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 Education

School — Major — Degree Duration

高雄醫學大學 — 藥學系(畢) — 博士

PhD, School of Pharmacy, Kaohsiung Medical University

2002/09 — 2008/06

高雄醫學大學 — 天然藥物研究所(畢) — 碩士

Master, Graduate Institute of Natural Products, Kaohsiung Medical University

2000/09 — 2002/06

嘉南藥學專科學校 — 藥學科(畢) — 五專

Associate, Department of Pharmacy, Chia Nan University of Pharmacy & Science

1989/09 — 1995/06

 Intramural Experience

Office/Department/Institute Position Duration
藥學科 Pharmacy Division   Pharmacist   —  
香菻~學系 Department of Fragrance and Cosmetic Science   Professor 2021/08/01 —  
藥學系 School of Pharmacy   Professor 2020/02/01 — 2021/07/31
藥學系 School of Pharmacy   Associate Professor 2016/03/01 — 2020/01/31
藥學系 School of Pharmacy   Assistant Professor 2013/02/01 — 2016/02/29

 Extramural Experience

 

 Discipline

NO Discipline Expertise
1 生物醫農類 Biology, Medicine and Agriculture 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy
2 自然科學類 Natural Sciences 化學 Chemistry

 Research & Technology Platform Open to the Outside

Synthesis and anticancer activity evaluation of small molecule compounds

 Interested Area(s)for Interdisciplinary Research

小分子化合物活性篩選與探討分子藥理活性機轉

compounds with specific activity on a screening assay and molecular mechanism of action

 Area(s) of Expertise & Research

有機合成,藥物化學,藥物設計,化合物抗癌活性評估

organic synthesis, medicinal chemistry, drug design, anticancer assay

 Publication

NO Publication
1

Discovery of triazolyl thalidomide derivatives as anti-fibrosis agents
湯鎧瑋, 許玟俐#, 陳承儒, 蔡明憲, 顏佳蓉, 曾志華* - - 1 - New Journal of Chemistry - NEW JOURNAL OF CHEMISTRY 2021 45卷(7期):3589-3599頁
(IF: 3.591, 領域排名: 75, 領域期刊數: 179, 領域排名: 41.90%)

Discovery of triazolyl thalidomide derivatives as anti-fibrosis agents
Tang, K. W.; Hsu, W. L.; Chen, C.R.; Tsai, M. H.; Yen, C. J.; Tseng, C. H.* - - 1 - New Journal of Chemistry - NEW JOURNAL OF CHEMISTRY 2021;45(7):3589-3599
(IF: 3.591, Journal Ranking: 75, Number of Journals of this Field: 179, Ranking: 41.90%)

2

Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis.
Kant R, Yang MH, 曾志華, 顏嘉宏, Li WY, 田育彰, Chen M, 曾誠齊, Chen WC, You K, Wang WC, 陳義龍, Chen YA. - - 1 - JOURNAL OF MEDICINAL CHEMISTRY - JOURNAL OF MEDICINAL CHEMISTRY 2021 64卷(13期):8992-9009頁
(IF: 7.446, 領域排名: 5, 領域期刊數: 63, 領域排名: 7.94%)

Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis.
Rajni Kant, Ming-Hui Yang, Chih-Hua Tseng, Chia-Hung Yen, Wei-You Li, Yu-Chang Tyan, Marcelo Chen, Cherng-Chyi Tzeng, Wei-Cheng Chen, Kaiting You, Wen-Chieh Wang, Yeh-Long Chen, Yi-Ming Arthur Chen - - 1 - JOURNAL OF MEDICINAL CHEMISTRY - JOURNAL OF MEDICINAL CHEMISTRY 2021;64(13):8992-9009
(IF: 7.446, Journal Ranking: 5, Number of Journals of this Field: 63, Ranking: 7.94%)

3

Enhancement of Anticancer Potential of Pterostilbene Derivative by Chalcone Hybridization
湯鎧瑋#, 柯建志#, 曾志華, Yeh-Long Chen, Cherng-Chyi Tzeng, 陳怡瑾, 許家綺, 戴曉婷, 謝雅茹* - - 1 - Molecules - MOLECULES 2021 26卷(16期):4840頁
(IF: 4.411, 領域排名: 63, 領域期刊數: 179, 領域排名: 35.20%)

Enhancement of Anticancer Potential of Pterostilbene Derivative by Chalcone Hybridization
Kai-Wei Tang#, Chien-Chih Ke#, Chih-Hua Tseng, Yeh-Long Chen, Cherng-Chyi Tzeng, Yi-Jin Chen, Chia-Chi Hsu, Hsiao-Ting Tai, Ya-Ju Hsieh* - - 1 - Molecules - MOLECULES 2021;26(16):4840
(IF: 4.411, Journal Ranking: 63, Number of Journals of this Field: 179, Ranking: 35.20%)

4

Synthetic Naphthofuranquinone Derivatives Are Effective in Eliminating Drug-Resistant Candida albicans in Hyphal, Biofilm, and Intracellular Forms: An Application for Skin-Infection Treatment
Fang J. Y., 湯鎧瑋, Yang S. H., Alalaiwe A., Yang Y. C., 曾志華*, Yang S. C.* - - 1 - Frontiers in Microbiology - FRONTIERS IN MICROBIOLOGY 2020 11卷(-期):2053頁
(IF: 5.64, 領域排名: 28, 領域期刊數: 137, 領域排名: 20.44%)

Synthetic Naphthofuranquinone Derivatives Are Effective in Eliminating Drug-Resistant Candida albicans in Hyphal, Biofilm, and Intracellular Forms: An Application for Skin-Infection Treatment
Fang, J. Y.; Tang, K. W.; Yang, S. H.; Alalaiwe, A.; Yang, Y. C.; Tseng C. H.*; Yang, S. C.* - - 1 - Frontiers in Microbiology - FRONTIERS IN MICROBIOLOGY 2020;11(-):2053
(IF: 5.64, Journal Ranking: 28, Number of Journals of this Field: 137, Ranking: 20.44%)

5

Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes
湯鎧瑋, 林資展, Wang P. W., Alalaiwe A., 曾志華*, 方嘉佑* - - 1 - JOURNAL OF DERMATOLOGICAL SCIENCE - JOURNAL OF DERMATOLOGICAL SCIENCE 2020 99卷(2期):90-99頁
(IF: 4.563, 領域排名: 14, 領域期刊數: 68, 領域排名: 20.59%)

Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes
Tang K. W., Lin Z. C., Wang P. W., Alalaiwe A., Tseng C. H.*, Fang J. Y.* - - 1 - JOURNAL OF DERMATOLOGICAL SCIENCE - JOURNAL OF DERMATOLOGICAL SCIENCE 2020;99(2):90-99
(IF: 4.563, Journal Ranking: 14, Number of Journals of this Field: 68, Ranking: 20.59%)

6

Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators.
高毓澤, 陳宜孝, 湯凱偉, 李景欽, 曾志華, 曾誠齊, 顏嘉宏*, 陳義龍* - - 1 - Molecules (Basel, Switzerland) - MOLECULES 2020 25卷(14期):3133頁
(IF: 4.411, 領域排名: 63, 領域期刊數: 179, 領域排名: 35.20%)

Discovery of 4-Anilinoquinolinylchalcone Derivatives as Potential NRF2 Activators.
Yu-Tse Kao, Yi-Siao Chen, Kai-Wei Tang, Jin-Ching Lee, Chih-Hua Tseng, Cherng-Chyi Tzeng, Chia-Hung Yen*, Yeh-Long Chen* - - 1 - Molecules (Basel, Switzerland) - MOLECULES 2020;25(14):3133
(IF: 4.411, Journal Ranking: 63, Number of Journals of this Field: 179, Ranking: 35.20%)

