/2)( )
|
2018/01/01 ~ 2019/03/31 |
| 34 |
106 — Z 大專學生研究計畫及博士後 — MOST107-2813-C-037-050-B — 8 大專學生研究計畫
107年度大專學生研究計畫-王詩涵(香粧3)( )
|
2018/07/01 ~ 2019/02/28 |
| 35 |
105 — N 國科會(原科技部) — MOST104-2320-B-037-031-MY3 — 1 個人型
氧化還原狀態在肉瘤狀肝細胞癌形成過程之角色及在抗肝癌藥物開發之應用(2/3)( )
|
2016/08/01 ~ 2018/07/31 |
| 36 |
105 — N 國科會(原科技部) — MOST105-2633-B-037-001 — 1 個人型
利用表現HA7及NA9的桿狀病毒為新型藥物篩選平台進行抗H7N9流感病毒之新藥開發(2/2)( )
|
2016/08/01 ~ 2017/07/31 |
| 37 |
105 — N 國科會(原科技部) — MOST106-2321-B-037-002 — 1 個人型
建立適用於高通量藥物篩選之天然物純化劃分層藥庫(1/2)( )
|
2017/01/01 ~ 2017/12/31 |
| 38 |
105 — TP 頂尖計畫(高醫) — KMU-TP105E14 —
子計畫十四、利用高通量藥物篩選平台及天然物藥庫進行PREX2抑制劑之開發 (2)( )
|
2016/11/01 ~ 2017/10/31 |
| 39 |
105 — TP 頂尖計畫(高醫) — KMU-TP105H05 —
子計畫五、由中草藥開發抗癌新藥-以肝癌動物模式測試藥物活性及其作用機轉探討( )
|
2016/11/01 ~ 2017/10/31 |
| 40 |
105 — Z 大專學生研究計畫及博士後 — MOST105-2811-B-037-028 — 9 博士後研究員
博士後研究員--康竣磊( )
|
2016/09/01 ~ 2017/07/31 |
| 41 |
104 — N 國科會(原科技部) — MOST104-2320-B-037-031-MY3 — 1 個人型
氧化還原狀態在肉瘤狀肝細胞癌形成過程之角色及在抗肝癌藥物開發之應用(1/3)( )
|
2015/08/01 ~ 2018/07/31 |
| 42 |
104 — N 國科會(原科技部) — MOST104-2633-B-037-001 — 1 個人型
利用表現HA7及NA9的桿狀病毒為新型藥物篩選平台進行抗H7N9流感病毒之新藥開發(1/2)( )
|
2015/08/01 ~ 2016/07/31 |
| 43 |
104 — TP 頂尖計畫(高醫) — KMU-TP104D07 —
子計畫七、發展抑制L5/V5 功能之新藥( )
|
2015/10/01 ~ 2016/09/30 |
| 44 |
104 — TP 頂尖計畫(高醫) — KMU-TP104E14 —
子計畫十四、利用高通量藥物篩選平台及天然物藥庫進行PREX2 抑制劑之開發( )
|
2015/10/01 ~ 2016/09/30 |
| 45 |
104 — TP 頂尖計畫(高醫) — KMU-TP104E32 —
平台一、非侵入式小動物超音波平台( )
|
2015/10/01 ~ 2016/09/30 |
| 46 |
104 — TP 頂尖計畫(高醫) — KMU-TP104E33 —
平台二、基因轉殖小鼠動物模式( )
|
2015/10/01 ~ 2016/09/30 |
| 47 |
104 — TP 頂尖計畫(高醫) — KMU-TP104E37 —
平台六、高通量藥物篩選平台( )
|
2015/10/01 ~ 2016/09/30 |
| 48 |
104 — TP 頂尖計畫(高醫) — KMU-TP104H05 —
子計畫五、由中草藥開發抗癌新藥-以肝癌動物模式測試藥物活性及其作用機轉探討( )
|
2015/10/01 ~ 2016/09/30 |
| 49 |
103 — N 國科會(原科技部) — MOST103-2320-B-037-016 — 1 個人型
建立高通量藥物篩選平台並尋找新型抗脂肪肝之植物藥暨其有效成分( )
|
2014/08/01 ~ 2015/07/31 |
| 50 |
103 — Q 新聘教師計畫(校內) — KMU-Q104007 —
探討Annexin A3在肉瘤狀肝細胞癌產生過程中所扮演的角色( )
|
2015/01/01 ~ 2015/12/31 |
| 51 |
103 — TP 頂尖計畫(高醫) — KMU-TP103E09 —
探討致癌基因PREX2在肝癌發生所扮演的角色及其調控機制( )
|
2014/08/01 ~ 2015/07/31 |
| 52 |
103 — TP 頂尖計畫(高醫) — KMU-TP103E21 —
建立台灣本土植物天然物藥庫暨高通量藥物篩選系統( )
|
2014/08/01 ~ 2015/07/31 |
| 53 |
103 — TP 頂尖計畫(高醫) — KMU-TP103H13 —
以高通量平台進行抗HIV病毒藥物篩選及藥效評估( )
|
2014/08/01 ~ 2015/07/31 |
| 54 |
102 — Q 新聘教師計畫(校內) — KMU-Q103004 —
已PREX2-PTEN交互作用為標的篩選新型抗癌藥物( )
|
2014/01/01 ~ 2014/12/31 |
Patent
| NO | Patent Name | Country | Certified Date | Patent No |
|---|---|---|---|---|
| 1 | 抗癌化合物的製備方法和抗癌組合物的用途 | 中華民國 | 2018/06/11 | I626051 |
| 2 | 抗癌組合物及其用途 | 世界專利(日本) | 2020/04/17 | 6692830 |
| 3 | 抗癌組合物及其用途 | 世界專利(美國) | 2021/05/11 | 11,000,535 |
| 4 | 使用台灣白鳳菜之經水萃取的產物來治療肝細胞癌以及抑制肝細胞癌幹細胞的生長 | 中華民國 | 2019/06/11 | I661831 |
| 5 | 甘胺酸N-甲基轉移?增強劑、其製備方法及其用途 | 中華民國 | 2022/03/01 | I757011 |
| 6 | 甘氨酸N-甲基轉移?增強劑、其製備方法及其用途 | 世界專利(中國) | 2024/04/19 | 6928457 |
| 7 | 包含齊墩果酸的眼膜的製造方法 | 中華民國 | 2025/04/01 | I878717 |
| 8 | 蕤核萃取物及其製備方法、組合物及抗光損傷的用途 | 中華民國 | 2025/11/21 | I905465 |
| 9 | ?酸??衍生物作為甘胺酸-氮-甲基轉移?專一促進劑於治療肝癌之應用(K系列) | 世界專利(日本) | 2024/11/07 | 7584163 |
| 10 | 一種新穎化合物及其用於製備抑制發炎相關病症之藥物的用途 | 日本 | 2026/04/10 | 7847786 |