Education
| School — Major — Degree | Duration |
|---|---|
|
高雄醫學院 — 醫學研究所(畢) — 博士 Doctorate, Graduate Institute of Medicine, Kaohsiung Medical College |
1989/09 — 1994/06 |
|
高雄醫學院 — 醫學研究所(畢) — 碩士 Master, Graduate Institute of Medicine, Kaohsiung Medical College |
1987/09 — 1989/06 |
|
高雄醫學院 — 藥學系(畢) — 學士 Bachelor, School of Pharmacy, Kaohsiung Medical College |
1983/09 — 1987/06 |
Intramural Experience
| Office/Department/Institute | Position | Duration |
|---|---|---|
| 教務處 Office of Academic Affairs | Associate Vice President for Academic Affairs | 2026/08/01 — 2027/07/31 |
| 天然藥物研究所 Graduate Institute of Natural Products | Professor | 2009/08/01 — 2009/08/01 |
| 藥理學科 Department of Pharmacology | Professor | 2009/08/01 — |
| 藥理學科 Department of Pharmacology | Professor | 2007/08/01 — 2009/07/31 |
| 藥理學研究所 Graduate Institute of Pharmacology | Associate Professor | 2005/11/24 — 2005/07/31 |
| 藥理學研究所 Graduate Institute of Pharmacology | Professor | 2005/08/01 — 2007/07/31 |
| 藥理學 Pharmacology | Associate Professor | 1998/08/01 — 2005/11/23 |
| 藥理學 Pharmacology | Lecturer | 1989/08/01 — 1998/07/31 |
Extramural Experience
Discipline
| NO | Discipline | Expertise |
|---|---|---|
| 1 | 生物醫農類 Biology, Medicine and Agriculture | 藥理及毒理 Pharmacology and Toxicology |
| 2 | 生物醫農類 Biology, Medicine and Agriculture | 藥學及中醫藥 Pharmacy and Chinese Medicine and Pharmacy |
Research & Technology Platform Open to the Outside
Interested Area(s)for Interdisciplinary Research
心臟血管疾病及其藥物研發、粥狀動脈硬化之機轉及其藥物研發、抗發炎藥物及其機轉探討
Cardiovascular pharmacology; Inflammation and bone pharmacology; Drug development in myocardial ischemia-reperfusion, atherosclerosis and restenosis; Traditional Chinese (Herbal) Medicine
Area(s) of Expertise & Research
心臟血管藥理學、心臟缺血缺氧研究、抗血管增生、血管瘤研究、抗骨鬆藥物研究、中草藥藥理研究、心肌梗塞與心肌肥厚之藥物研發、治療粥狀動脈硬化與血管瘤之藥物研發、抗血管細胞增生藥物之研究 治療心臟血管疾病之中草藥物研究 影響骨骼之藥物研發
Cardiovascular pharmacology Drug development in atherosclerosis and restenosis Drug development in myocardial ischemia-reperfusion Inflammation and bone pharmacology
Publication
| NO | Publication |
|---|---|
| 1 | Calcitonin gene-related peptide/protein kinase A: A novel pathway to regulate patency of ductus arteriosus Calcitonin gene-related peptide/protein kinase A: A novel pathway to regulate patency of ductus arteriosus |
| 2 | Regenerative Effect of Vaginal Injections of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Ovariectomized Rats. Regenerative Effect of Vaginal Injections of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Ovariectomized Rats. |
| 3 | 穿心蓮內酯調節人類肺成纖維細胞的纖維化和氧化壓力反應 Andrographolide Modulates Fibrogenic and Oxidative Stress Responses in Human Lung Fibroblasts. |
| 4 | 硼替佐米抑制主動脈平滑肌細胞的異常增生、遷移和表型轉換。 Bortezomib Suppresses Abnormal Proliferation, Migration, and Phenotypic Switching of Aortic Smooth Muscle Cells. |
| 5 | Exploring ruthenium(II)-arene-nitrite complexes for NO release and vasodilatory applications Exploring ruthenium(II)-arene-nitrite complexes for NO release and vasodilatory applications |
| 6 | 補骨脂寧對抗慢性腎臟病引起的平滑肌細胞重塑是經由 JDP2-Nrf2 抗氧化軸發揮血管保護作用 Corylin Confers Vasoprotection via JDP2-Nrf2 Antioxidant Axis against Chronic Kidney Disease-Induced Smooth Muscle Cell Remodelling |
| 7 | 利用桿狀病毒傳遞超氧化物歧化酶3基因可抑制TNF-α引發的血管平滑肌細胞增生和炎症 Delivery of Superoxide Dismutase 3 Gene with Baculoviruses Inhibits TNF-α Triggers Vascular Smooth Muscle Cell Proliferation and Inflammation |
| 8 | 黃嘌呤衍生物 KMUP-3 透過抑制破骨細胞生成和巨噬細胞焦亡來減輕牙周骨吸收 Xanthine Derivative KMUP-3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis |
| 9 | 可溶性 CD93 凝集素樣結構域在關節炎中的治療潛力及其在發炎性骨溶解的抑製作用的驗證 Validation of the therapeutic potential of soluble CD93 lectin-like domain in arthritis and its inhibitory role in inflammatory osteolysis. |
| 10 | 黃嘌呤衍生物 KMUP-1 在 ApoE 基因剔除鼠的抗動脈粥狀硬化和心臟保護作用 Antiatherogenic and Cardioprotective Effects of a Xanthine Derivative KMUP-1 in ApoE Knockout Mice |
