Education
| School — Major — Degree | Duration |
|---|---|
|
國立國防醫學院 — 生命科學研究所(畢) — 博士 Doctorate, Graduate Institute of Life Sciences, National Defense Medical Center |
1997/08 — 2003/06 |
|
國立國防醫學院 — 生理學研究所(畢) — 碩士 Master, Graduate Institute of Physiology, National Defense Medical Center |
1995/08 — 1997/06 |
|
高雄醫學院 — 生物學系(畢) — 學士 Bachelor, Department of Biology, Kaohsiung Medical College |
1991/08 — 1995/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 醫學研究所 Graduate Institute of Medicine | Associate Professor | 2019/02/01 — |
| 醫學研究所 Graduate Institute of Medicine | Assistant Professor | 2015/08/01 — 2019/01/31 |
| 神經學科 Department of Neurology | Assistant Professor | 2011/08/01 — 2015/07/31 |
| 神經學科 Department of Neurology | Assistant Professor | 2011/02/14 — 2011/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 生物學之生化及分子生物 Biochemistry and Molecular Biology |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 生理 Physiology |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
神經藥理、 神經免疫、 藥物濫用、 臨床神經醫學
Neuropharmacology, Neuroimmunity, Drug abuse, Clinical Neuromedicine
Area(s) of Expertise & Research
專長：神經生物學、神經藥理學、分子與細胞生物學、人體生理學、普通生物學 領域：神經分化與神經退化、細胞凋亡、壓力訊息傳遞、肺癌
Neurobiology Neuropharmacology Molecular and cellular biology Human physiology General biology
Publication
| NO | Publication |
|---|---|
| 1 | 互動式語音人體器官模型結合團隊學習提升護校生學習解剖生理學的動機與表現 Interactive audio human organ model combined with team-based learning improves the motivation and performance of nursing students in learning anatomy and physiology. |
| 2 | SGLT2 Inhibitor Canagliflozin Alleviates High Glucose-Induced Inflammatory Toxicity in BV-2 Microglia. SGLT2 Inhibitor Canagliflozin Alleviates High Glucose-Induced Inflammatory Toxicity in BV-2 Microglia. |
| 3 | EGFR Mutation-Harboring Lung Cancer Cells Produce CLEC11A with Endothelial Trophic and Tumor-Promoting Activities EGFR Mutation-Harboring Lung Cancer Cells Produce CLEC11A with Endothelial Trophic and Tumor-Promoting Activities |
| 4 | 雙酚 a 通過 HO-1 和 AMPK 誘導自噬缺陷和 AIF 依賴性細胞凋亡以退化 N2a 神經元 Bisphenol a Induces Autophagy Defects and AIF-Dependent Apoptosis via HO-1 and AMPK to Degenerate N2a Neurons |
| 5 | 1,25-Dihydroxyvitamin D3 modulates the effects of sublethal BPA on mitochondrial function via activating PI3K-Akt pathway and 17β-estradiol secretion in rat granulosa cells 1,25-Dihydroxyvitamin D3 modulates the effects of sublethal BPA on mitochondrial function via activating PI3K-Akt pathway and 17β-estradiol secretion in rat granulosa cells |
| 6 | 急性葡萄糖波動影響微膠細胞活性，導致發炎活化或自我分解 Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation |
| 7 | Highly electronegative low-density lipoprotein L5 evokes microglial activation and creates a neuroinflammatory stress via Toll-like receptor 4 signaling Highly electronegative low-density lipoprotein L5 evokes microglial activation and creates a neuroinflammatory stress via Toll-like receptor 4 signaling |
| 8 | Electronegative Low-density Lipoprotein L5 Impairs Viability and NGF-induced Neuronal Differentiation of PC12 Cells via LOX-1 Electronegative Low-density Lipoprotein L5 Impairs Viability and NGF-induced Neuronal Differentiation of PC12 Cells via LOX-1 |