7

Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo
鄭凱文#, 曾志華#, 曾誠齊, 呂玉玲, 鄭達駿, 王照元, 張嘉銘, 呂韻綺, 鄭秋敏, 陳怡如, 鄭以安, 陳義龍*, 鄭添祿* - - 1 - Pharmacological Research - PHARMACOLOGICAL RESEARCH 2019 139卷(-期):41-49頁
(IF: 5.893, 領域排名: 19, 領域期刊數: 270, 領域排名: 7.04%)

Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo
Cheng, K. W. #; Tseng, C. H.#; Tzeng, C. C.; Leu, Y. L.; Cheng, T. C.; Wang, J. Y.; Chang J. M.; Lu, Y. C.; Cheng, C. M.; Chen, I. J.; Cheng, Y. A.; Chen Y. L.*; Cheng, T. L.* - - 1 - Pharmacological Research - PHARMACOLOGICAL RESEARCH 2019;139(-):41-49
(IF: 5.893, Journal Ranking: 19, Number of Journals of this Field: 270, Ranking: 7.04%)

8

Phytochemical Naphtho[1,2-b] furan-4,5-dione Induced Topoisomerase II-mediated DNA Damage Response in Human Non-small-Cell Lung Cancer
簡啟民, Juan-Cheng Yang, Pin-Hsuan Wu, 吳長益, Guan-Yu Chen, Yang-Chang Wu, 曹俊傑, 曾志華, 陳義龍*, 王麗芳*, 邱建智* - - 1 - Phytomedicine - PHYTOMEDICINE 2019 54卷(-期):109-119頁
(IF: 4.268, 領域排名: 2, 領域期刊數: 28, 領域排名: 7.14%)

Phytochemical naphtho[1,2-b] furan-4,5‑dione induced topoisomerase II-mediated DNA damage response in human non-small-cell lung cancer.
Ching-Ming Chien, Juan-Cheng Yang, Pin-Hsuan Wu, Chang-Yi Wu, Guan-Yu Chen, Yang-Chang Wu, Chon-Kit Chou, Chih-Hua Tseng, Yeh-Long Chen*, Li-Fang Wang*, Chien-Chih Chiu* - - 1 - Phytomedicine - PHYTOMEDICINE 2019;54(-):109-119
(IF: 4.268, Journal Ranking: 2, Number of Journals of this Field: 28, Ranking: 7.14%)

9

Liposomal Avicequinone-B formulations: Aqueous solubility, physicochemical properties and apoptotic effects on cutaneous squamous cell carcinoma cells
胡楚松,蘇雍順,賴怡蒨,曾志華,顏峰霖* - - 1 - Phytomedicine - PHYTOMEDICINE 2019 58卷(-期):152870頁
(IF: 4.268, 領域排名: 2, 領域期刊數: 28, 領域排名: 7.14%)

Liposomal Avicequinone-B formulations: Aqueous solubility, physicochemical properties and apoptotic effects on cutaneous squamous cell carcinoma cells
Hu SC, Su YS, Lai YC, Tseng CH, Yen FL*. - - 1 - Phytomedicine - PHYTOMEDICINE 2019;58(-):152870
(IF: 4.268, Journal Ranking: 2, Number of Journals of this Field: 28, Ranking: 7.14%)

10

Discovery of Furanoquinone Derivatives as a Novel Class of DNA Polymerase and Gyrase Inhibitors for MRSA Eradication in Cutaneous Infection
楊世駿, 湯鎧瑋, 林志鴻, Alalaiwe A., 曾志華*, 方嘉佑* - - 1 - Frontiers in Microbiology - FRONTIERS IN MICROBIOLOGY 2019 10卷(-期):1197頁
(IF: 4.235, 領域排名: 34, 領域期刊數: 135, 領域排名: 25.19%)

Discovery of Furanoquinone Derivatives as a Novel Class of DNA Polymerase and Gyrase Inhibitors for MRSA Eradication in Cutaneous Infection
Yang S. C., Tang K. W., Lin C. H., Alalaiwe A., Tseng C. H.*, Fang J. Y.* - - 1 - Frontiers in Microbiology - FRONTIERS IN MICROBIOLOGY 2019;10(-):1197
(IF: 4.235, Journal Ranking: 34, Number of Journals of this Field: 135, Ranking: 25.19%)

11

Improvement of skin penetration, antipollutant activity and skin hydration of 7,3′,4′- trihydroxyisoflavone cyclodextrin inclusion complex
黃寶嫻,胡楚松, 顏峰霖*, 曾志華* - - 1 - Pharmaceutics - PHARMACEUTICS 2019 11卷(0期):399頁
(IF: 4.421, 領域排名: 44, 領域期刊數: 270, 領域排名: 16.30%)

Improvement of skin penetration, antipollutant activity and skin hydration of 7,3′,4′- trihydroxyisoflavone cyclodextrin inclusion complex
Huang, P.H.; Hu, S.C.S.; Yen, F.L.*; Tseng, C.H.* - - 1 - Pharmaceutics - PHARMACEUTICS 2019;11(0):399
(IF: 4.421, Journal Ranking: 44, Number of Journals of this Field: 270, Ranking: 16.30%)

12

Design, synthesis, and anti-bacterial evaluation of triazolyl-pterostilbene derivatives
湯鎧瑋, 楊世駿*, 曾志華* - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019 20卷(18期):4564頁
(IF: 4.556, 領域排名: 74, 領域期刊數: 297, 領域排名: 24.92%)

Design, synthesis, and anti-bacterial evaluation of triazolyl-pterostilbene derivatives
Kai-Wei Tang, Shih-Chun Yang *, Chih-Hua Tseng* - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019;20(18):4564
(IF: 4.556, Journal Ranking: 74, Number of Journals of this Field: 297, Ranking: 24.92%)

13

Discovery of 3-Arylquinoxaline Derivatives as Potential Anti-Dengue Virus Agents
曾志華*, 韓承睿, 湯鎧瑋 - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019 20卷(19期):4786頁
(IF: 4.556, 領域排名: 74, 領域期刊數: 297, 領域排名: 24.92%)

Discovery of 3-Arylquinoxaline Derivatives as Potential Anti-Dengue Virus Agents
Tseng, C. H.*; Han, C. R.; Tang, K. W. - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019;20(19):4786
(IF: 4.556, Journal Ranking: 74, Number of Journals of this Field: 297, Ranking: 24.92%)

14

Discovery of 2-Substituted 3-Arylquinoline Derivatives as Potential Anti-Inflammatory Agents Through Inhibition of LPS-Induced Inflammatory Responses in Macrophages.
Cheng-Yao Yang, Yung-Li Hung, 湯鎧瑋, 王述綺, 曾志華, 曾誠齊, 劉博侖, 李佳陽*, 陳義龍* - - 1 - Molecules (Basel, Switzerland) - MOLECULES 2019 24卷(6期):1162頁
(IF: 3.267, 領域排名: 141, 領域期刊數: 297, 領域排名: 47.47%)

Discovery of 2-Substituted 3-Arylquinoline Derivatives as Potential Anti-Inflammatory Agents Through Inhibition of LPS-Induced Inflammatory Responses in Macrophages.
Cheng-Yao Yang,Yung-Li Hung,Kai-Wei Tang,Shu-Chi Wang,Chih-Hua Tseng,Cherng-Chyi Tzeng,Po-Len Liu,Chia-Yang Li*,Yeh-Long Chen* - - 1 - Molecules (Basel, Switzerland) - MOLECULES 2019;24(6):1162
(IF: 3.267, Journal Ranking: 141, Number of Journals of this Field: 297, Ranking: 47.47%)