| 11 | 臺灣族群中身體質量指數與非手術性牙周治療成效之相關性 The correlation between body mass index and the effectiveness of non-surgical periodontal treatment in Taiwan population |
| 12 | 茶鹼衍生物KMUP-3透過PI3K/Akt/eNOS增強自噬作用優化心肌細胞保護 Optimizing myocardial cell protection with xanthine derivative KMUP-3 potentiates autophagy through the PI3K/Akt/eNOS axis. |
| 13 | 蛋白酶體抑制劑bortezomib阻止肺動脈平滑肌細胞的增生和遷移 Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells |
| 14 | 黃嘌呤衍生物 KMUP-1 抑制低氧誘導 TRPC1 表現及鈣池調控鈣離子流在肺動脈血管平滑肌細胞 The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca Entry in Pulmonary Arterial Smooth Muscle Cells. |
| 15 | Exendin-4, a glucagon-like peptide-1 receptor agonist, regulates ductus arteriosus by vasodilation and anti-remodeling through the PKA pathway Exendin-4, a glucagon-like peptide-1 receptor agonist, regulates ductus arteriosus by vasodilation and anti-remodeling through the PKA pathway |
| 16 | 葛根素在停經後心臟保護中的抗炎和抗氧化作用：Akt 和血紅素加氧酶-1 的角色 Anti-Inflammatory and Anti-oxidative Effects of Puerarin in Postmenopausal Cardioprotection: Roles of Akt and Heme Oxygenase-1. |
| 17 | Autologous Fat Grafting in Female Genital Area Improves Sexual Function by Increasing Collagenesis, Angiogenesis, and Estrogen Receptors. Autologous Fat Grafting in Female Genital Area Improves Sexual Function by Increasing Collagenesis, Angiogenesis, and Estrogen Receptors. |
| 18 | 黃嘌呤衍生物 KMUP-1 可改善視網膜病變 Xanthine derivative KMUP-1 ameliorates retinopathy. |
| 19 | 可溶性 CD93 凝集素樣結構域隔離 HMGB1 以改善炎症性疾病 Soluble CD93 lectin-like domain sequesters HMGB1 to ameliorate inflammatory diseases |
| 20 | 黃芩素透過抑制發炎和氧化壓力對血管緊張素 II 注入的腹主動脈瘤具有血管保護作用 Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress |
| 21 | YULINK在肺動脈平滑肌細胞遷移、增生和糖解作用中的新作用：對肺動脈高壓的影響 The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension |
| 22 | 黃嘌呤衍生物KMUP-1減緩實驗性牙周炎經由減少噬骨細胞分化與發炎作用 Xanthine derivative KMUP-1 attenuates experimental periodontitis by reducing osteoclast differentiation and inflammation |
| 23 | 黃芩素在體外和體內預防平滑肌細胞血管鈣化的潛在作用 Potential actions of baicalein for preventing vascular calcification of smooth muscle cells in vitro and in vivo |
| 24 | Clinical Patterns of Traditional Chinese Medicine for Ischemic Heart Disease Treatment: A Population-Based Cohort Study Clinical Patterns of Traditional Chinese Medicine for Ischemic Heart Disease Treatment: A Population-Based Cohort Study |
| 25 | 肺門脈高壓臨床前標靶治療之探討 The Potential Application and Promising Role of Targeted Therapy in Pulmonary Arterial Hypertension |
| 26 | 動脈導管重塑的潛在分子機制：超越前列腺素 Molecular Mechanisms Underlying Remodeling of Ductus Arteriosus: Looking Beyond the Prostaglandin Pathway |
| 27 | 血管緊張素轉換酶2激活劑可減輕左肺切除與VEGF抑制的大鼠模型中的嚴重肺動脈高壓 Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition |
| 28 | KMUP-1恢復周邊神經損傷誘發背根神經節BKCa 通道抑制作用 BKCa channel inhibition by peripheral nerve injury is restored by the xanthine derivative KMUP-1 in dorsal root ganglia |
| 29 | In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis |
| 30 | Cinaciguat 通過血管舒張和抗重塑預防新生大鼠出生後動脈導管關閉 Cinaciguat Prevents Postnatal Closure of Ductus Arteriosus by Vasodilation and Anti-remodeling in Neonatal Rats |
| 31 | Loganin 預防 CXCL12/CXCR4 調控神經性疼痛透過 NLRP3發炎體在神經損傷的大鼠 Loganin prevents CXCL12/CXCR4-regulated neuropathic pain via the NLRP3 inflammasome axis in nerve-injured rats. |
| 32 | Loganin 預防慢性神經壓迫損傷引發神經性疼痛透過降低 TNF-α/IL-1β 誘發NF-κB 活化及許旺細胞之去髓鞘化 Loganin prevents chronic constriction injury-provoked neuropathic pain by reducing TNF-α/IL-1β-mediated NF-κB activation and Schwann cell demyelination |
| 33 | Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice |
| 34 | Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice. Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice. |
| 35 | Extracellular heat shock protein HSC70 protects against lipopolysaccharide-induced hypertrophic responses in rat cardiomyocytes Extracellular heat shock protein HSC70 protects against lipopolysaccharide-induced hypertrophic responses in rat cardiomyocytes |