| 9 | NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish |
| 10 | A central role of TRAX in the ATM-mediated DNA repair A central role of TRAX in the ATM-mediated DNA repair |
| 11 | Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons |
| 12 | NITRIC OXIDE PLAYS A DUAL ROLE IN THE OXIDATIVE INJURY OF CULTURED RAT MICROGLIA BUT NOT ASTROGLIA NITRIC OXIDE PLAYS A DUAL ROLE IN THE OXIDATIVE INJURY OF CULTURED RAT MICROGLIA BUT NOT ASTROGLIA |
| 13 | 1,25-Dihydroxyvitamin D3 increases testosterone-induced 17beta-estradiol secretion and reverses testosterone-reduced connexin 43 in rat granulosa cells 1,25-Dihydroxyvitamin D3 increases testosterone-induced 17beta-estradiol secretion and reverses testosterone-reduced connexin 43 in rat granulosa cells |
| 14 | L-Ascorbate attenuates methamphetamine neurotoxicity through enhancing the induction of endogenous heme oxygenase-1 L-Ascorbate attenuates methamphetamine neurotoxicity through enhancing the induction of endogenous heme oxygenase-1 |
| 15 | Vaccinia H1-related phosphatase (VHR) is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer. Vaccinia H1-related phosphatase (VHR) is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer. |
| 16 | The A2A adenosine receptor rescues neuritogenesis impaired by p53 blockage via Kif2A, a kinesin family member. The A2A adenosine receptor rescues neuritogenesis impaired by p53 blockage via Kif2A, a kinesin family member. |
| 17 | NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells. NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells. |
| 18 | Biochemical and biological characterization of a neuroendocrine-associated phosphatase. Biochemical and biological characterization of a neuroendocrine-associated phosphatase. |
| 19 | Oxidative neurotoxicity in rat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3. Oxidative neurotoxicity in rat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3. |
| 20 | Role of nitric oxide in inflammation-mediated neurodegeneration. Role of nitric oxide in inflammation-mediated neurodegeneration. |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
113 — M 高醫(種子計畫) — KMU-M114029 —
在活體驗證BPA透過HO-1損害神經免疫，進而促進神經退化( )
|
2025/01/01 ~ 2025/12/31 |
| 2 |
108 — M 高醫(種子計畫) — KMU-109011 —
以體外及體內研究探討在間歇性缺氧與高血糖的綜合效應下腦退化的致病機轉以模擬阻塞型睡眠呼吸中止症合併糖尿病的臨床情境( )
|
2020/01/01 ~ 2020/12/31 |
| 3 |
107 — M 高醫(種子計畫) — KMU-M108003 —
探討活體與離體給予微生素C對抗雙酚A神經毒性的效果( )
|
2019/01/01 ~ 2019/12/31 |
| 4 |
105 — M 高醫(種子計畫) — KMU-M106005 —
陰電性低密度脂蛋白在神經退化的致病角色: 以活體動物模式探討陰電性低密度脂蛋白誘發腦組織發炎與損傷( )
|
2017/01/01 ~ 2017/12/31 |
| 5 |
104 — N 國科會(原科技部) — MOST104-2314-B-037-069 — 1 個人型
陰電性低密度脂蛋白在阿茲海默氏症的致病角色:探討血腦屏障完整性、神經發炎與毒性( )
|
2015/08/01 ~ 2016/07/31 |
| 6 |
101 — Q 新聘教師計畫(校內) — KMU-Q102011 —
探討發生在大鼠混合神經膠質細胞的氧化毒性：一氧化氮對微小膠細胞與星狀膠細胞凋亡時所扮演的角色( )
|
2012/12/01 ~ 2013/12/31 |
| 7 |
100 — Q 新聘教師計畫(校內) — KMU-Q110011 —
維生素C之神經保護作用對抗甲基安非他命毒性之研究:探討heme oxygenase-1之角色( )
|
2011/12/15 ~ 2012/12/31 |