15

Discovery of naphtho[1,2-d]oxazole derivatives as potential anti-HCV agents through inducing heme oxygenase-1 expression
曾志華*,林俊光,陳義龍,曾敬凱,李佳育,李景欽* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med. Chem. 2018 143卷(0期):970-982頁
(IF: 4.816, 領域排名: 4, 領域期刊數: 59, 領域排名: 6.78%)

Discovery of naphtho[1,2-d]oxazole derivatives as potential anti-HCV agents through inducing heme oxygenase-1 expression
Tseng C. H.*; Lin, C. K.; Chen Y. L.; Tseng C. K.; Lee J. Y.; Lee J. C.* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med. Chem. 2018;143(0):970-982
(IF: 4.816, Journal Ranking: 4, Number of Journals of this Field: 59, Ranking: 6.78%)

16

Discovery of pyrazolo[4,3-c]quinolines derivatives as potential anti-inflammatory agents through inhibiting of NO production
曾志華*,童俊維,彭馨誼,陳義龍,曾誠齊,鄭智美* - - 1 - MOLECULES - MOLECULES 2018 23卷(5期):1036頁
(IF: 3.098, 領域排名: 68, 領域期刊數: 171, 領域排名: 39.77%)

Discovery of pyrazolo[4,3-c]quinolines derivatives as potential anti-inflammatory agents through inhibiting of NO production
Tseng, C. H.*; Tung, C. W.; Peng, S. I.; Chen Y. L.; Tzeng, C. C.; Cheng C. M.* - - 1 - MOLECULES - MOLECULES 2018;23(5):1036
(IF: 3.098, Journal Ranking: 68, Number of Journals of this Field: 171, Ranking: 39.77%)

17

Synthesis and Biological Evaluation of Thalidomide Derivatives as Potential Anti-Psoriasis Agents
湯鎧瑋, 林資展, 陳義龍, 曾誠齊, 方嘉佑*, 曾志華* - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018 19卷(10期):3061頁
(IF: 4.183, 領域排名: 78, 領域期刊數: 299, 領域排名: 26.09%)

Synthesis and Biological Evaluation of Thalidomide Derivatives as Potential Anti-Psoriasis Agents
Tang, K. W.; Lin, Z. C.; Chen, Y. L.; Tzeng, C. C.; Fang, J. Y.*; Tseng C. H.* - - 1 - International Journal of Molecular Sciences - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018;19(10):3061
(IF: 4.183, Journal Ranking: 78, Number of Journals of this Field: 299, Ranking: 26.09%)

18

Discovery of 3-amino-2-hydroxypropoxyisoflavone derivatives as potential anti-HCV agents
李景欽,林俊光,曾敬凱,陳義龍,曾誠齊,曾志華* - - 1 - Molecules - Molecules 2018 23卷(11期):2863頁
(IF: 3.098, 領域排名: 68, 領域期刊數: 171, 領域排名: 39.77%)

Discovery of 3-amino-2-hydroxypropoxyisoflavone derivatives as potential anti-HCV agents
Lee J. C.; Lin, C. K.; Tseng C. K.; Chen Y. L.; Tzeng, C. C.; Tseng C. H.* - - 1 - Molecules - Molecules 2018;23(11):2863
(IF: 3.098, Journal Ranking: 68, Number of Journals of this Field: 171, Ranking: 39.77%)

19

Preparation, characterizations and anti-pollutant activity of 7,3′,4′-trihydroxyisoflavone nanoparticles in particulate matter- induced HaCaT keratinocytes
黃寶嫻,曾志華,林佳俞,李江文,顏峰霖* - - 1 - International Journal of Nanomedicine - Int. J. Nanomed. 2018 13卷(0期):3279-3293頁
(IF: 4.37, 領域排名: 31, 領域期刊數: 261, 領域排名: 11.88%)

Preparation, characterizations and anti-pollutant activity of 7,3′,4′-trihydroxyisoflavone nanoparticles in particulate matter- induced HaCaT keratinocytes
Huang P. H., Tseng C. H., Lin C, Lee C. W., Yen F. L.* - - 1 - International Journal of Nanomedicine - Int. J. Nanomed. 2018;13(0):3279-3293
(IF: 4.37, Journal Ranking: 31, Number of Journals of this Field: 261, Ranking: 11.88%)

20

9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ), a quinoline derivative inhibits human hepatocellular carcinoma cells by inducing ER stress and apoptosis.
張文燦, 馮瑤, 莊世昌, 曹俊傑, 周翰林, 楊俊峰, 曾志華, 陳義龍*, 邱建智* - - 1 - Anti-Cancer Agents in Medicinal Chemistry - ANTI-CANCER AGENT ME 2017 17卷(0期):692-700頁
(IF: 2.598, 領域排名: 129, 領域期刊數: 217, 領域排名: 59.45%)

9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ), a quinoline derivative inhibits human hepatocellular carcinoma cells by inducing ER stress and apoptosis.
Chang WT, Fong Y, Chuang SC, Chou CK, Chou HL, Yang CF, Tseng CH, Chen YL, Chiu CC - - 1 - Anti-Cancer Agents in Medicinal Chemistry - ANTI-CANCER AGENT ME 2017;17(0):692-700
(IF: 2.598, Journal Ranking: 129, Number of Journals of this Field: 217, Ranking: 59.45%)

21

Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells.
馮堯, 吳長益(共同第一), 張國峰, 陳炳宏, 周琬儒, 曾志華, 陳讌君, 王惠民, 陳義龍*, 邱建智* - - 1 - Cancer Cell International - Cancer Cell Int. 2017 17卷(37期):1-13頁
(IF: 2.74, 領域排名: 121, 領域期刊數: 217, 領域排名: 55.76%)

Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells.
Fong Y, Wu CY, Chang KF, Chen BH, Chou WJ, Tseng CH, Chen YC, Wang HD, Chen YL, Chiu CC - - 1 - Cancer Cell International - Cancer Cell Int. 2017;17(37):1-13
(IF: 2.74, Journal Ranking: 121, Number of Journals of this Field: 217, Ranking: 55.76%)

22

Discovery of Indeno[1,2-c]quinoline Derivatives as Potent Dual Antituberculosis and Anti-Inflammatory Agents
曾志華,童俊維,吳政炘,曾誠齊,陳彥旭*,黃聰龍*,陳義龍* - - 1 - MOLECULES - MOLECULES 2017 22卷(6期):1001頁
(IF: 2.861, 領域排名: 17, 領域期刊數: 59, 領域排名: 28.81%)

Discovery of Indeno[1,2-c]quinoline Derivatives as Potent Dual Antituberculosis and Anti-Inflammatory Agents
Tseng CH, Tung CW, Wu CH, Tzeng CC, Chen YH*, Hwang TL*, Chen YL* - - 1 - MOLECULES - MOLECULES 2017;22(6):1001
(IF: 2.861, Journal Ranking: 17, Number of Journals of this Field: 59, Ranking: 28.81%)

23

Naphtho[1,2-b]furan-4,5-dione is a potent anti-MRSA agent against planktonic, biofilm, and intracellular bacteria
楊世駿, 顏峰霖, 王蓓雯, Aljuffali I. A., 翁依涵, 曾志華*, 方嘉佑* - - 1 - Future Microbiology - Future Microbiol. 2017 0卷(0期):0頁
(IF: 3.19, 領域排名: 47, 領域期刊數: 125, 領域排名: 37.60%)