| 36 | Role of Extracellular Matrix in Pathophysiology of Patent Ductus Arteriosus: Emphasis on Vascular Remodeling Role of Extracellular Matrix in Pathophysiology of Patent Ductus Arteriosus: Emphasis on Vascular Remodeling |
| 37 | Vasculoprotective effects of Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats Vasculoprotective effects of Centella asiatica, Justicia gendarussa and Imperata cylindrica decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats |
| 38 | 黃腐醇防止維生素D3和尼古丁誘導之血管鈣化 The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D Plus Nicotine. |
| 39 | The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction. The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction. |
| 40 | Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene |
| 41 | KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO-cGMP-MAPK Signaling Pathways KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO-cGMP-MAPK Signaling Pathways |
| 42 | Glucagon-Like Peptide-1 Receptor Agonist Attenuates Autophagy to Ameliorate Pulmonary Arterial Hypertension through Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3β Pathways Glucagon-Like Peptide-1 Receptor Agonist Attenuates Autophagy to Ameliorate Pulmonary Arterial Hypertension through Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3β Pathways |
| 43 | 黃嘌呤衍生KMUP-1反轉高糖毒性活化之Kv通道經由cAMP/PKA訊息路徑於大鼠胰島乙型細胞 Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells |
| 44 | Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure |
| 45 | Exogenous heat shock Cognate protein 70 suppresses LPS-induced inflammation by down-regulating NF-κB through MAPK and MMP-2/-9 pathways in macrophages Exogenous heat shock Cognate protein 70 suppresses LPS-induced inflammation by down-regulating NF-κB through MAPK and MMP-2/-9 pathways in macrophages |
| 46 | B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats B-type natriuretic peptide prevents postnatal closure of ductus arteriosus by both vasodilation and anti-remodeling in neonatal rats |
| 47 | GPCR 調控物質KMUP-1減少三酸甘油脂蓄積包含MAPKs/Akt/PPARγ及PKA/PKG/HSL訊息在3T3-L1前脂肪細胞 KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes |
| 48 | Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release |
| 49 | Statins Ameliorate Pulmonary Hypertension Secondary to Left Ventricular Dysfunction Through the Rho-Kinase Pathway and NADPH Oxidase Statins Ameliorate Pulmonary Hypertension Secondary to Left Ventricular Dysfunction Through the Rho-Kinase Pathway and NADPH Oxidase |
| 50 | Indonesian herbal medicine prevents hypertension-induced left ventricular hypertrophy by diminishing NADPH oxidase-dependent oxidative stress Indonesian herbal medicine prevents hypertension-induced left ventricular hypertrophy by diminishing NADPH oxidase-dependent oxidative stress |
| 51 | Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization |
| 52 | 髓系凝血酶調節素類凝集素功能區抑制食骨細胞生成作用與發炎性骨質流失 Myeloid thrombomodulin lectin-like domain inhibits osteoclastogenesis and inflammatory bone loss |
| 53 | 黃嘌呤衍生物可藉由活化內皮細胞一氧化氮合酶以減少內皮前驅細胞在缺氧情況下所誘導的細胞凋亡現象 Activation of endothelial NO synthase by a xanthine derivative ameliorates hypoxia-induced apoptosis in endothelial progenitor cells. |
| 54 | Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway |
| 55 | Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways |
| 56 | Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release |
| 57 | 3度燙傷引發脊髓腹角運動神經元細胞凋亡, 坐骨神經及肌肉萎縮 Third-Degree Hindpaw Burn Injury Induced Apoptosis of Lumbar Spinal Cord Ventral Horn Motor Neurons and Sciatic Nerve and Muscle Atrophy in Rats |
| 58 | Xanthine 衍生物 KMUP-1 減弱 Serotonin 引起肺動脈血管狹窄及鉀離子通道抑制活性透過 PKC 路徑 The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K+-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries |
| 59 | Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury. Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury. |