Naphtho[1,2-b]furan-4,5-dione is a potent anti-MRSA agent against planktonic, biofilm, and intracellular bacteria
Yang, S. C.; Yen, F. L.; Wang, P. W.; Aljuffali, I. A.; Weng, Y. H.; Tseng, C. H.*; Fang, J. Y.* - - 1 - Future Microbiology - Future Microbiol. 2017;0(0):0
(IF: 3.19, Journal Ranking: 47, Number of Journals of this Field: 125, Ranking: 37.60%)

24

Pterostilbene, a methoxylated resveratrol derivative, efficiently eradicates planktonic, biofilm, and intracellular MRSA by topical application
楊世駿, 曾志華, 王蓓雯, 盧柏樑, 翁依涵, 顏峰霖*, 方嘉佑* - - 1 - Frontiers in Microbiology - Front. Microbiol. 2017 8卷(0期):1103頁
(IF: 4.076, 領域排名: 26, 領域期刊數: 125, 領域排名: 20.80%)

Pterostilbene, a methoxylated resveratrol derivative, efficiently eradicates planktonic, biofilm, and intracellular MRSA by topical application
Yang, S. C.; Tseng, C. H.; Wang, P. W.; Lu, P. L.; Weng, Y. H.; Yen, F. L.*; Fang, J. Y.* - - 1 - Frontiers in Microbiology - Front. Microbiol. 2017;8(0):1103
(IF: 4.076, Journal Ranking: 26, Number of Journals of this Field: 125, Ranking: 20.80%)

25

Discovery of novel diarylpyrazolylquinoline derivatives as potent anti-dengue virus agents
李景欽,曾敬凱,林俊光,曾志華* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med. Chem. 2017 141卷(0期):282-292頁
(IF: 4.519, 領域排名: 4, 領域期刊數: 60, 領域排名: 6.67%)

Discovery of novel diarylpyrazolylquinoline derivatives as potent anti-dengue virus agents
Lee, J. C.; Tseng, C. K.; Lin, C. K.; Tseng C. H.* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med. Chem. 2017;141(0):282-292
(IF: 4.519, Journal Ranking: 4, Number of Journals of this Field: 60, Ranking: 6.67%)

26

Specific inhibition of bacterial -glucuronidase by pyrazolo[4,3-c]quinoline derivatives via a pH-dependent manner to suppress chemotherapy-induced intestinal toxicity
鄭凱文#, 曾志華#, 楊佳寧, 曾誠齊, 鄭達駿, 呂玉玲, 莊祐仲, 王照元, 呂韻綺, 陳義龍*, 鄭添祿* - - 1 - Journal of Medicinal Chemistry - J. Med. Chem. 2017 60卷(22期):9222-9238頁
(IF: 6.253, 領域排名: 3, 領域期刊數: 59, 領域排名: 5.08%)

Specific inhibition of bacterial -glucuronidase by pyrazolo[4,3-c]quinoline derivatives via a pH-dependent manner to suppress chemotherapy-induced intestinal toxicity
Cheng, K. W. #; Tseng, C. H.#; Yang, C. N.; Tzeng, C. C.; Cheng, T. C.; Leu, Y. L.; Chuang, Y. C.; Wang, J. W.; Lu, Y.C.; Chen Y. L.*; Cheng, T. L.* - - 1 - Journal of Medicinal Chemistry - J. Med. Chem. 2017;60(22):9222-9238
(IF: 6.253, Journal Ranking: 3, Number of Journals of this Field: 59, Ranking: 5.08%)

27

探索indeno[1,2-b]quinoxaline 衍生物成為具有潛力之抗癌藥劑
曾志華,陳宥任,曾誠齊,劉旺達,曹俊傑,邱建智*,陳義龍* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med. Chem. 2016 108卷(0期):258-273頁
(IF: 3.902, 領域排名: 6, 領域期刊數: 59, 領域排名: 10.17%)

Discovery of indeno[1,2-b]quinoxaline derivatives as potential anticancer agents
Tseng, C. H.; Chen, Y. R.; Tzeng, C. C.; Liu, W.; Chou, C. K.; Chiu, C. C.*; Chen, Y. L.* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med. Chem. 2016;108(0):258-273
(IF: 3.902, Journal Ranking: 6, Number of Journals of this Field: 59, Ranking: 10.17%)

28

以酸性依賴性聚合物包覆7,3′,4′-trihydroxyisoflavone之奈米顆粒製劑作為外用給藥系統
黃寶, 胡楚松(共同第一), 李江文, 葉安祺, 曾志華*, 顏峰霖* - - 1 - International Journal of Nanomedicine - INT J NANOMED 2016 11卷(-期):1615-1627頁
(IF: 4.32, 領域排名: 41, 領域期刊數: 255, 領域排名: 16.08%)

Design of acid-responsive polymeric nanoparticles for 7,3′,4′-trihydroxyisoflavone topical administration
Huang PH (equal first author), Hu SC (equal first author), Lee CW, Yeh AC, Tseng CH*, Yen FL*. - - 1 - International Journal of Nanomedicine - INT J NANOMED 2016;11(-):1615-1627
(IF: 4.32, Journal Ranking: 41, Number of Journals of this Field: 255, Ranking: 16.08%)

29

TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP
Liao H. F., 李建志, Hsiao P. C., Chen Y. F., 曾志華, 曾誠齊, 陳義龍, Chen J. C., Chang Y. S.*, 張建國* - - 1 - BIOMEDICINE & PHARMACOTHERAPY - BIOMED PHARMACOTHER 2016 82卷(-期):649–659頁
(IF: 2.326, 領域排名: 129, 領域期刊數: 255, 領域排名: 50.59%)

TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP
Liao H. F., Lee C. C., Hsiao P. C., Chen Y. F., Tseng C. H., Tzeng C. C., Chen Y. L., Chen J. C., Chang Y. S.*, Chang J. G.* - - 1 - BIOMEDICINE & PHARMACOTHERAPY - BIOMED PHARMACOTHER 2016;82(-):649–659
(IF: 2.326, Journal Ranking: 129, Number of Journals of this Field: 255, Ranking: 50.59%)

30

Quinoline-Based Compound BPIQ Exerts Anti-Proliferative Effects on Human Retinoblastoma Cells via Modulating Intracellular Reactive Oxygen Species
鄭凱駿, 洪春姿,陳國任, 吳文權, 孫昭玲, 張丞賢, 呂濟宇, 曾志華, 陳義龍*, 邱建智* - - 1 - ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS - ARCH IMMUNOL THER EX 2016 64卷(2期):139-147頁
(IF: 2.04, 領域排名: 116, 領域期刊數: 150, 領域排名: 77.33%)

Quinoline-Based Compound BPIQ Exerts Anti-Proliferative Effects on Human Retinoblastoma Cells via Modulating Intracellular Reactive Oxygen Species
Kai-Chun Cheng, Chun-Tzu Hung, Kuo-Jen Chen, Wen-Chuan Wu, Jau-Ling Suen, Cheng-Hsien Chang, Chi-Yu Lu, Chih-Hua Tseng, Yeh-Long Chen, Chien-Chih Chiu* - - 1 - ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS - ARCH IMMUNOL THER EX 2016;64(2):139-147
(IF: 2.04, Journal Ranking: 116, Number of Journals of this Field: 150, Ranking: 77.33%)