| 60 | Fat Grafting in Burn Scar Alleviates Neuropathic Pain via Anti-Inflammation Effect in Scar and Spinal Cord. Fat Grafting in Burn Scar Alleviates Neuropathic Pain via Anti-Inflammation Effect in Scar and Spinal Cord. |
| 61 | KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways |
| 62 | KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin |
| 63 | Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia |
| 64 | Autologous fat grafting alleviates burn-induced neuropathic pain in rats. Autologous fat grafting alleviates burn-induced neuropathic pain in rats. |
| 65 | B型利鈉鉎肽於肺血管平滑肌細胞之抗增生與抗遷徙作用 B-type Natriuretic Peptide Inhibits Angiotensin Ⅱ-induced Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells |
| 66 | Dual ELE/NEP抑制可改善主動脈縮窄狀況造成心室失常之舒張功能失常及心室再模化 Dual ELE/NEP inhibition improved diastolic function and ameliorated cardiac remodeling in rats with myocardial dysfunction secondary to pressure overload by aortic banding |
| 67 | Baicalein Inhibits HMGB1 Release and MMP-2/-9 Expression in Lipopolysaccharide-Induced Cardiac Hypertrophy Baicalein Inhibits HMGB1 Release and MMP-2/-9 Expression in Lipopolysaccharide-Induced Cardiac Hypertrophy |
| 68 | Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production, calcium overload and apoptosis via MAPK pathways. Baicalein, an active component of Scutellaria baicalensis Georgi, prevents lysophosphatidylcholine-induced cardiac injury by reducing reactive oxygen species production, calcium overload and apoptosis via MAPK pathways. |
| 69 | Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock. Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock. |
| 70 | 內皮一氧化氮合成酶促進G蛋白結合受體拮抗劑抑制肺動脈高血壓在野百荷鹼模式是藉由ET-1相關及ET-1不相關的路進 Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model. |
| 71 | No donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling. No donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling. |
| 72 | Lercanidipine and labedipinedilol-A attenuate lipopolysaccharide/interferon-γ-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities Lercanidipine and labedipinedilol-A attenuate lipopolysaccharide/interferon-γ-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities |
| 73 | KMUP-1 Suppresses RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss: Roles of MAPKs, Akt, NF-κB and Calcium/Calcineurin/NFATc1 Pathways KMUP-1 Suppresses RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss: Roles of MAPKs, Akt, NF-κB and Calcium/Calcineurin/NFATc1 Pathways |
| 74 | 三黃瀉心湯保護心臟抗缺氧再給氧傷害是經由抑制氧化壓力引起細胞程式凋亡 San-Huang-Xie-Xin-Tang protects cardiomyocytes against hypoxia/reoxygenation injury via inhibition of oxidative stress-induced apoptosis |
| 75 | KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin. KMUP-1 inhibits hypertension-induced left ventricular hypertrophy through regulation of nitric oxide synthases, ERK1/2, and calcineurin |
| 76 | Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil |
| 77 | KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance KMUP-3 attenuates ventricular remodelling after myocardial infarction through eNOS enhancement and restoration of MMP-9/TIMP-1 balance |
| 78 | Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis |
| 79 | Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kB and AP-1 through inhibition of MAPKs and Akt/IkBa signaling pathways in macrophages Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kB and AP-1 through inhibition of MAPKs and Akt/IkBa signaling pathways in macrophages |
| 80 | Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis |
| 81 | 三黃瀉心湯防止大鼠心臟經缺氧再給氧引起之細胞凋亡是經由eNOS和MAPK路徑 San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways |
| 82 | Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis. Labedipinedilol-A prevents lysophosphatidylcholine-induced vascular smooth muscle cell death through reducing reactive oxygen species production and anti-apoptosis. |
| 83 | KMUP-1經由NO/cGMP/PKG和ERK1/2/calcineurin A路徑減低isoprenaline誘導大鼠的心肌肥厚 KMUP-1 attenuates isoproterenol-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways |
| 84 | 茶鹼衍生物KMUP-1經由NO/cGMP依賴性抑制RhoA/Rho kinase 表現治療肺高壓 The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase |
| 85 | KMUP-1 經由 serotonin 受體/transporter 與 NO synthase 及 抑制 RhoA 與 AKT/ERK 磷酸化降低肺動脈增生 KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation |
| 86 | Protective effects if a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat Protective effects if a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat |
| 87 | Protective effects of a dual endothelin converting enzyme/neutral endothpeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat Protective effects of a dual endothelin converting enzyme/neutral endothpeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat |
| 88 | Lercanidipine抑制血管平滑肌細胞增生和新生內層的形成是經由減低自由基及去活化Ras-ERK1/2訊息路徑 Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1/2 signaling |
| 89 | 一個選擇性甲一型腎上腺素性受體阻斷劑Labedipinedilol-A抑制攝護腺癌細胞增生是相關於細胞生長週期停止和細胞凋亡 Inhibition of human prostate cancer cells proliferation by a selective alpha1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis |
| 90 | 第三代鈣離子拮抗劑Zanidip對血管平滑肌的生長抑制作用 Growth inhibitory effects of Zanidip, a third-generation calcium antagonist, on vascular smooth muscle cells |
| 91 | labedipinedilol-A抑制大鼠腦血管平滑肌細胞電位相關性 L型鈣離子通道牽涉蛋白激𡓨C Inhibition of voltage-gated L-type calcium channels by labedipinedilol-A involves protein kinase C in rat cerebrovascular smooth muscle cells |
| 92 | Isoeugenodilol抑制血管平滑肌細胞增生和氣球擴張術新生內層經由ERK1/2去活化作用 Isoeugenodilol inhibits smooth muscle cell proliferation and neointimal thickening after balloon injury via inactivation of ERK1/2 pathway |
| 93 | Tc-99m (V) DMSA與人類血漿蛋白質作用機轉之研究 EVALUATION OF TC-99M (V) DMSA BINDING TO HUMAN PLASMA PROTEINS |
| 94 | 第3代二氫砒啶型鈣離子阻斷劑Labedipinedilol-A對ouabain引起心律不整之作用 Effects of labedipinedilol-A, third-generation dihydropyridine-type calcium blocker, on ouabain-induced arrhythmia |
| 95 | 應用多站迷你面試（MMI）選擇學士後醫學系學生 Using aMultiple Mini-interview Approach to Select Graduate Entry Medical Students |
| 96 | Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats Effects of sildenafil on pulmonary hypertension and levels of ET-1, eNOS, and cGMP in aorta-banded rats |
| 97 | Differential change in expression of pulmonary ET-1 and eNOS in rats after chronic left ventricular pressure overload. Differential change in expression of pulmonary ET-1 and eNOS in rats after chronic left ventricular pressure overload. |
| 98 | 黃嘌呤衍生物KMUP-1及KMUP-3抑制大鼠氣管前,發炎物質TNF-a引發誘導型一氧化氮酶,關連於溶解型鳥糞嘌呤環化酶及G蛋白激酶 Inhibition of Proinflammatory Tumor Necrosis Factor--Induced Inducible Nitric-Oxide Synthase by Xanthine-Based 7-[2-[4- (2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in Rat Trachea: The Involvement of Soluble Guanylate Cyclase and Protein Kinase G |
| 99 | Protective effect of labedipinedilol-A, a novel dihydropyridine-type calcium channel blocker, on myoardial apoptosis in ischemia -- reperfusion injury. Protective effect of labedipinedilol-A, a novel dihydropyridine-type calcium channel blocker, on myoardial apoptosis in ischemia -- reperfusion injury. |
| 100 | Liberadipinedilol-A之血管鬆弛作用相關鈣離子內流引發內皮細胞衍生一氧化氮及其合成酶表現 The vasorelaxing action of labedipinedilol-A involves endothelial cell-derived NO and eNOS expression caused by calcium influx. |
| 101 | 癲癇誘發細胞內GABA A型受體堆積 Status epilepticus increases the intracellular accumulation of GABA(A) receptors |
| 102 | Labedipinedilol C: 第三代dihydropyridine型鈣離子通道拮抗劑，呈現鉀離子通道開啟、一氧化氮相關與腎上腺拮抗活性 Labedipinedilol-C: a third-generation dihydropyridine-type calcium channel antagonist displaying K+ channel opening, NO-dependent and adrenergic antagonist activities. |
| 103 | 在繼發性到先天性心臟病的幼兒與小孩會增加血液循環的 big endothelin-1、endothelin-1及atrial natriuretic peptide Increased circulating big endothelin-1, endothelin-1 and atrial natriuretic peptide in infants and children with heart failure secondary to congenital heart disease. |