31

探索2-[2-(5-nitrofuran-2-yl)vinyl]quinoline 為新型抗腫瘤轉移藥劑
曾志華,曾誠齊,邱建智,許智堯,曹俊傑,陳義龍* - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY - BIOORGAN MED CHEM 2015 23卷(1期):141-148頁
(IF: 2.793, 領域排名: 15, 領域期刊數: 58, 領域排名: 25.86%)

Discovery of 2-[2-(5-nitrofuran-2-yl)vinyl]quinoline derivatives as a novel type of antimetastatic agents
Tseng, C. H.; Tzeng, C. C.; Chiu, C. C.; Hsu, C. Y.; Chou, C. K.; Chen Y. L.* - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY - BIOORGAN MED CHEM 2015;23(1):141-148
(IF: 2.793, Journal Ranking: 15, Number of Journals of this Field: 58, Ranking: 25.86%)

32

探索Benzo[f]indole-4,9-dione衍生物為新型抗發炎藥劑
陳宥任,曾志華,陳義龍,黃聰龍*,曾誠齊* - - 1 - International Journal of Molecular Sciences - Int. J. Mol. Sci. 2015 16卷(3期):6532-6544頁
(IF: 3.257, 領域排名: 51, 領域期刊數: 163, 領域排名: 31.29%)

Discovery of Benzo[f]indole-4,9-dione Derivatives as New Types of Anti-Inflammatory Agents
Chen, Y. R.; Tseng, C. H.; Chen, Y. L.; Hwang, T. L.*; Tzeng, C. C.* - - 1 - International Journal of Molecular Sciences - Int. J. Mol. Sci. 2015;16(3):6532-6544
(IF: 3.257, Journal Ranking: 51, Number of Journals of this Field: 163, Ranking: 31.29%)

33

探索新型N-alkyl 4-anilinofuro[2,3-b]quinoline (CIL-102)衍生物對前列腺癌細胞之作用
羅偉棻,周育緯,曾志華,許雅惠,陳郁旻, 楊世群,陳義龍,林明豐*,曾誠齊* - - 1 - Anti-Cancer Agents in Medicinal Chemistry - ANTI-CANCER AGENT ME 2015 15卷(4期):493-500頁
(IF: 2.722, 領域排名: 27, 領域期刊數: 59, 領域排名: 45.76%)

Discovery of Novel N-alkyl 4-anilinofuro[2,3-b]quinoline Derivatives (CIL-102 Derivatives) Against Castration-Resistant Human Prostate Cancers
Lo, W. F.; Chou, Y. W.; Tseng, C. H.; Shiu, Y. H.; Chen, Y. W.; Yang, S. C.; Chen, Y. L.; Lin, M. F.* Tzeng, C. C.* - - 1 - Anti-Cancer Agents in Medicinal Chemistry - ANTI-CANCER AGENT ME 2015;15(4):493-500
(IF: 2.722, Journal Ranking: 27, Number of Journals of this Field: 59, Ranking: 45.76%)

34

探索3-phenylquinolinylchalcone衍生物具有選擇性抗乳癌之潛力藥物
曾志華,曾誠齊,許智堯,鄭智美,楊佳寧*,陳義龍* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med. Chem. 2015 97卷(0期):306-319頁
(IF: 3.902, 領域排名: 6, 領域期刊數: 59, 領域排名: 10.17%)

Discovery of 3-phenylquinolinylchalcone derivatives as potent and selective anticancer agents against breast cancers
Tseng, C. H.; Tzeng, C. C.; Hsu, C. Y.; Cheng, C. M.; Yang C. N.*; Chen Y. L.* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med. Chem. 2015;97(0):306-319
(IF: 3.902, Journal Ranking: 6, Number of Journals of this Field: 59, Ranking: 10.17%)

35

Naphtho[1,2-b]furan-4,5-dione藉由抑制 Src-mediated 信號途徑抑制 MDA-MB-231 細胞遷移和侵襲
蔡沛倩,朱巧倫,傅耀賢,曾志華,陳義龍,張榮賢,林信仁* - - 1 - MOLECULAR AND CELLULAR BIOCHEMISTRY - MOL CELL BIOCHEM 2014 387卷(1-2期):101–111頁
(IF: 2.388, 領域排名: 123, 領域期刊數: 185, 領域排名: 66.49%)

Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways
Pei-Chien Tsai, Chiao-Lun Chu, Yaw-Syan Fu, Chih-Hua Tseng, Yeh-long Chen, Long-Sen Chang, Shinne-Ren Lin* - - 1 - MOLECULAR AND CELLULAR BIOCHEMISTRY - MOL CELL BIOCHEM 2014;387(1-2):101–111
(IF: 2.388, Journal Ranking: 123, Number of Journals of this Field: 185, Ranking: 66.49%)

36

合成2-aroyl-3-arylquinoline衍生物並評估其抗增生與抗登革病毒活性
曾志華*, 林俊光,陳義龍, 許智堯, 吳惠南, 曾敬凱, 李景欽* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med Chem. 2014 79卷(0期):66-76頁
(IF: 3.432, 領域排名: 13, 領域期刊數: 58, 領域排名: 22.41%)

Synthesis, antiproliferative and anti-dengue virus evaluations of 2-aroyl-3-arylquinoline derivatives.
Tseng CH*, Lin CK, Chen YL, Hsu CY, Wu HN, Tseng CK, Lee JC* - - 1 - European Journal of Medicinal Chemistry - Eur. J. Med Chem. 2014;79(0):66-76
(IF: 3.432, Journal Ranking: 13, Number of Journals of this Field: 58, Ranking: 22.41%)

37

Furano-1,2-Naphthoquinone 抑制 Ca9-22 人類口腔鱗癌細胞之Src 和 PI3K/Akt 信號途徑。
林桂莉, 簡啟民, 曾志華, 張榮賢, 林信仁* - - 1 - Integrative Cancer Therapies - Integr Cancer Ther 2014 13卷(3期):18-28頁
(IF: 2.354, 領域排名: 4, 領域期刊數: 18, 領域排名: 22.22%)

Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells.
Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR - - 1 - Integrative Cancer Therapies - Integr Cancer Ther 2014;13(3):18-28
(IF: 2.354, Journal Ranking: 4, Number of Journals of this Field: 18, Ranking: 22.22%)

38

合成9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinoline-11-one衍生物並評估其抗增生活性-第四部分
曾志華, 曾誠齊, 邱建智, 楊巧麗, 呂佩融, 周俊傑, 劉俊彥, 陳義龍* - - 1 - Medicinal Chemistry Communications - Med. Chem. Comm. 2014 5卷(0期):937-948頁
(IF: 2.626, 領域排名: 26, 領域期刊數: 58, 領域排名: 44.83%)

Synthesis and antiproliferative evaluation of 9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c] quinoline-11-one derivatives. Part 4.
Tseng, C. H.; Tzeng, C. C.; Chiu, C. C.; Yang, C. L.; Lu, P. J.; Chou, C. K.; Liu, C. Y.; Chen Y. L.* - - 1 - Medicinal Chemistry Communications - Med. Chem. Comm. 2014;5(0):937-948
(IF: 2.626, Journal Ranking: 26, Number of Journals of this Field: 58, Ranking: 44.83%)

39

NFD 對於肝細胞生長因子誘導 MDA-MB-231 細胞的遷移與侵襲之抑制作用:作用機制
蔡沛倩,朱巧倫,曾志華,陳義龍,張榮賢,林信仁* - - 1 - Clinical and Experimental Pharmacology and Physiology - Clin Exp Pharmacol Physiol 2014 41卷(9期):716-726頁
(IF: 2.405, 領域排名: 118, 領域期刊數: 256, 領域排名: 46.09%)

Inhibitory action of naphtho[1,2-b]furan-4,5-dione on hepatocyte growth factor-induced migration and invasion of MDA-MB-231 cells: Mechanisms of action
Pei-Chien Tsai, Chiao-Lun Chu, Chih-Hua Tseng, Yeh-long Chen, Long-Sen Chang, and Shinne-Ren Lin* - - 1 - Clinical and Experimental Pharmacology and Physiology - Clin Exp Pharmacol Physiol 2014;41(9):716-726
(IF: 2.405, Journal Ranking: 118, Number of Journals of this Field: 256, Ranking: 46.09%)

40

合成3-phenylquinolinylchalcone 衍生物並評估其抗肺癌與抗乳癌活性
曾志華,陳義龍,許智堯,陳自強,鄭智美,左先正,盧彥嘉,曾誠齊* - - 1 - European Journal of Medicinal Chemistry - EUR J MED CHEM 2013 59卷(-期):274-282頁
(IF: 3.499, 領域排名: 13, 領域期刊數: 59, 領域排名: 22.03%)

Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers
Tseng CH, Chen YL, Hsu CY, Chen TC, Cheng CM, Tso HC, Lu YJ, Tzeng CC.* - - 1 - European Journal of Medicinal Chemistry - EUR J MED CHEM 2013;59(-):274-282
(IF: 3.499, Journal Ranking: 13, Number of Journals of this Field: 59, Ranking: 22.03%)

41

合成β-lapachone 衍生物並評估其抗發炎活性
曾志華,鄭智美,曾誠齊,彭馨誼,楊巧麗,陳義龍* - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY - BIOORGAN MED CHEM 2013 21卷(2期):523-531頁
(IF: 2.903, 領域排名: 20, 領域期刊數: 59, 領域排名: 33.90%)

Synthesis and anti-inflammatory evaluations of β-lapachone derivatives
Tseng CH, Cheng CM, Tzeng CC, Peng SI, Yang CL, Chen YL.* - - 1 - BIOORGANIC & MEDICINAL CHEMISTRY - BIOORGAN MED CHEM 2013;21(2):523-531
(IF: 2.903, Journal Ranking: 20, Number of Journals of this Field: 59, Ranking: 33.90%)

42

NFD經由抑制EGF/EGFR活化而阻斷乳癌細胞轉移的作用和機制
謝奇穎,蔡沛倩,曾志華,陳義龍,張榮賢,林信仁* - - 1 - TOXICOLOGY IN VITRO - TOXICOL IN VITRO 2013 27卷(1期):1-10頁
(IF: 2.65, 領域排名: 34, 領域期刊數: 85, 領域排名: 40.00%)

Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells
Hsieh CY, Tsai PC, Tseng CH, Chen YL, Chang LS, Lin SR. - - 1 - TOXICOLOGY IN VITRO - TOXICOL IN VITRO 2013;27(1):1-10
(IF: 2.65, Journal Ranking: 34, Number of Journals of this Field: 85, Ranking: 40.00%)

43

TCH-1030 targeting on topoisomerase I induces S-phase arrest, DNA fragmentation, and cell death of breast cancer cells
Liu, Y. P., Chen, H. L.,曾誠齊, 呂佩融, Lo, C. W., Lee, Y. C., 曾志華, 陳義龍*, 楊佳寧* - - 1 - Breast Cancer Res. Treat. - BREAST CANCER RES TR 2013 138卷(2期):383-393頁
(IF: 4.859, 領域排名: 34, 領域期刊數: 182, 領域排名: 18.68%)

TCH-1030 targeting on topoisomerase I induces S-phase arrest, DNA fragmentation, and cell death of breast cancer cells
Liu, Y. P.; Chen, H. L.; Tzeng, C. C.; Lu, P. J.; Lo, C. W.; Lee, Y. C.; Tseng , C. H.; Chen, Y. L., Yang, C. N. - - 1 - Breast Cancer Res. Treat. - BREAST CANCER RES TR 2013;138(2):383-393
(IF: 4.859, Journal Ranking: 34, Number of Journals of this Field: 182, Ranking: 18.68%)

44

合成Aminoalkoxy 4,5-Diphenylisoxazole 作為抗骨質疏鬆試劑
陳義龍,曾志華,羅友志,林儒緯,陳建復,王國照,何美泠,曾誠齊* - - 1 - Medicinal Chemistry - Med. Chem. 2013 9卷(5期):748-755頁
(IF: 1.373, 領域排名: 48, 領域期刊數: 59, 領域排名: 81.36%)

Synthesis of Aminoalkoxy Substituted 4,5-Diphenylisoxazole Derivatives as Potential Anti-osteoporotic Agents
Chen YL, Tseng CH, Lo YC, Lin RW, Chen CF, Wang GJ, Ho ML, Tzeng CC - - 1 - Medicinal Chemistry - Med. Chem. 2013;9(5):748-755
(IF: 1.373, Journal Ranking: 48, Number of Journals of this Field: 59, Ranking: 81.36%)

45

探索Indeno[1,2-c]quinoline衍生物作為拓樸異構酶I&II抑制劑,第三部份
曾志華, 曾誠齊, 楊巧麗, 呂佩融, Liu YP, Chen HL, Chen CY, 楊佳寧, 陳義龍* - - 1 - Molecular Diversity - Mol. Divers. 2013 17卷(4期):781-799頁
(IF: 2.861, 領域排名: 13, 領域期刊數: 71, 領域排名: 18.31%)

Discovery of indeno[1, 2 - c] quinoline derivatives as dual topoisomerases I/II inhibitors: part 3
Tseng CH, Tzeng CC, Yang CL, Lu PJ, Liu YP, Chen HL, Chen CY, Yang CN, Chen YL* - - 1 - Molecular Diversity - Mol. Divers. 2013;17(4):781-799
(IF: 2.861, Journal Ranking: 13, Number of Journals of this Field: 71, Ranking: 18.31%)

46

確認furo[3', 2':3,4]naphtho[1,2-d]imidazole 衍生物為口服mPGES-1抑制劑
曾志華,曾誠齊,施秉庚,楊佳寧,彭馨誼,林漳聲,鄭智美,陳義龍* - - 1 - MOLECULAR DIVERSITY - MOL DIVERS 2012 16卷(2期):215-229頁
(IF: 3.153, 領域排名: 9, 領域期刊數: 71, 領域排名: 12.68%)

Identification of furo[3', 2':3,4]naphtho[1,2-d]imidazole derivatives as orally active and selective inhibitors of microsomal prostaglandin E(2) synthase-1 (mPGES-1)
Tseng CH, Tzeng CC, Shih PK, Yang CN, Chuang YC, Peng SI, Lin CS, Wang JP, Cheng CM, Chen YL.* - - 1 - MOLECULAR DIVERSITY - MOL DIVERS 2012;16(2):215-229
(IF: 3.153, Journal Ranking: 9, Number of Journals of this Field: 71, Ranking: 12.68%)

47

合成6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one為具有潛力之抗癌試劑
曾志華,陳義龍,楊巧麗,鄭智美,韓建華,曾誠齊* - - 1 - Bioorg. Med. Chem. - BIOORGAN MED CHEM 2012 20卷(14期):4397-4404頁
(IF: 2.978, 領域排名: 15, 領域期刊數: 54, 領域排名: 27.78%)