| 104 | 存在於肺動脈瓣閉鎖合併完整心室中隔的依賴右心室的冠狀動脈循環 Increased circulating calcitonin gene-related peptide in congestive heart failure caused by congenital heart disease. |
| 105 | Vanylidilol: 一苯乙醛基腎上腺素激性甲/乙型阻斷劑具內皮細胞相關與甲離子通道開啟相關的血管鬆弛活性之抗高血壓作用 Anti-Hypertension Effect of Vanylidilol: A Phenylaldehyde /-Adrenoceptor Blocker with Endothelium-Dependent and K+ Channels Opening-Associated Vasorelaxant Activities |
| 106 | 內皮性一氧化氮合成酵素及內皮素-1在心衰竭引起的肺高壓狀況下有上升趨勢 Upregulation of Endothelial Nitric Oxide Synthase and Endothelin-1 in Pulmonary Hypertension Secondary to Heart Failure in Aorta-Banded Rats |
| 107 | Labedipinedilol-A 在大鼠平滑肌細胞抑制增生是經由PKC 和 ERK 1/2 途徑 Inhibition of Mitogen-Mediated Proliferation of Rat Vascular Smooth Muscle Cells by Labedipinedilol-A through PKC and ERK 1/2 Pathway |
| 108 | 番椒晶素衍生物VOA經由CGRP, NO, cGMP及血管內皮相關作用引起大白鼠腸繫膜動脈及主動脈之鬆弛作用 A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP and endothelium-dependent activities |
| 109 | Pyrrolo-Benzylisoquinoline的合成及抗血小板活性探討 Antiplatelet Activity of Synthetic Pyrrolo-benzylisoquinolines |
| 110 | 番椒晶素衍生物VOA經由CGRP, NO, cGMP及血管內皮相關作用引起大白鼠腸繫膜動脈及主動脈之鬆弛作用 A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP and endothelium-dependent activities |
| 111 | Labedipinedilol-A 對於DOCA-Salt 大鼠心室性PKC- 及內分泌性訊息之影響 Ventricular PKC- and humoral signaling in DOCA-Salt rats treated with labedipinedilol-A |
| 112 | Labedipinedilol-A 對於DOCA-Salt大鼠心室性PKC-及內分泌性訊息之影響 Ventricular PKC-e and Humoral Signaling in DOCA-Salt Rats Treated with Labedipinedilol-A |
| 113 | 新一代具有4-Phenyl Oxypropanolamine的二氫呲啶型鈣離子通道阻斷劑呈現腎上腺甲/乙型受體拮抗及長期抗高血壓的 活性 The New Generation Dihydropyridine Type Calcium Blockers, Bearing 4-Phenyl Oxypropanolamine, Display alpha-/beta-Adrenoceptor Antagonist and Long Acting Antihypertensive Activities |
| 114 | 由Hernandia nymphaeifolia 純化之lignans對腎小管細胞內鈣離子之作用探討 Novel action of lignans isolated from Hernandia nymphaeifoliaon Ca2+ signaling in renal tubular cells |
| 115 | 香夾蘭胺為骨架的丙醇胺衍生物具有腎上腺素甲/乙型受體阻斷和血管鬆弛特性 A Vanillylamide-Based Propanolamine Derivative Displays alpha/beta-Adrenoceptor Blocking and Vasodilating Properties |
| 116 | KMUP 880708:一種以vanillylamide架構腎上腺乙一型受體拮抗劑具有甲型受體阻斷及鉀離子通道開啟活性 KMUP 880708: A Vanyllilamide-Based beta1-Adrenoceptor Antagonist With alpha-Adrenoceptor Blocking and Potassium Channel Opening Activities |
| 117 | 香夾蘭胺為骨架的丙醇胺衍生物具有腎上腺素甲/乙型受體阻斷和血管鬆弛特性 A Vanillylamide-Based Propanolamine Derivative Displays alpha/beta-Adrenoceptor Blocking and Vasodilating Properties |
| 118 | 以血漿中尿紫質螢光檢測輔助診斷及追(9e53)遲發性皮膚紫質病 Detection of plasma uroporphyrin fluorescence as an adjuvant diagnostic and follow-up tool of porphyria cutanea tarda. |
| 119 | 第三代二氫砒啶型鈣離子阻斷劑 Labedipinedilol-B 具有甲/乙型腎上腺激性阻斷活性 The Third Generation Dihydropyridine Type Calcium Channel Blocker Labedipinedilol-B displaying α/β-Adrenoceptor Blocking Activities |
| 120 | 第三代二氫砒啶型鈣離子阻斷劑 Labedipinedilol-B 具有甲/乙型腎上腺激性阻斷活性 The Third Generation Dihydropyridine Type Calcium Channel Blocker Labedipinedilol-B displaying α/β-Adrenoceptor Blocking Activities |
| 121 | Vanidipinedilol: 一個以Vanilloid為骨架且具有阻斷鈣離子通道及血管擴張活性之乙型腎上腺素性受體阻斷劑 Vanidipinedilol: A Vanilloid-Based beta-Adrenoceptor Blocker Displaying Calcium Entry Blocking and Vasorelaxant Activities |
| 122 | 一個醛基型甲/乙型腎上腺受體阻斷劑具有血管鬆弛特性之藥理作用 Pharmacological effects of an aldehyde type /-adrenoceptor blocking agent with vasodilating properties |
| 123 | Labedipinedilol-A:一個以Vanilloid為骨架並具有鈣離子通道阻斷及長效性抗高血壓特性之腎上腺素性甲/乙型受體阻斷劑 Labedipinedilol-A: A Vanilloid-Based alpha/beta-Adrenoceptor Blocker With Calcium Entry Blocking and Long Acting Anti-hypertensive Properties |
| 124 | 一個醛基型甲/乙型腎上腺受體阻斷具有血管鬆弛特性之藥理作用 Pharmacological effects of an aldehyde type/-adrenoceptor blocking agent with vasodilating properties |
| 125 | 鉀離子相關藥物對鉈201進入幼鼠心肌培養細胞的影響--初步報告 The interference of uptake of thallium 201 in cultured rat myocardial cells with existence of potassium related pharmaceuticals - A prelliminary report. |
| 126 | 一個醛基型甲/乙型腎上腺受體阻斷劑具有血管鬆弛特性之藥理作用 Pharmacological effects of an aldehyde typw/-adrenoceptor blocking agent with vasodilating properties |
| 127 | Ferulidilol:兼具有乙二型腎上腺激性致效劑作用之血管鬆弛及抗氧化作用之腎上腺激性及鈣離子通道阻斷劑 Ferulidilol: A vasodilatory and antioxidant adrenoceptor and calcium entry blocker, with ancillary b2-agonist activity |
| 128 | 硝基化蕃椒晶素重新考量氫質子酸於蕃椒晶素誘發之感覺神經活性之角色 Nitrated nonivamide displaying a drawback of proton’s role in capsaicin associated sensory and neuronal activities |
| 129 | Ionic effects of capsinolol, a calcitonin gene-related peptide releasing b-adrenoceptor blocker, on isolated cardiac muscle |
| 130 | Capsazocaine : a capsaicin-sensitivity functional antagonist displays an argument on sensory capsaicin receptor 待補 |
| 131 | Capsinolol: the first β-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart |
| 132 | Comparative study on the pharmacokinetic bioequivalence of two intravascular ceftriazone preparations |
Project
| NO |
YEAR — Source — No — Type
Project Name
|
Duration |
|---|---|---|
| 1 |
115 — N 國科會(原科技部) — NSTC115-2320-B-037-027 — 1 個人型
來自海綿活性成分manoalide用於口腔和顎面疾病治療效果之研究探討( )
|
2026/08/01 ~ 2027/07/31 |
| 2 |
114 — DK 前瞻重點(原校院) — KMU-DK(N)115004 —
補骨脂寧用於肺動脈高血壓之新治療劑探討( )
|
2026/01/01 ~ 2026/12/31 |
| 3 |
114 — N 國科會(原科技部) — NSTC112-2320-B-037-019-MY3 — 1 個人型
探討補骨脂寧用於牙周炎和停經後骨質疏鬆齧齒動物模型對發炎性骨損壞和蝕骨細胞過度活化之治療劑(3/3)( )
|
2025/08/01 ~ 2026/07/31 |
| 4 |
114 — Z 大專學生研究計畫及博士後 — NSTC114-2811-B-037-007 — 9 博士後研究員
博士級研究人員--黃上恩( )
|
2025/08/01 ~ 2026/01/31 |
| 5 |
114 — Z 大專學生研究計畫及博士後 — NSTC115-2811-B-037-003 — 9 博士後研究員
博士級研究人員--黃識紘( )
|
2026/03/01 ~ 2026/07/31 |
| 6 |
113 — DN 前瞻-國合前導專案計畫 — KMU-DN(A)114004 —
茶鹼衍生物KMUP-3透過優化心肌細胞自噬減輕氧化壓力: 離體與活體研究( )
|
2025/07/01 ~ 2025/12/31 |
| 7 |
113 — N 國科會(原科技部) — NSTC112-2320-B-037-019-MY3 — 1 個人型
探討補骨脂寧用於牙周炎和停經後骨質疏鬆齧齒動物模型對發炎性骨損壞和蝕骨細胞過度活化之治療劑(2/3)( )
|
2024/08/01 ~ 2026/07/31 |
| 8 |
113 — Z 大專學生研究計畫及博士後 — NSTC113-2811-B-037-008 — 9 博士後研究員
博士級研究人員--黃上恩( )
|
2024/08/01 ~ 2025/07/31 |
| 9 |
112 — DK 前瞻重點(原校院) — KMU-DK(A)113001 —
甘草素衍生物的抗發炎和抗蝕骨細胞新生作用可減緩實驗性牙周炎之研究( )
|
2024/01/01 ~ 2024/12/31 |
| 10 |
112 — N 國科會(原科技部) — NSTC112-2320-B-037-019-MY3 — 1 個人型
探討補骨脂寧用於牙周炎和停經後骨質疏鬆齧齒動物模型對發炎性骨損壞和蝕骨細胞過度活化之治療劑(1/3)( )
|
2023/08/01 ~ 2026/07/31 |
| 11 |
112 — X 高奇合作計畫 — 113CM-KMU-09 —
探討黃腐酚和芒果苷用於腎衰竭引起之動脈粥狀硬化大鼠的治療效果( )
|
2024/08/01 ~ 2025/07/31 |
| 12 |
112 — Z 大專學生研究計畫及博士後 — NSTC112-2811-B-037-006 — 9 博士後研究員
博士級研究人員--黃上恩( )
|
2023/08/01 ~ 2024/07/31 |
| 13 |
112 — Z 大專學生研究計畫及博士後 — NSTC113-2813-C-037-078-B — 8 大專學生研究計畫
113年度大專學生研究計畫-韓昀穎(醫學2)( )
|
2024/07/01 ~ 2025/02/28 |
| 14 |
111 — DK 前瞻重點(原校院) — KMU-DK(A)112010 — 1 個人型
探討茶鹼衍生物減緩實驗性關節炎的分子機轉研究( )
|
2023/01/01 ~ 2023/12/31 |
| 15 |
111 — N 國科會(原科技部) — MOST109-2320-B-037-024-MY3 — 1 個人型
探討茶鹼衍生物抑制破骨細胞生成和牙周炎引起的牙槽骨破壞的治療機轉(3/3)( )
|
2022/08/01 ~ 2023/07/31 |
| 16 |
111 — Z 大專學生研究計畫及博士後 — NSTC112-2813-C-037-059-B — 8 大專學生研究計畫
112年度大專學生研究計畫-廖芮渝(護理3)( )
|
2023/07/01 ~ 2024/02/29 |
| 17 |
110 — N 國科會(原科技部) — MOST109-2320-B-037-024-MY3 — 1 個人型
探討茶鹼衍生物抑制破骨細胞生成和牙周炎引起的牙槽骨破壞的治療機轉(2/3)( )
|
2021/08/01 ~ 2023/07/31 |
| 18 |
110 — Z 大專學生研究計畫及博士後 — MOST111-2813-C-037-062-B — 8 大專學生研究計畫
111年度大專學生研究計畫-林芝樂(醫學2)( )
|
2022/07/01 ~ 2023/02/28 |
| 19 |
109 — DK 前瞻重點(原校院) — KMU-DK(A)110002 —
探討榛仁球蛋白減緩血管鈣化病變的保護機轉( )
|
2021/01/01 ~ 2021/12/31 |
| 20 |
109 — N 國科會(原科技部) — MOST109-2320-B-037-024-MY3 — 1 個人型
探討茶鹼衍生物抑制破骨細胞生成和牙周炎引起的牙槽骨破壞的治療機轉(1/3)( )
|
2020/08/01 ~ 2023/07/31 |
| 21 |
108 — N 國科會(原科技部) — MOST106-2320-B-037-010-MY3 — 1 個人型
黃芩素及類似物對腹主動脈瘤和粥狀動脈硬化調節粒腺體動態和自噬作用的機轉探討(3/3)( )
|
2019/08/01 ~ 2020/07/31 |
| 22 |
108 — X 高奇合作計畫 — 109CM-KMU-11 —
探討黃芩素對於維生素D3加尼古丁引起心血管鈣化的保護機轉( )
|
2020/05/01 ~ 2021/04/30 |
| 23 |
108 — Z 大專學生研究計畫及博士後 — MOST109-2813-C-037-019-B — 8 大專學生研究計畫
109年度大專學生研究計畫-陳云芷(醫學2)( )
|
2020/07/01 ~ 2021/02/28 |
| 24 |
107 — N 國科會(原科技部) — MOST106-2320-B-037-010-MY3 — 1 個人型
黃芩素及類似物對腹主動脈瘤和粥狀動脈硬化調節粒腺體動態和自噬作用的機轉探討(2/3)( )
|
2018/08/01 ~ 2020/07/31 |
| 25 |
107 — Y 高醫-彰基合作計畫 — 108-CCH-KMU-009 — 1 個人型