Synthesis of 6-substituted 9-methoxy-11H-indeno[1,2-c]quinoline-11-one derivatives as potential anticancer agents
Tseng CH,Chen YL,Yang CL,Cheng CM,Han CH,Tzeng CC.* - - 1 - Bioorg. Med. Chem. - BIOORGAN MED CHEM 2012;20(14):4397-4404
(IF: 2.978, Journal Ranking: 15, Number of Journals of this Field: 54, Ranking: 27.78%)

48

Combretastatin A-4衍生物:合成2,4,5-triaryl-1H-imidazoles為抗肺癌H1299試劑
曾志華,李奇逸,邱建智,胡惠婷,韓建華,陳義龍,曾誠齊* - - 1 - Mol. Divers. - MOL DIVERS 2012 16卷(4期):697-709頁
(IF: 3.721, 領域排名: 2, 領域期刊數: 70, 領域排名: 2.86%)

Combretastatin A-4 derivatives: synthesis and evaluation of 2,4,5-triaryl-1H-imidazoles as potential agents against H1299 (non-small cell lung cancer cell)
Tseng CH, Li CY, Chiu CC, Hu HT, Han CH, Chen YL, Tzeng CC.* - - 1 - Mol. Divers. - MOL DIVERS 2012;16(4):697-709
(IF: 3.721, Journal Ranking: 2, Number of Journals of this Field: 70, Ranking: 2.86%)

49

發現Indeno[1,2-c]quinoline衍生物經由RANKL抑制蝕骨細胞增生
曾志華,林儒緯,陳義龍,王國照,何美泠,曾誠齊* - - 1 - J. Med. Chem. - J MED CHEM 2011 54卷(8期):3103–3107頁
(IF: 5.207, 領域排名: 3, 領域期刊數: 54, 領域排名: 5.56%)

Discovery of indeno[1,2-c]quinoline derivatives as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL)
Tseng CH, Lin RW, Chen YL, Wang GJ, Ho ML, Tzeng CC.* - - 1 - J. Med. Chem. - J MED CHEM 2011;54(8):3103–3107
(IF: 5.207, Journal Ranking: 3, Number of Journals of this Field: 54, Ranking: 5.56%)

50

2,3-diarylquinoline 衍生物之合成以及抗增生之研究
曾志華,陳義龍,鍾昆宇,王記慧,彭馨誼,鄭智美,曾誠齊* - - 1 - Org. Biomol. Chem. - 2011 9卷(9期):3205–3216頁
(IF: 3.451, 領域排名: 12, 領域期刊數: 56, 領域排名: 21.43%)

Synthesis and antiproliferative evaluation of 2,3-diarylquinoline derivatives
Tseng CH, Chen YL, Chung KY, Wang CH, Peng SI, Cheng CM, Tzeng CC.* - - 1 - Org. Biomol. Chem. - 2011;9(9):3205–3216
(IF: 3.451, Journal Ranking: 12, Number of Journals of this Field: 56, Ranking: 21.43%)

51

6-aryl-11-iminoindeno[1,2-c]quinoline 衍生物合成與抗增生活性評估
曾志華,曾誠齊,鍾昆宇,高佳麟,許智堯,鄭智美,黃耿祥,陳義龍* - - 1 - Bioorg Med Chem. - BIOORGAN MED CHEM 2011 19卷(24期):7653-7663頁
(IF: 2.978, 領域排名: 15, 領域期刊數: 54, 領域排名: 27.78%)

Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives
Tseng CH, Tzeng CC, Chung KY, Kao CL, Hsu CY, Cheng CM, Huang KS, Chen YL.* - - 1 - Bioorg Med Chem. - BIOORGAN MED CHEM 2011;19(24):7653-7663
(IF: 2.978, Journal Ranking: 15, Number of Journals of this Field: 54, Ranking: 27.78%)

52

發現4-anilinofuro[2,3-b]quinoline 衍生物為口服抗肺癌試劑
陳郁旻,陳義龍,曾志華,梁治中,楊佳寧,姚雲欽,呂佩融,曾誠齊* - - 1 - J Med Chem. - J MED CHEM 2011 54卷(13期):4446-4461頁
(IF: 5.207, 領域排名: 3, 領域期刊數: 54, 領域排名: 5.56%)

Discovery of 4-anilinofuro[2,3-b]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers
Chen YW, Chen YL, Tseng CH, Liang CC, Yang CN, Yao YC, Lu PJ, Tzeng CC.* - - 1 - J Med Chem. - J MED CHEM 2011;54(13):4446-4461
(IF: 5.207, Journal Ranking: 3, Number of Journals of this Field: 54, Ranking: 5.56%)

53

Indeno[1,2-c]quinoline類衍生物的合成與抗增生活性評估-第二報
曾志華,曾誠齊,楊巧麗,呂佩融*,陳慧琳,楊佳寧,;陳義龍* - - 1 - J. Med. Chem. - J MED CHEM 2010 53卷(16期):6164–6179頁
(IF: 5.207, 領域排名: 3, 領域期刊數: 54, 領域排名: 5.56%)

Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2
Tseng CH, Tzeng CC, Yang CL, Lu PJ*, Chen HL, Li HY, Chuang YC, Yang CN, Chen YL.* - - 1 - J. Med. Chem. - J MED CHEM 2010;53(16):6164–6179
(IF: 5.207, Journal Ranking: 3, Number of Journals of this Field: 54, Ranking: 5.56%)

54

確認benzofuro[2,3-b]quinoline 衍生物為抗肺結核試劑
楊巧麗,曾志華,陳義龍,盧智明,高佳麟,吳明續,曾誠齊* - - 1 - Eur. J. Med. Chem. - EUR J MED CHEM 2010 45卷(2期):602-607頁
(IF: 3.193, 領域排名: 11, 領域期刊數: 54, 領域排名: 20.37%)

Identification of benzofuro[2,3-b]quinoline derivatives as a new class of antituberculosis agents
Yang CL, Tseng CH, Chen YL, Lu CM, Kao CL, Wu MH, Tzeng CC.* - - 1 - Eur. J. Med. Chem. - EUR J MED CHEM 2010;45(2):602-607
(IF: 3.193, Journal Ranking: 11, Number of Journals of this Field: 54, Ranking: 20.37%)

55

Furo[3',2':3,4]naphtho[1,2-d]imidazole衍生物為敗血症抗發炎抑制劑
曾志華,林漳聲,施秉庚,曹羅悌,王繼平,鄭智美*,曾誠齊,陳義龍* - - 1 - Bioorg. Med Chem. - BIOORGAN MED CHEM 2009 17卷(18期):6773–6779頁
(IF: 2.978, 領域排名: 15, 領域期刊數: 54, 領域排名: 27.78%)

Furo[3',2':3,4]naphtho[1,2-d]imidazole derivatives as potential inhibitors of inflammatory factors in sepsis.
Tseng CH, Lin CS, Shih PK, Tsao LT, Wang JP, Cheng CM*, Tzeng CC, Chen YL* - - 1 - Bioorg. Med Chem. - BIOORGAN MED CHEM 2009;17(18):6773–6779
(IF: 2.978, Journal Ranking: 15, Number of Journals of this Field: 54, Ranking: 27.78%)

56

3-amino-2-hydroxypropoxyisoflavone衍生物的合成與抗骨質疏鬆活性評估
曾志華,陳義龍,盧智明,王志光,蔡銀棟,林儒緯,陳建復,張玉芳,王國照,何美泠*,曾誠齊*  - - 1 - Eur. J. Med. Chem. - EUR J MED CHEM 2009 44卷(9期):3621–3626頁
(IF: 3.193, 領域排名: 11, 領域期刊數: 54, 領域排名: 20.37%)

Synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives
Tseng CH, Chen YL, Lu CM, Wang CK, Tsai YT, Lin RW, Chen CF, Chang YF, Wang GJ, Ho ML*, Tzeng CC* - - 1 - Eur. J. Med. Chem. - EUR J MED CHEM 2009;44(9):3621–3626
(IF: 3.193, Journal Ranking: 11, Number of Journals of this Field: 54, Ranking: 20.37%)

57

6-arylindeno[1,2-c]quinoline衍生物的合成與抗增生活性評估
曾志華,陳義龍,鍾昆宇,鄭智美,王記慧,曾城齊* - - 1 - Bioorg. Med. Chem. - BIOORGAN MED CHEM 2009 17卷(21期):7465–7476頁
(IF: 2.978, 領域排名: 15, 領域期刊數: 54, 領域排名: 27.78%)

Synthesis and antiproliferative evaluation of 6-arylindeno[1,2-c]quinoline derivatives
Tseng CH, Chen YL, Chung KY, Cheng CM, Wang CH, Tzeng CC* - - 1 - Bioorg. Med. Chem. - BIOORGAN MED CHEM 2009;17(21):7465–7476
(IF: 2.978, Journal Ranking: 15, Number of Journals of this Field: 54, Ranking: 27.78%)

58

indeno[1,2-c]quinoline 衍生物的合成與抗增生活性評估
曾志華,陳義龍,呂佩融,楊佳寧,曾誠齊* - - 1 - Bioorg. Med Chem. - BIOORGAN MED CHEM 2008 16卷(6期):3153–3162頁
(IF: 2.978, 領域排名: 15, 領域期刊數: 54, 領域排名: 27.78%)

Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives
Tseng CH, Chen YL, Lu PJ, Yang CN, Tzeng CC* - - 1 - Bioorg. Med Chem. - BIOORGAN MED CHEM 2008;16(6):3153–3162
(IF: 2.978, Journal Ranking: 15, Number of Journals of this Field: 54, Ranking: 27.78%)

59

4-anilino-8-methoxy-2-phenylquinoline 與 4-anilino-8-hydroxy-2-phenylquinoline衍生物合成及抗增生活性評估
陳義龍,黃照傑,黃尊遠,曾志華,張峰碩,楊勝惠,林信仁,曾誠齊* - - 1 - Bioorg. Med Chem. - BIOORGAN MED CHEM 2006 14卷(9期):3098–3105頁
(IF: 2.978, 領域排名: 15, 領域期刊數: 54, 領域排名: 27.78%)

Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives
Chen YL, Huang CJ, Huang ZY, Tseng CH, Chang FS, Yang SH, Lin SR, Tzeng CC* - - 1 - Bioorg. Med Chem. - BIOORGAN MED CHEM 2006;14(9):3098–3105
(IF: 2.978, Journal Ranking: 15, Number of Journals of this Field: 54, Ranking: 27.78%)

 Project

NO
YEAR — Source — No — Type
Project Name
Duration
1
109 — KI 高醫國衛院 — KMU-KI110003 —  
罕見疾病家族性腸息肉症(FAP)標靶藥物TCH-3511之Non-GLP藥理與毒理分析( )
2020/08/01 ~ 2021/07/31
2
109 — N 科技部(原國科會) — MOST108-2320-B-037-026-MY2 — 1 個人型
設計合成雜環化合物作為登革病毒複製的抑制劑(2/2)( )
2020/08/01 ~ 2021/07/31
3
108 — N 科技部(原國科會) — MOST108-2320-B-037-026-MY2 — 1 個人型
設計合成雜環化合物作為登革病毒複製的抑制劑(1/2)( )
2019/08/01 ~ 2021/07/31
4
107 — N 科技部(原國科會) — MOST107-2320-B-037-015 — 1 個人型
設計合成含有1,2,3-三唑結構的雜環化合物作為抗登革病毒藥( )
2018/08/01 ~ 2019/07/31
5
107 — Z 大專學生研究計畫及博士後 — MOST108-2813-C-037-040-B — 8 大專學生研究計畫
108年度大專學生研究計畫-陳承儒(香3)( )
2019/07/01 ~ 2020/02/29
6
107 — Z 大專學生研究計畫及博士後 — MOST108-2813-C-037-042-B — 8 大專學生研究計畫
108年度大專學生研究計畫-黃育堂(藥學3)( )
2019/07/01 ~ 2020/02/29
7
106 — N 科技部(原國科會) — MOST106-2320-B-037-015 — 1 個人型
設計合成三唑喹啉化合物與芳酰基喹喔啉化合物並評估其抗登革病毒活性( )
2017/08/01 ~ 2018/07/31
8
105 — N 科技部(原國科會) — MOST103-2320-B-037-011-MY3 — 1 個人型
合成吡唑基喹啉與苯胺基喹啉類衍生物作為抗登革病毒試劑(3/3)( )
2016/08/01 ~ 2017/07/31
9
105 — TP 頂尖計畫(高醫) — KMU-TP105E16 —  
子計畫十六、合成3‐m啶喹膩繵葩嵾l生物作為甘胺酸氮甲基轉移酶(GNMT)表現之調控劑( )
2016/11/01 ~ 2017/10/31
10
105 — TP 頂尖計畫(高醫) — KMU-TP105H08 —  
子計畫八、合成芳香環偶氮類衍生物並其抗登革病毒活性( )
2016/11/01 ~ 2017/10/31
11
104 — N 科技部(原國科會) — MOST103-2320-B-037-011-MY3 — 1 個人型
合成吡唑基喹啉與苯胺基喹啉類衍生物作為抗登革病毒試劑(2/3)( )
2015/08/01 ~ 2017/07/31
12
104 — TP 頂尖計畫(高醫) — KMU-TP104E16 —  
子計畫十六、探索新型苯基偶氮衍生物作為調控苷胺酸氮甲基轉移酶(GNMT)表現以治療肝癌( )
2015/10/01 ~ 2016/09/30
13
104 — TP 頂尖計畫(高醫) — KMU-TP104H08 —  
子計畫八、合成芳香環偶氮類衍生物並評估其抗登革病毒活性( )
2015/10/01 ~ 2016/09/30
14
103 — N 科技部(原國科會) — MOST103-2320-B-037-011-MY3 — 1 個人型
合成吡唑基喹啉與苯胺基喹啉類衍生物作為抗登革病毒試劑(1/3)( )
2014/08/01 ~ 2017/07/31
15
103 — Q 新聘教師計畫(校內) — KMU-Q104016 —  
合成茚[1,2-b]喹喔休類衍生物作為抗腫瘤藥物( )
2015/01/01 ~ 2015/12/31
16
103 — TP 頂尖計畫(高醫) — KMU-TP103H08 —  
研發具有抗登革熱潛能之喹螢衍生物( )
2014/08/01 ~ 2015/07/31
17
102 — Q 新聘教師計畫(校內) — KMU-Q103028 —  
硝基呋喃乙烯茚[1,2-c]喹啉與硝基呋喃乙烯喹啉類化合物之合成及生物活性評估( )
2014/01/01 ~ 2014/12/31
18
101 — N 科技部(原國科會) — NSC102-2320-B-037-001 — 1 個人型
2-芳酰基-3-芳香環喹啉類化合物與2-芳酰基-4-苯胺基類化合物之合成及抗登革病毒活性評估( )
2013/05/01 ~ 2014/07/31

 Patent