探討茶鹼衍生物緩解心臟缺血所產生的心臟細胞凋亡之研究( )
|
2019/01/01 ~ 2019/12/31 |
| 26 |
106 — N 國科會(原科技部) — MOST106-2320-B-037-010-MY3 — 1 個人型
黃芩素及類似物對腹主動脈瘤和粥狀動脈硬化調節粒腺體動態和自噬作用的機轉探討(1/3)( )
|
2017/08/01 ~ 2020/07/31 |
| 27 |
105 — Z 大專學生研究計畫及博士後 — MOST106-2813-C-037-023-B — 8 大專學生研究計畫
106年度大專學生研究計畫-張尹綺(生技3)( )
|
2017/07/01 ~ 2018/02/28 |
| 28 |
104 — N 國科會(原科技部) — NSC102-2320-B-037-028-MY3 — 1 個人型
探討茶鹼衍生物誘導心肌細胞自體吞噬行為之心臟保護機轉(3/3)( )
|
2015/08/01 ~ 2016/07/31 |
| 29 |
104 — TP 頂尖計畫(高醫) — KMU-TP104PR03 —
探討蚶殼草、車桑子和白茅萃取物複方之抗高血壓及心臟保護作用機轉( )
|
2015/11/01 ~ 2016/09/30 |
| 30 |
104 — X 高奇合作計畫 — 105CM-KMU-07 —
探討黃芩素抑制血管收縮素II誘導腹主動脈瘤的分子機轉( )
|
2016/05/01 ~ 2017/04/30 |
| 31 |
103 — N 國科會(原科技部) — NSC102-2320-B-037-028-MY3 — 1 個人型
探討茶鹼衍生物誘導心肌細胞自體吞噬行為之心臟保護機轉(2/3)( )
|
2014/08/01 ~ 2016/07/31 |
| 32 |
103 — X 高奇合作計畫 — 104CMKMU010 —
探討細胞外熱林克蛋白抑制由脂多醣體刺激之巨噬細胞發炎反應的作用機轉( )
|
2015/05/01 ~ 2016/04/30 |
| 33 |
102 — N 國科會(原科技部) — NSC102-2320-B-037-028-MY3 — 1 個人型
探討茶鹼衍生物誘導心肌細胞自體吞噬行為之心臟保護機轉(1/3)( )
|
2013/08/01 ~ 2016/07/31 |
| 34 |
101 — N 國科會(原科技部) — NSC99-2320-B-037-015-MY3 — 1 個人型
探討磷酸二酯酶抑制劑對蝕骨細胞新生作用之分子調控機制(3/3)( )
|
2012/08/01 ~ 2013/07/31 |
| 35 |
100 — N 國科會(原科技部) — NSC99-2320-B-037-015-MY3 — 1 個人型
探討磷酸二酯酶抑制劑對蝕骨細胞新生作用之分子調控機制(2/3)( )
|
2011/08/01 ~ 2013/07/31 |
| 36 |
099 — N 國科會(原科技部) — NSC99-2320-B-037-015-MY3 — 1 個人型
探討磷酸二酯酶抑制劑對蝕骨細胞新生作用之分子調控機制(1/3)( )
|
2010/08/01 ~ 2013/07/31 |
| 37 |
098 — N 國科會(原科技部) — NSC96-2628-B-037-008-MY3 — 1 個人型
探討Rho-kinase抑制劑在心肌梗塞和血管痙攣性心絞痛模式的細胞保護機轉(3/3)( )
|
2009/08/01 ~ 2010/07/31 |
| 38 |
097 — N 國科會(原科技部) — NSC96-2628-B-037-008-MY3 — 1 個人型
探討Rho-kinase抑制劑在心肌梗塞和血管痙攣性心絞痛模式的細胞保護機轉(2/3)( )
|
2008/08/01 ~ 2010/07/31 |
| 39 |
096 — N 國科會(原科技部) — NSC96-2628-B-037-008-MY3 — 1 個人型
探討Rho-kinase抑制劑在心肌梗塞和血管痙攣性心絞痛模式的細胞保護機轉(1/3)( )
|
2007/08/01 ~ 2010/07/31 |
| 40 |
095 — C 中醫藥 — CCMP 96-RD-014 — 1 個人型
三黃瀉心湯對心臟缺血再灌流傷害動物模式之療效評估( )
|
2007/05/01 ~ 2008/04/30 |
| 41 |
095 — N 國科會(原科技部) — NSC95-2320-B-037-041- — 1 個人型
探討第三代呲啶型鈣離子阻斷劑抗氧化低密度脂蛋白引起傷害之防止動脈粥狀硬化作用( )
|
2006/08/01 ~ 2007/07/31 |
| 42 |
094 — N 國科會(原科技部) — NSC94-2320-B-037-042- — 1 個人型
探討呲啶型鈣離子通道阻斷劑抑制血管損傷後內層增生現象之血管保護機轉( )
|
2005/08/01 ~ 2006/07/31 |
| 43 |
093 — N 國科會(原科技部) — NSC93-2320-B-037-036- — 1 個人型
探討呲啶型鈣離子阻斷劑抗內皮細胞氧化傷害之血管保護作用( )
|
2004/08/01 ~ 2005/07/31 |
| 44 |
092 — N 國科會(原科技部) — NSC92-2320-B-037-024- — 1 個人型
第三代呲啶型鈣離子通道阻斷劑在血管平滑肌及內皮細胞之血管保護作用機轉探討( )
|
2003/08/01 ~ 2004/07/31 |
| 45 |
091 — N 國科會(原科技部) — NSC91-2320-B-037-062 — 1 個人型
第三代呲啶型鈣離子通道阻斷劑抗缺血再灌流傷害之分子機轉探討( )
|
2002/08/01 ~ 2003/07/31 |
| 46 |
090 — N 國科會(原科技部) — NSC90-2315-B-037-001 — 1 個人型
探討第三代呲啶型鈣離子通道阻斷劑對心臟缺血再灌流傷害之保護作用(Cardiopective effect of the third generation dihydropy-ridine type calcium chennel blockers on myocardial ischemia/reperfusion in jury)
|
2001/08/01 ~ 2002/07/31 |
| 47 |
089 — N 國科會(原科技部) — NSC 89-2320-B-037-082- — 1 個人型
具鉀通道抑制性質的腎上腺素性受體甲/乙型阻斷劑之藥理探討(Pharmacological approach of novel type alpha/beta-adrenocep-tor blocker with potassium channel blocking properties)
|
2000/08/01 ~ 2001/07/31 |
| 48 |
088 — N 國科會(原科技部) — NSC 89-2320-B-037-003- — 1 個人型
具鉀通道抑制性質的腎上腺素性受體甲/乙型阻斷劑之藥理探討(1/3)(Pharmacological approach of novel type alpha/beta-adrenocep-tor blocker with potassium channel blocking properties)
|
1999/08/01 ~ 2000/07/31 |
| 49 |
087 — N 國科會(原科技部) — NSC88-2314-B-037-010- — 1 個人型
探討新型具有CGRP釋出作用之甲/乙型腎上腺素性受體阻斷劑(Studies on novel alpha- and beta-adrenoceptor blockeer with an associated calcitonin gene-related peptide releasing activity)
|
1998/08/01 ~ 1999/07/31 |
| 50 |
086 — N 國科會(原科技部) — NSC87-2314-B037-098 —
CAPSINOLOL在副交感神經傳入及傳出途徑之藥理特性(Pharmacological characteristics of capsinolol in the parasympathetic afferent and efferent pathways)
|
1997/08/01 ~ 1998/07/31 |
Patent
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| 1 | 茶鹼化合物之抑制骨質疏鬆症活性 | 中華民國 | 2013/06/21 | I399205 |
| 2 | 茶鹼化合物之抑制骨質疏鬆症活性 | 美國 | 2013/08/13 | 8,507,506 |
| 3 | 一種TMD1蛋白質用於製備發炎性骨流失藥物的用途 | 美國 | 2017/10/03 | 9,775,885 |
| 4 | TMD1 蛋白用於治?骨質?失疾病 | 中華民國 | 2019/02/11 | I650135 |